ADVANCED ENGINEERING MATERIALS
·
2024
·
IF 3.4
Zihao Song,Longjin Huang,Sheng Cui
In this work, a novel strategy for preparing Ga-doped TiO 2 composite aerogel antibacterial agent through the sol–gel method and supercritical technology is demonstrated. The specific surface area of the samples is as high as 175 m 2 g −1 and exhibits a 3D network structure with a multistage pore distribution. The obtained antibacterial agent combines the phototoxicity of TiO 2 , photo-independent toxicity of Ga 3+ , and structural properties of aerogels, showing a synergistic antibacterial effect. On the one hand, TiO 2 produces reactive oxygen species in the presence of light, thus destroying the structure of bacteria. On the other hand, Ga 3+ competitively replaces Fe 3+ and hinders the metabolic process of bacteria. Moreover, the structural properties of aerogels promote superior antimicrobial performance of antibacterial agents. Their antibacterial properties against Escherichia coli and Staphylococcus aureus bacteria are mainly investigated through the inhibition zone and natural colony counting method. In the results, it is shown that the structure and bactericidal activity of TiO 2 aerogel is effectively optimized with Ga 3+ doping. The maximum zone of inhibition of the composite aerogel against E. coli and S. aureus is 17.5 and 16 mm, and the bactericidal rate is as high as 98.57% and 96.60%, which exhibit outstanding bactericidal performance.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Wenwen Jiao,Hao Li,Yingjie Wu,Qing Wen,Wenzhen Wang,Jia Tian,Yulong Ren,Jinyuan Ma,Danxiang Zhao,Junli Zhao,Yu Zhang,Guang Han
Hepatocellular carcinoma (HCC) is a challenging cancer to treat due to its high malignancy, strong invasiveness, and high risk of metastasis. Inhibiting lymphatic metastasis in the early stages is crucial for HCC therapy. Active targeted drug delivery systems, imbued with tumor and lymphatic targeting capability via ligand–receptor mediation, represent a promising therapeutic strategy. Cantharidin (CTD), the primary effective component of poisonous traditional Chinese medicine (PTCM) Mylabris, has unique therapeutic effects on HCC. However, its high toxicity limits its clinical application. In this study, based on the high expression of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) in the peritumoral lymphatic vessels and glycyrrhetinic acid receptor (GA-R) in hepatocellular carcinoma cells, we developed CTD-loaded poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles modified with glycyrrhetinic acid (GA)–hyaluronic acid (HA) copolymers (GA-HA-PLGA/CTD NPs) through electrostatic interactions. This nanoparticle platform could preferentially accumulate cargo into the tumors and peritumoral lymphatic vessels, increasing drug accumulation in tumors and lymph nodes while decreasing drug accumulation in other organs, particularly the heart and kidney. As a result, it could enhance antitumor efficacy and inhibit lymphatic metastasis better than PLGA/CTD NPs while also reducing systemic toxicity. Furthermore, the variation of HA molecular weights and degrees of GA substitution could regulate the distribution of nanoparticles within tumors and lymph nodes. Overall, GA-HA-PLGA/CTD NPs exhibit promising potential as a therapeutic approach for HCC treatment and lymphatic metastasis inhibition, providing a potential strategy for the application of PTCMs in HCC treatment.
研究领域:
肿瘤学
·
药学
·
纳米技术
·
分子生物学
✓ 已验证
DOI
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Mingxia Zhou,Linping Lu,Xinyu Xu,Yefan Zhou,Huan Fang,Xue Wang,Dongxu Li,Xiaoyan Li,Jiaqi Hua,Jiahe Liu,Yingxia Li,Libin Jiang,Qiuju Miao,Hongtao Wen,Jing He,Shenyu Yang
Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), manifests as chronic diarrhea, abdominal pain, and bloody mucoid stools. Current treatment approaches for UC are typically limited by inadequate targeted delivery, premature gastrointestinal degradation, and systemic off-target effects. To address these challenges, we engineered PL&GA@EUK, EUK-134 nanozymes encapsulated in polylysine (PL) and glycyrrhizic acid (GA) coacervate droplets. PL&GA@EUK exhibited potent superoxide dismutase- and catalase-mimetic activities, scavenging hydroxyl radicals and demonstrating anti-inflammatory efficacy in both in vivo and in vitro models. In mice with dextran sulfate sodium-induced colitis, oral administration of PL&GA@EUK for 14 days significantly ameliorated the disease activity index and colonic damage. By maintaining the integrity of the intestinal mucosal barrier and modulating redox homeostasis, it protects the intestinal epithelial cells against ferroptosis, ultimately attenuating colitis progression. 16S rDNA sequencing revealed that PL&GA@EUK significantly enriched beneficial commensals, while suppressing opportunistic pathogens. Metabolomic analysis further indicated that it modulates lipid peroxidation-associated metabolites by regulating the biosynthesis of polyunsaturated fatty acids. Crucially, PL&GA@EUK achieved enhanced colon-targeted delivery with minimal systemic toxicity, thereby overcoming the key limitations of conventional treatments. The multifaceted mechanism of PL&GA@EUK, involving reactive oxygen species scavenging, gut microbiome remodeling, and ferroptosis suppression, underscores its immense promise for the clinical management of IBD.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Shuyue Jiang,Wensi Zhang,Donghao Cui,Jia Lou,Shilun Feng,Kaihuan Zhang
Flexible electrochemical sensors are essential for next-generation wearable health monitoring systems, yet their long-term stability is constrained by mechanical fragility and biofouling in complex biological environments. Here, we present a dual self-healing glucose biosensor incorporating uniquely raspberry-shaped Ga@TiO 2 particles that enable both mechanical and chemical regeneration. These particles facilitate ultrasensitive glucose detection (limit of detection = 0.14 μM) via efficient redox interactions, while also enhancing the device's structural and surface resilience. The Ga@TiO 2 /PVA hydrogel sensor exhibits exceptional multilayer physical self-healing behavior, arising from the synergistic combination of PVA's dynamic hydrogen bonding and the intrinsic fluidity of the liquid metal core, maintaining 101.2 ± 4.13% of its original sensitivity after fracture healing. In addition, the sensor achieves reproducible biofouling self-healing, recovering 100.4 ± 1.35% of its initial signal after contamination, owing to the biomimetic surface morphology and self-renewing liquid metal interface. The gallium-based conductive network further ensures stable electrical performance under mechanical deformation due to its high conductivity and flow adaptability. This dual self-healing mechanism—analogous to biological tissue regeneration and self-cleaning surfaces—offers a robust strategy for constructing durable, high-performance flexible biosensors capable of reliable operation in dynamic and bioactive environments.
✓ 已验证
产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2023
·
IF 3.8
Jie Zheng,Yu Tang,Yujie Xiang,Yonggui Tao,Kaiyuan Shen,Lanxian Shen,Wen Ge,Peizhi Yang,Shukang Deng
β-Zn4Sb3 is a promising thermoelectric (TE) material, as it contains low-cost and environment-friendly elements. However, its application has long been limited due to the lower figure of merit (ZT), poor mechanical properties, and inferior thermodynamic stability. In this research, we successfully synthesized Na/Ga codoped β-Zn4Sb3 with high thermoelectric performance and stability. The power factor (PF) value of the Ga-doped sample is significantly improved by optimizing carrier concentration, the maximum value of 2.28 × 10–3 W m–1 K–2 is obtained at 690 K, and the maximum ZT reaches 1.73 at 690 K for the Zn4.1Sb3(NaCl)7Ga0.12 sample. Moreover, the TG-DSC and oxidation resistance tests show that Na and Ga codoped β-Zn4Sb3 possess good stability. This work provides an attractive method for improving the thermoelectric properties and stability of β-Zn4Sb3 through diatomic doping.
研究领域:
材料科学
·
热电学
·
固态化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Binyu Lu,Liuyi Hu,Wenkui Zhang,Jun Zhang,Yang Xia,Yongping Gan,Xinping He,Xinhui Xia,Ruyi Fang,Hui Huang
Construction of quasi-solid-state lithium metal batteries (LMBs) by in situ polymerization is considered a key strategy for the next generation of energy storage systems with high specific energy and safety. Poly(1,3-dioxolane) (PDOL)-based electrolytes have attracted wide attention among researchers, benefiting from the low cost and high ionic conductivity. However, interfacial deterioration and uncontrollable growth of lithium dendrites easily appeared in LMBs due to the high reactivity of lithium metal, resulting in the failure of LMBs. In this work, a strategy is developed of using Ga(OTF)3 as the initiator to obtain a PDOL-based gel electrolyte (GaPD). In addition, a hybrid stable solid electrolyte interphase (SEI) of lithium fluoride/Li2O/Li–Ga alloys is observed on the surface of lithium metal. Combined with density functional theory calculations, the hybrid SEI shows high affinity toward Li+, indicating that a uniform deposition of Li+ could be achieved. Therefore, the Li/GaPD/Li cell operates stably for 1600 h at room temperature. In addition, the LiFePO4/GaPD/Li cell retains a capacity retention rate of 90.2% over 200 cycles at 1 C. This work provides a reference for the practical application of in situ polymerization technology in high-performance and safe LMBs.
研究领域:
储能
·
电化学
·
材料科学
·
电池技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Wei Wang,Jian Bao,Changhao Wang,Guoqiang He,Xin Wang,Diming Xu,Biaobing Jin,Zhongqi Shi,Moustafa Adel Darwish,Yawei Chen,Qixin Liang,Meirong Zhang,Di Zhou
The advancement of millimeter-wave communication desires the ceramic substrate with low permittivity ( ԑ r ) to meet the requirements of high transmission rates, low latency and wide bandwidth. However, the thermal conductivity of most low- ԑ r ceramics is too low to deal with heat dissipation in millimeter-wave applications. In this paper, we reported novel dielectric ceramics Li M SiO 4 ( M = Ga, Sc and Y) with excellent performances of low ԑ r (< 10) and high thermal conductivity (> 6 W mK −1 ). Their dielectric properties in both microwave and THz were investigated, where the LiGaSiO 4 ceramic achieved the lowest ԑ r of ∼5.2, the LiScSiO 4 ceramic presented extremely low loss ( Q × f ∼ 96,700 GHz, Q = 1/dielectric loss, f is resonant frequency), and the LiYSiO 4 ceramic showed a positive temperature coefficient of f (TCF ∼ +32 ppm °C −1 ). The distinct dielectric behavior was subsequently studied by structure-performance relationship in terms of M -site cations and bond parameters using bond valence theory, Phillips–Van Vechten–Levine chemical bond theory and so on. Moreover, a 36 GHz microstrip array antenna was designed and simulated using the LiGaSiO 4 ceramic substrate, obtaining high realized gain, high radiation efficiency and low sidelobe. The result demonstrated the great potential of LiMSiO 4 -type dielectric ceramics in millimeter-wave communications.
研究领域:
材料科学
·
电子工程
·
通信技术
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Xiaoxia Ye,Feiyang Wang,Juan Liu,Yifan Liu,Yuancai Lv,Chunxiang Lin,Liang Song,Minghua Liu,Ying Zhang,Jie Chen
Radioactive 137 Cs poses a severe threat in nuclear wastewater. Conventional powdered adsorbents suffer from poor recoverability and are ill-suited for large-scale continuous-flow operations. To address these limitations, a novel three-dimensional bulk ammonium phosphomolybdate-gelatin composite adsorbent (AMP@GA) was fabricated. Through this strategy, highly selective AMP particles were uniformly immobilized within a porous (92%) gelatin network. Rapid adsorption kinetics (reaching equilibrium within 30 min), a Langmuir-fitted theoretical maximum Cs + adsorption capacity of 142.17 mg·g −1 at 45 °C, and acceptable chemical stability across a broad pH range (2.0-11.0) were exhibited by the resulting AMP@GA. Most significantly, the material demonstrated outstanding selectivity over competing ions ( K d = 7.48 × 10 4 mL·g −1 ). Its practical viability was confirmed by achieving over 88% removal efficiency in authentic seawater. Furthermore, in fixed-bed column tests, the material sustained continuous operation for 163.5 h. The mechanism is dominated by NH 4 + -Cs + ion exchange, assisted by electrostatic interactions. This work presents a scalable, easily recoverable bulk adsorbent that effectively helps address the engineering bottlenecks of traditional powdered materials.
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2026
·
IF 7.8
Kaixuan Bian,Lili Feng,Yongyan Yan,Jiawei Geng,Yue Zhang,Mengyang Sun
This study systematically investigated the enrichment behavior, occurrence modes, and speciation evolution of critical metals—indium (In), lithium (Li), gallium (Ga), and rare earth elements with yttrium (REY)—during the combustion of Ningxia coal. Simulated combustion experiments were conducted over a temperature range of 500–900 °C, coupled with sequential chemical extraction procedure (SCEP), X-ray diffraction (XRD), and thermodynamic modeling (FactSage). Results indicate that these metals are significantly enriched in the ash, with In exhibiting the highest enrichment ratio (up to 23.64). Mineral phase transformations—especially the formation of hematite, anhydrite, quartz, and amorphous glass—govern the redistribution of the metals. For In, the primary host shifts from metal oxides at lower temperatures to sulfate and quartz phases at higher temperatures, while Li and Ga remain predominantly associated with aluminosilicate glass and sulfate phases. REY migrate from metal oxide carriers toward sulfate and quartz phases as temperature increases. Thermodynamic predictions further confirm the predominance of solid phases such as In 2 O 3 , LiAlSi 4 O 10 , and Ga 2 O 3 under the investigated combustion conditions. These findings provide critical insights into optimizing the recovery of critical metals from coal fly ash, supporting its high-value utilization and sustainable resource strategies.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2025
·
IF 12.1
Hao Wu,Jinyi Pan,Chao Wu,Jie Wang,Chunyi Jiang,Chenyu Guo,Zhihao Yu,Zhenyang Wang,Sichao Du,Daoyou Guo,Jun Hu
Solar-blind photodetection plays a crucial role in environmental monitoring, corona detection, and covert battlefield communication due to its unique high signal-to-noise ratios in the UVC band. Aluminum quantum dots (AlQDs) emerge as promising optical materials owing to their extended photoresponse in the ultraviolet region, along with their low cost and compatibility with optoelectronic devices. Herein, an AlQDs-based cascade solar-blind photodetector is presented with enhanced sensitivity, achieved through the quantum confinement effect. By employing a gradient double-layer AlQDs stack integrated with β -Ga₂O₃, the heterojunction demonstrates a significantly suppressed dark current, reduced from 3 nA to 2 pA, and a spectral noise density of 2.8 × 10 −11 A Hz⁻ 1 / 2 compared to the single-layer device. The optimized photodetector achieves a high UV–vis rejection ratio ( R 250 / R 400 ) of 2.5 × 10 3 , a specific detectivity of ≈2.3 × 10 1 2 Jones, a relatively fast response time of 25 ms, and a responsivity of 35.1 mA W −1 under a 1 V bias. Furthermore, the device demonstrates robust interference-resistant imaging capabilities, enabling ultra-weak photodetection down to 23 nW cm −2 . These results highlight the potential of AlQDs-based cascade devices for advanced solar-blind photodetection applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 12
·1-14
·
IF 2.8
Mei Rui,Yan Feng,Hu Sizheng,Gong Zonggui,Guo Haoxuan,Wang Qijing,Zheng Xinghua
With the increasingly urgent safety requirement of lithium-ion batteries, more and more attention has been paid to Li 7 La 3 Zr 2 O 12 (LLZO)-based solid electrolytes with high ion conductivity and excellent electrochemical performance. Unfortunately, owing to the serious “Li-loss” and the abnormal grain growth (AGG) during the long-time high-temperature sintering process, it is difficult to achieve the high-quality LLZO electrolyte with uniform and fine grains, high density and excellent electrochemical performance. In this work, Ga/Mo co-doped LLZO solid-state electrolytes have been prepared by traditional sintering (TS) and two-step sintering (TSS). And the sintering mechanism, phase stability, microstructure evolution, and electrochemical performance have been systematically investigated. A small amount of Ga/Mo doping not only promotes the formation of the cubic garnet LLZO phase, but also enhances the stability of cubic phase. High density of 92.3% and uniform microstructure without AGG have been achieved via a small amount of Ga doping and TSS. Li 6.3 Ga 0.1 La 3 Zr 1.8 Mo 0.2 O 12 electrolytes, prepared by TSS of 1200 °C/15 min-1100 °C/8 h, exhibits high ion conductivity of 2.59 × 10 –4 S·cm −1 and critical current density (CCD) value of 0.5 mA·cm −2 , low electric conductivities of 4.77 × 10 –9 S·cm −1 , which suggests it is a potential electrolyte to apply in all-solid-state batteries.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2024
·
IF 3.3
Yujie Zong,Yizhou Wang,Jinze Zhai,Wenbin Su,Chang Tan,Zhihao Li,Yuqing Sun,Hongxiang Wang,Chunlei Wang,Hongchao Wang
By virtue of temperature differences, which are in hundreds of kelvin, the optimized carrier concentration may vary within an order of magnitude. Ga has shown potential in providing temperature-dependent carrier concentration due to its deep level of impurity states, which can ionize and release electrons at higher temperature. However, because of the low solubility, the decreasing of lattice thermal conductivity in the Ga-doped PbTe system is constrained. In this study, monovalent I is introduced, which leads to the solubility of Ga in PbTe reaching 5% and tunes the carrier concentration in PbTe simultaneously. An enhanced maximum PF of 21 μW K–2 cm–1 and ultralow lattice thermal conductivity of 0.61 W m–1 K–1 are attained because of the incorporation of Ga, which together enable an enhanced peak zT of 1.2, an average value of zT to 0.61, and a thermoelectric conversion efficiency η of 9.3% for the Pb0.95Ga0.05Te0.995I0.005 sample.
研究领域:
材料科学
·
热电学
·
半导体物理
·
能量转换材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）