Journal of Semiconductors
·
2020
·Vol. 41
·期 12
·122501
·
IF 0
Zhiguo Sun,Bo Cai,Xi Chen,Wenxian Wei,Xiaoming Li,Dandan Yang,Cuifang Meng,Ye Wu,Haibo Zeng
The possibility to induce a macroscopic magnetic moment in lead halide perovskites (LHPs), combined with their excellent optoelectronic properties, is of fundamental interest and has promising spintronic applications. However, these possibilities remain an open question in both theory and experiment. Here, theoretical and experimental studies are performed to explore ferromagnetic states in LHPs originated from lattice defects. First-principle calculations reveal that shallow-level Br vacancies in defective CsPbBr3 can produce spin-splitting states and the coupling between them leads to a ferromagnetic ground state. Experimentally, ferromagnetism at 300 K is observed in room-temperature synthesized CsPbBr3 nanocrystals, but is not observed in hot-injection prepared CsPbBr3 quantum dots and in CsPbBr3 single crystals, highlighting the significance played by vacancy defects. Furthermore, the ferromagnetism in the CsPbBr3 nanocrystals can be enhanced fourfold with Ni2+ ion dopants, due to enhancement of the exchange coupling between magnetic polarons. Room-temperature ferromagnetism is also observed in other LHPs, which suggests that vacancy-induced ferromagnetism may be a universal feature of solution-processed LHPs, which is useful for future spintronic devices.
研究领域:
材料科学
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凝聚态物理
·
自旋电子学
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DOI
PHYTOPATHOLOGY
·
2025
·
IF 3.1
Chengyan Xia,Xiansu Wang,Miss Zeqi Qi,Miss Fenghua Liu,Miss Dongxue Li,Miss Xiaolin Zhang,Libo Zhang,Delu Wang,Zhuo Chen
Gray mold is an important disease of crops and is widespread, harmful, difficult to control, and prone to developing fungicide resistance. Screening new fungicides is an important step in controlling this disease. Hydroxychloroquine is an anti-inflammatory and anti-malarial agent, which has shown marked inhibitory activity against many fungi in medicine. This study evaluated the inhibitory activity of hydroxychloroquine against several phytopathogenic fungi, finding a half-maximal effective concentration of 113.82 μg/ml against the hyphal growth of Botrytis cinerea , with significant in-vivo curative effects of 92.37% or 78.37% for gray mold on detached tomato leaves or fruits at 10.0 or 200.0 mg/ml, respectively. Ultrastructural studies indicated that hydroxychloroquine induced collapse of hyphae, with a wrinkled surface, unclear organelle boundaries, and organelle disintegration. Transcriptomic assays revealed that hydroxychloroquine could affect the expression of metabolism-related genes. Molecular docking and molecular dynamics analyses indicated that hydroxychloroquine bound to glucose-methanol-choline oxidoreductase, with low free energy value of −11.4 kcal/mol. Cell membrane permeability assays and hyphal staining confirmed that hydroxychloroquine damaged the cell membrane, causing leakage of hyphal contents and disturbing cell function. Biochemical assays indicated that hydroxychloroquine reduced the concentration of soluble proteins and reducing sugars in the hyphae. In total, hydroxychloroquine disturbed amino acid metabolism, therefore inhibiting the production of biomacromolecules, damaging the cell membrane, and restraining the growth of hyphae, and hence inhibiting gray mold on tomato. This study will explore the use of medicine in the development of agricultural fungicides and their application in managing crop diseases, providing valuable background information.
研究领域:
植物病理学
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分子生物学
·
农业科学
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DOI
PubMed
高影响因子
LASER PHYSICS LETTERS
·
2015
·Vol. 12
·期 11
·116003
·
IF 2.458
L P Zhou,G Y Wu,H J Wei,Z Y Guo,H Q Yang,Y H He,S S Xie
In this study, we presented the research of the penetration of zinc oxide nanoparticles (ZnO NPs) (30 and 90 nm), and electroporation (EP) assisted penetration of the ZnO NPs in the human normal colon (NC) and adenomatous colon (AC) tissues studied with optical coherence tomography (OCT) and diffuse reflectance (DR) measurement. The results have shown that the attenuation coefficient of colon tissue after the application of 30 or 90 nm ZnO NPs alone decreased approximately by 28% and 14% for NC tissue, 35% and 22% for AC tissue, respectively; while the attenuation coefficient of colon tissue after combined application of 30 or 90 nm ZnO NPs/EP decreased approximately by 46% and 30% for NC tissue, and 53% and 42% for AC tissue, respectively. The results illustrate EP can significantly increase the penetration of ZnO NPs in the colon tissue, especially in AC tissue. Through the analysis of attenuation coefficient and reflectance intensity of the colon tissue, we find that the accumulation of the ZnO NPs in the colon tissue greatly influenced the tissue optical properties.
研究领域:
生物医学工程
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肿瘤学
·
纳米医学
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DOI
高影响因子
Journal of Environmental Sciences
·
2013
·
IF 1.773
Xiaolin Yu,Shengrui Tong,Maofa Ge,Lingyan Wu,Junchao Zuo,Changyan Cao,Weiguo Song
A novel nanoadsorbent for the removal of heavy metal ions is reported. Cotton was first hydrolyzed to obtain cellulose nanocrystals (CNCs). CNCs were then chemically modified with succinic anhydride to obtain SCNCs. The sodic nanoadsorbent (NaSCNCs) was further prepared by treatment of SCNCs with saturated NaHCO 3 aqueous solution. Batch experiments were carried out with SCNCs and NaSCNCs for the removal of Pb 2+ and Cd 2+ . The effects of contact time, pH, initial adsorption concentration, coexisting ions and the regeneration performance were investigated. Kinetic studies showed that the adsorption equilibrium time of Pb 2+ and Cd 2+ was reached within 150 min on SCNCs and 5 min on NaSCNCs. The adsorption capacities of Pb 2+ and Cd 2+ on SCNCs and NaSCNCs increased with increasing pH. The adsorption isotherm was well fitted by the Langmuir model. The maximum adsorption capacities of SCNCs and NaSCNCs for Pb 2+ and Cd 2+ were 367.6 mg/g, 259.7 mg/g and 465.1 mg/g, 344.8 mg/g, respectively. SCNCs and NaSCNCs showed high selectivity and interference resistance from coexisting ions for the adsorption of Pb 2+ . NaSCNCs could be efficiently regenerated with a mild saturated NaCl solution with no loss of capacity after two recycles. The adsorption mechanisms of SCNCs and NaSCNCs were discussed.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
MOLECULAR PLANT-MICROBE INTERACTIONS
·
2021
·
IF 4.171
Xingtao Bao,Rui Yang,Shilong Jiang,Jinping Zhao,Delu Wang,Dongxue Li,Xian Wu,Baoan Song,Zhuo Chen
Diseases caused by fungi can affect the quality and yield of the leaves of tea [ Camellia sinensis (L.) Kuntze]. At present, the availability of highly effective and safe fungicides for controlling tea plants remains limited. The objectives of this study were to identify novel compounds with antifungal activities and to determine their molecular mechanisms. A series of sulfone compounds containing 1,3,4-oxadiazole were evaluated in China for their antifungal activities against several pathogens causing foliar diseases and high production losses. Transcriptomics and bioinformatics were used to analyze the differentially expressed genes of Lasiodiplodia theobromae treated with a representative compound, jiahuangxianjunzuo (JHXJZ). Moreover, the effects of JHXJZ on ergosterol content, membrane permeability, cell structure, and seven key genes involved in the ergosterol biosynthetic pathway were investigated. JHXJZ had a strong antifungal activity against L. theobromae in vitro, with an effective concentration giving 50% inhibition of 3.54 ± 0.55 μg/ml, and its curative efficacies on detached tea leaves reached 41.78% at 100 μg/ml. JHXJZ upregulated 899 genes ( P < 0.05) and downregulated 1,185 genes ( P < 0.05) in L. theobromae . These genes were found to be associated with carbohydrate metabolic processes, which are closely related to steroid biosynthesis in the Kyoto Encyclopedia of Genes and Genomes pathways. Because JHXJZ regulates the key genes of sterol biosynthesis, it decreased the ergosterol content, increased cell-membrane permeability, changed the cellular structure, enhanced the roughness of the surface of the hyphae, and resulted in degradation of the hyphal nuclei and necrosis of the hyphal cytoplasm. Our study demonstrates that JHXJZ is a fungicide with a novel mechanism of action that differs from that of triazole fungicides. JHXJZ has potential for applications in controlling tea plant diseases.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF RARE EARTHS
·
2012
·
IF 0.901
Fang WANG,Chenglu LIU,Zhiqiang ZHOU,Peiyun JIA,Jun LIN
YVO 4 :Eu nanocrystalline phosphors were successfully prepared at 400 °C in equal moles of NaNO 3 and KNO 3 molten salts. NaOH concentration and annealing temperature played important roles in phase purity and crystallinity of the nanocrystallines, and the optimum NaOH concentration and annealing temperature were 6:40 and 400 °C, respectively. The nanocrystallines were well crystallized with a cubic morphology in an average grain size of 18 nm. Upon excitation of the vanadate groups at 314 nm, YVO 4 :Eu nanocrystallines exhibited the characteristic emission of Eu 3+ , which indicated that there was an energy transfer from vanadate groups to Eu 3+ . Moreover, the influence of superficial effect, especially the dangling bonds on the structure and luminescent properties of the nanocrystallines was discussed in detail.
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DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2012
·
IF 0.901
Xiaoming PENG,Yufeng HU,Chuanwei JIN,Zhixin WANG,Chao MIAO,Zheyu LI
Viscosities were measured for the ternary systems Y(NO 3 ) 3 +La(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +Ce(NO 3 ) 3 +H 2 O, and La(NO 3 ) 3 +Nd(NO 3 ) 3 + H 2 O and their binary subsystems Y(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +H 2 O, Ce(NO 3 ) 3 +H 2 O, and Nd(NO 3 ) 3 +H 2 O at 293.15, 298.15 and 308.15 K. The results were used to test the applicability of simple equations for the viscosity of the mixed solutions. The predictions agreed well with measured values, implying that the viscosities of the examined electrolyte solutions could be related to those of their constituent binary solutions using these simple equations.
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DOI
高影响因子
NANOTECHNOLOGY
·
2016
·Vol. 27
·期 12
·125601
·
IF 3.573
Meili Yin,Zhenhua Li,Li Zhou,Kai Dong,Jinsong Ren,Xiaogang Qu
Recently, antibiotic drug-resistant therapies have become very important due to the emergence of antibiotic-resistant bacterial strains. The development of novel antibacterial materials has received significant attention. Here, quaternized chitosan hydrogels incorporated with NaYF4:Er/Yb/Mn@photosensitizer-doped silica (UCNPs/MB) were synthesized for effective killing of both gram-positive oxacillin-resistant S. aureus (DR-S. aureus) and gram-negative kanamyclin-resistant E. coli (DR-E. coli) bacteria upon near-infrared (NIR) laser irradiation. In this system, the cationic macroporous nature of the hydrogel acts as a molecular 'anion sponge', which sucks the outer part of the anionic microbe membrane into the gel interior voids and causes microbe membrane disruption. By incorporating UCNPs/MB-doped silica into the hydrogel, we have combined photodynamic therapy (PDT) with quaternized chitosan to obtain a high therapeutic index via a synergistic effect. In vitro experiments have demonstrated that our system had excellent antibacterial efficiency to both DR-S. aureus and DR-E. coli bacteria. More importantly, our new synergistic treatment modality provided an excellent therapy platform for drug-resistant bacteria, which could improve antimicrobial efficiency.
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DOI
PubMed
高影响因子
CANCER RESEARCH
·
2013
·Vol. 73
·期 4
·1362-1373
·
IF 8.65
Cao Jie,Cui Sisi,Li Siwen,Du Changli,Tian Junmei,Wan Shunan,Qian Zhiyu,Gu Yueqing,Chen Wei R.,Wang Guangji
Adriamycin (ADM) has been effective against many types of solid tumors in clinical applications. However, its use is limited because of systemic toxicities, primarily cardiotoxicity, and multidrug resistance. In this study, a new active receptor-mediated complex, ADM conjugated with 2-amino-2-deoxy- d -glucose and succinic acid (2DG–SUC–ADM), was designed to target tumor cells through glucose transporter 1 (GLUT1). MTT assay and confocal images showed that the complex had better inhibition rate to tumor cells and low toxicity to normal cells. Most importantly, the complex displayed a potential to reverse overcome multidrug resistance in cancer cells, with more complex transported into the nucleus of tumor cells. Our in vivo experiments also showed that this new complex could significantly decrease organ toxicity and enhance the antitumor efficacy compared with free ADM, indicating a promising drug of 2DG–SUC–ADM for targeted cancer therapy. Cancer Res; 73(4); 1362–73. ©2012 AACR .
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DOI
PubMed
高影响因子
PURE AND APPLIED CHEMISTRY
·
2012
·Vol. 85
·期 2
·417-425
·
IF 2.789
Xiao Wang,Feng Hao,Huiyuan Chen,Gang Wang,Jianbao Li,Hong Lin
Single-crystalline anatase TiO 2 nanorods (TiO 2 -SANRs) were synthesized through a facile solvothermal method and successfully applied as the photoanodes for efficient dye-sensitized solar cells (DSCs). The prepared samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The power conversion efficiencies of TiO 2 -SANRs decorated Degussa P25 nanoparticle solar cells increased by 13.5 % compared with commercial Degussa P25 TiO 2 solar cells under standard illumination conditions (AM 1.5G, 100 mW/cm –2 ). The improved performance of the TiO 2 -SANRs decorated Degussa P25 nanoparticle solar cells was primarily ascribed to the enhanced short-circuit photocurrent density ( J sc ) despite a declined dye-loading capacity. The light-scattering effect in the long-wavelength region, as evidenced from the incident photon-to-current conversion efficiency (IPCE) response and the diffuse reflectance spectroscopy was recognized as the main reason for the photocurrent enrichment.
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DOI
高影响因子
Chinese Journal of Natural Medicines
·
2012
·
IF 0
Yi LI,Ming RUAN,Jian-Guang LUO,Ling-Yi KONG
A novel on-line method using high performance liquid chromatography (HPLC) with a diode array detector (DAD) and a chemiluminescence (CL) detector was successfully developed for simultaneously analyzing the antioxidant efficacies of 15 components in Guan-Xin-Ning (GXN) injection, a traditional Chinese medicinal preparation consisting of Radix Salvia miltiorrhiza and Rhizoma Ligusticum chuanxiong for the treatment of coronary heart disease and angina pectoris. The analytical conditions were optimized, validated and applied to determine H 2 O 2 inhibition rates of the 15 phenolic acids in GXN injections from 14 different production batches. The results showed that antioxidant diversities were found in the 15 compounds and that danshensu, protocatechuic aldehyde and rosmarinic acid were largely responsible for the antioxidant activity of GXN injection (25.82%-51.19%). In addition, 14 batches of GXN injections were divided into five groups corresponding with five different factories by principal component analysis (PCA) assay. Therefore, the proposed HPLC-DAD-CL method was simple, rapid and low-cost for screening antioxidant constituents in a complex system, which can be used to reveal the antioxidant mechanism of GXN injection and is applicable for its quality control in terms of activity, which was different from the routine chemical assessment.
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DOI
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2012
·
IF 0.826
Jianxian ZENG,Xiahui SUN,Lifeng ZHENG,Qincheng HE,Shu LI
Polyquaternium-6 (PQ6) as the water-soluble polymer was used for complexing the anion forms of tungsten (VI) before ultrafiltration. Tungsten (VI)-PQ6 complex was retained by polysulfone hollow fiber ultrafiltration membrane in the complexation-ultrafiltration process. Effects of various operating parameters such as polymer metal ratio(PMR), pH and chloride ion concentration on permeate flux ( J ) and tungsten rejection coefficient ( R ) were investigated. The integration of four experiments including concentration, decomplexation, diafiltration and reuse of regenerated polymer was carried out. In the process of concentration, J declines slowly and R is about 1 at PMR of 3 and pH of 7. Tungsten concentration in the retentate increases linearly with volume concentration factor. Tungsten is concentrated efficiently with the membrane. The concentrated retentate was used further for the decomplexation. It takes about 6 min to reach the decomplexation equilibrium at chloride ion concentration of 50 mgL −1 . The decomplexation percentage of tungsten (VI)-PQ6 complex reaches 56.1%. In the diafiltration process, tungsten (VI) can be extracted effectively by using 50 mgL −1 chloride ion solution, and the purification of the regenerated PQ6 is acceptably satisfactory. The regenerated PQ6 was used to bind tungsten (VI) at various pH values. The binding capacity of the regenerated PQ6 is close to that of fresh PQ6, and the recovery percentage of binding capacity is higher than 90%.
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高影响因子
危险品化学品经营许可证（带存储）