POULTRY SCIENCE
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2025
·
IF 4.2
Yawen Sun,Guangxiao Zhang,Bowen Zhao,Chenxue Fu,Bin Li,Fang Wang,Ming Tian,Minghui Wang,Hai Lin,Haifang Li
Laying hens are prolific egg producers, and the nutrient composition of breeder eggs critically influences the growth and development of offspring chicks. This study investigated the long-term effects of in ovo vitamin D3 injection (IOI-VD3) on bone development in chicks hatched from eggs laid during the late laying stage (68 weeks old, termed eggs-late). Compared to eggs from the peak laying period (44 weeks old, eggs-peak), eggs-late exhibited significantly lower phosphorus (↓7%, P =0.077) and vitamin D3 (↓26.9%, P <0.001). Consequently, chicks from eggs-late demonstrated inferior bone development at both 1 day (lower leg bone weight by 18%, P <0.05) and 4 weeks (reduced bone mineral content by 10%; P <0.05) of age relative to eggs-peak chicks. Notably, IOI-VD3 efficiently improved embryonic and long-term bone growth in late-egg-derived chicks, increasing bone mass by 14% and accelerating growth rate by 10% ( P <0.05). Further in vivo and in vitro analyses revealed that vitamin D3 promoted bone development by activating osteogenesis-related genes ( P <0.05) and suppressing osteoclastogenic markers ( P <0.05), with the vitamin D receptor (VDR) mediating these effects. Chromatin immunoprecipitation (ChIP) assays confirmed that 1,25-(OH)2D3 strengthened VDR binding to promoter regions of RANKL ( P =0.016) and RUNX2 ( P =0.031). In conclusion, this study highlights the disparity in egg quality between late and peak laying periods and its impact on chick bone development. IOI-VD3 ameliorated bone deficits in eggs-late chicks via VDR-dependent mechanisms.
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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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2025
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IF 3
Jianbin Xiong,Jian Song,Xing Jiang,Zhuanzhuan Huang,Yijie Zhang
Chronic pancreatitis (CP) is a progressive inflammatory disorder with no effective treatment, which underscores the urgent need for novel therapeutic strategies. In this study, single-cell sequencing data retrieved from the Gene Expression Omnibus (GEO) database revealed that Prkcq and IL-4 were highly induced in group 2 innate lymphoid cells (ILC2s), while Mitf and Tgm2 were highly expressed in tissue-resident macrophages (TRMs). A mouse model of CP was established using dibutyltin dichloride (DBTC), and pathological evaluations via H&E, Masson, and Sirius Red staining confirmed typical features of CP, including acinar atrophy, inflammatory cell infiltration, and increased fibrosis. Notably, the numbers of ILC2s and TRMs in pancreatic tissues were significantly elevated in DBTC-treated mice. Functional experiments showed that the Prkcq knockdown in ILC2s suppressed the expression of IL-4, IL-5 and IL-13, while in TRMs, the transcription factor Mitf upregulated Tgm2 expression. In CP mice, Prkcq knockdown reduced TRM abundance, ultimately alleviating pancreatic fibrosis. Collectively, this study identifies Prkcq as a key regulator of CP by modulating TRM populations.
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Advanced Powder Materials
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2025
·
IF 24.9
Jin Liang,Siying Zhu,Dewei Chen,Yinjun Li,Dong Zhou,Nan Meng,Yaozu Liao,Hanxu Sun,Jie Kong
Built-in electric fields (BIEF), engineered via space charge manipulation, represent an effective strategy for enhance electromagnetic loss. However, single BIEF fail to reconcile the impedance matching and strong electromagnetic attenuation across broad frequency spectra, resulting in limited effective absorption bandwidth (EAB). To address this, dual-BIEF are constructed utilizing an asymmetric gradient electric field structure and multi-polarization center coordination to achieve high-efficiency broad EAB. Herein, heterostructure Ni-Co bimetallic nanocomposites (Ni 0.5 Co 0.5 @NiCoO 2 /NCP) are constructed via Ni-Co-based nanocomposites (NiCoO 2 and Ni 0.5 Co 0.5 ) integrated with nitrogen-doped nanoporous carbon (NCP). This configuration forms dual heterojunctions the NCP-NiCoO 2 -semiconductor heterojunction and the NiCoO 2 -Ni 0.5 Co 0.5 Mott-Schottky heterojunction—forming the dual-BIEF system. The superposed dual-BIEF drives charge-pumping dynamics facilitating oriented transfer and transition of charges that strengthen interfacial polarization and reduced relaxation times. Theoretical calculations confirm this system simultaneously modulates conductivity, intensifies polarization relaxation, promotes charge separation, and optimizes dipole distribution. Dielectric loss from semiconductor junctions dominates the low-frequency regime, while conductive loss via Mott-Schottky junctions prevails at high frequencies. Thus, the Ni 0.5 Co 0.5 @NiCoO 2 /NCP achieves excellent microwave absorption with a remarkable minimum reflection loss of -51.5 dB, and an EAB of 6.4 GHz at 2.8 mm thickness. This work establishes a dual-BIEF strategy for effectively engineering high-performance electromagnetic wave absorption materials.
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Small Structures
·
2025
·
IF 11.3
Zhipeng Hu,Houxin Fan,Yuwei Sun,Zhenchao Liu,Yi Jin,Sailing He
Recent advances in titanium oxide (TiO 2 ) nanophotonics have highlighted this material's exceptional potential for low-loss visible and near-infrared photonic applications, yet challenges in microstructuring have hindered its broader adoption. Herein, a transformative approach for creating subwavelength TiO 2 structures through controlled thermal oxidation of titanium (Ti) is demonstrated. Spectroscopic characterization confirms that the oxide product exhibits excellent behavior, closely resembling that of natural TiO 2 , and the geometrical extension of the subwavelength structures during the oxidation can be precisely predicable following some found rules. As a demonstration, a metasurface consisting of a periodic array of slitted TiO 2 disks supporting a quasi-bound state in the continuum to enhance fluorescence is designed and fabricated, and the experimental result is well consistent with the theoretical prediction. It is striking that the width of the slits may be reduced below 10 nm, difficult for conventional top-down fabrication methods, and the quality factor of the resonant metasurface can reach the level of 1000. This oxidation-mediated nanofabrication strategy is valuable for forming sub-10 nm gaps and establishes a potential pathway for large-scale, cost-effective production of subwavelength TiO 2 devices.
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JOURNAL OF APPLIED TOXICOLOGY
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2025
·
IF 2.8
Kai Wang,Aneela Perveen,Jiakun Shen,Niaz Ali Kaka,Yansen Li,Dan Shen,Chunmei Li
T-2 mycotoxin is a highly toxic type A trichothecene mycotoxin that widely contaminates livestock feed, posing a serious threat to animal and human health. Long-term exposure can lead to immunosuppression, growth retardation, and liver damage, causing significant economic losses to the livestock industry. Offspring are particularly susceptible to maternal dietary influences during pregnancy and lactation. This research aimed to evaluate the impact of T-2 mycotoxin exposure on both dams and their pups. Thirty pregnant mice were randomly allocated into three groups ( n = 10). From gestational day 14 to lactational day 21, the dams received gavage doses of T-2 mycotoxin at concentrations of 0, 0.005, and 0.05 mg/kg/day. Randomly selected one male pup and one female pup from each dam were sacrificed on LD 1, 7, and 21; dams were dosed until the day they were sacrificed. T-2 mycotoxin decreased the relative body/organ weights of the dams and offspring ( p < 0.05). Moreover, T-2 mycotoxin-induced oxidative stress in dams and offspring increased the malondialdehyde content, which led to reduced activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase, and total antioxidant capacity in the serum and liver ( p < 0.05). T-2 mycotoxin induced histomorphological changes in the liver and early involution of the mammary gland acini in dams. The concentrations of liver-metabolizing enzymes such as glutamic oxaloacetic transaminase and glutamic pyruvic transaminase increased in offspring ( p < 0.05). The serum insulin-like growth factor-1 level in offspring was decreased, which may impair the development of vital organs such as the liver, kidneys, and spleen in offspring. Consequently, the body weight and length of the offspring of exposed dams decreased. This study revealed that T-2 mycotoxin exposure during late gestation and entire lactation harms dams, damages mammary gland acini, alters liver biochemistry, induces oxidative stress, and delays offspring growth while also impairing maternal weight gain during lactation.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Lei Zhang,Xinyu Liu,Jinghan Li,Yanhong Zhu,Yufan Xiao,Jianqiang Zhang,Yang He
In alpine meadow regions, macropore flow is a critical but inadequately understood pathway for antibiotic transport. The complex relationship between macropore structure, flow dynamics, and solute properties presents a significant research gap. Methodological limitations hinder the accurate characterization of solute migration mechanisms due to complex macropore structures. This study investigated sulfadiazine (SD) and florfenicol (FF) migration behaviors in alpine meadow soil using leaching experiments in soil columns with artificially constructed macropores. Findings reveal that while greater macropore flow intensity (> 1.75 cm/h) and connectivity accelerate solute transport, the effect is not linear. A fundamental shift in transport control occurs with changing macropore flow intensity. At lower velocities, solute mobility is primarily controlled by adsorption reactivity, particularly for the strongly reactive SD. Conversely, at high velocities, hydrodynamic dispersion becomes the dominant factor governing the transport. Moderate dispersion (1.7–1.8 cm 2 /h) optimizes retention by increasing adsorption opportunities, while high dispersion (3.06 cm 2 /h) accelerates solute transport and reduces retention. This causes the transport of the strongly reactive SD to become dispersion-driven, significantly narrowing the behavioral differences between it and the weakly reactive FF. This highlights that under certain hydraulic conditions, physical transport processes can override chemical properties in controlling contaminant fate.
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Gels
·
2025
·Vol. 11
·期 8
·623
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IF 5.3
Yu Wang,Fan Zhang,Liangbin Dou,Yutong Li,Kaiwen Wang,Zhengli Shi,Leyao Du,Wangyuan Zhang,Zonglun Wang
To address the issue of drilling fluid performance drop and wellbore instability induced by desorption between treatment agents and clay in the high-temperature environment of ultra-deep drilling, this study synthesized three organosilicon polymers (ADE, ADM, ADD) with different substituents. The study confirmed that the covalent bond significantly improved the high-temperature adsorption resistance of clay, which is closely related to the interface behavior of gels. Through rolling recovery, rheology, and filtration experiments for performance evaluation, these organic silicon polymers showed excellent high-temperature performance: the shale rolling recovery rate exceeded 80% at 210 °C, and the filtration loss was reduced to 14 mL, with a reduction rate of 53.3%. The adsorption capacity of the three polymers on clay remained unchanged from 150 °C to 210 °C, among which the adsorption amount of trimethoxy groups stabilized at 8–11 mg/g after 150 °C. The adsorption capacity of ethoxy groups increased by 7.9% at 150–210 °C. The adsorption capacity of dimethoxy groups with methyl steric hindrance increased by 28.1% at 150–210 °C. These results indicate that covalent bonds effectively enhance the high-temperature adsorption of clay, allowing for polymer molecules to firmly anchor on the clay surface at high temperatures. This breakthrough overcomes the limitations of traditional inhibitors in high-temperature desorption, and provides a valuable reference for the preparation of high-temperature adsorption resistant functional materials in water-based drilling fluid gel systems.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Siyao Zhang,Chen Song,Zengguang Ji,Zhihao Liu,Jinlong Gao,Guixin Lv,Guohua Zhang,Yan Jiang,Yuanna Sun
The increasing demand for durable and high-performance energy storage systems, particularly for flexible and extreme-environment applications, drives innovation in solid-state electrolytes. Zinc-air batteries (ZABs) offer high energy density and intrinsic safety yet suffer from zinc dendrite growth and interfacial degradation in alkaline environments. Zinc dendrite growth remains a critical barrier for zinc-air batteries. Herein, we develop a double-network hydrogel electrolyte integrating bacterial cellulose (BC)-reinforced polyacrylamide (PAM) for mechanical robustness and quaternized Poly[3-(Methacryloylamino) propyl] trimethylammonium chloride (PMPTC) for ion conduction. The BC nanofibers form a percolating hydrogen-bond network that enables efficient proton hopping (Grotthuss mechanism), while the quaternary ammonium groups of PMPTC create continuous hydrophilic channels for vehicular ion transport. This unique combination enables synergistic Vehicular-Grotthuss conduction, achieving ultra-high ionic conductivity of 269.47 mS·cm −1 . Additionally, the polarized functional groups in both components help guide zincate ions (Zn (OH) 4 2− ) toward stable (002) plane deposition, effectively suppressing dendrite formation in ZABs. This design achieves exceptional water retention and enables ZABs operating over a wide temperature range. They exhibit a peak power density of 89.76 mW·cm −2 at room temperature, along with extended cycling stability. Multi-scale simulations confirm homogenized ion flux for uniform plating. This work establishes a paradigm for dendrite-suppressed, temperature-resilient zinc-air batteries.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Sifan Bao,Xudong Zheng,Zihuai Xu,Zhouzhou Yang,Wei Sun,Jinfeng Mei,Jian Rong,Zhongyu Li
Carbon aerogel is limited in its application in CO 2 capture due to its poor surface properties. Heteroatom doping is conducive to the adsorption of CO 2 by biochar. Therefore, by in-situ synthesis of nitrogen-doped carbon nanotubes on BC, Ni/N co-doped cellulose carbon aerogel was synthesized, and the results showed excellent adsorption capacity and reversible adsorption/desorption properties. The synthesis of nitrogen-doped carbon nanotubes made the material realize N doping and provided more adsorption sites for CO 2 adsorption. When Ni is dispersed in the material, it not only increases the carbon dioxide adsorption sites but also enhances the thermal stability and cycling performance of the composite material. Meanwhile, the coordination effect between nickel and nitrogen further enhances the capture capacity of carbon dioxide. Ultimately, the adsorption capacity of the modified biochar reached 4.89 mmol/g, and it also has good recycling performance. The unique co-doping design strategy reduces the dependence of traditional carbon materials on surface area when adsorbing CO 2 , providing a new direction for the modification of carbon materials.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-19
·
IF 15.7
Shen Xuecheng,Qiao Wenxuan,Yan Wei,Xie Hao,Zhang Chenyang,Sun Yang,Luo Qiong,Xu Qiang
IL-17 signaling contributes to the pathogenesis of psoriasis; however, IL-17 involvement in keratinocyte hyperactivation of epidermis remains unclear. Here, we describe an IL-17A-induced, skin-specific, positive feedback loop, which operates independently of canonical chemokine production, thus untangling skin inflammation and epithelial hyperproliferation in psoriasis. We show that IL-17A-induced, keratinocyte-specific KLK8 interacts with IL-17R to promote histone H4 lysine lactylation (H4K12la) catalyzed by the acetyltransferase HAT1. H4K12la further promotes IL-17A-mediated keratinocyte proliferation and the expression of KLK8 and IL-17R, creating a feedback loop that drives psoriasis progression. Importantly, excessive lactate in the microenvironment exacerbates H4K12la and psoriasis severity, thereby impairing the efficacy of anti-IL-17A antibody. Silencing KLK8, HAT1, or inhibiting lactate accumulation attenuates psoriasis in mice. Moreover, combining lactylation inhibition with anti-IL-17A therapy exhibits synergistic effects against antibody-resistant psoriasis. Thus, our findings unveil a lactylation-driven, keratinocyte-specific IL-17A signaling and offer a promising approach for psoriasis treatment, particularly in patients with comorbid metabolic syndrome.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Huifang Zhao,Xiunan Xu,Mi Shi,Yi Chen,Bowei Guan,Fujuan Peng,Jinze Li,Yuanyuan Zhao,Lu Zhang,Ruiping Zhang
Spatial lipidomics analysis of three-dimensional (3D) tumor cell spheroids enables in-situ investigation of metabolic reprogramming across distinct regions cellular regions within a single spheroid. However, it is still a challenge to study the effect of 5-fluorouracil (5-FU) with 3D HepG2 spheroid on the alteration of abundance and spatial distribution of endogenous lipid species. Herein, we systematically optimized the matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) methodologies for extending spatial lipidomics to in-situ screening and visualizing lipid changes in 3D HepG2 spheroids treated with 5-FU at the microregional level. The embedding protocols in carboxymethyl cellulose (CMC), gelatin, and optimal cutting temperature (OCT) compound of 3D HepG2 spheroid were evaluated for MALDI MSI analysis with 10 μm spatial resolution, respectively. Subsequently, CMC embedding of 3D HepG2 spheroid completely preserved the 3D spatial structure and enabled the division into the core necrotic area, intermediate quiescent area, and outer proliferative area from the spatial lipidic ion spectra. Furthermore, we spatially screened and identified 35, 40, and 30 distinct lipid molecules associated with 5-FU treatment in the 3D HepG2 spheroid of necrotic, quiescent, and proliferative areas, respectively. The main dysregulated metabolic pathway was the biosynthesis of glycerophospholipid metabolism, providing the reliable evidence for the mechanism of 5-FU anticancer effect on hepatocellular carcinoma (HCC). In addition, the spatial lipidomic results demonstrated that PA, PC, PG, PI, and SM contents in 5-FU treated tumor spheroids were significantly changed and limited the formation of the central necrotic area. This innovative combination of MALDI MSI with 3D HepG2 spheroids can be conducive to our better understanding of the biological processes between 5-FU triggered lipid metabolism and HCC heterogeneous structure.
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APPLIED CATALYSIS A-GENERAL
·
2025
·
IF 4.8
Hongying Sha,Yuxuan Feng,Jingbo Mao,Hui Lv,Jinxia Zhou
The hydrodeoxygenation of lignin-derived syringol to phenol faces challenges in selectively cleaving C Aryl –O bonds while maintaining aromatic ring and a phenolic -OH group integrity. Herein, we developed a trimetallic CoFeAg/SiO 2 catalyst that achieves 100 % syringol conversion and 52.4 % phenol selectivity, surpassing bimetallic CoAg/SiO 2 (42.2 mol%) and monometallic Co/SiO 2 (7.6 mol%) catalysts. As promoters, Ag facilitates the low-temperature reduction of Co 3 O 4 to CoO and further to metallic Co, while Fe prevents excessive reduction of CoO to metallic Co. Through the synergistic effects of Fe and Ag on Co, the CoFeAg/SiO 2 catalyst undergoes in situ reduction under reaction conditions (1 MPa H 2 , 330 °C), forming a polycrystalline CoO-Co structure with abundant oxygen vacancy (O ᴠ ) and Lewis acid sites. The CoO-Co-O v active sites facilitate heterolytic H 2 cleavage while preferentially adsorbing and activating oxygen-containing functional groups over the aromatic ring of syringol. This dual functionality selectively promotes C Aryl –O bond dissociation while suppressing undesired ring hydrogenation, providing an effective catalyst design strategy for sustainable phenol production from biomass-derived syringol.
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危险品化学品经营许可证（带存储）