Nanoscale
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2016
·Vol. 8
·期 12
·6754-6760
·
IF 7.76
Han Cao,Yuhong Yang,Xin Chen,Zhengzhong Shao
Stimuli-responsive nanomaterials have been receiving much attention as drug delivery carriers, however understanding of multi-drug release from the carriers for efficient therapeutics is highly challenging. Here, we report a novel nanosystem, Janus particle Dox-CMR-MS/Au-6MP (Dox: doxorubicin, CMR: 7-hydroxycoumarin-3-carboxylate, MS: mesoporous silica, Au: gold, 6MP: 6-mercaptopurine) with opposing MS and Au faces, which can monitor intracellular dual-drug (Dox and 6MP) controlled release in real time based on fluorescence resonance energy transfer (FRET) and surface-enhanced Raman scattering (SERS). The FRET acceptor Dox is attached to CMR (as a FRET donor) conjugated MS with a pH-responsive linker hydrazone, and 6MP is conjugated to the Au surface through the gold–thiol interaction. As the Janus nanoparticle enters into tumor cells, the breakage of the hydrazone bond in an acidic environment and the substitution of glutathione (GSH) overexpressed in cancer cells give rise to the release of Dox and 6MP, respectively. Thus, the change of the CMR fluorescence signal and the SERS decrease of 6MP can be used to monitor the dual-drug release within living cells in real time. In addition, this work demonstrates the enhanced anticancer effect of the designed dual-drug loaded nanosystem. Therefore, the current study may provide new perspectives for the real-time study of intelligent multi-drug delivery and release, as well as cellular responses to drug treatment.
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高影响因子
RSC Advances
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2016
·Vol. 6
·期 25
·21204-21209
·
IF 3.289
Yafan Wan,Pucha Zhou,Yaodong Liu,Hongxiang Chen
This study focused on the preparation of wearable polyacrylonitrile (PAN)/phase-change material (PCM) sheath/core nano-fibers by coaxial electro-spinning technology. PAN was used as the sheath material to make fibers comfortable to human skin, and isopropyl palmitate and paraffin oil were used as sample PCMs. The electro-spinning conditions are critical for encapsulating a PCM by a PAN shell and forming a uniform sheath–core structure. Our experiments show that these PCMs could be well encapsulated in PAN hollow fibers and function to stabilize environmental temperature in a narrow range. This study provides a versatile and feasible way to fabricate PAN/PCM sheath/core homo-thermal nano-fibers with various temperature stabilization windows. Using these homo-thermal nano-fibers as clothing materials will be able to abate people’s discomfort during a sudden environmental temperature change.
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PROPELLANTS EXPLOSIVES PYROTECHNICS
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2017
·Vol. 42
·期 11
·1252-1260
·
IF 1.908
Na Sun,Zhenggang Xiao
A nanocomposite microsphere consisting of solid paraffin, nano-TiO 2 , nano-BN, zeolitic imidazolate framework-67 particles and polymethyl methacrylate was prepared and applied as a functional additive for high energy propellants (with about 23 wt % RDX) to reduce the barrel erosion and improve its combustion performance as well. High energy propellants modified with the nanocomposite were manufactured by a solvent extrusion technique. According to the scanning electron microscope and differential scanning calorimetry results, there exists a good compatibility between the nanocomposite and propellant matrix. The energy and combustion performance as well as erosion of the modified propellants were studied by a closed bomb test and an erosion tube device, respectively. Results showed that compared with the unmodified propellant, both the erosion and energy performance of modified high energy propellant gradually decreased with the increase of nanocomposites contents. When the content of nanocomposites was 5.1 %, the erosion mass of the modified propellant reduced to 37.0 % while the propellant force only decreased 5.7 %, indicating that the nanocomposite has enormous ability to improve gun erosion resistance while barely affect energy performance of propellant. Furthermore, the closed bomb burning curves of the samples showed that addition of nanocomposites to propellant matrix could prolong the combustion time, efficiently inhibit the initial generation rate of combustion gas, and further achieve the progressive burning of the propellants.
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ENERGY & FUELS
·
2017
·
IF 3.091
Na Sun,Zhenggang Xiao
Paraffin was encapsulated in a poly(methyl methacrylate) (PMMA)/BN/TiO2 hybrid shell to obtain a novel phase change material (PCM) microcapsule for latent-heat storage. Scanning electron microscope micrographs showed that the resultant composite PCMs exhibited a nearly spherical morphology with a size of 10–20 μm and BN/TiO2 nanoparticles were tightly embedded on the microcapsule surface. The results of thermogravimetric analysis and thermal conductivity test demonstrated that the PMMA/BN/TiO2 composite shell gave the microencapsulated paraffin an excellent thermal performance. Compared to pure paraffin, the thermal conductivity of microcapsules could significantly be enhanced by 117.0%, and the maximum decomposing temperature has an increase of 25.4 °C. The analysis of differential scanning calorimetry and thermal reliability test indicated that the composite PCMs also presented good heat storage capacity and high thermal reliability for latent-heat storage and release. After a heating–cooling cycle test was repeated 100 times, the composite microcapsule still showed a similar phase change performance as before, which can be attributed to the protective effect of PMMA/BN/TiO2 hybrid shell. With increased demands for economical and high-performance renewed energy storage materials, the prepared composite PCMs show great potential applications in thermal energy storage.
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LANGMUIR
·
2017
·
IF 3.833
Jinghui Wang,Renliang Huang,Wei Qi,Rongxin Su,Zhimin He
Enzyme-loaded water-in-oil Pickering emulsion is a promising system for biphasic catalytic reactions. In this paper, we report on oriented enzyme immobilization at the oil/water interface in a Pickering emulsion, in which CHO-Janus silica nanoparticles (CHO-JNPs) are utilized as a stabilizer of the emulsion and support for the enzyme to enhance both catalytic activity and recyclability. The catalytic performance of this immobilized enzyme (lipase from Candida sp.) was evaluated by esterification of hexanoic acid and 1-hexanol in a water/heptane biphasic medium. The results show that the specific catalytic activity of the immobilized enzyme (33.2 U mL–1) was 6.5 and 1.4 times higher than that of free enzyme (5.1 U mL–1) and encapsulated enzyme in the liquid core (23.3 U mL–1), respectively. Moreover, the immobilized enzyme demonstrated good stability and recyclability, retaining 75% of its activity after 9 cycles. We expect that oriented enzyme immobilization at the oil/water interface will be an important strategy for enhancing catalytic performance in Pickering emulsions.
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JOURNAL OF MEMBRANE SCIENCE
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2017
·
IF 6.035
Guoping Chen,Xiong Song,Suqing Wang,Ying Wang,Tuo Gao,Liang-Xin Ding,Haihui Wang
Lithium–sulfur (Li–S) battery is considered as one of the most promising advanced energy storage devices. However, several critical issues remain which restrict their practical applications, especially the shuttle effect of soluble lithium polysulfides . Herein, we designed a lightweight multifunctional layer comprising reduced graphene oxide (rGO) and cobalt/nitrogen co-doped carbon nanofibers (Co-N-C) to modified the polypropylene (PP) separator to facilitate the electrochemical performance of Li–S batteries. The Co-N-C/rGO layer with abundant mesopores possesses strong immobilization ability of polysulfides and high electronic conductivity, which could work as an intrinsic physical/chemical frame work barrier and an upper current collector to trap and reutilize the polysulfides. Consequently, the Li–S battery with the modified Co-N-C/rGO/PP separator exhibits excellent cycling performance and good rate capability. A high discharge capacity of 1344 mAh g –1 at 0.1 C, 658 mAh g –1 at 5 C and a low capacity degradation rate of 28.8% after 500 cycles at 0.5 C were obtained. These exciting results indicate that this multifunctional Co-N-C/rGO/PP separator could be a promising separator candidate for Li–S batteries.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2016
·Vol. 409
·期 1
·161-168
·
IF 3.125
Song Yonggui,Su Dan,Shen Yuan,Liu Hongyu,Wang Li
A novel open circuit potential biosensor (OCPS) composed of a working electrode and a Ag/AgCl reference electrode was designed for in vivo continuous glucose monitoring in this work. The macroporous carbon derived from kenaf stem (KSC) was used to construct a KSC microelectrode (denoted as KSCME) which was subsequently used to load glucose oxidase (GOD) as the working electrode. The resulting GOD/KSCMEs could catalyze the oxidation of glucose directly to result in changes of the open circuit potential ( V
oc ) of the OCPS. The V
oc of OCPS was dependent on the glucose concentration, showing a linear range of 0.03–10.0 mM ( R = 0.999) with a detection limit of 10 μM. In addition, the OCPS exhibited good selectivity for glucose over other common endogenous interferences. The feasibility of the proposed OCPS for glucose detection in mice skin tumors and normal tissue homogenate samples (in vitro experiment) and rat subcutaneous glucose monitoring (in vivo experiment) was also demonstrated with satisfactory results. The biosensor represents a novel example of a superficial cancer diagnostic device, and the proposed OCPS also provides new ideas for the development of a simple and highly selective device for continuous glucose sensing.
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CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
Fupo He,Guowen Qian,Weiwei Ren,Jinhuan Ke,Peirong Fan,Xuetao Shi,Yanling Cheng,Shanghua Wu,Xin Deng,Jiandong Ye
Ceramic-metal composite materials, namely cermets, are provided with characteristics of both ceramic and metal. Herein, for the first time bio-cermets based on β-tricalcium phosphate (β-TCP) bioceramic with biodegradable iron being reinforcement phase, were fabricated using the powder metallurgic method. The phase composition, microstructure, mechanical properties and in vitro cell behaviors of bio-cermets were investigated. The results revealed that atomic diffusion occurred between the iron and β-TCP matrix during the sintering process. The bio-cermets attained remarkable increase in fracture toughness (1.16–1.55 MPa m 1/2 ) compared to the β-TCP bioceramic (0.54 MPa m 1/2 ). The bio-cermets with 10 vol% iron showed the highest compressive strength (640 MPa), significantly higher than that of plain β-TCP bioceramic (285 MPa). The in vitro cell behaviors test indicated that the bio-cermets did not showed any sign of toxicity; the iron ions released from bio-cermets up-regulated bone-related gene expression of bone mesenchymal stem cells. The bio-cermets developed in this study represent potential bone substitutes for application in the load-bearing bone defects.
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LANGMUIR
·
2024
·
IF 3.7
Man Li,Min Luo,Xiaoxiao Niu,Angsen Sheng,Zhen Wang,Xiaoqing He,Huaiyu Bu,Gang Xie
Synthesis methods of carbon nanomaterials have been developed vigorously in recent years, among which a simple, green, and mature approach is of more research significance. Carbon nanomaterials have depicted an impact on the growth and development of plants. In this study, a new type of carbon nanomaterial, superhydrophilic carbon aerogel (CA), was synthesized via a hydrothermal process using carbohydrates and water-soluble polymers as raw materials. Characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, powder X-ray diffraction, and N2 adsorption analysis, the exemplified CA presented to have porous three-dimensional network structure composed of individual particles with diameters of 25 nm, with reactive surface, single composition, high specific surface area (89.94 m2·g–1), and wide range of density variation. The 9 mg·mL-1 CA suspension had a significant positive effect on the root growth of wheat seedlings, with promoted root elongation (about 67.17% longer) and root diameter (about 28.95% thicker) compared with those of the control group. The cytological results suggested that CA treatment triggered the propagation of meristematic cells, and the increased number of meristematic cells (65.79% more than the control group) led to enhanced root growth by upregulated expression of related phytohormone genes in wheat seedlings.
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CARBON
·
2025
·
IF 11.6
Xiao Chen,Jinjie Lin,Yuhao Feng,Keke Chen,Mulin Qin,Shenghui Han,Yu Jiang,Zhenghui Shen,Yang Li
The pivotal attributes of high light absorption and thermal conductivity are paramount for initiating photothermal conversion and storage within phase change materials (PCMs). However, previous photothermal initiators predominantly harness single- or dual-dimensional hybrid frameworks, the exploration of multidimensional engineering design remains scarce. Herein, we constructed multidimensional heterogeneous carbon-metal interconnected network integrating three-dimensional carbon foam (CF), one-dimensional carbon nanotubes (CNTs), and zero-dimensional Co nanoparticles via in-situ chemical synthesis and high-temperature carbonization protocols. This obtained hierarchical heterogeneous carbon-metal hybrid, when endowed with phase change properties via stable encapsulation of PCMs, exhibits remarkable thermal energy storage without liquid leakage and photothermal conversion capacity. The integration of localized surface plasmon resonance-active Co nanoparticles and photophilic CF/CNTs carbon hybrid confers excellent broadband full-spectrum sunlight absorption to composite PCMs. The cobalt-catalyzed interconnected multidimensional carbon-metal network with low interfacial thermal resistance facilitates fast transport of photons and phonons in composite PCMs. Resultantly, carbon-metal hybrid based composite PCMs synergistically yield an ultrahigh photothermal conversion efficacy of 97.07 %, a stable high voltage output of 246.9 mV, and robust cyclic operational stability. Our proposed multidimensional engineering design strategy offers new insights into the development of next-generation high-performance photothermal PCMs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Haixin Chen,Ziyun Zhou,Bingde Zheng,Hongjie Yang,Yi Chen,Yayan Huang,Na Zhang,Xueqin Zhang,Meitian Xiao,Jing Ye,Yucheng Yang
As environmental awareness grows, developing non-toxic, environmentally friendly, and biodegradable water- and oil-resistant coating layers using bio-based materials for paper-based packaging has become a key field of research. In this work, sodium alginate (SA) and sodium carboxymethyl cellulose (CMC) were used as the oil-resistant coating layer, while shellac (LAC) and ethyl cellulose (EC) formed the water-resistant coating layer, to produce a water- and oil-resistant coated paper. The effect of the mass ratio of these materials on performance was analyzed, demonstrating that the interaction between SA and CMC enhances the compactness of coating, thereby improving oil resistance. Similarly, the addition of LAC to EC increases coating compactness, which improves water resistance. The resulting coated paper has excellent water resistance (Cobb value: 3.42 g/m 2 ) and oil resistance (Kit rating: 12/12) and shows no leakage after holding hot water and hot oil for 30 min, indicating good resistance to both. Additionally, the coated paper demonstrates good mechanical properties, thermal stability, biodegradability and recyclability. The materials used are widely available and low-cost, and the preparation method is straightforward, making this research highly valuable for advancing paper-based packaging materials.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yongqiang Wang,Kai Du,Bo Liu,Changhui He,Baoming Zhao,Zhenggang Xiao
The gun barrel erosion caused by the burning of high energy propellants is becoming increasingly severe, significantly reducing the useful life of gun barrel. In order to address this problem, erosion reducing additives, including TiO 2 , paraffin, polyurethane or a combination of these, were introduced into the gun propellant or propellant charge system to alleviate the gun barrel erosion. In this article, a new type of flexible phase change composite materials (FPCMs) having excellent thermal stability and superior mechanical performance was successfully designed by incorporating paraffin/BN@PMMA (microPCMs) mixed with different binders of waterborne polyurethane (WPU), carboxylic butadiene-styrene latex (cBSL), and butadiene-styrene latex (BSL) on the fabric surface and applied as protective liners of cartridge case. Therein, the microPCMs was constructed with paraffin as the core and polymethyl methacrylate (PMMA) enforced by nano boron nitride (BN) as the shell by Pickering emulsion polymerization method. The morphology, chemical composition , and phase change behaviors of these prepared FPCMs were analyzed by SEM, FTIR, and DSC , respectively. Results show that these microPCMs with spherical structure but a little rough surface could be evenly distributed in the warp and weft structure of pristine fabric. The resulting FPCM sample containing WPU has the highest phase change latent heat of 38.77 J/g among these FPCMs. Additionally, TG and isothermal TG experiments reveal that the incorporation of binders has a positive effect on FPCMs thermal stability and FPCM sample containing cBSL exhibit the most remarkable thermal stability. The tensile experiments demonstrate that these FPCMs display the desirable mechanical performance and exhibit brittle fraction model. The tensile strength and elongation at break of FPCMs can be enhanced by the introducing of these binders. Pretreating pure fabric with gelatin is proved to be the most effective way in improving the mechanical performance of FPCMs. Herein, FPCM containing WPU has the highest ultimate tensile strength that can be up to 293.53 MPa. The novel flexible phase change composite materials could be a promising candidate to be used as protective liners to reduce the gun barrel erosion induced by the combustion of high energy propellants.
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危险品化学品经营许可证（带存储）