ACS Nano
·
2023
·
IF 17.1
Bo Yuan,Zicong Tan,Qiang Guo,Xiutong Shen,Chao Zhao,Jian Lin Chen,Yung-Kang Peng
Nanozymes are promising alternatives to natural enzymes, but their use remains limited owing to poor specificity. For example, CeO2 activates H2O2 and displays peroxidase (POD)-like, catalase (CAT)-like, and haloperoxidase (HPO)-like activities. Since they unavoidably compete for H2O2, affecting its utilization in the target application, the precise manipulation of reaction specificity is thus imperative. Herein, we showed that one can simply achieve this by manipulating the H2O2 activation pathway on pristine CeO2 in well-defined shapes. This is because the coordination and electronic structures of Ce sites vary with CeO2 surfaces, wherein the (100) and (111) surfaces display nearly 100% specificity toward POD-/CAT-like and HPO-like activities, respectively. The antibacterial results suggest that the latter surface can well-utilize H2O2 to kill bacteria (cf., the former), which is promising for anti-biofouling applications. This work provides atomic insights into the synthesis of nanozymes with improved activity, reaction specificity, and H2O2 utilization.
研究领域:
生物化学
·
材料科学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jiaxing Xie,Qun Liu,Lijuan Huang,Xingyu Chen,Chunlin Zhao,Xiao Wu,Tengfei Lin,Yong Wu,Min Gao,Cong Lin
The Fenton reaction, an effective advanced oxidation process (AOP) for degrading organic pollutants, requires the addition of H 2 O 2 that is expensive and not environmentally friendly to some extent. It has been reported that piezocatalysis can generate H 2 O 2 under mechanical excitation. Therefore, it is promising to carry out the Fenton catalysis utilizing in situ H 2 O 2 generated by piezocatalysis. However, the current piezocatalysis-assisted Fenton (Piezo-Fenton) reaction was realized by adding piezoelectric nanoparticles and Fe(II) ions to pollutant solutions, which would induce more iron-based chemicals that are not easy to recycle. Herein, Fe 3 O 4 -BaTiO 3 nanocomposites were prepared to demonstrate the feasibility of piezo-Fenton catalysis without the addition of H 2 O 2 or Fe(II) ions. The organic dye degradation efficiency of 98.2% is obtained using Fe 3 O 4 -BaTiO 3 nanocomposites in the acidic solution, one-third and two-thrid greater than that of pure piezocatalysis and that of iron-based Fenton reaction , respectively. Moreover, since the piezocatalysis process is the rate-determining step of the whole piezo-Fenton reaction, all the H 2 O 2 generated can be consumed. Considering that the solid nanocomposites can be magnetically recycled, piezo-Fenton catalysis leaves no additional chemicals in clean water and thus provides an environmentally friendly and low-cost approach for organic dye degradation.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
WATER RESEARCH
·
2021
·
IF 11.236
Bingliang Zhang,Xuening Wang,Zhuoyao Fang,Shu Wang,Chao Shan,Si Wei,Bingcai Pan
ABSTRACT Ultraviolet-based advanced oxidation processes (UV-AOPs) are very promising in advanced treatment of municipal secondary effluents. However, the transformation of dissolved effluent organic matter (dEfOM) in advanced treatment of real wastewater, particularly at molecular level, remains unclear. In this study, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) coupled with multiple statistical analysis were performed to better understand the transformation of dEfOM in UV/H 2 O 2 , UV/persulfate (UV/PS), and UV/chlorine treatments. An obvious increase in oxygen content of dEfOM was observed after every UV-AOPs treatment, and the detailed oxygenation processes were further uncovered by mass difference analysis based on 24 types of typical reactions. Generally, UV/H 2 O 2 process was subjected to the most oxygenation reactions with the typical tri-hydroxylation one (+3O), whereas di-hydroxylation reaction (+H 2 O 2 ) was dominant in UV/PS and UV/chlorine processes. Additionally, the three UV-AOPs shared the majority of precursors, and more proportions of unique products were identified for each process. The precursors with lower H/C and higher aromaticity were readily degraded by UV/chlorine over UV/H 2 O 2 and UV/PS, with the products featuring lower molecular weight. Moreover, dEfOM of high aromaticity tended to produce chlorinated byproducts through addition reactions in chlorination and UV/chlorine processes. Among these UV-AOPs, the highest reduction of both acute toxicity and specific UV absorbance at 254 nm (SUVA 254 ) was observed for UV/chlorine, implying the potential for UV/chlorine process in advanced treatment of wastewater. In addition, acute toxicity was highly correlated with SUVA 254 and CHOS compounds. This study is believed to help better understand the different fates of dEfOM in real wastewater during UV-AOPs treatment.
研究领域:
环境科学
·
废水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yunqi Wang,Peng Zhou,Qingguo Wang,Xiaowei Huo,Xue Huang,Qian Ye,Hao Xu,Guanyu Zhou,Yuhang Liu,Jing Zhang
Hydroxylated fullerene, Fullerol, has applied in many areas because of its high electron affinity and antioxidant potential, while it was few used in wastewater treatment. In this study, the mechanism involved that Fullerol accelerated the regeneration of Fe(II) in the Fe(III)/H 2 O 2 system under dark condition, which was investigated with chloramphenicol (CAP) as a model pollutant. In Fullerol/Fe(III)/H 2 O 2 system, CAP removal was completely achieved at 60 min via a non-photochemical pathway. In addition, the quenching experiments and electron spin resonance (ESR) results indicated that hydroxyl radical ( OH) was the main reactive oxygen species (ROSs). The Fullerol/Fe(III)/H 2 O 2 system had a rate constant of CAP degradation about 5.0 × 10 −2 min −1 , which was about 22 times higher than it in Fe(III)/H 2 O 2 Fenton-like system (2.3 × 10 −3 min −1 ). Fe(II) was ascertained the effective component that was responsible for H 2 O 2 activation to produce OH, which derived from 1) the first pathway: Fullerol complexed with Fe(III) and the redox potential of the complex is much lower than Fe(III)/Fe(II); 2) the second pathway: Fullerol acted as an electron donor to reduce Fe(III) into Fe(II). Moreover, CAP degradation intermediates were identified and its degradation pathways were proposed. This study suggested a new approach for improving the Fe(III)/H 2 O 2 system by accelerating Fe(III)/Fe(II) cycles with Fullerol.
研究领域:
环境科学
·
废水处理
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Suzhou Xu,Can Liu,Xuping Jiang,Xinyu Wang,Shijin Zhang,Yanting Zhang,Qingguo Wang,Weiling Xiong,Jing Zhang
The performance and mechanisms of a titanium carbide (Ti 3 C 2 ) MXene modified Fe 3+ /hydrogen peroxide (H 2 O 2 ) system were compared in detail under dark and visible light conditions, with a new mechanism proposed for the reaction and reduction of MXene by Fe 3+ . Using Bisphenol A (BPA) as the target pollutant, the degradation of BPA by the Fe 3+ /H 2 O 2 system was improved after adding MXene in the dark, and the degradation rate of BPA was ≥ 95 % within 12.5 min under visible light, six times higher than that in the dark. Fe 2+ was ascertained to be the effective component responsible for H 2 O 2 activation to produce ·OH. SEM , XPS, ICP, XRD, and FTIR spectroscopy , analyses show that MXene and Fe 3+ form a complex, and then MXene reacts with Fe 3+ by breaking the Ti–C bonding to accelerate the Fe 3+ /Fe 2+ cycle. MXene uses photogenerated electrons to promote this reaction under visible light. In addition, quenching experiments and electron spin resonance spectroscopy results show that ·OH and O 2 •− are the main reactive oxygen species under visible light, while ·OH is the main active species in the dark. MXene thus effectively uses O 2 to form O 2 •− under visible light and promotes the Fe 3+ /Fe 2+ cycle. This study provides a theoretical basis for the combination of visible light catalysis and the advanced oxidation process of a Ti 3 C 2 MXene.
研究领域:
环境科学
·
化学工程
·
材料科学
·
高级氧化过程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Yingshi Zhu,Fengxia Deng,Shan Qiu,Fang Ma,Yanshi Zheng,Ruqian Lian
Facing low reactivity/selectivity of oxygen reduction reaction (ORR) in electro-Fenton (EF), N, S atoms were introduced into carbon-based cathode. “End-on” O 2 adsorption was achieved by adjusting electronic nature via N doping, while *OOH binding capability was tuned by spin density variation via S doping. Results showed the optimized N, S co-doped cathode presented a 42.47% improvement of H 2 O 2 accumulation (7.95 ± 0.02 mg L −1 cm −2 ). According to density functional theory (DFT), N, S co-doped structure favored the “end-on” O 2 adsorption as adsorption energy dropped to − 2.24 eV. Moreover, O-O/C-O bond lengths variation proved a possibility for *OOH desorption. The elaborated cathode was used in EF for sulfonamides (SAs) decay. A 100% removal rate of sulfadiazine (SDZ), sulfathiazole (STZ) and sulfadimethoxine (SDM) was achieved within 60 min, among which SDZ tended to be degraded easily. Because the absolute hardness ( η ) of those pollutants is ranked as follows: η SDM > η STZ > η SDZ . Degradation pathways were proposed based on the detected byproducts, along with toxicity was evaluated by ecological structure-activity relationship (ECOSAR) program. Results showed that toxic intermediates generated were reduced or even disappeared. EF with N, S co-doped cathode provides a promising process for antibiotics wastewater treatment .
研究领域:
环境科学
·
化学工程
·
污染控制
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LUMINESCENCE
·
2016
·Vol. 32
·期 3
·277-284
·
IF 1.452
Jianqiu Chen,Juan Shu,Jiao Chen,Zhiran Cao,An Xiao,Zhengyu Yan
S,N co-doped carbon quantum dots (N,S-CQDs) with super high quantum yield (79%) were prepared by the hydrothermal method and characterized by transmission electron microscopy, photoluminescence, UV–Vis spectroscopy and Fourier transformed infrared spectroscopy. N,S-CQDs can enhance the chemiluminescence intensity of a luminol–H 2 O 2 system. The possible mechanism of the luminol–H 2 O 2 –(N,S-CQDs) was illustrated by using chemiluminescence, photoluminescence and ultraviolet analysis. Ranitidine can quench the chemiluminescence intensity of a luminol–H 2 O 2 –N,S-CQDs system. So, a novel flow-injection chemiluminescence method was designed to determine ranitidine within a linear range of 0.5–50 μg ml −1 and a detection limit of 0.12 μg ml −1 . The method shows promising application prospects.
研究领域:
分析化学
·
药物分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2018
·
IF 3.457
Ji Ma,Maoru Li,Praveen Kumar Kalavagunta,Jiajing Li,Qiangqiang He,Yifan Zhang,Owais Ahmad,Hongli Yin,Tao Wang,Jing Shang
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with a broad spectrum of liver injury. Oxidant stress is believed to be the pathogenesis of NAFLD as the “second hit”. Hydrogen peroxide is widely used as an oxidant reagent to induce the oxidant injury of cells and larval zebrafish. Recently, cichoric acid is being studied extensively for its obesity attenuating, hepatic steatosis reduction and anti-oxidant effects. In this study, to identify whether CRA could protect the H 2 O 2 induced oxidant injury via anti-oxidant impact by using L02 and HepG2 hepatocytes as in vitro and larval zebrafish as in vivo injury models, and evaluated the protective and anti-oxidant effects of CRA by pretreated it on both in vitro and in vivo models. CRA was found to reduce the production of ROS and MDA, activate the anti-oxidant enzymes SOD and GSH-px, and pathways Keap1-Nrf2 and HO-1. These results demonstrated that CRA might protect the liver injury by its anti-oxidant effect, which could be a potential therapeutic agent of NAFLD.
研究领域:
药理学
·
毒理学
·
细胞生物学
·
斑马鱼模型
·
肝脏疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2024
·
IF 4.4
Hu Hanqiong,Sun Yifan,Yang Zhen,Che Limuge,Cai Mingyang,Li Xiaoxuan,Huang Xianju,Bagen Hurile,Qiqige Wulan,Guleng Wuyunsiri,Ma Liqun,Tong Haiying
Introduction: Zhachong Shisanwei Pill (ZSP) is a classical Mongolian formula that combines 13 types of Chinese medicinal materials and has been used for treating ischemic stroke (IS) for centuries. However, the underlying molecular mechanisms have yet to be fully elucidated. The aim of this study is to explore potential mechanism of ZSP on nerve cells in cerebral ischemic injury.Methods: To simulate the pathological process of oxidative stress following IS, an injury model using PC12 cells was induced with hydrogen peroxide (H2O2). Afterward, PC12 cells were treated with ZSP medicated serum at low, medium, and high doses. Various assays were conducted to assess cell viability and oxidative stress indicators, including lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reactive oxygen species (ROS), and mitochondrial membrane potential (MMP). Cell apoptosis was evaluated through morphological assessment and flow cytometry. Additionally, the expression levels of apoptosis-related proteins (Bcl-2, Bax, Caspase-9, Caspase-3, PARP) and signaling pathway proteins (JNK, phosphorylated JNK, ERK, phosphorylated ERK, p38, and phosphorylated p38) were measured using automated Western blotting.Results: Our findings indicate that ZSP medicated serum preconditioning improves the condition of PC12 cells injured by H2O2. Specifically, it increased cell survival rates and reduced LDH release. Additionally, ZSP treatment decreased ROS levels and MDA content, while enhancing the activity of SOD and CAT in the injured PC12 cells. ZSP also reversed the depolarization of mitochondrial membrane potential and protected cells from apoptosis by modulating the expression of apoptosis-related proteins, including Bcl-2, Bax, Caspase-9, Caspase-3, and PARP. Furthermore, the overactivation of the MAPK signaling pathway due to H2O2-induced injury was inhibited, as evidenced by the downregulation of phosphorylated JNK, ERK, and p38 levels.Discussion: Mongolian medicine ZSP demonstrates protective effects against H2O2-induced oxidative stress and apoptosis in PC12 cells. The underlying mechanism may involve the inhibition of the MAPK signaling pathway, enhancement of antioxidant enzyme activity, reduction of intracellular peroxidation levels, and suppression of intrinsic apoptosis pathways.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
传统医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 12
·5359-5368
·
IF 5.251
Yadong Liu,Zhanwei Zhou,Yidi Liu,Yanhui Li,Xinzhi Huang,Chenggen Qian,Minjie Sun
Photodynamic therapy (PDT) is a clinically approved cancer treatment approach that relies on the generation of excess reactive oxygen species (ROS) to eradicate tumor cells by inducing oxidative stress. Unfortunately, if the tumor's endogenous glutathione (GSH) is overexpressed, it will eliminate the ROS and restrict the therapeutic efficacy of PDT. Herein, we report a H2O2-activated oxidative stress amplifier (OSA) for enhancing the ROS generation for PDT via GSH scavenging. Cinnamaldehyde (Cin) and chlorin e6 (Ce6) were applied as the GSH scavenger and photosensitizer, respectively, which were assembled with the ROS-responsive amphipathic polymer (DPL) to form DPL@CC micelles as the OSA. In the circulation of blood, the OSA can effectively protect the Cin from albumin binding to retain its GSH depletion ability. Once the OSA reached the tumor site, the high level of H2O2 triggered the degradation of DPL and led to the release of Cin and Ce6. Subsequently, the released Cin reacted with the intracellular GSH by Michael Addition and downregulated the GSH level to about 18.9%, versus untreated cells, to weaken the anti-oxidation ability of tumor cells. Thus, it provided a suitable environment for PDT to obtain an amplifying effect on oxidative stress and superior anti-cancer efficacy of 94% growth inhibition. The preparation of the H2O2-activated oxidative stress amplifier is a convincing strategy for promoting intracellular ROS generation and enhancing the tumor PDT efficacy, which could also augment the clinical application of PDT.
研究领域:
癌症治疗
·
药学
·
生物医学工程
·
化疗
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Tianrong Zhan,Jingxia Kang,Xianjun Li,Lei Pan,Guangjiu Li,Wanguo Hou
The ultrathin NiFe-layered double hydroxide nanosheets (NiFe-LDHNS) were prepared by exfoliating bulk LDH in l -asparagine aqueous medium. The transmission electron microscopy and atomic force microscopy results reveal that NiFe-LDHNS have about 200–300 nm lateral size and less than 2 nm thickness with the broken edges rather than the original hexagon of hydrotalcite. The peroxidase-like activity of the 2D NiFe-LDHNS was investigated by using oxidation of the peroxidase substrate 3,3′,5,5′-tetramethylbenzidine in presence of H 2 O 2 . The 2D NiFe-LDHNS exhibited the superior enzyme mimic activity to the bulk NiFe-LDH, which was attributed to the more exposed active sites and more accessible inner surface of single or several layers. Thus, a simple and sensitive non-enzyme biosensor was developed for colorimetric detection of H 2 O 2 and glucose. The proposed method was successfully applied to glucose detection in real samples with satisfactory results.
研究领域:
纳米材料
·
分析化学
·
生物传感器
✓ 已验证
产品关联
DOI
高影响因子
Environmental Science-Water Research & Technology
·
2020
·Vol. 7
·期 3
·479-486
·
IF 3.449
Zhiwei Yang,Xiaonan Tan,Daojian Tang,Jing Li,Jiahai Ma
In this study, the contrasting activities and pathways of Mn2+/Cu2+–HCO3− systems for Congo red (CR) dye degradation are presented. The Mn2+–HCO3− system (with the well-known MnIVO as the reactive species) did not degrade CR, while the Cu2+–HCO3− system (with high-valent Cu proposed as the reactive species) had a good oxidizing ability for CR. Further, HO radicals in the classic Fenton-like system made no contribution to CR degradation with both Cu and Fe ions as catalysts. The results indicate that reactive species in metal–HCO3− AOPs need prudent examination and better understanding of the underlying mechanism would benefit the development of more efficient AOPs.
研究领域:
环境化学
·
水处理
·
高级氧化过程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）