JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Yunfan Li,Kaiwen Bao,Renzheng Huan,Tian Wang,Ya Wang,Shuai Wu,Xin Chen,Jiashang Huang,Li Zhu,Jianshu Li,Haifeng Yang,Wei Wu
Glioblastoma (GBM) is one of the most aggressive malignancies of the central nervous system. Gemcitabine (GEM), a pyrimidine analogue with broad-spectrum anticancer activity, can activate the cGAS-STING pathway and alleviate the immunosuppressive microenvironment of GBM. However, its clinical application is hampered by the formidable challenge of crossing the blood-brain barrier (BBB) and accumulating at the tumor lesion. Herein, a dual-responsive biomimetic nanoprodrug (RMM@GEM NPs) was exploited to enhance the efficient BBB penetration and target cargo delivery by functionalization of glioblastoma cell membranes (MM) camouflaging and further targeting peptide RAP modification. After its selective accumulation at glioma lesion, RMM@GEM NPs accelerates GEM release under the tumor pathological stimuli of reactive oxygen species (ROS) and acidic microenvironment to robustly activate the STING signaling cascades (increased p-STING, p-TBK1, p-IRF3, and p-NF-κB). Simultaneously, cyclodextrin-mediated cholesterol depletion further suppresses PD-L1 expression and alleviates T-cell exhaustion. These findings highlight RMM@GEM NPs as a promising strategy to enhance immune responses in “cold” tumor, providing a potential candidate for efficient and safe immunotherapy in GBM.
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高影响因子
Journal of Materials Chemistry A
·
2026
·
IF 9.2
Jiao Yang,Lishan Peng,Youpeng Cao,Lun Li,Zhichao Yu,Chengcheng Zhong,Wendi Zhang,Weng Fai Ip,Hui Pan
The precise construction of highly dispersed monometallic composites with abundant grain boundaries, beyond conventional gradient or core–shell structures, remains a key challenge. Herein, we report a chlorine-mediated strategy to achieve monometallic Ru–RuO2 featuring a high density of well-defined heterointerfaces. By leveraging the distinct binding energies of Ru–O and Ru–Cl, a controlled in situ reduction process selectively converts Cl-occupied regions in a RuOCl precursor into metallic Ru domains, yielding an intimately interwoven Ru/RuO2 heterostructure. This unique architecture provides a high density of interfacial active sites, leading to exceptional pH-universal hydrogen evolution reaction (HER) performance. The optimized Ru/RuO2 catalyst achieves remarkably low overpotentials of 22, 54, and 26 mV at 10 mA cm−2 in 1 M KOH, 1 M phosphate buffer solution (PBS), and 0.5 M H2SO4, respectively, surpassing commercial Pt/C. Density-functional-theory (DFT) calculations illustrated that the remarkable HER activity stems from synergistic metal–oxide interactions: RuO2 promotes efficient water dissociation, while adjacent metallic Ru sites optimize hydrogen adsorption, collectively accelerating the HER kinetics. This work provides a general design strategy for constructing high-performance heterointerface-enriched electrocatalysts.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2026
·Vol. 37
·期 1
·42
·
IF 4.7
Xiaomei Ye,Shuzhen Lu,Hao Peng,Zhirong Huang,Chunyu Pan,Yayan Huang,Kangrui Yuan,Youfa Qin
Mesoporous metal-organic frameworks (MOFs) have the advantages of high specific surface area, tunable pore size, and favorable biocompatibility, making them promising candidates for drug delivery in cancer therapy. In this study, a series of mesoporous zinc-based MOF, constructed using cyclopentane dicarboxylic acid as the organic linker, was successfully synthesized via a surfactant-assisted solvothermal method. Surface characterization revealed that MOF-2 exhibited high surface area (1325 m 2 /g), pore volume (0.273 cm 3 /g), and average pore diameter (5.69 nm). UV-Vis analysis showed that MOF-2 demonstrated improved drug loading (18% w/w), encapsulation efficiency (86%), and cumulative release (96%), along with both pH-responsive degradation and drug release properties. Furthermore, cisplatin-loaded MOF-2 exhibited potent antitumor activity against A549 cells and effectively inhibited cell migration and invasion, while maintaining minimal cytotoxicity toward LO2 normal hepatic cells. These findings suggest MOF-2 as a promising nanocarrier for pH-responsive anticancer drug delivery.
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高影响因子
PEST MANAGEMENT SCIENCE
·
2026
·
IF 4.2
Fuxin Li,Jingxian Ye,Jianjun Hao,Zexiao Liu,Dongyin Yi,Gaoming Zhang,Xinyu Luo,Yang Bi
BACKGROUND Prochloraz (Pro) is a broad-spectrum fungicide that is effective against various plant pathogens, including Colletotrichum fructicola , the causal agent of strawberry anthracnose. However, its limited absorption restricts its effectiveness. In this study, zeolitic imidazolate framework-8 (ZIF-8) was utilized as a nanocarrier and combined with the fungicide prochloraz (Pro) to develop an effective delivery system (Pro@ZIF-8), improving the fungicidal activity of prochloraz. RESULTS Characterization confirmed that Pro@ZIF-8 possesses a distinct dodecahedral crystal structure with an average particle size of 139.6 nm. The system exhibited pH-sensitive release, with 89.8% of the prochloraz released within 24 h at pH 5.0, while remaining stable at pH 7.4. Antifungal assays demonstrated that Pro@ZIF-8 had an EC 50 of 0.0150 mg L −1 against C. fructicola , which was significantly lower than that of free prochloraz (0.0429 mg L −1 ). Pro@ZIF-8 effectively delayed disease lesion development on strawberry leaves and fruits inoculated with C. fructicola . Under storage conditions, Pro@ZIF-8 prevented pathogen infection and kept the fruit fresh for an extended period. Additionally, by tracking fluorescein isothiocyanate (FITC)-labeled ZIF-8 after foliar and root applications, it was confirmed that it was systemically transported within strawberry plants. CONCLUSION These findings highlight the potential of Pro@ZIF-8 as a smart fungicide delivery system, offering a promising strategy for improving disease management in strawberries. © 2026 Society of Chemical Industry.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Huan Li,Rongbin Ye,Chenghao Xie,Hongxu Guo
N-doped carbon/CoFe₂O₄ nanozyme with pH-switchable POD/CAT activity from PBA precursor. • Enables sensitive colorimetric DA detection at pH 3–11 with LODs of 0.0179/0.0488 μM. • High selectivity and recovery (90–103%) in serum show potential for bioanalysis and POC diagnostics. In this work, the design and synthesis of a pH-responsive dual-enzyme nanozyme based on nitrogen-doped carbon-supported CoFe 2 O 4 spinel (C(N)@CoFe 2 O 4 ) derived from cobalt-doped Prussian blue analogues (PBAs) has been reported. The material was obtained through controlled calcination, with the 500 °C sample (C(N)@CoFe 2 O 4 _500) exhibiting high crystallinity, a large specific surface area (256.30 m 2 ·g −1 ), and uniform distribution of nitrogen-doped carbon layers and spinel active sites. Innovatively, the composite displays pH-regulated dual-enzyme mimetic activity: under acidic conditions (pH 2.9) it acts as a peroxidase mimic, catalyzing H 2 O 2 -mediated oxidation of dopamine (DA) to dopamine quinone (absorption at 370 nm), while under alkaline conditions (pH 9.0) it exhibits catalase-like behaviour, promoting H 2 O 2 -driven oxidative self-polymerization of DA to polydopamine (absorption at 470 nm). This pH-dependent catalytic switching, attributed to surface charge modulation and differential substrate affinity, enables reliable DA detection across a broad pH range — a key advance over conventional single-pH nanozyme sensors. The sensor demonstrates high sensitivity with detection limits of 0.0179 μM (acidic) and 0.0488 μM (alkaline),and quantification limits of 0.0597 μM (acidic) and 0.163 μM (alkaline), excellent selectivity against common interferents, and good recovery rates (90–103%) in spiked porcine serum samples. The work presents a new strategy for designing smart, environment-adaptive nanozymes from PBA precursors, with promising potential in bioanalysis and point-of-care diagnostics. In this work, the design and synthesis of a novel pH-responsive dual-enzyme nanozyme based on nitrogen-doped carbon-supported CoFe₂O₄ spinel (C(N)@CoFe₂O₄) derived from cobalt-doped Prussian blue analogues (PBAs) has been reported. The work presents a new strategy for designing smart, environment-adaptive nanozymes from PBA precursors, with promising potential in bioanalysis and point-of-care diagnostics. Download: Download high-res image (239KB) Download: Download full-size image
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Jiahui Gu,Xiliang Zhang,Zhengyin Ding,Kaiyue Wang,Yunfeng Xu,Shuang Liu,Haiqin Gu
The super-hydrophilic TiO₂ pH electrode was modified by oxygen-enriched annealing. • This post-treatment offered tunable production cost suitable for controlled-environment agriculture. • The underlying influence mechanism of modification has been elucidated. • Optimized electrode improved surface hardness and hydrophilicity with stable electrochemical response. • Durability assessment showed lower pH measurement error in unsaturated cultivation substrates. With the escalating demand for rapid and accurate pH detection in controlled-environment agriculture, super-hydrophilic TiO₂ pH electrodes fabricated via chemical etching have emerged as promising candidates for real-time sensing in cultivation substrates, offering tunable production cost and reliable performance. However, their practical deployment is often constrained by limited mechanical durability and unstable interfacial wetting in heterogeneous substrates. In this work, an oxygen-enriched annealing strategy is employed to deliberately tailor the surface structure of TiO₂ electrodes, aiming to enhance interfacial wettability and mechanical robustness rather than solely maximizing intrinsic sensitivity in buffer solutions. This post-treatment significantly modulates the surface morphology, roughness, and composition of the electrodes, elucidating the effects of annealing temperature and duration on their mechanical and wetting properties. The electrode annealed at 350 °C for 30 min (T350-30) developed a uniform interconnected porous microstructure, improving hardness to 208.7 HV0.05 and reducing contact angle to 8.57°. The enlarged specific surface area and abundant amorphous TiO₂ preserved stable pH response, delivering 50.9 mV/pH sensitivity, ≤10 s response time, as well as minimal drift and hysteresis. Durability tests in 66.7% cultivation substrates showed measurement error increased only from 0.07 to 0.14 pH units after 30 insertion–removal cycles, compared with 0.08 to 0.28 pH units for the unannealed electrode. In addition, the annealed electrode exhibited improved stability under sequential exposure to aqueous solutions and ambient air, supporting its stability for practical open-environment. Download: Download high-res image (158KB) Download: Download full-size image
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International Journal of Nanomedicine
·
2026
·
IF 8.7
Feixiao Ma,Anqi Ji,Beng Ma,Pingjuan Yang,Jiayi Li,Shuxin Liao,Haonan Yao,Xuanhu Xie,Zhiwei Wang,Linlin Shi,Shegan Gao,Xin Hou
Purpose Esophageal cancer (EC) ranks among the most prevalent and lethal malignancies worldwide, and conventional therapeutic modalities, including surgery, radiotherapy, and chemotherapy, are constrained by inherent limitations. Recent advances in nanomedicine have opened new avenues for EC treatment. To achieve efficient and precise tumor eradication, this study developed a pH-responsive composite nanoplatform featuring a hollow architecture to enable high-efficiency loading of photosensitizers and realize multimodal synergistic therapy against EC through the integration of photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT).Methods A pH-responsive Cu2-xSe/PDA/IR820 composite nanoplatform was constructed by coating hollow Cu2-xSe nanoparticles with polydopamine PDA and loading the near-infrared photosensitizer IR820. Morphology, crystalline phase, elemental composition, and surface chemistry were characterized by TEM, XRD, XPS, and FT-IR. Photothermal conversion efficiency was quantified under 808 nm laser irradiation. IR820 release kinetics were monitored under different pH conditions of 5.0, 6.0, and 7.0 to assess pH-responsive behavior. In vitro studies on KYSE-150 EC cells included viability by CCK-8 assay, apoptosis by flow cytometry, ROS generation by DCFH-DA probe, mitochondrial membrane potential by JC-1 staining, and cellular uptake analysis. In vivo antitumor efficacy and biosafety were evaluated in an AKR tumor-bearing C57BL/6J mouse model via intratumoral injection and 808 nm laser irradiation, followed by tumor volume measurement, histopathological analysis with H&E, Ki-67, and TUNEL staining, and systemic toxicity assessment.Results The hollow Cu2-xSe/PDA/IR820 nanoparticles exhibited a uniform size of approximately 164 nm, excellent colloidal stability, and a high photothermal conversion efficiency of 44.56% under 808 nm laser irradiation. IR820 release displayed pronounced pH sensitivity, with a cumulative release of 23.07% at pH 5.0 within 30 minutes. In vitro, the nanoplatform combined with laser irradiation reduced KYSE-150 cell viability to 1.2% at 100 μg/mL, with an IC50 value of 18.74 μg/mL, induced 28.57% apoptosis, elevated intracellular ROS levels, decreased mitochondrial membrane potential, and depleted glutathione to 335 μmol/gprot. In vivo fluorescence imaging confirmed effective tumor accumulation via the EPR effect, with peak signal at 24 hours post-injection. Combined PTT/PDT/CDT treatment significantly suppressed tumor growth, reducing final tumor volume to 17.8% of the control group, and induced extensive apoptosis and necrosis in tumor tissues. Systemic biosafety evaluations revealed no significant hematological or histopathological abnormalities.Conclusion Hollow Cu2-xSe/PDA/IR820 composite nanoparticles loaded with IR820 were successfully fabricated and demonstrated remarkable advantages in multimodal combination therapy against EC.
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高影响因子
Journal of Biological Engineering
·
2026
·Vol. 20
·期 1
·94
·
IF 6.3
Ye Gaobing,Liu Jing,Jin Yu,Hu Renren,Tian Tianli,Chen Peilei
Tumor hypoxia limits type-II photodynamic therapy (PDT) by restricting oxygen-dependent singlet oxygen production during irradiation. Here, we developed a pH-responsive ZnO 2 @ZIF-8/TCPP nanoplatform (PZZT) that integrates an acid-activated oxygen-generating core (ZnO 2 ), a ZIF-8 gatekeeper shell, and the photosensitizer TCPP, aiming to enhance PDT under hypoxic conditions. Under mildly acidic conditions, PZZT showed improved oxygen generation and enhanced DPBF consumption upon 660 nm irradiation, indicating elevated ¹O₂ production. In 4T1 cells, PZZT + laser induced stronger intracellular ROS signals and greater phototoxicity than free TCPP or control formulations. In 4T1 tumor-bearing mice, PZZT + laser achieved the most significant tumor growth inhibition without obvious systemic toxicity. Overall, PZZT provides a practical pH-activated self-oxygen-supplying strategy to improve PDT efficacy.
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高影响因子
Acta Biomaterialia
·
2026
·
IF 10.4
Qingche Pan,Xinwei Tao,Jianliang Li,Tianle Zhou,Huaping Tan
Polyacrylic acid-based composites hold substantial promise for intelligent wound dressing applications, owing to their intrinsic hydrophilicity and pH responsiveness. Nevertheless, their clinical translation is hindered by insufficient mechanical properties and excessive adhesion, which are directly induced by high hydrophilicity. Herein, a dual-network Janus hydrogel based on polyacrylic acid (PAA) and sodium alginate (SA), denoted as tannic acid–iron nanoparticles@polyacrylic acid/sodium alginate (TA-Fe NPs@PS Janus), was rationally fabricated. This hydrogel incorporates self-assembled TA-Fe nanoparticles (TA-Fe NPs) with inherent antibacterial activity and magnetic responsiveness. Magnetic enrichment of nanoparticles at the bottom side of the hydrogel not only significantly enhances mechanical toughness via metal–phenolic network (MPN) but also renders the top and bottom layers with distinct intelligent responses to heterogeneous pH microenvironments, thus enabling effective antibiotic-free treatment of infected wounds. TA-Fe NPs@PS Janus integrates high mechanical toughness, sensing performance, and pH responsiveness, enabling monitoring of wound microenvironmental changes through combined responses to pH and ionic variations throughout the recovery process. The physicochemical, mechanical, and rheological properties of the hydrogel were systematically characterized, and in vitro antibacterial assessments were conducted. Results demonstrate that TA-Fe NPs significantly enhance hydrogel toughness: compared with the pristine PAA/SA hydrogel (PS), the composite hydrogel incorporating 0.3% (w/v) TA-Fe NPs exhibits a 1200% increase in tensile toughness (from 0.06 MJ m⁻³ to 0.78 MJ m⁻³). The hydrogel displays high sensitivity and undergoes reversible deformation and intelligent responsive behavior under cyclic pH changes. It not only exhibits high antibacterial efficacy but also demonstrates favorable cytocompatibility. Therefore, this study proposes a smart, stimuli-responsive multifunctional hydrogel dressing for treating chronic wound inflammation and monitoring the healing process, highlighting its potential for clinical applications. Statement of significance Chronic infected wounds severely threaten human health, yet clinically viable smart wound dressings are lacking. Polyacrylic acid (PAA) hydrogels are attractive for wound management but suffer from poor mechanical toughness and over-adhesion. We fabricate a dual-network Janus hydrogel (TA-Fe NPs@PS Janus) incorporating PAA, sodium alginate and tannic acid-iron nanoparticles. Magnetically concentrated TA-Fe NPs form metal-phenolic networks, boosting toughness by 1044.2% and creating asymmetric pH responsiveness. This cytocompatible hydrogel achieves antibiotic-free antibacterial function and real-time infection monitoring via pH changes. It overcomes key drawbacks of PAA hydrogels, integrates diagnosis and therapy, and offers a translatable strategy for intelligent chronic wound dressings. Download: Download high-res image (298KB) Download: Download full-size image
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高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
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2026
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IF 3.2
Qiu Tianxiang,He Yangfan,Chai Meiying,Wang Minmin,Yuan Kaijun,Zhang Xin-Xing
The coordination chemistry of copper(II) with aspartic
acid (Asp)
is of fundamental interest in both biological systems and materials
science, yet the pH-dependent binding preferences of Cu(II) toward
the individual functional groups of Asp remain incompletely understood.
Here, we systematically investigate the pH-modulated coordination
and self-assembly of Cu-Asp complexes, establishing the vibrational
fingerprints of the four protonation states of free Asp. IR spectral
changes indicate that Cu(II) coordination strongly promotes amino
deprotonation but barely affects the carboxyl groups. Chelation proceeds
via the α-carboxylate and amino groups at pH 2, with the β-carboxylate
participating sequentially at pH 3. Polarization-dependent 2D IR spectroscopy
reveals a perpendicular alignment of the two carboxylate transition
dipoles within an eight-membered chelate ring, a structural motif
confirmed by crystallography. Above neutral pH, weakening of the Cu-amino
bond disrupts this rigidity, driving a morphological transition from
well-defined fiber-like assemblies to gel-like structures. These results
provide a molecular-level framework for understanding pH-responsive
changes in both the coordination environment and supramolecular morphology,
offering a design principle for stimuli-responsive metal–organic
materials.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Weiguang Su,Jianbin Liang,Dawei Wang,Siegfried Yeboah,Jiemeng Ding,Tian Lan,Ruirui Zhang,Qing Xu,Li Wang
Monodisperse 5-ASA microcapsules (CV < 3%) are engineered via microfluidics. • Nanocrystal-in-microcapsule architecture yields high drug loading (20.4 wt%). • pH 6.1 threshold enables release in the acidic IBD microenvironment. • Moving-boundary kinetics map single-particle to macro-scale release. The performance of targeted oral delivery systems for hydrophobic drugs like 5-aminosalicylic acid is limited by variable release kinetics and premature release in the upper gastrointestinal tract. To address this challenge, monodisperse 5-aminosalicylic acid nanocrystal-in-hydroxypropyl methylcellulose acetate succinate (5-ASA NCs@HPMCAS) composite microcapsules were prepared via microfluidic interfacial assembly and antisolvent precipitation. Droplet-templated solidification yielded microcapsules with an average diameter of 28.33 μm, a coefficient of variation < 3%, a drug loading of 20.4 wt% and an encapsulation efficiency of 83.3%. Driven by the pH-dependent transition of the HPMCAS shell, the microcapsules remained structurally intact under simulated gastric and proximal intestinal conditions (pH < 6.0) but underwent rapid interfacial erosion around pH 6.1. The model payload was released within approximately 3 min at pH 7.2 under quiescent in vitro conditions, while 5-ASA release reached 88.5% at pH 6.5 over 4 h. Ex vivo GI imaging of DiR-labeled microcapsules provided preliminary evidence of upper-GI retention and lower-GI localization after oral administration. Residual ethyl acetate was approximately 217 ppm, while dimethyl sulfoxide was below the assay’s quantification range. A 24-hour Caco-2 assay showed cell viability above 90%, supporting preliminary in vitro cytocompatibility under the tested conditions. The uniform particle size also enabled comparison between single-particle moving-boundary kinetics and macroscopic release behavior, providing a physicochemical basis for pH-responsive oral delivery.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Xu Yuyang,Zhao Yugeng,Liao Jie,Sun Peng,Hu Shoulei,Huo Taotao,Zhang Jinli,Jiang Zhiyi,Li Wei
To enhance the electrochemical performance of high-nickel and cobalt-free cathode material LiNi 0.9 Mn 0.1 O 2 (NM), this study proposes a synergistic strategy integrating high-shear pH-regulated precipitation to fabricate uniform micron-sized structured precursors, with Se-surface modification to enhance the cycling stability. First, the optimal sample NM-8.1 was synthesized via high-shear precipitation with the controlling pH value of 8.1, exhibiting the initial discharge capacity of 208.3 mAh g −1 at 25 °C and 0.1 C (2.7–4.4 V) and the capacity retention of 79.9% after 200 cycles at 1 C. Then, Se-driven surface coating was prepared to improve the cycle stability for NM-8.1, and the optimized NM-1Se shows the initial discharge capacity of 210.7 mAh g −1 (25 °C, 0.1 C, 2.7–4.4 V), the capacity retention of 88.5% after 200 cycles (1 C) and 82.3% after 500 cycles at 5 C. After 200 cycles (1 C), the R ct value equals 60.42 Ω for NM-8.1, whereas 29.08 Ω for NM-1Se. X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) analyses indicate that both the uniform, micron-sized structured precursors and the Se modification can promote Li + diffusion, stabilize the lattice oxygen and decelerate the growth of charge transfer impedance, thereby enhancing the cycling stability of the cathode material. This work offers a generalizable paradigm for the synthesis of advanced electrode materials, providing valuable guidelines for optimizing the preparation of other high-energy-density batteries. Graphical abstract Synergistic pH-regulated precipitation and Se surface modification enhance the capacity, cycling stability, and reaction kinetics of cobalt-free Ni-rich cathodes for high performance lithium-ion batteries.
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