Pharmaceutics
·
2022
·Vol. 14
·期 7
·1337
·
IF 6.525
Lijun Song,Jiabo Chen,Yuxuan Feng,Yujing Zhou,Feng Li,Guiqin Dai,Yue Yuan,Haosen Yi,Yupei Qian,Siyan Yang,Yang Chen,Wenchang Zhao
Genistein (Gen), a kind of natural isoflavone drug monomer with poor water solubility and low oral absorption, was incorporated into oral nanoparticles with a new mesoporous carrier material, NH2-MCM-41, which was synthesized by copolycondensation. When the ratio of Gen to NH2-MCM-41 was 1:0.5, the maximum adsorption capacity of Gen was 13.15%, the maximum drug loading was 12.65%, and the particle size of the whole core–shell structure was in the range of 370 nm–390 nm. The particles were characterized by a Malvern particle size scanning machine, XRD, Fourier transform infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption and desorption. Finally, Gen-NH2-MCM-41 was encapsulated by sodium alginate (SA), and the chimerism of this material, denoted as GEN-NH2[email protected], was investigated. In vitro release experiments showed that, after 5 h in artificial colon fluid (pH = 8.0), the cumulative release reached 99.56%. In addition, its anti-rotavirus (RV) effect showed that the maximum inhibition rate was 62.24% at a concentration of 30 μM in RV-infected Caco-2 cells, and it significantly reduced the diarrhea rate and diarrhea index in an RV-infected-neonatal mice model at a dose of 0.3 mg/g, which was better than the results of Gen. Ultimately, Gen-NH2[email protected]was successfully prepared, which solves the problems of low solubility and poor absorption and provides an experimental basis for the application of Gen in the clinical treatment of RV infection.Keywords:genistein;mesoporous silica;Caco-2 cells;sodium alginate;targeted release
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DOI
PubMed
高影响因子
Russian Journal of Physical Chemistry A
·
2026
·Vol. 100
·期 10
·2542-2555
·
IF 0.7
Lili Li,Li Jiaxin,Ma Yuyu,Shu Jing
The Ce-UiO-66-NH 2 material was successfully prepared by oil bath method, and TiO 2 and PANI were compounded on the basis of it, which improved the degradation efficiency of rhodamine B (RhB). XRD, TEM, and XPS characterization confirmed that the composite material formed a core-shell structure and polyaniline was uniformly coated. The composite with 20 μL aniline and CTAB surfactant showed the highest degradation efficiency, and the degradation rate of RhB reached 99.90% within 60 min under ultraviolet light irradiation. The band alignment and free radical trapping experiments show that it follows the ternary Z-type heterojunction mechanism, \( \bullet {\kern 1pt} {\text{O}}_{2}^{ - }\) is the main active species. It provides a new idea for the design of high-performance photocatalysts and is of great significance for promoting the application of photocatalytic technology in water pollution control.
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高影响因子
Defence Technology
·
2021
·
IF 3.172
Yu-lan Song,Qi Huang,Bo Jin,Ru-fang Peng
To improve the safety of HMX, HMX/NH 2 -GO composite was prepared with aqueous ammonia functionalized graphene oxide (NH 2 -GO). The composite was characterized by SEM, Zeta potential, XPS, Raman spectrum, XRD, HPLC, DSC and BAM sensitivity test. The results indicated that the functionalization with aqueous ammonia can enhance the interaction between GO and HMX, and more efficiently desensitize the explosive. The optimal impact sensitivity of the HMX/NH 2 -GO composite can be not less than 40 J, which is also the most insensitivity compared to the previous reports prepared by coating desensitization with non-energetic desensitized material. Moreover, the potential reason for the different impact and friction sensitivity was also discussed, which may bring a novel perspective to achieve the desensitization of energetic material.
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高影响因子
JOURNAL OF ANALYTICAL CHEMISTRY
·
2024
·Vol. 79
·期 4
·400-411
·
IF 1
Xing Yanyan,Chen Meiling,Lan Huining,Zhang Sijia,Xu Jiabi,Hou Xiaohong
Abstract Considering the application prospects of a cascade catalytic system in biomedical analysis, it remains significant to develop a cascade catalytic system for one-step rapid colorimetric detection. Herein, PVP/NH 2 -MIL-101(Fe) possessing enhanced peroxidase ( POD )-like activity was successfully synthesized by microwave-assisted and polyvinylpyrrolidone ( PVP ) modification strategies. Then, PVP/NH 2 -MIL-101(Fe) and glucose oxidase ( GOx ) were covalently coupled via the bifunctional cross-linker glutaraldehyde, the GOx@PVP/NH 2 -MIL-101(Fe) with dual enzymatic functional activities (POD-like and GOx activities) was subsequently synthesized. GOx@PVP/NH 2 -MIL-101(Fe) had strong affinities for the substrates glucose, 3,3',5,5'-tetramethylbenzidine, and hydrogen peroxide. Based on this specific nanozyme GOx@PVP/NH 2 -MIL-101(Fe), a one-step colorimetric assay for rapid glucose determination was built. This detection method not only took 20 min to analyze but also possessed a linear range of 10–250 µM with a detection limit of 1.05 µM. Furthermore, the cascade catalytic system was applied to determine glucose concentrations in human serum samples. Compared with commercial blood glucose meters, the proposed method was also accurate and effective, making it a candidate method for determining blood glucose.
研究领域:
生物医学分析
·
材料科学
·
酶工程
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高影响因子
RSC Advances
·
2022
·Vol. 12
·期 9
·5062-5071
·
IF 4.036
Zhenshan Li,Qi Li,Rong Jiang,Yan Qin,Yan Luo,Jinsong Li,Wei Kong,Zhiguo Yang,Chao Huang,Xin Qu,Tao Wang,Lin Cui,Gang Wang,Shengchao Yang,Zhiyong Liu,Xuhong Guo
Cu(II) ions are one of the most common forms of copper present in water and can cause bioaccumulation and toxicity in the human body; therefore, sensitive and selective detection methods are required. Herein, a copper ion sensor based on a UiO-66-NH2/ZnO composite material is proposed. The UiO-66-NH2/ZnO nanocomposite was prepared by an ultrasonic mixing method. The morphology and structure of the nanocomposite were studied by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The sensitivity to Cu(II) is 6.46 μA μM−1 and the detection limit is 0.01435 μM. The composite material is rich in –OH and –NH2 groups, which are active sites for Cu(II) adsorption. The UiO-66-NH2/ZnO-modified electrode has good repeatability and anti-interference ability. The sensor was successfully used for the determination of Cu(II) in an actual water sample.
研究领域:
环境科学
·
分析化学
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DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Min Wang,Lingyi Zhang,Yameng Zhao,Weibing Zhang
In this study, a new molecularly imprinted material, MIP@UiO-66-NH 2 , was synthesized with glutathione (GSH) as template and mesoporous metal organic framework (UiO-66-NH 2 ) as matrix. The molecularly imprinted polymer was modified on the surface and into the pores of the UiO-66-NH 2 by surface molecular imprinting method with thin polymer layer. Based on high specific surface area (1091.93 m 2 g −1 ) and appropriate pore size (35 nm) of the ordered mesoporous UiO-66-NH 2 , the adsorption capacity for GSH reached 94.43 mg g −1 , and the adsorption equilibrium could be achieved within 30 min. The adsorption isotherm data of MIP@UiO-66-NH 2 could be described well by Freundlich model and the kinetic data complied well with pseudo-second-order model. In addition, the MIP@UiO-66-NH 2 showed low adsorption capacity to GSH structural analogs (Q L-cys = 6.51 mg g −1 ), suggesting great selectivity for GSH recognition. Finally, the MIP@UiO-66-NH 2 was successfully applied for selective separation of GSH from BSA, skim milk and egg white tryptic digest.
研究领域:
分析化学
·
材料科学
·
生物化学
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高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 26
·4153-4160
·
IF 5.047
Qi-Bao Yan,Ning Bao,Shou-Nian Ding
The poor stability of fully inorganic halide perovskite nanocrystals (PNCs) has always restricted their wider application, especially in cell imaging. It has attracted more and more attention to use ligand engineering to improve the stability of PNCs. In this work, CsPbBr3/mPEG-NH2 NCs were synthesized using a highly biocompatible functional polymer, methoxypolyethylene glycol amine, as the capping ligand. The as-prepared CsPbBr3/mPEG-NH2 NCs exhibited superior water solubility as a result of the hydrophilic properties of mPEG-NH2. More shockingly, a significantly enhanced fluorescence intensity was found when CsPbBr3/mPEG-NH2 NCs were dispersed in water for a period of time. Correspondingly, the fluorescence quantum yield increased from the initial 16% to 41% a week later. Meanwhile, the thermal stability of the product has been greatly improved; about 80% of the initial PL intensity was still maintained after heating the product to 100 °C. Finally, we directly utilized the CsPbBr3/mPEG-NH2 NCs as luminescent probes for cell imaging for the first time.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Ruiying Xie,Feng Zhang,Guishan Hu,Mengzhen Chen,Huixian Wang,Xiaoquan Feng,Xuerui Wang,Yatao Zhang,Meixia Shan
The widespread presence of toxic nitroaromatic compounds in industrial effluents demands advanced remediation strategies. Catalytic reduction is highly effective, while the practical application of powdered catalysts is limited by challenges in recovery and reuse. To overcome this issue, macroscopic Pd@NH 2 -MIL-101/AOPIM-1 porous composite beads were fabricated via a phase inversion method, combining the high surface area of NH 2 -MIL-101 with the excellent processability of amidoxime-functionalized polymers of intrinsic microporosity (AOPIM-1). The incorporation of NH 2 -MIL-101 enriches the composite with amino functional groups, thereby enhancing the adsorption and local enrichment of reactants. Furthermore, these nitrogen-rich sites provide robust anchoring points for the uniform dispersion of Pd nanoparticles, collectively boosting catalytic activity and structural stability. The beads exhibited outstanding catalytic activity for the reduction of nitroaromatics, achieving 99% conversion of 4-nitrophenol (4-NP) within 5 min. The catalyst also maintained excellent structural stability over multiple cycles and allowed easy separation. Furthermore, the catalyst exhibited over 90% efficiency in the reduction of other common nitroaromatic pollutants, underscoring its versatility and applicability in wastewater treatment. This work provides a sustainable and practical solution for wastewater treatment by transforming hazardous contaminants into valuable aromatic amines using an easily separable catalytic system.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2017
·
IF 3.615
Linlin Wan,Chen Zhou,Kai Xu,Bo Feng,Aisheng Huang
Compact and phase-pure UiO-66-NH 2 membranes were synthesized on the 3-aminopropy-ltriethoxysilane (APTES) modified macroporous Al 2 O 3 tubes through a repeated synthesis strategy. APTES acts as a molecular linker for anchoring the metal ions onto the support surface to promote the nucleation and the crystallization of UiO-66-NH 2 membrane. Therefore, well-intergrown UiO-66-NH 2 membranes could be prepared through a repeated synthesis method on the APTES-modified macroporous Al 2 O 3 tubes. The developed UiO-66-NH 2 membranes were evaluated for seawater desalination by pervaporation . It is found that the UiO-66-NH 2 membranes show high desalination performances attributing to the narrow pore size which is exactly in between the size of water molecules and hydrated ions . With increasing the feed temperature from 318 to 363 K, the water fluxes increase from 1.5 to 12.1 kg m −2 h −1 , with ions rejections of above 99.7%. Further, the UiO-66-NH 2 membranes display high stability for a long time in seawater desalination, which is very promising for seawater desalination.
研究领域:
材料科学
·
膜技术
·
脱盐
·
环境工程
·
纳米技术
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DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2024
·
IF 2.1
Yuan Ma,Lujie Wang,Haowen Wu,Qian Zhao,Jiying Men
Firstly, the SiO2 microspheres were prepared by Stӧber method, and then modified by 3-Aminopropyltrimethoxysilane (KH-540) to introduce –NH2 onto the microspheres. Then, SiO2-NH2 microspheres were mixed into polysulfone casting solution, and SiO2-NH2/PSF composite membrane was prepared by the phase conversion method. On this basis, the functional adsorbent SiO2-NH2/PSF-g-PMAA was prepared by grafting polymerization of methacrylic acid (MAA) as a functional monomer using –NH2/S2O82− surface initiation system. The samples were characterized by Fourier infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), the Brunauer–Emmett–Teller (BET) and weighing method. The adsorption properties of amlodipine (ADP) by functional adsorbents were investigated, and the adsorption mechanism was further studied. The results show that the adsorption reaches equilibrium at 180 min, and the adsorption kinetics can be well fitted by the pseudo-second-order model. The adsorption capacity of SiO2-NH2/PSF-g-PMAA for amlodipine in methanol with 1.4 mg/mL at 15 °C is 137 mg/g. The adsorption ability increases with the decrease of ionic strength and temperature via the hydrogen bond and ionic interactions, and the adsorption of ADP by SiO2-NH2/PSF-g-PMAA is consistent with the D-R adsorption isotherm model. Thermodynamic parameters imply that adsorption is a spontaneous and exothermic process.
研究领域:
材料科学
·
高分子化学
·
环境科学
·
化学工程
·
膜技术
·
吸附科学
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DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2021
·
IF 3.739
Dan-Dan Shao,Long Wang,Xiang-Yu Yan,Xue-Li Cao,Ting Shi,Shi-Peng Sun
Nanofiltration membranes show great potential in water treatment and resource recovery for their special separation mechanisms that can separate the small molecules effectively. However, their wide application needs to address the low separation efficiency caused by the similar solute sizes and charges while using the charged NF membranes with nanopores. This work reports a low-cost amine–carbon quantum dots (CQDs–NH 2 ) modified thin-film composite (CTFC) membrane via the facile interfacial polymerization process. The electrostatic force and competing reaction between the positively charged CQDs–NH 2 and the reactive monomers reformulated the interfacial polymerization process. The resultant CTFC membrane exhibits improved surface morphology and hydrophilicity. Besides, the incorporation of CQDs–NH 2 changed the original polyamide network structures to construct more transport space. The CTFC membrane permeance was boosted significantly (from 6.2 to 38.44 L m −2 h −1 bar −1 ) compared with the unmodified TFC membrane, showing precise dyes separation property. This work may offer valuable guidance for the low-cost loose nanofiltration membrane preparation towards molecular separation.
研究领域:
材料科学
·
环境工程
·
水处理
·
膜技术
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Senyang Song,Fangfang Shang,Mengwei Yin,Qianqian Wang,Yi Liu,Ran Bi,Xiaoyan Ma
Gallic acid (GA) chelates with exposed metal active sites of Ni/Co-DABD MOF, effectively protecting metal ions and elevating MOF coordination stability. • The GA-modified Ni/Co-DABD MOF@NH₂-MXene composite electrode delivers a high specific capacitance of 2044 F g -1 at 1 A g -1 with superior rate capability and cycling durability. • GA modification strengthens the interfacial synergy between MOF and NH₂-MXene, significantly boosting charge transfer efficiency and structural stability of the composite. The limited active sites and poor electrochemical structural stability of metal-organic frameworks (MOF) severely limit their application in electrochemical energy storage. In this study, we used the acid properties of gallic acid (GA) as an etching agent to etch MOF surface active sites. Subsequently, the protonated GA is further chelated with the exposed metal active site, which can effectively protect the metal ions. At the same time, GA provides a large number of phenolic hydroxyl groups, which greatly improves the coordination stability of MOF. A new MOF@MXene composite electrode material was obtained by solvothermal synthesis of GA-modified MOF and aminated MXene. The electrochemical test results show that the new MOF@MXene composite electrode material synthesized by this scheme has high specific capacitance and high rate stability. The functional modification of MOF by GA greatly improves the synergistic binding performance between MOF and MXene, and thus significantly improves the electrochemical stability of composite electrode materials. The mechanism of the electrochemical reaction was investigated by in-situ X-ray diffraction and theoretical calculation. In this paper, the functional mechanism of polyphenols on MOF is described, which provides a new idea for the electrochemical application of MOF. The GA-modified Ni/Co-DABD MOF@NH₂-MXene composite electrode delivers a high specific capacitance of 2044 F g -1 at 1 A g -1 with superior rate capability and cycling durability. Download: Download high-res image (296KB) Download: Download full-size image
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高影响因子
危险品化学品经营许可证（带存储）