ACS Applied Nano Materials
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2026
·
IF 5.8
Shoulong Wang,Fengmeng Teng,Fengmin Wu,Changlong Li,Hui Zhang,Chunbing Zhang,Dong Zhang
In recent years, the abuse of antibiotics has led to the emergence of numerous drug-resistant bacteria. Given that single antimicrobial materials can hardly achieve satisfactory inhibition against pathogenic bacteria, it is urgent to develop composite antimicrobial materials and strategies. In this work, inorganic piezoelectric ZnO nanoparticles were used as the core, modified to improve hydrophilicity, coated with polyethylene glycol (PEG), and then conjugated with the sonosensitizer chlorin e6 (Ce6) via amide bonds to form ZnO@PEG@Ce6 (ZGC) nanocomposites. The nanocomposites were characterized by Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), cavitation intensity, absorbance, band gap, zeta potential, and particle size analysis. ZGC exhibits an octahedral structure with a uniform particle size distribution, and FTIR verified the stable chemical linkage among components. Synergy between ZnO piezoelectricity and Ce6 sonosensitivity greatly enhances ROS generation and results in superior sonodynamic antimicrobial activity. Gram-negative bacterium Pseudomonas aeruginosa, Gram-positive bacterium Staphylococcus aureus, and Candida albicans were selected as experimental subjects to study the antimicrobial activity and mechanism of the composite material ZGC. The experiment showed that under the action of ultrasound, the inhibition rates of ZGC against P. aeruginosa, S. aureus, and C. albicans were 58.7%, 68.29%, and 94.55%, respectively, which overcomes the disadvantage of the narrow antimicrobial spectrum of traditional sonosensitizers. Scanning Electron Microscope (SEM) images revealed that the synergistic effect of ZGC and ultrasound destroyed the surface structure of pathogenic strains, allowing reactive oxygen species to penetrate and damage the pathogens. ZGC-mediated sonodynamic therapy shows promising applications in chronic infected wound healing and implant-related infections, enabling efficient elimination of drug-resistant bacteria and precise antimicrobial treatment. This study provides insights and theoretical support for the development of broad-spectrum and highly efficient sonodynamic antimicrobial therapy.
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Science Advances
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2026
·Vol. 12
·期 13
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IF 13.9
Jiansong Zhao,Tian Yin,Yaxin Deng,Hongbing Liu,Mingli Wei,Chenxiao Chu,Xinxin Liang,Xiaoshuang Bi,Haibing He,Jingxin Gou,Xing Tang,Yu Zhang
Exosomes, despite their promise as drug carriers for crossing biological barriers, remain underexplored for noninvasive posterior ocular delivery. Here, we demonstrate that semen-derived exosomes (SEVs) penetrate ocular barriers effectively, owing to their epidermal growth factor expression, which mediates reversible tight-junction disruption. SEVs reach the posterior segment via dual corneal and conjunctival routes. Using this, we engineered FA-SEVs@CMG eye drops, where SEVs are modified with folic acid (FA) and loaded with a nanozyme system (CMG) composed of carbon dots, manganese dioxide, and glucose oxidase. This eye drop leverages SEVs’ excellent penetration ability and FA’s targeting effect to enhance drug delivery to retinoblastoma (RB) cells. Internalized CMG induces intense oxidative stress, disrupts the autophagy-apoptosis balance, and triggers RB cell self-destruction. In vivo, FA-SEVs@CMG effectively inhibits RB growth while preserving retinal function. This work establishes the first SEV-based platform for noninvasive posterior segment delivery, offering a transformative strategy for treating posterior ocular diseases.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2026
·Vol. 132
·期 4
·342
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IF 3
Yang Qianpeng,Yuan Xin,Huang Yumin,Luo Qizhao,Wang Jing,Lan Weiyun,Jiang Haifeng
The growing pressure on global energy and freshwater resources necessitates continuous innovation in resource management technologies to ensure long-term sustainability. Solar energy, as a widely accessible and renewable resource, is of strategic importance for sustainable development. This has driven advancements in photothermal membrane distillation (PMD), which integrates interfacial solar conversion with phase-change separation. However, under prolonged exposure to hypersaline feed solutions, solute accumulation at the thermal interface of hydrophobic membranes often leads to crystalline deposition within micropores. This results in irreversible membrane fouling and a severe decline in permeate flux stability. Aimed at resolving this issue, a highly salt-resistant PTFE/PEGDA/graphene hydrogel composite membrane was developed. In this design, a PEGDA hydrogel forms a hydrophilic cross-linked polymer network that reduces membrane surface adhesion to salt crystals. The incorporation of graphene further inhibits crystal adhesion on the inner pore walls and mitigates excessive local concentration, thereby enhancing resistance to salt crystallization. The water production performance of this composite membrane was evaluated under varying light intensities. In low-concentration brine, water production increased by nearly 35%. The enhancement was even more pronounced at higher salinities, with a production increase of nearly 74%, the water production rate reached 2.08 kg·m −2 ·h −1 . The membrane distillation system maintained strong salt resistance over 3 h of operation, and the desalination rate of the produced water exceeded 99.9%. These results demonstrate that the PTFE/PEGDA/graphene hydrogel composite membrane significantly improves membrane surface resistance to salt crystallization, thereby greatly enhancing system stability and efficiency in high-salinity environments.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·303
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IF 38.5
Zhu Huang,Wang Ting,Gao Shihuan,Geng Wei,Ma Tian,Cheng Liang,Han Xianglong,Deng Jiuhong,Gao Shanshan,Cheng Chong
The phage-inspired de novo design of the artificial peroxidase (IrNC@TiO 2 ) features robust subnanometer cluster sites and a sea-urchin-like topography.
The potent enzymatic activity of Ir clusterzymes and the topological advantages of the spiky substrate endow IrNC@TiO 2 with the ability to effectively capture and eradicate planktonic Streptococcus mutans while inhibiting biofilm formation.
IrNC@TiO 2 can significantly inhibit tooth-surface biofilm development, prevent enamel demineralization, and reduce caries incidence in anticaries experiments
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HYDROMETALLURGY
·
2026
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IF 6.3
Yangxiang Huang,Mengyao Chen,Lixin Xue,Hangqing Xue,Juexin Wang,Fei Huang,Congjie Gao
To simultaneously increase the Mg 2+ /Li + separating performance under high Mg 2+ /Li + ratios of polyethylene/polyamide (PE/PA) thin film composite (TFC) nanofiltration (NF) membranes, 1,4,7,10-tetraazacyclododecane (Cyclen) was added in the aqueous phase with polyethyleneimine (PEI) monomer. During reverse interface polymerization (RIP) on polyethylene (PE) substrates, phthaloyl chloride (PC) was added to the organic phase with terephthaloyl chloride (TPC) monomer. It was found that the addition of Cyclen and/or PC could both increase the hydrophilicity, surface roughness and average pore sizes of formed virgin PE/PA TFC NF membranes, leading to increased water permeability. The Li + /Mg 2+ separating factor S Li/Mg first increased and then decreased with maximum points at the TPC/PC ratio of 5:1 and Cyclen addition level of 0.02 wt%. Cation absorption, especially Mg(II)-Cyclen interactions in the PA layers under higher Mg 2+ /Li + ratio led to increased surface Zeta potential, decreased average pore diameters μ p, and greatly increased Li + /Mg 2+ separating factor (S Li/Mg ). S Li/Mg value of PEI-TPC/PC 5:1 -Cyclen 0.02 membranes could be increased from 5.0 to 55.47, keeping the water permeability around 6.5 L m −2 h −1 bar −1 when Mg 2+ /Li + ratio increased from 1 to 100 in the brine.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Ruofei Li,Hao Zhou,Jing Yao,Tiefeng Xu,Gangqiang Wang,Wangyang Lu
The conversion of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) via aerobic oxidation is a crucial step toward transforming biomass into sustainable bio-based energy materials. In this study, a mesoporous Au-CoO x /m-CeO 2 catalyst was prepared using vacuum-assisted in situ self-assembly to realise this conversion. The well-defined mesostructure, as confirmed by transmission electron microscopy and nitrogen adsorption–desorption analyses, significantly enhanced active site accessibility and facilitated reactant diffusion, thereby accelerating the selective oxidation of HMF to produce FDCA. This catalytic system achieved complete conversion of HMF and an FDCA yield of 99.89 ( ± 0.03)% under ambient pressure at 90 °C. Using Au/m-CeO 2 or Au-CoO x /CeO 2 as catalysts under identical conditions, the FDCA yields were limited to 56.8 ( ± 1.9)% and 78.1 ( ± 0.8)%, respectively. The optimal catalyst also demonstrated outstanding durability, retaining 93.9 ( ± 0.7)% FDCA yield after 18 reuse cycles. This remarkable activity was attributed to the integrated Au-CoO x /m-CeO 2 architecture, wherein a synergistic metal–oxide interaction coupled with the ordered mesoporous CeO 2 framework collectively optimised the reaction–diffusion process, driving efficient HMF oxidation. This study therefore provides a new perspective for designing efficient catalysts for the conversion of HMF to FDCA, which is conducive to the conversion of biomass resources.
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GREEN CHEMISTRY
·
2026
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IF 10.6
Runfeng Zhang,Yan Zhang,Zongmao Lv,Hai Yu,Xuejing Zheng,Keyong Tang,Jie Liu
The development of high-performance conductive hydrogels through green and sustainable strategies remains a pivotal challenge in flexible electronics. Conventional methods often rely on toxic crosslinkers, energy-intensive processes, or excessive metal ions, limiting their environmental compatibility and scalability. Furthermore, susceptibility to freezing at sub-zero temperatures poses a major obstacle for their use in extreme climates, typically addressed by organic antifreezes that compromise mechanical integrity. Herein, we report a green and efficient strategy for fabricating a multifunctional polyacrylamide/polyvinyl alcohol/CaCl₂/AgNPs/proanthocyanidins/MXene (PPCAPM) composite hydrogel using natural proanthocyanidins (PA) as a multifunctional green mediator. Molecular dynamics simulations reveal that PA enhances interlayer electrostatic repulsion between MXene nanosheets, effectively suppressing van der Waals-driven restacking and increasing the diffusion coefficient by 48%. Notably, PA and MXene synergistically catalyze the in-situ reduction of AgNPs at ultralow Ag⁺ concentrations, avoiding the use of conventional toxic reductants. Crucially, the incorporation of CaCl₂ serves as a green and potent antifreeze, enabling exceptional cryoresistance (-40 °C) by significantly lowing the freezing-point of the solution, thereby eliminating the need for environmentally harmful organic antifreeze agents. The resulting hydrogel exhibits autonomous moisture retention, high conductivity (1.84 S/m), excellent impact factor (GF=3.73), and intrinsic adhesion, enabling high-fidelity monitoring of both large-scale joint movements and subtle physiological signals such as EMG and ECG. This work demonstrates a green and sustainable paradigm for designing multifunctional hydrogel sensors via natural polyphenol-mediated interfacial engineering and ion-regulated antifreezing, offering a promising platform for nextgeneration wearable diagnostics and human-machine interfaces operable under harsh conditions.
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MEDIATORS OF INFLAMMATION
·
2026
·Vol. 2026
·期 1
·8826129
·
IF 4.9
Ying Gong,Zi-Hua Xuan,Yue Dong,Chun-Bin Zhang,Yu-Chen Liu,Jin-Hui Zhang,Qing Li,Cong-Bin Liu,Dong-Mei Xie
Objective This study investigates the therapeutic effects of Zengwei Chengqi Decoction (ZW) on acute intestinal obstruction (AIO), focusing on its ability to alleviate inflammation and reduce associated tissue damage. Network pharmacology and experimental animal models were used to explore the mechanisms of action. Methods Using network pharmacology, we identified 228 active compounds in ZW and 420 corresponding targets linked to inflammation. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to identify the biological pathways influenced by ZW. In vivo, an SD rat model of AIO was induced, and the therapeutic effects of ZW were assessed by histological examination of tissue damage and serum cytokine levels. Results Treatment with ZW significantly mitigated tissue damage in AIO rats. Additionally, serum levels of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, were substantially reduced in the ZW-treated group compared to the control group ( p < 0.01). Conclusion ZW shows strong potential for modulating inflammation in AIO, as evidenced by reduced cytokine levels and improved tissue integrity. These findings provide valuable insights into the mechanisms underlying its therapeutic effects, positioning ZW as a promising treatment for AIO.
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Advanced Science
·
2026
·
IF 14.1
Lan Liu,Han-Zhe Liu,Zhe-Nan Liu,Tong Wang,Li-Li Yu,Qiu-Jing Li,Zi-Yi Chen,Guo-Feng Luo,Zheng-Jun Shang
Tumor-associated bone invasion often occurs in aggressive tumors and strongly compromises the efficacy of tumor treatment, which makes it challenging for comprehensive tumor therapy, highlighting the importance of simultaneous tumor elimination and tumor-associated osteolysis restoration. To achieve this goal, this study reports a versatile nanohybrid (CaO 2 @CuMOF@HAP) synthesized by coating bimetallic nanoclusters (CaO 2 @CuMOF) with osteogenic growth peptide (OGP)-modified hyaluronic acid (HAP) for high-performance oncotherapy. On-demand sequential release is realized in specific tumor environments, where OGP can be released into matrix metalloproteinase-9 (MMP9)-enriched tumor extracellular space through cleavage of the MMP9-responsive linker between OGP and HA, and dual ions (Cu 2+ and Ca 2+ ) are liberated via pH-triggered decomposition of the nanohybrid following tumor cell internalization. On the basis of this, small-sized OGP could penetrate into deep-seated, tumor-involved, bone areas for promoting effective osteogenesis, while the excessive ions in targeted tumor cells synergistically disrupted intracellular ion homeostasis for effective metal ion interference therapy. Having killed tumor cells and promoted osteogenesis, CaO 2 @CuMOF@HAP exhibited highly efficient antitumor effects on an orthotopic oral squamous cell carcinoma tumor-bearing mouse model with mandibular bone invasion. Without cytotoxic drugs, this nanohybrid circumvents drug resistance and nonspecific toxicity, offering excellent biocompatibility and high antitumor efficiency for clinical application.
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CANCER SCIENCE
·
2026
·
IF 4.9
Xinyu Xu,Jiayuan Wang,Meng Jiang,Ling Ouyang
Ovarian cancer is one of the most prevalent gynecologic malignancies worldwide. Dysregulated cell proliferation and angiogenesis are well-recognized to be involved in the pathogenesis of ovarian cancer. Nucleolar Protein 7 (NOL7), a novel RNA-binding protein, has been identified as a tumor suppressor and a key anti-angiogenetic factor. However, the function of NOL7 and its underlying molecular mechanisms in ovarian cancer remain unclear. In this study, we demonstrated that NOL7 expression was down-regulated in ovarian cancer tissues, and low NOL7 expression was associated with poorer prognosis in patients with ovarian cancer. Overexpression of NOL7 decreased cell viability, inhibited cell cycle entry and proliferation, and promoted apoptosis in OVCAR-3 and SKOV-3 cells. Additionally, NOL7 overexpression decreased VEGF-A level, increased TSP-1, and suppressed angiogenesis of human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of NOL7 in ovarian cancer cells enhanced cell proliferation and angiogenesis, while reducing apoptosis. In vivo experiments further confirmed that NOL7 overexpression inhibited tumor growth and angiogenesis. Mechanistic studies revealed that NOL7 could bind to the 3′UTR of growth arrest and DNA damage inducible alpha (GADD45A), and overexpression of NOL7 up-regulated GADD45A expression by stabilizing GADD45A mRNA in ovarian cancer cells. The anti-cancer effects of the NOL7/GADD45A were mediated by inhibiting the phosphorylation of STAT3 at Ser727. Collectively, our findings indicate that NOL7 functions as a tumor suppressor in ovarian cancer and provide a novel therapeutic target for the treatment of ovarian cancer.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2026
·Vol. 34
·期 4
·80
·
IF 5.6
Zhou Xiaorui,Yang Ying,Lv Chang,Cheng Xinru,Hao Wenbo,Su Tingting,Huang Chenhao,Hu Bing
To adjust and optimize the structure and characteristics of biodegradable poly (butylene succinate) (PBS)-type polyesters, seven aliphatic polyesters with different chain lengths were synthesized by introducing azelaic acid. It can be finded that the melting points of the six polyesters gradually rise with increasing carbon chain length, with the exception of poly(propylene azelate) (PPAz). The XRD analysis reveals that the odd–even effect exerts a certain influence on the diffraction peaks. Specifically, the diffraction angles of odd-odd carbon polyesters demonstrate a systematic shift in comparison to those of odd–even carbon polyesters. Except for PPAz and poly(hexylene azelate) (PHAz), the hydrophilicity of the polyesters decreases with increasing chain length, with PHAz being the most hydrophilic polyester. The thermal decomposition temperatures of the seven polyesters exceed 315.0 °C, indicating good thermal stability. Among them, poly(decylene azelate) (PDAz) exhibits the highest thermal decomposition temperature, reaching as high as 358.1 °C. Enzyme hydrolysis studies show that poly(pentylene azelate) (PPeAz) has the best biodegradability, with the polyester experiencing 100% weight loss after 12 h of enzymatic degradation. Graphical
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Surfaces and Interfaces
·
2026
·
IF 6
Xingtong Yan,Yue Li,Qianhong Shen,Hui Yang
To overcome the challenges of agglomeration and the difficulty in achieving oriented alignment of hexagonal boron nitride nanosheets (BNNSs) in epoxy matrices, a magnetically responsive Fe 3 O 4 /BNNSs composite was successfully prepared. Fe 3 O 4 nanoparticles grown in situ on the BNNS surface impart magnetic responsiveness to the nanosheets, enabling their alignment under an external magnetic field, while the BNNSs themselves serve as the primary impermeable barrier filler. By applying a horizontal magnetic field during the curing stage, the nanofillers are driven to align parallel to the substrate, forming an ordered layered structure. Comprehensive characterization confirmed the in-situ growth of Fe 3 O 4 nanoparticles on the BNNS surface and demonstrated the composite’s strong superparamagnetic behavior. Performance evaluation revealed that the epoxy coating containing magnetically aligned Fe 3 O 4 /BNNS fillers (BFM/EP) exhibited the most superior overall properties. After 20 days of immersion in deionized water, the BFM/EP coating displayed a remarkably low water absorption of only 6.48%, compared with 19.28% for the pure epoxy coating, indicating significantly enhanced anti-permeability. Benefiting from the improved barrier performance, the BFM/EP coating also retained the highest adhesion after 14 days of salt-spray exposure. Long-term electrochemical impedance spectroscopy (EIS) over 40 days further demonstrated that BFM/EP exhibited the highest coating resistance (1.93 × 10 8 Ω·cm 2 ), the lowest coating capacitance (1.99 × 10 -10 F·cm 2 ), and the largest low-frequency impedance modulus (1.69 × 10 10 Ω·cm 2 ). These results indicate that the dominant enhancement in corrosion protection originates from the magnetic-field-induced parallel alignment of high-aspect-ratio BNNSs, while Fe 3 O 4 functionalization mainly enables magnetic manipulation and contributes to improved filler dispersion. The resulting ordered filler network effectively enhances the tortuous diffusion pathway for corrosive species, leading to superior impermeability and long-lasting corrosion protection.
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