Polymer Chemistry
·
2012
·Vol. 4
·期 5
·1430-1438
·
IF 5.321
Longlong Chang,Jinjian Liu,Jianhua Zhang,Liandong Deng,Anjie Dong
A novel pH-sensitive, amphiphilic and biodegradable copolymer brush, methoxy poly(ethylene glycol)-block-(polycaprolactone-graft-poly(methacrylic acid)) (mPEG-b-(PCL-g-PMAA)), was developed for NPs for the oral delivery of hydrophobic drugs. The copolymer brush was synthesized by combining ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP), followed by selective hydrolysis. The structure and composition of the copolymer and its precursors were characterized by 1H-NMR, FT-IR and GPC. The critical micelle concentrations (CMC) of mPEG-b-(PCL-g-PMAA) in aqueous medium were determined to be 6.8 × 10−4 and 9.6 × 10−4 mg mL−1. The copolymer could self-assemble into NPs in aqueous solution with an average size of 104–129 nm, determined by DLS. The morphology of the NPs was spherical, as observed by TEM. The zeta potentials of the NPs were about −25 mV, measured by zeta potential measurements. Ibuprofen (IBU), a poorly water-soluble drug, was chosen as the model drug and encapsulated into the core of the NPs via a nano-precipitation method. The drug loading content (DLC) of the NPs prepared from mPEG-b-(PCL-g-PMAA) reached about 13%, with a drug loading efficiency (DLE) of above 75%. The in vitro release behavior of IBU from the NPs was pH-dependent. Typically, at pH 3.0 (0.01 M), the cumulative release percentage of IBU was about 40% over 12 h, whereas at pH 7.4 (0.01 M), more than 95% was released within 12 h for NPs prepared from mPEG113-b-(PCL91-g-PMAA155). The MTT assay indicated that blank NPs prepared from mPEG-b-(PCL-g-PMAA) did not show significant toxicity against NCL-H460 cells. These results indicated that this new type of pH-dependent polymeric NPs prepared from mPEG-b-(PCL-g-PMAA) has great potential to be used as a drug carrier for the oral administration of hydrophobic drugs.
研究领域:
药剂学
·
高分子科学
·
纳米医学
·
药物递送系统
·
生物材料
·
药代动力学
·
分子药理学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Siyuan Dong,Yingqi Jia,Xiaozhi Xu,Jianeng Luo,Jingbin Han,Xiaoli Sun
Poly(ethylene terephthalate) (PET) generally suffers from low crystallization rate and long molding duration, which as a result limit its application as engineering plastics. To overcome these drawbacks, series of PET/layered double hydroxide (LDH) nanocomposites were prepared by a solution blending process. The effect of metal composition (MgAl and CaAl) and organo-modification (stearic acid intercalated) for LDH fillers on the crystallization behavior of the nanocomposites was investigated. It was revealed that, compared with PET/CaAl-LDH, the PET/MgAl-LDH nanocomposite exhibits a higher crystallization temperature and faster crystallization rate, which is associated with the superior nucleation ability of MgAl-LDH. The nucleation mechanism of PET induced by LDHs was explored by means of Avrami equation and theory of Hoffman-Lauritzen, pointing out that the incorporation of LDHs reduce the free energy of nucleation and the fold surface free energy of PET. In order to improve the compatibility between LDH and PET, stearic acid (SA) intercalated MgAl-LDH was prepared and filled into PET matrix. The resultant PET/MgAl-LDH-SA shows a further enhanced crystallization temperature and accelerated crystallization rate, in comparison with PET/MgAl-LDH nanocomposites. In addition, the thermal stability, gas barrier and mechanical properties of PET/LDH composites were improved upon incorporation of LDH fillers.
研究领域:
高分子科学
·
材料化学
·
纳米复合材料
·
结晶动力学
·
聚合物物理
·
功能材料
·
工程塑料
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Nan Lu,Xi Zhang,Ruiqi Na,Wendi Ma,Chongyang Zhang,Yuchao Luo,Yongfeng Mu,Shuling Zhang,Guibin Wang
The synthesis of a nanocomposite gel polymer electrolytes (NGPEs) using Li + -functionalized SPEEK (SPEEK(Li)) nanofiber membrane as a matrix, cross-linked PVA as a gelled agent and LiClO 4 as an electrolytic salt for electric double layer capacitors (EDLCs) were reported in this work. Compared with conventional PVA based gel electrolyte, the “SO 3 − Li + ” functional groups and the pores structure of the SPEEK(Li) nanofiber membrane improves the ionic conductivity as well as mechanical stability , which made the prepared NGPEs exhibited a high ionic conductivity of 8.9 × 10 −3 S cm −1 at ambient temperature and a large voltage stability window range from 0 to 2.0 V. The fabricated symmetric EDLCs showed a specific capacitance of 146.96 F g −1 at a current density of 0.5 A g −1 , with a maximum energy density of 18.26 W h kg −1 . Meanwhile, the EDLCs showed outstanding cyclical stability of 98% specific capacitance retention after 3000 cycles GCD testing, all of these results indicated that the NGPEs should be appropriate to EDLCs and next-generation energy storage systems .
研究领域:
材料科学
·
电化学
·
能源存储
·
高分子化学
·
纳米技术
·
固体电解质
✓ 已验证
DOI
高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Yang-he Mo,Hui Wang,Shao-hua Jin,Ke-lin Peng,Zi-ming Yang,Pu-wang Li,Yu Chen
Fast curing hydrogels are highly valuable in the skin care industry. Multi-arm polyethylene glycol (PEG) is a commonly used crosslinking agent for the preparation of fast curing hydrogels. However, the hydrogel preparation using multi-arm PEG crosslinking agents usually requires the end group modifications of reactants, which makes the preparation process complicated and produces hydrogels with low curing rates. In the present study, a fast in situ curing hydrogel, 4-arm-PEG-succinimidyl carbonate/carboxymethyl chitosan (PEG-SC/CMCS), was prepared using 4-arm-PEG-SC as the crosslinking agent and carboxymethyl chitosan (CMCS), a derivative of natural polysaccharide with excellent comprehensive properties, as the framework without any end groups modified. The structure and properties of the prepared hydrogel were characterized by FTIR, XRD, SEM, rheology and swelling kinetics. The effects of reaction conditions on the structure and properties of hydrogel were investigated. The PEG-SC/CMCS hydrogel exhibited pH-sensitive swelling behaviors. Its application potential in skin care products is demonstrated with its excellent sustained-release performance of Vitamin C, a model drug for skin treatment, and high adsorption capacity of heavy metal ions that are easily deposited on skin surface. Our work has provided a new strategy for building multifunctional gel materials for skin care and offered a PEG-SC/CMCS hydrogel with great application potentials.
研究领域:
生物材料
·
高分子化学
·
药剂学
·
皮肤科学
·
组织工程
·
药物递送系统
·
环境毒理学
✓ 已验证
DOI
高影响因子
AAPS PHARMSCITECH
·
2019
·Vol. 20
·期 1
·1-14
·
IF 2.608
Wang Xingqi,Zhang Yong,Huang Jie,Tian Chunling,Xia Mengqiu,Liu Liu,Li Zhengguang,Cao Jiaojiao,Gui Shuangying,Chu Xiaoqin
The purpose of this paper was to investigate the potential of liquid crystalline (LC) gels for ophthalmic delivery, so as to enhance the bioavailability of pilocarpine nitrate (PN). The gels were prepared by a vortex method using phytantriol and water (in the ratio of 73:27 w / w ). Their inner structures were confirmed by crossed polarized light microscopy, small-angle X-ray scattering, attenuated total reflectance-Fourier transform infrared spectrum, and rheology. The in vitro release studies revealed that PN could keep sustained release from the gels over a period of 12 h. The ex vivo apparent permeability coefficient of the gels demonstrated a 3.83-folds ( P < 0.05) increase compared with that of eye drops. The corneal hydration levels of the gel maintained in the normal range of 79.46 ± 2.82%, hinting that the gel could be considered non-damaging and safe to the eyes. Furthermore, in vivo residence time evaluation suggested that a better retention performance of LC gel was observed in rabbit’s eyes compared to eye drops. In vivo ocular irritation study indicated that LC gel was nonirritant and might be suitable for various eye applications. In conclusion, LC gels might represent a potential ophthalmic delivery strategy to overcome the limitations of eye drops.
研究领域:
药剂学
·
药物递送系统
·
眼科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）