Colloid and Interface Science Communications
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2025
·
IF 4.7
Qiaoyue Ren,Rui Wang,Bingfeng Wu,Dingming Huang,Ding Xiong,Yu Shi,Zhenming Wang
Effective wound healing remains a challenge in clinical medicine due to limitations in traditional dressings, which often lack the necessary biocompatibility, breathability and ability to provide bioenergy. In this study, we developed bioenergetic-active cryogels using adenosine salts (AMP 2Na, ADP-2Na, and ATP 2Na) as crosslinkers to enhance tissue regeneration through improved energy metabolism. The cryogels feature a porous and loose structure that facilitates water and gas exchange, as well as the absorption of wound exudate. Additionally, ATP-2Na-coordinated cryogel (G-ATP) stimulates cellular proliferation and migration, while exhibiting anti-inflammatory properties, thus creating an optimal environment for wound repair. In vivo experiments in a full-thickness wound model showed accelerated healing with the G-ATP group, which outperformed control groups in wound contraction and collagen deposition. These findings suggest that G-ATP serve as breathable physical barriers and bioactive dressings that enhance healing by supporting cellular energy needs. This novel approach provides a promising platform for advanced wound care, with potential applications in tissue engineering and regenerative medicine.
研究领域:
生物材料学
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再生医学
·
伤口护理
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DOI
高影响因子
Catalysts
·
2025
·Vol. 15
·期 3
·252
·
IF 4
Haitao Zhang,Jian Shi,Chaoya Han,Zhizhao Song,Yao Xiao,Xiazhang Li
With the increasing demand for air pollution control, the development of efficient and stable catalysts to degrade hazardous VOCs such as toluene has become particularly important. Herein, various copper-doped attapulgite-supported cobalt oxide spinel composites (CuxCo3−xO4/ATP) were synthesized using an ultrasonic-assisted precipitation method. The results showed that the abundant Si-OH groups on the surface of ATP played a crucial role in anchoring Co, and the instantaneous high-energy input of ultrasonication facilitated the formation of Si-O-Co bonds in Co3O4/ATP. The doping of Cu ions induced the expansion of the Co3O4lattice, resulting in a significant number of oxygen vacancies. The ultrasound-induced synthesized Cu0.1Co2.9O4/ATP catalyst exhibited the best catalytic oxidation performance, achieving a 99% toluene degradation rate at 300 °C under a weight hourly space velocity (WHSV) of 10,000 mL·g−1h−1and initial toluene concentration of 1000 ppm, along with high stability during 12 h of continuous running. This work presents a new strategy for the cost-effective catalytic elimination of VOCs.
研究领域:
环境科学
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催化材料
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空气污染控制
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2024
·
IF 8
Min Long,Jiayang He,Xinyue Jia,Yuqing Zhang,Zhihan Zhang,Yaqin Chai,Ruo Yuan,Wenju Xu
To better balance background leakage and disassociation kinetics in traditional ligand-aptamer competition-based transduction, herein we explore the ratiometric fluorescence ability of red- and green-emissive Ag cluster ( r AgC and g AgC) that is illuminated by the adenosine triphosphate (ATP)-induced proximity hybridization. For proof-of-concept, an ATP-recognizable strand (AS) encoding the aptamer sequence (aS) in the middle and a stem-loop bi-template hairpin ( b TH) are introduced. Originally, the partial sequence for r AgC is blocked in the stem of hairpin-structured b TH, while tethering an exposed g AgC-clustering toehold for ‘green-on’ emission . Upon inputting ATP, the specific ATP-aptamer binding induces the dynamic switch of random-coil AS into stable hairpin structure (off-to-on transition) with a short-paired stem, in which two split invaders are oriented closely as a parent invader to interfere the unpaired loop of b TH. Through perfect proximity hybridization, rapid orthogonal DNA assembly urges b TH to lose its hairpin conformation geometry, thereby connecting the contiguous stem for preferable development of r AgC with ‘red-on’ emitting signal. Thus, ligand ATP and aptamer AS are like a logic ‘key/switch’ pair to execute an input-output connection. As predicted, the fluorescence intensity of r AgC and g AgC reversely changes in a tailored ATP-responsive route, obtaining the dose-dependent ratiometric response for sensing ATP. The conformation alteration by ligand-aptamer recognition would be more beneficial to guide precise proximity hybridization between two reactive species, constructing an applicable biosensing platform with simplification, specificity, low background and rapid reaction kinetics.
研究领域:
生物化学
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分子生物学
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分析化学
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高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
·
2018
·Vol. 186
·期 2
·467-473
·
IF 2.361
Cao Changyu,Luo Junchong,Li Xiaowen,Zhang Mengdan,Zhang Haoji,Zhang Jipei,Wang Kai
The aim of this study was to evaluate the protective effects of SeY (selenium-rich yeast) against Al (aluminum)-induced inflammation and ionic imbalances. Male Kunming mice were treated with Al (10 mg/kg) and/or SeY (0.1 mg/kg) by oral gavage for 28 days. The degree of inflammation was assessed by mRNA expression of inflammatory biomarkers. Ionic disorders were assessed by determining the Na + , K + , and Ca 2+ content, as well as the alteration in ATP-modifying enzymes (ATPases), including Na + K + -ATPase, Ca 2+ -ATPase, Mg 2+ -ATPase, Ca 2+ Mg 2+ -ATPase, and the mRNA levels of ATPase’s subunits in kidney. It was observed here that SeY exhibited a significant protective effect on the kidney against the Al-induced upregulation of pro-inflammatory and downregulation of anti-inflammatory cytokines. Furthermore, a significant effect of Al on the Na + , K + , Ca 2+ , and Mg 2+ levels in kidney was observed, and Al was observed to decrease the activities of Na + K + -ATPase, Mg 2+ -ATPase, and Ca 2+ Mg 2+ -ATPase. The mRNA expression of the Na + K + -ATPase subunits and Ca 2+ -ATPase subunits was regulated significantly by Al. Notably, SeY modulated the Al-induced alterations of ion concentrations, ATPase activity, and mRNA expression of their subunits. These results suggest that SeY prevents renal toxicity caused by Al via regulation of inflammatory responses, ATPase activities, and transcription of their subunits.
研究领域:
毒理学
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营养学
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分子生物学
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DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
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2023
·Vol. 234
·期 2
·1-12
·
IF 2.9
Khatun Most Munera,Islam Ashraful,Yan Chunjie,Nesa Most Jinnatun
A nano-ZnO semiconductor material loaded with mineral attapulgite (ATP) photocatalyst has been investigated. Using ATP as a carrier, a variety of various mixtures of ZnO/ATP composites was synthesized. A scanning electron microscope (SEM), X-ray diffractometry (XRD), and UV-Vis spectrophotometer (UV-Vis) were used to examine the morphology, synergistic effects, and photocatalytic properties of ZnO/ATP nanocomposites. The target pollutant for photocatalytic degradation is methylene blue solution. When ATP is mixed with pure ZnO, the degrading performance of composite nanomaterials in methylene blue solution is considerably enhanced. The degree of methylene blue degradation increases as the amount of ATP in the composite grows, and the degradation rate of ZnO/40% ATP can reach 96% in 45 min under solar light illumination. The amount of ATP in the system is excessive, and the adsorption effect is visible. The optimal composite ratio was determined to be ZnO/30% ATP. After discovering the ideal composite ratio and synergy of ZnO/ATP, g-C 3 N 4 was compounded in the aforesaid system, dramatically increasing the composite’s photocatalytic activity. At 45 min, the degradation rate of methylene blue reaches 97%. The absorption range and intensity of ternary composites increased, and the photogenerated electron-hole recombination rate decreases significantly. The reaction rate constant increases from 0.033 to 0.069 min −1 . SEM revealed rod-like attapulgite particles packed with tiny zinc oxide particles and a moderate layered structure of C 3 N 4 . The XRD pattern indicated that C 3 N 4 ’s crystallinity is poor and ZnO’s peak intensity is excessively high, masking the composite material’s distinctive peaks. The degradation rate of g-C 3 N 4 /ZnO/30% ATP to methylene blue was found to be 91.5% after 5 cycles.
研究领域:
材料科学
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环境科学
·
纳米技术
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DOI
高影响因子
Materials
·
2023
·Vol. 16
·期 6
·2292
·
IF 3.4
Zhixiang Zhu,Shengyuan Wang,Ya Zhong,Qi You,Jun Gao,Sheng Cui,Xiaodong Shen
Dye wastewater has caused great harm to the environment, which is an urgent problem to be solved. As typical three-dimensional porous materials, aerogels have attracted great interest in dye wastewater treatment. In this work, spherical attapulgite/silica (ATP/SiO2) gels were initially prepared by easily scalable sol-gel dripping methods and then dried to aerogels with three drying techniques, namely, supercritical CO2drying (SCD), freeze-drying (FD), and ambient pressure drying (APD). The effect of the drying techniques and heat-treated temperature on the physical characteristic, morphological properties, microstructure, and chemical structure of the spherical ATP/SiO2aerogels were investigated. The macroscopic morphology of the spherical ATP/SiO2aerogels was homogeneous and integrated without local cracking. The average pore diameter and specific surface area of the spherical ATP/SiO2aerogels prepared by the three drying techniques were in the range of 6.8–8.6 nm and 218.5–267.4 m2/g, respectively. The heat treatment temperature had a significant effect on the pore structure and the wetting properties of the aerogels. The 600 °C heat-treated aerogels were subjected to adsorption tests in methylene blue (MB) solution (60 mg/g, 100 mL), which exhibited a great adsorption capacity of 102.50 mg/g. Therefore, the resulting spherical ATP/SiO2aerogels possessed multipath preparation and exhibited an efficient adsorption performance, with the potential to be applied as an adsorbent for dye wastewater.Keywords:spherical ATP/SiO2aerogels;drying techniques;heat treatment;adsorption performance
研究领域:
环境科学
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材料科学
·
废水处理
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DOI
PubMed
高影响因子
Acupuncture and Herbal Medicine
·
2024
·Vol. 4
·期 2
·243
·
IF 0
Wu Jianzhi,Ma Zhi,Zhang Yinhao,Duan Shuni,Sun Rong,Liu Runping,Li Yijie,Li Xiaojiaoyang
Objective: Drug-induced liver injury (DILI) is the leading cause of acute liver failure and poses a significant challenge to human health. Rhubarb ( Rheum officinale Baill . DaHuang) has been clinically used for its heat-clearing and diuresis-promoting effects. However, its toxic effects on different organelles in the liver require further validation. Methods: We analyzed the potential targets affecting hepatotoxicity in rhubarb and the potential damage relationship with five major organelles, including microsomes, mitochondria, endoplasmic reticulum (ER), Golgi apparatus (GA), and lysosomes through Integrated Traditional Chinese Medicine (ITCM)/HERB databases and network pharmacology. We isolated and purified different organelles, incubated them with different fractions and monomers of rhubarb in an adenosine triphosphate (ATP) culture system and examined the structural and functional changes in the organelles using particle size analysis and molecular biological experiments to investigate whether rhubarb affects the damage and rupture of major organelles in the liver. Results: By combining virtual predictions and experimental verification, our research confirmed that emodin isolated from the anthraquinone of rhubarb, catechin in the tannins of rhubarb, and palmitic acid in the organic acids of rhubarb caused the most significant functional and structural damage to the representative organelles. Among all the monomeric compounds, emodin caused the most damage to the microsome, mitochondria, ER, and lysosome; catechin induced microsome and GA damage; and palmitic acid caused the most damage to microsomes and GA in the liver, suggesting that rhubarb components may exert hepatotoxicity through multi-organelle injury. Conclusions: Our findings revealed that rhubarb has varying degrees of damaging effects on different organelles, which in turn affects cellular life activities by impairing organelle morphology and function. This study provides a theoretical basis and technical support for a refined analysis of the toxic components and targets of rhubarb. Export
研究领域:
中药学
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药理学
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细胞生物学
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生物化学
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DOI
FASEB JOURNAL
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2010
·
IF 6.401
Keri A. Barksdale,Emma Perez-Costas,Johanna C. Gandy,Miguel Melendez-Ferro,Rosalinda C. Roberts,Gautam N. Bijur
Neuronal function in the brain requires energy in the form of ATP, and mitochondria are canonically associated with ATP production in neurons. The electrochemical gradient, which underlies the mitochondrial transmembrane potential (ΔΨ mem ), is harnessed for ATP generation. Here we show that ΔΨ mem and ATP-production can be engaged in mitochondria isolated from human brains up to 8.5 h postmortem. Also, a time course of postmortem intervals from 0 to 24 h using mitochondria isolated from mouse cortex reveals that ΔΨ mem in mitochondria can be reconstituted beyond 10 h postmortem. It was found that complex I of the mitochondrial electron transport chain was affected adversely with increasing postmortem intervals. Mitochondria isolated from postmortem mouse brains maintain the ability to produce ATP, but rates of production decreased with longer postmortem intervals. Furthermore, we show that postmortem brain mitochondria retain their ΔΨ mem and ATP-production capacities following cryopreservation. Our finding that ΔΨ mem and ATP-generating capacity can be reinitiated in brain mitochondria hours after death indicates that human postmortem brains can be an abundant source of viable mitochondria to study metabolic processes in health and disease. It is also possible to archive these mitochondria for future studies.—Barksdale, K. A., Perez-Costas, E., Gandy, J. C., Melendez-Ferro, M., Roberts, R. C., Bijur, G. N. Mitochondrial viability in mouse and human postmortem brain.
研究领域:
神经科学
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细胞生物学
·
代谢研究
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DOI
PubMed
高影响因子
Metabolites
·
2024
·Vol. 14
·期 6
·345
·
IF 3.4
Dewang Zhou,Jianxu Huang,Haoxiang Zheng,Yujun Liu,Shimao Zhu,Yang Du
Bladder cancer usually has been diagnosed in elderly patients as it stays asymptomatic until it presents. Current detection methods for bladder cancer cannot be considered as an adequate screening strategy due to their high invasiveness and low sensitivity. However, there remains uncertainty about targets with high sensitivity and specificity for non-invasive bladder cancer examination. Our study aims to investigate the actionable non-invasive screening biomarkers in bladder cancer. Here, we employed scRNA-seq to explore the crucial biological processes for bladder cancer development. We then utilized bidirectional Mendelian randomization (MR) analysis to explore the bidirectional causal relationship between ATP-associated metabolites in urine and bladder cancer. Lastly, we used a BBN-induced mouse model of bladder cancer to validate the crucial gene identified by scRNA-seq and MR analysis. We found that (1) the ATP metabolism process plays a critical role in bladder cancer development; (2) there is a bidirectional and negative causal relationship between fructose-to-sucrose ratio in urine and the risk of bladder cancer; and (3) the higher expression of TPI1, a critical gene in the fructose metabolism pathway, was validated in BBN-induced bladder tumors. Our results reveal that fructose-to-sucrose ratio can serve as a potential target of urinalysis in bladder cancer.
研究领域:
肿瘤学
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分子生物学
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代谢组学
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DOI
PubMed
高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2017
·Vol. 86
·期 12
·2744-2751
·
IF 0.553
Ying S.,Wang Jia,Xu C.,Kang Y.,Zhang X.,Shi L.,Fan L.,Wang Z.,Zhou J.,Wu X.,Wu J.,Li W.,Liang G.
Fibroblast growth factor receptor 1 (FGFR1) is considered a therapeutic target for multiple cancers, including gastric cancer. FGFR1 inhibitors, being ATP competitors, can prevent the kinase domain and the downstream signaling cascade from phosphorylation and thus have the potential to treat cancers associated with aberrant FGFR1 activation. However, untargeted inhibition may cause numerous side effects. Thus, a non-ATP competitive FGFR1 inhibitor should be urgently identified and explored. In this study, we designed and synthesized 17 derivatives of nordihydroguaiaretic acid (NDGA), a known ATP-independent FGFR3 inhibitor. In the kinase activity assay, 3,5-bis(2-fluorobenzylidene)piperidin-4-one ( 1B ) showed the highest kinase inhibitory activity among all derivatives and was thus identified as a non-ATP-competitive FGFR1 inhibitor. In the biological effect evaluation, 1B restrained the FGFR−FRS2−ERK signaling pathway in a dose-dependent manner and inhibited the growth of two gastric cancer cell lines. Overall, 1B can be considered as a potential candidate for treating gastric cancer and as an outstanding lead compound for the discovery of novel non-ATPcompetitive FGFR1 inhibitors.
研究领域:
癌症研究
·
药理学
·
药物化学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Ting Zhang,Lu Zhang,Jiaojiao Qiao,Qingsong Li,Ding Wei,Jianpeng Zhang,Yi Wang
Attapulgite-waste newspaper cellulose aerogel (ATP-WNCA) was fabricated. • ATP-WNCA got 99.9% adsorption removal ratio of MB. • ATP-WNCA got an MB adsorption capacity of 59.61 mg/g (6.5 times that of pure WNCA). • Due to its unique 3D porous structure, ATP-WNCA has multiple adsorption mechanisms. In this study, waste newspaper cellulose (WNC) was extracted from waste newspapers and compounded with natural attapulgite (ATP) to develop a novel three-dimensional porous composite material attapulgite-waste newspaper cellulose aerogel (ATP-WNCA). Cellulose was obtained from waste newspapers through an acid-base combined treatment, and ATP-WNCA was successfully prepared using a sol-gel method with a freeze-drying process. The prepared aerogel material was characterized by XRD, FT-IR, and XPS techniques, and the results indicated that in ATP-WNCA, the rod like fiber of attapulgite is used as the skeleton, and cross-linked with cellulose to form aerogel. Its thermal stability was significantly enhanced, and its specific surface area was dramatically increased from 9.56 m²/g of WNC to 127.91 m²/g of ATP-WNCA. The adsorption performance experiments of ATP-WNCA for methylene blue (MB) demonstrated that under the optimal conditions of adsorbent dosage of 900 mg/L, temperature of 30°C, and pH of 11, ATP-WNCA got 99.9% adsorption removal ratio of MB, with an adsorption capacity of 59.61 mg/g (6.5 times that of pure WNCA). According to the experimental and adsorption isotherm fitting and kinetic fitting results, the adsorption mechanism mainly includes electrostatic adsorption, ion exchange, pore filling, hydrogen bonding, and surface complexation. Different from prior waste cellulose adsorbents suffering from low surface area, poor thermal resistance, this work innovatively employs natural ATP as a reinforcing skeleton to overcome the inherent limitations of pure waste newspaper cellulose aerogels; the ATP-WNCA exhibits competitive MB capture performance against some reported composite adsorbents and establishes a facile, cost-effective and sustainable strategy for converting waste paper into high-efficiency organic dye remediation materials, substantially advancing the development of biomass-clay composite adsorbents for practical wastewater treatment. Download: Download high-res image (366KB) Download: Download full-size image
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高影响因子
CARBON
·
2026
·
IF 12.7
Meng Cai,Can He,Xiaoqiang Fan,Kaiyun Wang,Minhao Zhu
Strong interfacial interactions between nanofillers and resin molecules are crucial for enhancing the corrosion/wear resistance of composite coating. Herein, an interface engineering strategy that integrates Ti 3 C 2 T x with attapulgite nanofibers to create a hierarchical 2D/1D heterostructure (P–Ti 3 C 2 T x @ATP) is reported. The as-prepared P–Ti 3 C 2 T x @ATP with woolen-like structure is incorporated into epoxy resin coating to enhance the anticorrosion and tribological properties. The corresponding enhancement mechanisms are thoroughly investigated. The results indicate that the energy storage modulus of composite coating with P–Ti 3 C 2 T x @ATP (PMX@ATP) is increased by 972 MPa compared to pure epoxy resin coating (EP). The PMX@ATP shows reductions of 0.12 in friction coefficient and 77% in wear rate. And its coating resistance (2.97 × 10 6 Ω cm 2 ) surpasses that of EP (2.70 × 10 5 Ω cm 2 ) by an order of magnitude after 21 days of immersion. The woolen-like P–Ti 3 C 2 T x @ATP has strong interfacial interactions with resin molecules, which exerts the barrier effect of Ti 3 C 2 T x and improves the resistance of composite coating to plastic deformation. This work provides a new idea for the design of MXene-based coatings. Download: Download high-res image (265KB) Download: Download full-size image
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DOI
高影响因子
危险品化学品经营许可证（带存储）