DALTON TRANSACTIONS
·
2019
·Vol. 48
·期 28
·10537-10546
·
IF 4.052
Guofeng Liu,Yeqing Chen,Mochen Jia,Zhen Sun,Binbin Ding,Shuai Shao,Fan Jiang,Zuoling Fu,Ping'an Ma,Jun Lin
Rare earth ion-doped fluoride upconversion nanoparticles (UCNPs), emerging as a novel class of probes and drug carriers, exhibit superior promise for bio-applications in diagnostics and treatment on account of their strong luminescence, fine biocompatibility, and high drug loading. However, the fine control and manipulation of particle size and the distribution of rare earth ion-doped oxides has remained an insurmountable challenge to date. In this work, we construct and synthesize silica-coated Gd2(WO4)3:Yb3+/Ho3+ nanoparticles by one-pot co-precipitation, with uniform distribution (∼130 nm) and enhanced yellow fluorescence. Particularly, the nanoparticles not only possess outstanding temperature sensing performance at biological temperatures in water by utilizing the fluorescence intensity ratio (FIR) method, but also allow a further serviceable contrast effect in vitro and in vivo based on the prominent T1-weighted magnetic resonance (MR) signal of Gd3+. Compared with cisplatin and platinum(IV) (DSP), the Gd2(WO4)3@SiO2 nanoparticles functionalized with DSP (Gd2(WO4)3@SiO2-Pt-PEG) exert higher lethality against CT26 cells and significantly inhibit the growth of tumors at the same concentration of Pt. This effect occurs through the greater level of cell endocytosis. The lethality value of the latter is 10 times higher than the former after the same length of time according to inductively coupled plasma-mass spectrometry (ICP-MS) results. In short, the monodisperse and strongly fluorescent Gd2(WO4)3@SiO2-Pt-PEG nanoparticles are endowed with dual-mode imaging, temperature sensing and anticancer functions, which provide a significant guide for synthesis and bio-application of lanthanide ion-doped oxides.
研究领域:
生物医学工程
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纳米医学
·
材料科学
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DOI
PubMed
高影响因子
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
·
2021
·
IF 1.811
Safi Ullah,Keisuke Ogumi,Xuelin Zhen,Huan Wang,Yutaka Matsuo
A Suzuki–Miyaura coupling reaction was performed to synthesize 5,15- meso -bis(2-chlorothiophen-3-yl)porphyrins in order to obtain a building block for further functional porphyrins. Photophysical and electrochemical properties were investigated to understand the effect of 2-chloro substituted thiophenes which are connected at their 3-position to the meso -position of the porphyrin. A computational calculation with counterpoise method was demonstrated to estimate the relative intermolecular interaction in order to compare solubility. Installed chloro atoms at the 2-position of thiophen-3-yl decreased in intermolecular interaction which caused an increase in solubility.
研究领域:
有机化学
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材料科学
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计算化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Yini Liu,Debao Wang,Zhilan Sun,Fang Liu,Lihui Du,Daoying Wang
In this study, antibacterial nanofiber films were prepared by electrospinning gelatin, chitosan, and 3-phenyllactic acid (PLA). The addition of PLA improved the microstructures of the nanofibers, and the nanofiber films (GCP-1 and GCP-2) had uniform and continuous structures with a diameter range of 40‐–70 nm when the PLA concentrations in the polymers were 1% and 2%. Under acidic conditions, chitosan and PLA interacted and formed hydrogen bonds , which decreased the crystallinity of the nanofiber films. The GCP-2 nanofiber film had the best thermal stability , water stability, and water vapor permeability. Compared with the control GCP-0 film, the four nanofiber films with PLA (GCP-1, GCP-2, GCP-3, and GCP-4) had more effective antibacterial effects, and GCP-2 film reduced approximately 4 log CFU/mL of Salmonella enterica Enteritidis and Staphylococcus aureus in 30 min. Results suggested that the GCP-2 nanofiber film mat can be used as an active food packaging.
研究领域:
材料科学
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食品科学
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纳米技术
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DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2016
·
IF 2.336
Kun Liu,Kai-Kai Liu,Mu-Jeng Cheng,Ming-Han Han
A combined experimental and theoretical study was conducted to investigate the isomerization of 2-methyl-3-butenenitrile (2M3BN) to 3-pentenenitrile (3PN) and to 2-methyl-2-butenenitrile (2M2BN) catalyzed by nickel diphosphine complexes. Ni(1,4-bis(diphenylphosphino)butane) (dppb) was identified as the most reactive catalyst among the complexes that we examined experimentally. Quantum mechanics (density functional theory) was then used to study the two isomerization mechanisms catalyzed by this complex. We find that for the 2M3BN → 3PN isomerization, the reaction is initiated with C CN bond cleavage, followed by an allyl direct rotation and C CN bond reformation. For the 2M3BN → 2M2BN isomerization, the most energetically favorable pathway begins with C H bond activation, followed by a π-σ-σ-π allyl rearrangement and C H bond reformation. Our proposed mechanism for the 2M3BN → 2M2BN isomerization is slightly different (yet energetically more favorable) than that described in previous studies, where it has been suggested that 2M2BN is obtained through a π-σ-σ allyl rearrangement rather than a π-σ-σ-π type rearrangement. Additionally, we investigated the effect of Lewis acids in the 2M3BN → 3PN isomerization, which has been shown in most experiments to attenuate the reaction. Notably, our calculations indicated that ZnCl 2 , which is used as a model Lewis acid, actually reduces the barriers for all elementary steps. However, the effective kinetic barrier for the isomerization increases from 23.7 (without ZnCl 2 ) to 24.0 kcal/mol because of the formation of a very stable Ni(π-allyl) (CN ZnCl 2 ) intermediate, causing a decrease in the reaction rate. This theoretical result was further confirmed by our own experiments.
研究领域:
有机化学
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理论化学
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DOI
高影响因子
Materials
·
2020
·Vol. 13
·期 24
·5733
·
IF 3.057
Tiancheng He,Caihuan Lv,Wenhao Li,Guohua Huang,Zhihui Hu,Jianmei Xu
The electronics related to the fifth generation mobile communication technology (5G) are projected to possess significant market potential. High dielectric constant microwave ceramics used as filters and resonators in 5G have thus attracted great attention. The Ba6−3x(Sm1−yNdy)8+2xTi18O54(x =2/3) ceramic system has aroused people’s interest due to its underlying excellent microwave dielectric properties. In this paper, the relationships between the dielectric constant, Nd-doped content, sintering temperature and the density of Ba6−3x(Sm1−yNdy)8+2xTi18O54(x =2/3) ceramics were studied. The linear regression equation was established by statistical product and service solution (SPSS) data analysis software, and the factors affecting the dielectric constant have been analyzed by using the enter and stepwise methods, respectively. It is found that the model established by the stepwise method is practically significant withY= −71.168 + 6.946x1+ 25.799x3, whereY,x1andx3represent the dielectric constant, Nd content and the density, respectively. According to this model, the influence of density on the dielectric constant is greater than that of Nd doping concentration. We bring the linear regression analysis method into the research field of microwave dielectric ceramics, hoping to provide an instructive for the optimization of ceramic technology.Keywords:microwave dielectric ceramics;Ba6−3x(Sm1−yNdy)8+2xTi18O54(x =2/3) system;dielectric constant;linear regression analysis
研究领域:
材料科学
·
电子工程
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DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2024
·
IF 3.4
Dingyu Guo,Zhengchao Wang,Wanqing Wei,Wei Song,Jing Wu,Jian Wen,Guipeng Hu,Xiaomin Li,Cong Gao,Xiulai Chen,Liming Liu
D-allulose is a naturally occurring rare sugar and beneficial to human health. However, the efficient biosynthesis of D-allulose remains a challenge. Here, we mined a new D-tagatose 3-epimerase from Kroppenstedtia eburnean (KeDt3e) with high catalytic efficiency . Initially, crucial factors contributing to the low conversion of KeDt3e were identified through crystal structure analysis, density functional theory calculations (DFT), and molecular dynamics (MD) simulations. Subsequently, based on the mechanism, combining restructuring the flexible region, proline substitution based onconsensus sequence analysis, introducing disulfide bonds , and grafting properties, and reshaping the active center, the optimal mutant M5 of KeDt3e was obtained with enhanced thermostability and activity. The optimal mutant M5 exhibited an enzyme activity of 130.8 U/mg, representing a 1.2-fold increase; T m value increased from 52.7 °C to 71.2 °C; and half-life at 55 °C extended to 273.7 min, representing a 58.2-fold improvement, and the detailed mechanism of performance improvement was analyzed. Finally, by screening the ribosome-binding site (RBS) of the optimal mutant M5 recombinant bacterium (G01), the engineered strain G08 with higher expression levels was obtained. The engineered strain G08 catalyzed 500 g/L D-fructose to produce 172.4 g/L D-allulose, with a conversion of 34.4% in 0.5 h and productivity of 344.8 g/L/h on a 1 L scale. This study presents a promising approach for industrial-scale production of D-allulose.
研究领域:
生物化学
·
食品科学
·
酶工程
✓ 已验证
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2026
·Vol. 156
·期 9
·242
·
IF 2.5
Shi Guopu,Shi Fangxu,Liang Fuxin,Wei Yulin,Li Yuanguang,Han Yubing,Wu Junyan,Huang Sai,Wang Honglei,Ji Jun,Wu Chao
Ethyl 3-piperidine-carboxylate is an important intermediate in the pharmaceutical field. To break through the limitations of poor mechanical strength and thermal stability of catalysts and low catalytic efficiency of foam ceramic carriers due to the lack of active sites in traditional synthesis, this study used the hydrogenation synthesis of ethyl nicotinate to produce this intermediate as the probe reaction. Pd-Ni/Ru-Al 2 O 3 -SiO 2 foam ceramic catalysts were prepared by the sol-gel method and the impregnation method. Relying on the bimetallic differentiated synergistic effect of Ni, Ru, and Pd, the above technical bottlenecks were overcome. A variety of characterization techniques reveal its core mechanism of action: Pd serves as the catalytic core, and Ni can optimize the electronic structure, enabling the Pd-Ni alloy to obtain the optimal d-band center and adsorption energy, laying an electronic foundation for efficient catalysis. Ru can precisely control the particle size of Pd-Ru alloy, which is 4.5 nm smaller than that of single-metal Pd, significantly improving the metal dispersion and the utilization rate of active sites. The three-dimensional network structure of foam ceramics enhances mass transfer efficiency. The γ-Al 2 O 3 -SiO 2 coating provides abundant active sites and excellent stability. The catalytic performance of this system has been significantly enhanced. Among them, the yield of the corresponding product of the Pd-Ni bimetallic catalyst reached 92.57%, and it still remained above 80% after five cycles of use, providing new prospects for the green and efficient synthesis of ethyl 3-piperidine-carboxylic acid esters and the development of low-cost hydrogenation catalysts. Graphical
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产品关联
DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2016
·Vol. 24
·期 9
·757-766
·
IF 1.357
Wang Zhen-Zheng,Duan Hong-Dong,Meng Xia,Zhang Yi-Fan,Qi Hui-Min
Two novel types of thiol-based chelating resins were fabricated by modifying poly(2-hydroxyethyl methacrylate- co -glycerol dimethacrylate) (P(HEMA-GDMA)) and poly(2-hydroxyethyl methacrylate- co -ethylene glycol dimethacrylate) (P(HEMA-EGDMA)) with (3-mercaptopropyl) trimethoxysilane(MPS), and used to adsorb lead(II) from aqueous solution. The effects of initial lead(II) concentrations, solution pH, coexisting ions on adsorption of lead(II) were investigated. After modifying, the product P(HEMA-GDMA)-SH has excellent adsorption capacity (118.56 mg/g) for lead(II) at initial lead(II) concentration of 200 mg/L. The resins could easily be regenerated and were reused 6 times without significant loss of adsorption capacity. Besides, the presence of coexisting ions did not markedly influence the adsorption capacities of the resins. The results indicate that the functional thiol-based resins are efficient adsorbents for the removal of toxic lead(II) ions in water treatment.
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Wei Zhao,Xunhui Xiong,Yingbang Yao,Bo Liang,Ye Fan,Shengguo Lu,Tao Tao
The construction of high capacity cathode materials consisting of two active components, LiFe x Mn 1-x PO 4 and Li 3 V 2 (PO 4 ) 3 , is rarely reported. Herein, 5LiFe 0.9 Mn 0.1 PO 4 ∙4Li 3 V 2 (PO 4 ) 3 /C (LFMVP/C) composites are synthesized by a simple two-step process, including ball milling and heat-treatment. The electrochemical reactivity of the composites with lithium is evaluated. The cathode assembled with LFMVP/C shows better electrochemical performance than that of the single active component (LiFePO 4 , LiMnPO 4, or Li 3 V 2 (PO 4 ) 3 ) during charging and discharging in the potential range of 2.4 and 4.8 V. It delivers the specific capacities of 195, 173, and 158 mAh∙g −1 at 0.1C, 0.5C, and 2C, and retains 88% of the initial discharge capacity after 100 cycles at 0.1 C. Compared with the single active component (LiFePO 4 , LiMnPO 4, or Li 3 V 2 (PO 4 ) 3 ), the lithium-ion diffusion coefficient of the composite composed of two active components (LFMVP/C) is higher.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
AAPS PHARMSCITECH
·
2021
·Vol. 22
·期 7
·1-7
·
IF 3.246
Wang Beilei,Shan Xiaoxiao,Lv Shujie,Zha Liqiong,Zhang Caiyun,Dong Qiannian,Chen Weidong
3-O-β-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-β-D-galactose (Gal) in our previous study. In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were prepared using polydopamine (PDA) as a drug carrier. The drug loading (DL %) and entrapment efficiency (EE %) of Gal-Res NPs were 46.80% and 88.06%. The average particle size, polydispersity index (PDI), and Zeta potential of Gal-Res NPs were 179.38 ± 2.83 nm, 0.129 ± 0.013, and − 28.05 ± 0.36 mV, respectively. The transmission electron microscope (TEM) showed that Gal-Res NPs had uniform spherical morphology. Compared with the fast release of raw Gal-Res, the in vitro release of Gal-Res NPs was slow and pH-sensitive. The results of the blood vessel irritation and hemolysis test demonstrated that Gal-Res NPs had good hemocompatibility. The pharmacokinetics study in rats showed that area under the curve of plasma drug concentration time (AUC 0→600 ) and half-life (t 1/2 ) of Gal-Res NPs were enhanced 1.82-fold and 2.19-fold higher than those of raw Gal-Res. The in vivo biodistribution results showed that Gal-Res NPs were more distributed in liver tissue than Gal-Res. Gal-Res NPs with high bioavailability and liver accumulation were hopeful drug delivery systems (DDS) to treat liver diseases. Graphical abstract
研究领域:
药剂学
·
生物医学工程
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Biological Sciences
·
2024
·Vol. 20
·期 8
·2904-2921
·
IF 8.2
Xiong Tianxin,Li Yi,Yang Molin,Huo Bo,Guo Xian,Liu Liyuan,Huang Yanxin,Zhu Xuehai,Hu Qinghua,Wei Xiang,Jiang Ding-Sheng,Yi Xin
Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is one of the critical pathological mechanisms of pulmonary hypertension (PH), and therefore is gradually being adopted as an important direction for the treatment of PH. Metallothioneins (MTs) have been reported to be associated with PH, but the underlying mechanisms are not fully understood. Here, we demonstrated that the expression level of metallothionein 3 (MT3) was significantly increased in pulmonary arterioles from PH patients and chronic hypoxia-induced rat and mouse PH models, as well as in hypoxia-treated human PASMCs. Knockdown of MT3 significantly inhibited the proliferation of human PASMCs by arresting the cell cycle in the G1 phase, while overexpression of MT3 had the opposite effect. Mechanistically, we found that MT3 increased the intracellular zinc (Zn2+) concentration to enhance the transcriptional activity of metal-regulated transcription factor 1 (MTF1), which promoted the expression of autophagy-related gene 5 (ATG5), facilitating autophagosome formation. More importantly, MT3-induced autophagy and proliferation of human PASMCs were largely prevented by knockdown of MTF1 and ATG5. Therefore, in this study, we identified MT3-Zinc-MTF1-ATG5 as a novel pathway that affects PASMC proliferation by regulating autophagosome formation, suggesting that MT3 may be a novel target for the treatment of PH.
研究领域:
心血管疾病
·
分子生物学
·
细胞生物学
·
病理生理学
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DOI
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Yanfang Zhou,Mianrong Chen,Piaoyi Chen,Xiaotian Zhao,Hua Zhou,Jingmiao Wu,Xufeng Li,Qiuxia Li,Runxing Lin,Yugang Huang,Yingying Lun,Guodong Ye
Preparing polymers from allyl monomers without being hindered by degradative chain transfer (DCT) remains a challenge. Herein, we report the synthesis and characterization of embolic microspheres based on allyl monomers for transcatheter arterial embolization using a photodriven radical-mediated [3 + 2] cyclization reaction (PRMC) without metal catalysis. The mechanism of PRMC was validated by thermal and spectral experiments, indicating that PRMC overcomes the restrictions of DCT and makes it possible to synthesize a variety of well-defined polymers from inert allyl monomers. The embolization microspheres based on poly(sucrose allyl ether) were characterized by morphological determination, degradation and swelling tests. Cell experiments show that the microspheres have good biocompatibility. The complete arterial occlusion of the embolized kidneys was observed, indicating that microspheres have broad application prospects in embolization interventional therapy.
研究领域:
高分子化学
·
介入医学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）