ACS Applied Materials & Interfaces
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2025
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IF 8.2
Xujian Yang,Gao He,Jiarui Wang,Jilin Zhong,Yu Luo,Feng Jiang,Lile Dong,Xiang Li
To overcome the efficiency limitations of cuproptosis in oncology, we engineered a piezoelectric Cu-loaded Bi4Ti3O12 nanosheet system for synergistic cuproptosis and ROS-mediated tumor therapy. The incorporation of Cu2+ not only enhanced the material’s piezoelectric coefficient (d33 = 22.3 pm·V–1) but also facilitated valence-state modulation under ultrasound (US) stimulation. The resulting piezoelectric field significantly promoted charge separation, accelerating Cu2+/Cu+ conversion and boosting reactive oxygen species (ROS) generation. This strategy synergistically induces tumor cell death through a dual tumoricidal pathway: on one hand, the accumulation of Cu+ under US stimulation further amplifies cuproptosis, and on the other hand, the continuous accumulation of ROS triggers excessive oxidative stress. In a murine breast cancer model, this synergistic approach achieved a 90.6% tumor inhibition rate. This study pioneeringly combines piezoelectric material properties and copper valence transformation, providing insights for breast cancer treatment.
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PubMed
高影响因子
Frontiers in Nutrition
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2025
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IF 5.1
Mo Li,Xueguo Chen,Xinxin Xia,Ting Zhang,Wenji Zhang,Qingxin Xu,Xin Zhao
Objective Aluminum (Al) and copper (Cu), as two common elements, have specific applications in the modern food industry. However, excessive levels of Al 3+ and Cu 2+ pose a major risk to ecosystems and human health. Thus, fast, sensitive, and portable detection technologies are indispensable for achieving source control of such hazardous substances. Methods We synthesized GSH-stabilized gold nanoclusters (G-AuNCs) and Nitrogen-doped graphene quantum dots (N-GQDs) via a straightforward hydrothermal method, and constructed GQDs@AuNCs ratiometric fluorescent sensors through electrostatic interactions for the rapid detection of Al 3+ and Cu 2+ in food samples. Results When the concentration of Al 3+ in the reaction medium increases, the fluorescence intensity (FI) of G-AuNCs incrementally enhances; in contrast, when the concentration of Cu 2+ increases, the FI of G-AuNCs is gradually quenched. Notably, the FI of N-GQDs remains unchanged throughout this process. When the concentrations of Al 3+ and Cu 2+ ions are within the ranges of 0.5–500 μM and 1–200 μM, respectively, the FI ratio (I 528 /I 412 )/(I 528 /I 412 ) 0 shows a strong linear correlation with the ion concentrations, with corresponding limits of detection (LOD) of 0.66 μM and 0.44 μM. Conclusion The fluorescent sensor features simple synthesis, rapid detection, and high sensitivity, making it well-suited for the rapid detection of Al 3+ and Cu 2+ in foods such as fried dough twists and shellfish.
研究领域:
分析化学
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食品科学
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纳米技术
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环境监测
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高影响因子
Journal of Environmental Chemical Engineering
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2017
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IF 0
Yunhong Yi,Junliang Lv,Nanjing Zhong,Gongqing Wu
The present study explored the ability of a novel spent chrysanthemum adsorbent prepared from acid acetaldehyde for the removal of Cu 2+ from an aqueous solution. The effect of various parameters, including solution pH, adsorbent dosage, contact time and temperature on adsorption of Cu 2+ were studied by batch experiments. According to the experimental results, the optimal pH range and optimum dosage were found to be 3.0–5.0 and 6.0 g/L, respectively. The adsorption amount at equilibrium decreased with the increase of temperature. Freudlich model provided better correlation for the adsorption of Cu 2+ by modified spent Chrysanthemum (MSC) (R = 0.99)and spent Chrysanthemum (SC)(R = 0.98). Adsorption capacity of MSC was 692 mg/g at 293 K, but it was 400 mg/g at 293 K for SC. The adsorption process on Cu 2+ proceeded rapidly and almost reached adsorption equilibrium within 20 min. The kinetics data of MSC were analyzed using the pseudo-first-order equations and pseudo-second-order equations. The pseudo-second-order equation fitted the experimental data very well (R = 0.99). The adsorption amount at equilibrium decreased with the increase of temperature. The thermodynamic parameters showed that the biosorption was exothermic and spontaneous. Experimental results showed that MSC could be used as an effective biosorbent for Cu 2+ removal from aqueous solutions.
研究领域:
环境科学
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生物学
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TETRAHEDRON
·
2017
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IF 2.651
Xu Tang,Juan Han,Yun Wang,Liang Ni,Longhua Li,Lei Wang,Wenli Zhang
A new on-off fluorescent probe 1 for Cu 2+ based on Schiff base compound was designed and synthesized by one-step reaction. The single probe 1 exhibited strong green fluorescence emission . A fluorescence quenching effect and faint color change were observed as soon as the Cu 2+ was added to the probe system in H 2 O/EtOH (v/v = 8:2, HEPES buffer, 0.05 M, pH = 7.4) solution. Other common metal cations did not cause the changes in the fluorescence and color of the probe 1. The optical properties were studied by the fluorescence emission and UV–Vis spectra. Meanwhile, the geometry optimizations of probe 1 and the [1-Cu 2+ ] coordination complexes were also carried out by DFT using the Gaussian 09 program, in which the B3LYP function was used. Based on experimental measurement and theoretical analysis, we can know that the combination ratio of the probe and Cu 2+ is 2:1 and the limit of detection (LOD) is as low as 5.3 × 10 −9 M Besides, the probe 1 was also used to analyze the Cu 2+ in living cells.
研究领域:
分析化学
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生物化学
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材料科学
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高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2016
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IF 2.196
Yong-Jie Geng,Jie Wang,Zhi-Hong Liu
Two transition metal borates with microporous structures for Na 2 Co 2 B 12 O 21 and Na 2 Cu 2 B 12 O 21 have been synthesized and characterized by XRD, FT-IR, and elemental analysis. The molar enthalpies of solution of Na 2 Co 2 B 12 O 21 (s) and Na 2 Cu 2 B 12 O 21 (s) in 1 mol dm −3 HCl(aq) were measured by microcalorimeter at T = 298.15 K, respectively. The molar enthalpies of solution of CoCl 2 ·6H 2 O(s) and CuCl 2 ·2H 2 O(s) in the mixture solvent of 2.00 cm 3 of 1 mol dm −3 HCl(aq) in which 5.30 mg of H 3 BO 3 and 0.84 mg of NaCl being added were also measured, respectively. With the incorporation of the previously determined enthalpy of solution of H 3 BO 3 (s) in 1 mol dm −3 HCl(aq), together with the standard molar enthalpies of formation for CoCl 2 ·6H 2 O(s)/CuCl 2 ·2H 2 O(s), NaCl(s), H 3 BO 3 (s), HCl(aq) and H 2 O(l), the standard molar enthalpies of formation of – (9072.4 ± 9.7) kJ mol −1 for Na 2 Co 2 B 12 O 21 (s) and – (8887.5 ± 9.7) kJ mol −1 for Na 2 Cu 2 B 12 O 21 (s) at T = 298.15 K were obtained on the basis of the appropriate thermochemical cycles. It is obvious that Na 2 Co 2 B 12 O 21 (s) is more thermal stable than that of Na 2 Cu 2 B 12 O 21 (s).
研究领域:
材料科学
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热化学
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2026
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IF 4.9
Lei Xu,Wei Bi,Guorong Zhao,Yanfei Lin,Chuanli Ren,Lianpeng Zhang,Li Liu,Guanben Du
A new cellulose-based fluorescent probe for highly sensitive detection and adsorption of Cu 2+ was designed. • Fluorescence quenching occurred after binding to Cu 2+ through N Cu coordination with detection limit of 1.142 μM. • Combined with smartphone RGB imaging technology, the visual quantitative analysis of Cu 2+ in water was realized. • Fluorescent aerogel exhibits a maximum adsorption capacity of 83.264 mg/g for Cu 2+ . Developing new fluorescent probes for highly sensitive detection and adsorption of Cu 2+ has important research value and broad application prospects. In this work, based on microcrystalline cellulose (MCC), a cellulose-based naphthalimide fluorescent probe MNFP and a fluorescent aerogel MN-TCP were successfully constructed by amination modification and grafting of fluorescent molecules, which were used for the specific detection and efficient removal of Cu 2+ in water. MNFP showed yellow-green fluorescence in water, and fluorescence quenching occurred after binding to Cu 2+ through N Cu coordination. The detection limit was 1.142 μM, the response time was about 140 s, and the stability was good in the range of pH 5–10. Combined with smartphone RGB imaging technology, the visual quantitative analysis of Cu 2+ in water was realized. On this basis, a fluorescent aerogel MN-TCP with both detection and adsorption functions was constructed, which realized the specific recognition and efficient removal of Cu 2+ in water, and could be visually detected by color change and fluorescence dual signals. The material integrates high selective detection, high removal rate and visualization functions, and provides a green and efficient new solution for simultaneous monitoring and treatment of Cu 2+ in water. Download: Download high-res image (281KB) Download: Download full-size image
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Shuai Zhang,Wen-Da Zhang,Han Zhao,Baoxin Wu,Jia-an Li,Cheng Zheng,Jiangyong Liu,Jian Wang,Jing Wang,Heng Zhao,Lin Zeng,Xiaodong Yan,Zhangxing Chen
Operando ATR-SEIRAS, DEMS, and DFT reveal an NH 2 OH-mediated AOR pathway at an enzyme-mimicking interface. • Cu 2 NCN/CuO achieves 98.93% FE at 1.50 V vs. RHE and a NO X - yield rate of 249.3 μmol cm -2 h -1 at 1.70 V vs. RHE. • A regeneration strategy mitigates surface poisoning and enables recovery of the oxidized products as crystalline KNO 3 . Electrochemical ammonia oxidation reaction (AOR) provides a promising route for the synthesis of nitrite and nitrate (termed NO x − ) under mild conditions. However, the selective conversion of NH 3 to NO x − is kinetically limited by the conventional stepwise dehydrogenation pathway. Herein, we report an ammonia monooxygenase (AMO)-inspired Cu 2 NCN/CuO heterostructure catalyst, in which the [N C–N] 2− framework provides a charge-buffering effect to stabilize Cu + -related species under oxidative AOR conditions. This biomimetic architecture enables the selective oxidation of NH 3 to NO x − by promoting a hydroxylamine (NH 2 OH)-mediated pathway that features early-stage N–O bond formation. As a result, it achieves a NO x − Faradaic efficiency as high as 98.93% at 1.50 V vs. RHE, with a corresponding yield rate of 48.48 μmol cm −2 h −1 . Operando attenuated total reflection surface-enhanced infrared absorption spectroscopy, differential electrochemical mass spectrometry, and density functional theory calculations collectively reveal that this catalytic architecture facilitates NH 2 OH intermediate formation and lowers the energy barrier for its subsequent oxidation, thereby underpinning its outstanding NO x − selectivity. These findings demonstrate that the AMO-inspired catalytic architecture provides an effective strategy for achieving efficient NO x − electrosynthesis via an NH 2 OH-mediated pathway. Download: Download high-res image (161KB) Download: Download full-size image An AMO-inspired biomimetic Cu 2 NCN/CuO heterostructure enables the selective conversion of NH 3 to NO 2 − and NO 3 − via an NH 2 OH-mediated pathway featuring early N–O bond formation.
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JOURNAL OF FLUORESCENCE
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2025
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IF 3.1
Dong Xuemei,Hu Zhongfei,Xiao Xuan,Zhang Keying,Ding Yujie
Excessive Cu 2+ levels pose severe threats to human health and ecosystems, necessitating sensitive and selective detection methods. A novel ratiometric fluorescent probe (CDs@RBH) based on fluorescence resonance energy transfer (FRET) was developed through electrostatic assembly. This nanoplatform employs carbon quantum dots (CDs) as the energy donor and rhodamine hydrazide (RBH) as the acceptor. Upon Cu 2+ addition, the spirolactam ring of RBH opens, triggering a distinct UV–Vis absorption peak at 550 nm, which overlaps with the emission spectrum of CDs (450 nm), enhancing FRET efficiency. This mechanism enables dual-signal readout: the fluorescence intensity of CDs at 450 nm decreases, while the RBH-Cu 2+ emission at 575 nm increases, allowing for precise ratiometric detection. The probe exhibits high selectivity and exceptional sensitivity, with a detection limit (LOD) of 0.65 μM and quantification limit (LOQ) of 2.09 μM. Practical applications in tap water samples demonstrate excellent recovery rates (96–108%). This work presents a straightforward synthesis method, environmental stability, and dual-channel signal verification for detection, making it a promising tool for real-world Cu 2+ monitoring in environmental and biological systems.
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ANALYTICA CHIMICA ACTA
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2025
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IF 6
Guofeng Wang,Shiwei Xu,Chao Deng,Yueyue Feng,Liying Huang,Qin Guo,Yajun Wang,Min Zhang,Qian Shi,Nannan Liu
Copper ions (Cu + and Cu 2+ ) are vital for physiological functions, and their imbalance is implicated in disease progression. However, simultaneous detection of both species is challenging due to their similar properties. Here, we report a dual-functionalized glass micropipette sensor enabling independent detection of Cu + and Cu 2+ . UiO-66-NH 2 was grown in situ on the inner wall to capture Cu 2+ via amino coordination, reducing ionic current. Glutathione-functionalized carbon nanotubes (GCNTs) coated on the outer surface bind Cu + , increasing SERS signal via enhanced surface defects. The sensor exhibits a wide detection range (10 -1 –10 5 μM), a detection limit of 0.1 μM, and allows simultaneous monitoring of Cu + /Cu 2+ in the physiological range (2–10 μM). It further distinguishes copper ion levels in MCF-10A and MCF-7 cells, revealing altered copper homeostasis in cancer. This platform offers a sensitive, selective tool for studying copper in biological systems.
研究领域:
生物化学
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分析化学
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医学
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高影响因子
MATERIALS & DESIGN
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2024
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IF 7.6
Wen Luo,Zhenzhen Li,Congling Ren,Huanhuan Xu,Huali Zhang,Zezhong Cao,Taoxia Wang,Xiaoli Liu,Guiying Li,Lin Jin
Immunoregulation is one of the important factors in wound healing. Currently, wound dressings with immunoregulation is necessary to overcome the complicated interventions, high-cost treatments and uncontrolled release behaviors. In this study, a novel Cu and Zn loaded nanofiber dressing (FM-Cu-Zn) with immunoregulation and controllable release without external intervention was prepared by electrospinning. The dressing is composed of ZnCl 2 , CuS nano particles, poly-3-hydroxybutyrate-co-4-hydroxybutyrate (P34HB). Where Zn 2+ is the “promoter” of immunotherapeutic activity by reducing the environmental pH to trigger H 2 S and Cu 2+ releasing from CuS. Then, H 2 S and Cu 2+ can regulate the inflammatory response and accelerate wound healing. The results in vivo indicated the FM-Cu-Zn nanofiber dressing showed better anti-inflammatory and wound healing ability, the wound healing rate was upto 95 % after 11 days treatment by the obtianed dressing, which was much higher compared to control groups. Notably, the dressing can promote macrophage polarization toward a pro-regenerative M2 phenotype without any external intervention. Therefore, the FM-Cu-Zn nanofiber with the immunomodulatory property can serve as a promising dressing in wound healing field.
研究领域:
生物材料学
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免疫学
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医学
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Xingtian Zhang,Boyuan Yang,Yong Zhang,Xiaoyu Du,Liwei Hou,Tao Zhou,Hongtao Chu,Wenhui Ma
Polyacrylamide, a classic polymer material, has been extensively applied in both industrial production and daily life, owing to its outstanding physical and chemical properties. However, the absence of a conjugated π -electron system in its molecular structure severely restricts its application in the field of fluorescence. In this study, a novel fluorescent polyacrylamide sensor ( P ) was synthesized via free-radical precipitation polymerization using acrylamide and 3-[(Allylaminothiocarbonyl)hydrazinecarbonyl]-7-(diethylamino)-2H-chromen-2-one as monomers. Compared with conventional polyacrylamide, P exhibited great optical signals in pure water. Experimental results demonstrated that upon the presence of copper (Cu 2+ ), P could rapidly respond through significant changes in its colorimetric or fluorescence signals. The detection process was characterized by a fast combination time (∼1.5 s), low detection limit (8.8 nM), and minimal interference from other cations. Moreover, P showed good response performance when exposed to exogenous Cu 2+ in both tap water samples and HeLa cells, offering a potential application value in real-world environmental monitoring and biomedicine. Furthermore, by integrating with smartphone-based color recognition programs, this dual-mode polymeric sensor not only expands the application boundaries of polyacrylamide in the field of fluorescence detection but also offers a feasible solution for the portable detection of Cu 2+ .
研究领域:
材料科学
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分析化学
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环境科学
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生物化学
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高分子科学
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高影响因子
ELECTROCHIMICA ACTA
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2025
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IF 5.6
Liying Huang,Shiwei Xu,Yueyue Feng,Guofeng Wang,Qian Shi,Min Zhang,Ying Liu,Nannan Liu
The fluctuation of copper ion (Cu 2+ ) content is closely related to the physiological state of the human body. Developing a facile and highly selective micropipette sensor to precisely monitor Cu 2+ content has become crucial for the diagnosis, treatment, and prognosis of diseases. Herein, we propose a hydrogen-bonded organic framework (HOF-101)-functionalized micropipette sensor, which enables highly sensitive and real-time detection of copper ions based on an ionic current-voltage response. This micropipette sensor is capable of detecting Cu 2+ in human serum with a remarkably low limit of detection (LOD) of 0.11 μM, while offering a broad dynamic detection range of 10 –1 –10 4 μM. The adsorption mechanism was elucidated through density functional theory (DFT) calculations, revealing the coordination effect and electrostatic interactions between Cu 2+ and the -COOH groups of HOF-101. This study not only fulfills the requirements of simple and sensitive detection of Cu 2+ , but also provides a new method for HOFs to detect ions in vivo.
研究领域:
分析化学
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材料科学
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传感器
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生物化学
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纳米技术
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高影响因子
危险品化学品经营许可证（带存储）