RSC Advances
·
2018
·Vol. 8
·期 16
·8965-8975
·
IF 2.936
Meng Xia,Wenjie Dong,Minyan Gu,Cheng Chang,Zheng Shen,Yalei Zhang
An experimental study was carried out to convert carbohydrates using bimetal modified beta zeolite to obtain a maximum yield of lactic acid. The relationship between the properties and the catalytic performance of various bimetal modified beta zeolites was evaluated. The results showed that the maximum yield of lactic acid reached 52% with more than 99% glucose conversion over Pb–Sn-beta (0.3 mmol g−1, Pb/Sn = 4 : 7) at 190 °C for 2 h under ambient air pressure. To evaluate the synergetic mechanism of lead and tin, key intermediates such as fructose, dihydroxyacetone, glyceraldehyde and pyruvaldehyde were used as probe reactants that were catalyzed by Pb-beta, Sn-beta and Pb–Sn-beta. The revealed key role of lead was to promote the isomerization of glucose to fructose and the retro-aldol condensation reaction from fructose to dihydroxyacetone and glyceraldehyde; meanwhile, tin had a superior catalytic performance in the dehydration of dihydroxyacetone, the hydration of pyruvaldehyde and the isomerization of pyruvic aldehyde hydrate.
研究领域:
催化
·
化学工程
·
生物质转化
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材料科学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
·
IF 3.973
Xiufang Li,Hui Liu,Jianbing Li,Zhiwei Deng,Lingjun Li,Junjun Liu,Jing Yuan,Peiru Gao,Yanjing Yang,Shian Zhong
We developed intelligent, star-shaped amphiphilic β-cyclodextrin (β-CD) co-polymer nanocarriers to circumvent the poor drug loading and water-solubility of β-CD. The secondary hydroxyl groups of β-CD were methylated to improve solubility, and the primary hydroxyl groups were conjugated with mPEG-b-PCL-SH through disulfide linkage to amplify the hydrophobic cavity and enhance the stability of the nanocarrier. A series of amphiphilic β-CD block copolymers (CCPPs) differing in molecular weights were synthesized that could self-assemble into core-shell nanospheres measuring 50–70 nm in water. The different CCPP carriers were screened for their drug loading, encapsulation and release efficiencies, and CCPP-2 showed the highest drug loading capacity of 31.9% by weight. These nanocarriers accumulated at the tumor site through the EPR effect and released the drug in a controlled manner in the reductive tumor microenvironment, with negligible premature leakage and side effects. Therefore, CCPP-2 shows significant potential as a smart and efficient nanovehicle for anticancer drug delivery.
研究领域:
药剂学
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生物材料
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
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2017
·
IF 2.896
Xiaojuan Yan,Tinggui Chen,Liwei Zhang,Huizhi Du
Increasing the acetylcholine level and fighting the neuroinflammation has always been taken as a treatment strategy for Alzheimer's disease (AD). Forsythoside A is a major component in Forsythia suspensa (Thunb.) Vahl (F. suspensa, Lianqiao in Chinese) that has been traditionally used as Chinese herbal medicine to treat the inflammation in China. This study examined the inhibitory acetylcholinesterase activities of Forsythoside A at chemical and biological level. Forsythoside A inhibited acetylcholinesterase in a mixed type of inhibition, with Ki of 47.68 μM. Docking analysis strongly supported these findings. In PC12 cells Forsythoside A increased cell viability and suppressed acetylcholinesterase increased by Aβ 25-35 , thus alleviated the corresponding apoptosis . Taken together, these results suggest that Forsythoside A has the protective effects on Aβ 25-35 -induced apoptosis in PC12 cells by downregulating acetylcholinesterase, making it a potential functional food ingredient or drug candidate for the treatment of AD.
研究领域:
神经科学
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药理学
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中医药
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2017
·
IF 2.714
Yagui Gao,Tifeng Jiao,Ruirui Xing,Lexin Zhang,Jingxin Zhou,Qiuming Peng
The design and preparation of functional beta-cyclodextrin-based composite films are of key importance for wide application fields. This study demonstrates a new route to construct composite films by Langmuir-Blodgett (LB) method via cholesterol-modified beta-cyclodextrin derivative (CD-CHOL). The inclusion complex formation of CD-CHOL and azobenzene derivative (N-Azo) at the air/water interface was investigated. It has been found that the interfacial host-guest recognition could easily occur in the in situ formed CD-CHOL/N-Azo composite films and relatively difficult to occur in the ex situ immersed composite films, because there exist host-guest interaction as well as intermolecular hydrogen bonding interaction. The inclusion complex formation was confirmed by changes in the surface pressure-area isotherms, circular dichroism (CD) and UV–vis spectra of the transferred LB films . And the solvent effect of the composite CD-CHOL/N-Azo films was also investigated, indicating that host-guest interaction between N-Azo and CD-CHOL could occur rather in the nonpolar solvent than the polar solvent . The present research work about beta-cyclodextrin-based composite films by LB method may provide new exploration to prepare organized composite films and demonstrate potential applications in many fields.
研究领域:
材料科学
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化学
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2014
·
IF 1.357
Fen Wang,Bo Yang,Yulin Zhao,Xiali Liao,Chuanzhu Gao,Ruijian Jiang,Bin Han,Jian Yang,Man Liu,Rongguang Zhou
The inclusion complexation behavior of scutellarein (SCUE) with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) has been investigated in both solution and in the solid state. SCUE/HP-β-CD solid system was prepared by suspension method. The formation of SCUE/HP-β-CD complex in aqueous solution was demonstrated by fluorescence spectroscopy, and the Job plot showed a maximum at a molar fraction of 0.5, indicating 1:1 inclusion complexation between SCUE and HP-β-CD. However, SCUE/HP-β-CD inclusion complex was characterized by means of XRD, DSC, 1H, and two-dimensional NMR. Through the complexation between HP-β-CD and SCUE, the water solubility and antitumor activity of SCUE were obviously increased. This satisfactory water solubility and high antitumor activity of the SCUE/HP-β-CD complex will be potentially useful for its application on human colon cancer chemotherapies.
研究领域:
药学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2014
·
IF 2.726
Zheng Huang,Ming Zhang,Junfang Cheng,Yingpeng Gong,Xi Li,Bo Chi,Jian Pu,Li Jian
In this paper, Ag nanoparticles decorated β-MnO 2 nanorods are studied as cathode catalyst for rechargeable lithium–oxygen battery (LOB). β-MnO 2 nanorods are prepared using a simple hydrothermal method based on MnO 4 − and the decoration of Ag nanoparticles is performed by in-situ composite technique in the presence of polymeric additives. The as-prepared materials are characterized by XRD , TEM, XPS , BET and Raman spectrum. Electrochemical charging and discharging capacity of β-MnO 2 and Ag/β-MnO 2 electrodes are investigated at the current density of 0.02 mA cm −2 in the voltage window of 2.0–4.0 V. LOB with Ag/β-MnO 2 electrode shows an initial discharge capacity of 873 mA hg −1 (electrode) , with reversible charge capacity of 811 mA hg −1 (electrode) while battery with only β-MnO 2 has discharge capacity of 541 mA hg −1 (electrode) and charge capacity of 445 mA hg −1 (electrode) . Ag/β-MnO 2 nanocomposite electrode shows good rate capability and cycle stability. After 10 cycles, the capacity of 742 mA hg −1 (electrode) is still retained at the current density of 0.02 mA cm −2 while only 219 mA hg −1 (electrode) is retained at 0.5 mA cm −2 . The capacity retention rate is 84.9% and 70.2% at 0.02 and 0.5 mA cm −2 , respectively. During discharging, Li 2 O is the main discharge product and no Li 2 CO 3 is formed. The results show that the electrochemical performance of β-MnO 2 is greatly enhanced when Ag nanoparticles are introduced. And it is highly effective for decreasing the charging potential close to the theoretical value. Ag nanoparticles can enhance the electronic conductivity of the network. The study confirms that Ag/β-MnO 2 catalyst is a promising effective catalyst for LOB.
研究领域:
材料科学
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电化学
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能源存储与转换
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DOI
高影响因子
RSC Advances
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2015
·Vol. 5
·期 13
·9852-9860
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IF 3.84
Yangyang Yuan,Peng Tian,Miao Yang,Dong Fan,Linying Wang,Shutao Xu,Chan Wang,Dehua Wang,Yue Yang,Zhongmin Liu
Hierarchical beta zeolites have been hydrothermally synthesized by using commercial cationic polymer PDADMA as both microporogen and mesoporogen. The influence of various synthetic parameters on the products was systematically investigated. Products with narrow SiO2/Al2O3 ratios were obtained under static crystallization conditions. By employing rotational conditions and adding seeds in the initial gel, higher SiO2/Al2O3 ratios over a wider range of 25 to 50 could be successfully achieved, which showed an obvious improvement. The 13C NMR, TG, XRF, N2 sorption as well as molecular mechanics simulation results indicated that PDADMA was incorporated in the final product without decomposition, acting as a SDA for the formation of beta zeolite and mesoporogen simultaneously. Further studies on the crystallization process revealed that hierarchical structures templated by PDADMA had been formed in the early solid. The amorphous Si–Al species around the micropore channels gradually evolved to the beta structure with the assistance of PDADMA, whereas the mesopores formed in the initial period remained less changed. A solid-mediated mechanism is thus proposed for the synthesis. Characterization results showed that the obtained products had sphere-like morphology composed of 10–20 nm crystalline domains, high mesopore volumes, and large external surface areas. More importantly, the hierarchical beta zeolites exhibited greatly enhanced catalytic activity and stability in the cracking reaction of triisopropylbenzene.
研究领域:
材料科学
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催化化学
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产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2018
·
IF 3.649
Xiong-Fei Zhang,Kai Zhang,Xingguang Zhang,Yi Feng,Jianfeng Yao
Hierarchical Beta (BEA-H) with intra-crystalline mesoporosity was synthesized by employing a designed template of N(CH 3 ) 2 -C 6 H 12 -N + (CH 3 ) 2 -CH 2 -(p-C 6 H 4 )-CH 2 -N + (CH 3 ) 2 -C 6 H 12 -N(CH 3 ) 2 [Cl-] 2 . Characterization results indicate that BEA-H was crystallized from the outer surface of quasi-spherical particle to the inner part. When it was used as a catalyst for the gas-phase Beckmann rearrangement of cyclohexanone oxime to ε-caprolactam, BEA-H exhibited a 2.3-fold longer lifetime in comparison to conventional Beta zeolite (BEA-C). The superior catalytic performance of BEA-H is attributed to its hierarchical pore structure and suitable acidity.
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Qing-Shan Liu,Ran Deng,Qing-Fang Yan,Lin Cheng,Yongming Luo,Keqin Li,Xiaoying Yin,Xiaoyan Qin
In order to efficiently screen and isolate β-tubulin inhibitors, β-tubulin was immobilized on core–shell PMMA/CS (poly(methyl methacrylate)/Chitosan) nanoparticles to produce a new type of immobilized affinity material named β-tubulin-immobilized nanoparticles (β-TIN). The selectivity and adsorption performance of β-TIN were characterized using various control drugs. The β-TIN, the paclitaxel molecularly imprinted ploymers (MIP), and the C18 adsorbing material were compared for selectivity and enrichment ratio. Microtubule-targeting antitumor compounds were screened and isolated from a typical Chinese medicine, Chloranthus multistachys, by β-TIN. Three active compounds (curcolnol, zedoarofuran, and codonolactone) in Chloranthus multistachys extract were captured successfully. Microscale thermophoresis demonstrated that these three compounds strongly bind to β-tubulin, and the dissociation constants (Kd) between the three active compounds and β-tubulin were 1820 ± 0.68 nM, 1640 ± 0.52 nM, and 284 ± 1.00 nM, respectively. Moreover, the binding affinity between codonolactone and β-tubulin was greater than that between paclitaxel and β-tubulin. The antitumor activities of the three compounds were confirmed by the microtubule inhibition model, and the results showed a similar antitumor mechanism as paclitaxel. Molecular dynamics simulations were performed to preliminarily investigate the potential binding sites and the structure–activity relationship between the three active molecules and β-tubulin. Our study is the first to report the use of this novel material which is highly efficient in capturing low-content β-tubulin inhibitors from a complex mixture. The three screened compounds exhibited potential antineoplastic activity, and these lead compounds utilize a new mechanism of action with promising development prospects. Because β-TIN is easily prepared, displays excellent adsorption and selectivity for targets, and can effectively maintain the steric conformation and activities of target proteins, it will be very useful in the screening of lead compounds for different drug target proteins.
研究领域:
药学
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纳米技术
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生物技术
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癌症研究
·
药物发现
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DOI
PubMed
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 1
·127
·
IF 4.034
Rong Guo,Ran Wang,Juanjuan Yin,Tifeng Jiao,Haiming Huang,Xinmei Zhao,Lexin Zhang,Qing Li,Jingxin Zhou,Qiuming Peng
Dye wastewater is one of the most important problems to be faced and solved in wastewater treatment. However, the treatment cannot be single and simple adsorption due to the complexity of dye species. In this work, we prepared novel composite fiber adsorbent materials consisting of ε-polycaprolactone (PCL) and beta-cyclodextrin-based polymer (PCD) by electrospinning. The morphological and spectral characterization demonstrated the successful preparation of a series of composite fibers with different mass ratios. The obtained fiber materials have demonstrated remarkable selective adsorption for MB and 4-aminoazobenzene solutions. The addition of a PCD component in composite fibers enhanced the mechanical strength of membranes and changed the adsorption uptake due to the cavity molecular structure via host–guest interaction. The dye removal efficiency could reach 24.1 mg/g towards 4-aminoazobenzene. Due to the admirable stability and selectivity adsorption process, the present prepared beta-cyclodextrin-based composite fibers have demonstrated potential large-scale applications in dye uptake and wastewater treatment.Keywords:beta-cyclodextrin polymer;host–guest interaction;dye removal;wastewater treatment;electrospinning
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Yong-Jian Tang,Bing-Jie Shen,Ben-Qing Huang,Zi-Ming Zhan,Zhen-Liang Xu
Based on the Freeman theory, tailoring polymer backbone stiffness can improve membrane performance. Therefore, a rigid monomer—bisphenol F—to enhance the backbone stiffness of polyester/polyamide was utilized to prepare high performance nanofiltration (NF) membranes in the previous work. Here, the three-dimensional (3D) hollow-bowl-structure monomer—beta cyclodextrin (β-CD)—is added into the polyester/polyamide backbone to fabricate a 3D-microstructure NF membrane. With the incorporation of β-CD, the pure water flux (PWF) increases by 68% (up to 152 L m −2 h −1 , 0.6 MPa), while the rejection of Na 2 SO 4 remains high (96.8%). Surprisingly, such NF membrane exhibits a very low rejection of NaCl (1.1%) and high rejection of Na 2 SO 4 (up to 95.8%) when dealing with a Na 2 SO 4 /NaCl mixed solution. The fabricated 3D-microstructure NF membrane shows the potential to be applied in the monovalent/divalent anion separation field.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-9
·
IF 3.8
Liu Yongtao,Duan Bin,Zhou Lin,Wu Yuxiang,Wang Fengyi,Ding Changchun,Hu Junshan
Here, this study reports single-band red upconversion emission in β-Ba 2 ScAlO 5 : Yb 3+ /Er 3+ phosphor by doping Mn 2+ . The optimum concentration of Mn 2+ ions in β-Ba 2 ScAlO 5 : Yb 3+ /Er 3+ phosphor was 0.20. The intensity of red and green emissions is increased by 27.4 and 19.3 times, respectively. Compared with the samples without Mn 2+ ions, the red-green integral strength ratio of β-Ba 2 ScAlO 5 : Yb 3+ /Er 3+ /Mn 2+ sample was significantly increased by 28.4 times, reaching 110.9. The UCL mechanism was explored by analyzing the down-conversion luminescence spectra, absorption spectra, UCL spectra, and upconversion fluorescence lifetime decay curves of Yb 3+ /Er 3+ /Mn 2+ co-doped β-Ba 2 ScAlO 5 . The enhancement of upconversion red light is achieved through energy transfer between defect bands and Er 3+ ions, as well as energy transfer between Mn 2+ ions and Er 3+ ions. In addition, the Mn 2+ doped β-Ba 2 ScAlO 5 : Yb 3+ /Er 3+ red UCL phosphors have great potential for ambient temperature sensing in the 298–523 K temperature range. The maximum sensitivity of β-Ba 2 ScAlO 5 : Yb 3+ /Er 3+ /Mn 2+ phosphor as a temperature sensor at 523 K is 0.0247 K −1 .
研究领域:
材料科学
·
光学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）