ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jiayi Zhang,Yang Li,Zhen Xiang,Daihua Fu,Yunbing Wang
Cardiovascular stents persistently struggle to reconcile rapid endothelialization with long-term prevention of thrombosis and restenosis. This study develops a spatiotemporally orchestrated dual-gas-releasing hydrogel coating that synchronizes H 2 S and NO delivery with the dynamic phases of vascular healing. The coating is fabricated by covalently grafting an alginate coating onto poly(L-lactic acid) stents via a benzophenone-mediated two-step surface photopolymerization. A thiol‑activated H 2 S donor is anchored within the coating, while alginate‑chelated Cu 2 ⁺ catalyzes NO generation from endogenous S‑nitrosothiols. An early H 2 S burst synergizes with NO to suppress thromboinflammation and prime a regenerative niche, while sustained NO release maintains vascular homeostasis and directs long-term remodeling. The coating reduces platelet adhesion by over 90%, virtually eliminates thrombosis in an arteriovenous shunt model, triples endothelial coverage, and suppresses smooth muscle cell proliferation by ≈73%. It also reprograms macrophage polarization, increasing the M2/M1 ratio tenfold, and reduces intracellular ROS levels by >90%. In a rabbit abdominal aorta model, the coating promotes flow-aligned endothelialization, achieving CD31⁺/eNOS⁺ coverage comparable to native tissue within 3 months, while decreasing neointimal thickness by 66% versus controls. This spatiotemporally tailored gasotransmitter delivery resolves the healing dichotomy of stents, providing a clinically translatable platform for next-generation vascular implants.
研究领域:
生物材料学
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心血管医学
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再生医学
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纳米医学
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转化医学
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分子药理学
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DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Wang Xuefeng,Mejia Esteban,Zuo Yujing,Lv Zhiyan,Wang Zonghua
The development of fluorescent probes for H 2 S detection especially in living cells is of great significance due to its fundamental role as signal molecule. A promising scaffold for the development of such probes is polydimethylsiloxanes (PDMS), which is cost-effectiveness, non-toxicity, flexibility, and biocompatibility and easy to post-functionalize. Surprisingly, fluorescent probes for H 2 S detection based on PDMS have not been investigated. Moreover, 4-nitro − 2,1,3-benzoxadiazole (NBD) derivates provides high fluorescence quantum yield, a large molar absorption coefficient, and sensitivity to environmental changes. Through reasonable design and adjustment of substituents on the NBD group, precise control of its fluorescence properties can be achieved. Herein, a novel H 2 S fluorescent probe, P-NBD, was designed and synthesized by a one-step aromatic ring nucleophilic substitution of Cl-NBD with a PDMS derivative. Due to the occurrence of the cleavage reaction strategy and the intramolecular charge transfer process, P-NBD can detect H 2 S via a colorimetric method. The limit of detection is down to 93 nM. P-NBD demonstrated considerable detection capability comparable to other reported types of H 2 S probes. Moreover, the probe can also be utilized for H 2 S imaging in HeLa cells. This work provides new insights into the design and synthesis of novel H 2 S probes while also offering experimental evidence for the application of PDMS in cellular imaging.
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DOI
PubMed
高影响因子
ACS Nano
·
2026
·
IF 17.3
Jinzhe Liang,Xianliu Luo,Ya-Qian Shi,Liang-Mei Yang,Caiying Li,Lixian Huang,Yuzhen Ma,Yong Huang,Shulin Zhao
Controlling ferroptosis through material redox dynamics represents a frontier in the field of catalytic nanomedicine. Here, we introduce nonstoichiometric bismuth ferrite (BiFeO3–x) as an H2S-activable semiconductor that couples oxygen-vacancy-enabled charge modulation with endogenous sulfur chemistry to achieve spatiotemporally controlled immunogenic ferroptosis. Upon exposure to tumor-enriched gasotransmitter H2S, BiFeO3–x undergoes a transformation into Bi2S3 while releasing Fe2+ ions to trigger Fenton-like lipid peroxidation. The material’s mixed-valence Fe redox pair amplifies reactive oxygen species generation under 808 nm excitation, coupling photothermal energy dissipation with catalytic ferroptotic stress. Biologically, this multiresponse process initiates mitochondrial collapse, glutathione peroxidase 4 depletion, and lipid peroxide accumulation, driving apoptosis–ferroptosis cascades. In vivo, photoacoustic-guided therapy and mass cytometry profiling reveal profound immune remodeling, such as dendritic cell maturation, CD8+ T cell infiltration, and M1 macrophage polarization, implying the conversion of “cold” colorectal tumors into immunogenic tumor microenvironments. This work establishes a defect-chemistry-oriented design framework for engineering redox-programmable nano semiconductors that translate lattice instability into biological selectivity, bridging ferroelectric materials science and immune oncology.
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Zhi Yuan Xie,Wan Xiang Qiu,Zi Yi Xu,Nian Bing Li,Hong Qun Luo
Hydrogen sulfide (H 2 S) has a comprehensive contribution to the normal operation and stability of organisms and is also present in environmental water samples and food deterioration. Thus, it is exceedingly promising and significant to develop a highly sensitive detection technique for tracing H 2 S. Inspired by this, we designed and synthesized a new fluorescent probe 2-[3-[2-[3-bromo-4-(2,4- dinitrobenzenesulfonate)] ethenyl]-5,5-dimethyl-2-cyclohexen-1-ylidene]propanedinitrile (SP-Br) for hydrosulfide ion detection by introducing bromine atom. Compared with reported H 2 S probes based on the same fluorescent parent, SP-Br has longer fluorescence emission (λ em = 670 nm), shorter response time (3 min), lower detection limit (149 nM), and wider detection range (0–30 nM). SP-Br can emit weak yellow fluorescence, and the emission intensity at 670 nm is considerably enhanced in the presence of hydrosulfide ions. The identification mechanism of hydrosulfide ion by SP-Br was verified by high-resolution mass spectrometry, fluorescence, and UV–vis absorption spectroscopy. In addition, SP-Br has been successfully applied to the monitoring of actual water samples and beer samples and has certain development prospects and value in the fields of environmental pollution and food quality analysis.
研究领域:
生物化学
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环境科学
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食品科学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Suqin Xiong,Shuguang Yan,Lichun Zhang,Yi Lv
Graphitic carbon nitride, as an excellent metal-free catalyst, is a promising candidate for cataluminescence (CTL) sensing of H 2 S owing to its high sulfur tolerance, environmental friendliness and low cost. Herein, in view of inner chemical inertness and low special surface area of g-C 3 N 4 , fluorine with strong electronegativity was employed to adjust the electron density of g-C 3 N 4 to obtain fluorine functionalized graphitic carbon nitride (F-g-C 3 N 4 ) for H 2 S sensing. As expected, the CTL response of F-g-C 3 N 4 exhibits more than 30 times higher towards H 2 S by contrast with that of g-C 3 N 4 . Results demonstrated that F-g-C 3 N 4 was more conducive to the adsorption of O 2 and H 2 S due to the enlarged special surface area, the easier formation of hydrogen bond and the changed electronic structure, which was also supported by density functional theory calculations. Additionally, the F-g-C 3 N 4 -based sensor exhibits as high sensitivity as that of metal catalyst-based sensors but a longer lifetime. Meanwhile, the F-g-C 3 N 4 -based sensor has much higher CTL responses in the range of 1.27∼64.00 μg mL −1 , lower detection limit of 0.07 μg mL −1 when comparing with previously reported metal-free catalyst-based sensors. Undoubtedly, this work not only opened up a novel approach to improve the sensing performance of g-C 3 N 4 , but also proposed an efficient strategy for obtaining satisfying catalytic performance of other metal-free layered materials.
研究领域:
材料科学
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环境科学
·
化学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xingyu Xiao,Liangliang Liu,Junhao Ma,Yuan Ren,Xiaowei Cheng,Yongheng Zhu,Dongyuan Zhao,Ahmed A. Elzatahry,Abdulaziz Alghamdi,Yonghui Deng
Owing to their distinct chemical and physical properties, mesoporous metal oxide semiconductors have shown great application potential in catalysis, electrochemistry, energy conversion, and energy storage. In this study, mesoporous crystalline SnO2 materials have been synthesized through an evaporation-induced co-assembly (EICA) method using poly(ethylene oxide)-b-polystyrene diblock copolymers as the template, tin chlorides as the tin sources, and tetrahydrofuran as the solvent. By controlling conditions of the co-assembly process and employing a carbon-supported thermal treatment strategy, highly ordered mesoporous SnO2 materials with a hexagonal mesostructure (space group P63/mmc) and crystalline pore walls can be obtained. The mesoporous SnO2 is employed for fabricating gas sensor nanodevices which exhibit an excellent sensing performance toward H2S with high sensitivity (170, 50 ppm) and superior stability, owing to its high surface area (98 m2/g), well-connected mesopores of ca. 18.0 nm, and high density of active sites in the crystalline pore walls. The chemical mechanism study reveals that both SO2 and SnS2 are generated during the gas sensing process on the SnO2-based sensors.
研究领域:
材料科学
·
传感技术
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DOI
高影响因子
Advanced Materials Interfaces
·
2022
·Vol. 9
·期 7
·2101908
·
IF 6.389
Meng Miao,Zhipeng Wang,Zhiming Guo,Jinfeng Xing
A quasi solid–liquid reaction strategy is proposed that is based on the instantaneous transformation of structured solid ligand aggregation into insoluble Cu 3 (HITP) 2 metal–organic framework (MOF) aggregation without morphologic change (HITP = 2,3,6,7,10,11-hexaiminotriphenylene). The initial 3D ordered submicron macropores (TOM) in ligand aggregation can be maintained during the transformation due to the extremely rapid rate of coordination reaction. In this case, the in situ synthesis of the Cu 3 (HITP) 2 MOF film with large-scale TOM structure (TOM-Cu 3 (HITP) 2 film) on ceramic-based gold interdigital electrode (IDE) is achieved. Scanning electron microscope is used to confirm the morphology in each stage of synthetic process. Spectroscopic characterizations prove that there is no essential difference between TOM-Cu 3 (HITP) 2 film and ordinary Cu 3 (HITP) 2 MOF, except for slight differences in the contents of individual surface functional group and integral crystallinities, respectively. Notably, TOM structure endows the TOM-Cu 3 (HITP) 2 film with a dramatic promotion in sensitivity to H 2 S gas. The resistive response of the IDE loaded with TOM-Cu 3 (HITP) 2 film to the 80 ppm H 2 S gas reaches 78.5 at room temperature, which is 6.7× more than that of the Cu 3 (HITP) 2 film without TOM structure. The method of obvious universality allows the authors to perform in situ synthesis directly on the desired substrate without transfer process.
研究领域:
材料科学
·
化学
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DOI
高影响因子
International Journal of Nanomedicine
·
2018
·
IF 4.37
Fei Tong,Rongkui Chai,Haiying Jiang,Bo Dong
Background The objective of this study was to survey the therapeutic function of curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect of calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (H 2 S). Methods Diabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks. The blood and myocardiums were collected, the level of serum H 2 S was observed, and the [Ca 2+ ] i content was measured in myocardial cells, and hematoxylin-eosin, CaSR, CSE, and calmodulin (CaM) expression were detected. Results Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H 2 S and [Ca 2+ ] i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect. Conclusion PBLG-PEG-PBLG could improve water-solubility and bioactivity of curcumin and curcumin/PBLG-PEG-PBLG significantly alleviated diabetic cardiomyopathy.
研究领域:
药理学
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心血管疾病
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2015
·
IF 4.321
Dongjing Liu,Weiguo Zhou,Jiang Wu
x Ce y Mn/ZSM-5 sorbents were prepared using sol–gel method and employed for H 2 S removal in the temperature range of 600–800 °C. The sorbents exhibited high performance in sulfur removal due to the cooperative effect of CeO 2 and MnO x . The presence of H 2 was unfavorable for sulfidation and obviously shortened the breakthrough time and reduced the sulfur capacity. However, the existence of CO had little impact on the sulfur-removal performance. The characterization results revealed that the ZSM-5 structure remained intact during preparation and sulfidation process. And active species, such as CeO 2 and Mn 2 O 3 , were well dispersed on ZSM-5, which would suppress the mechanical disintegration and improve the thermal stability of x Ce y Mn/ZSM-5.
研究领域:
环境催化
·
能源化学工程
·
材料科学
·
无机功能材料
·
气体净化技术
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DOI
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Wenying Li,Yueyue He,Qing Zhang,Yang Yue,Teik-Thye Lim,Guangren Qian
Iron oxide-based adsorbents offer strong potential for hydrogen sulfide (H2S) removal due to their cost-effectiveness and environmental compatibility. However, how to precisely control multiscale microstructural features that govern adsorption performance remains inadequately understood. Here, a pH-controlled hydrothermal synthesis strategy using ferrous sulfate heptahydrate as the iron precursor was developed to elucidate the relationship between the microstructure and the adsorption performance of Fe-based adsorbents. A distinct functional pH threshold (≥7) was identified, above which a pure-phase Fe3O4 was formed and the surface Fe2+/Fe3+ redox couple became stabilized/activated, enabling effective H2S capture. H2S fixed-bed tests were conducted at ambient temperature with an inlet concentration of 1000 ppm. The adsorbent synthesized at pH = 13.0 integrated mixed-valence Fe2+/Fe3+ sites, defect-rich surfaces with enhanced basicity, mesoporosity, and exposed {111} facets, delivering a breakthrough capacity of 85 mg/g (H2S outlet concentration < 0.01 ppm), which was 7 times higher than that at the threshold (pH = 7), and an estimated total sulfur uptake of 250 mg/g. This work clarifies how multiscale microstructural features govern H2S capture and provides a design strategy for tuning redox-active sites, defects, and surface basicity.
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高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Luan Fu,Lulu Du,Weizhong Tan,Zihao Liang,Xiaohui Shi,Li Lv,Pinhua Zhang,Guangliang Cui
Abstract The rapid and accurate detection of H2S in exhaled breath at room temperature remains a critical technical challenge. Herein, we developed a Pt@ZIF-8/Cu2O heterojunction sensor via a two-dimensional electrodeposition in-situ assembly strategy for sensitive H2S detection. This sensor exhibits superior room-temperature sensing performance: a remarkably high response of 8931 toward 10 ppm of H2S, an ultralow detection limit of 10 ppb (response ∼0.61), and a 11.8-fold enhancement in response to 500 ppb H2S relative to pristine Cu2O. The exceptional sensing performance is attributed to the synergistic effects of the high-specific-surface-area structure, the catalytic activity of Pt nanoparticles, and optimized interfacial charge transfer at the heterojunction. Notably, as the relative humidity increases from 37 to 94%, the response time toward 5 ppm of H2S decreased by ∼33% (from 330 to 220 s), while the response magnitude concurrently increases by ∼117% (from 3183 to 6907). This humidity-induced performance improvement significantly enhances operational reliability in practical applications, thereby eliminating the requirement for complex humidity control systems. This unique phenomenon is associated with the [Zn–OH]+ active sites within the ZIF-8 framework, which facilitate the adsorption of H2S molecules. More importantly, the sensor enables sensitively quantification of H2S concentrations in human exhaled breath, highlighting its great potential for noninvasive disease diagnosis.
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DOI
高影响因子
ACS Sensors
·
2025
·
IF 9.1
Zhaorui Zhang,Chonghui Zhu,Yu Liang,Jinkui Chu,Yuxia Shan,Minghui Yang
Real-time, remote monitoring of human biomarkers is essential for personalized medical diagnostics. Hydrogen sulfide (H2S), a key endogenous gas, serves as a crucial biomarker for conditions such as oral diseases. However, accurately detecting ppb-level H2S in high-humidity environments remains a challenge. Herein, we develop a Pt-loaded CrVN2 fuel cell-type H2S sensor that exhibits high humidity resistance, ultralow detection limits (50 ppb), rapid response (4 s), and exceptional selectivity. The stable electronic structure of CrVN2 ensures a consistent response across a wide relative humidity range (9%–79%). Furthermore, a wireless detection system incorporating the Pt/CrVN2 sensor was designed and validated for breath diagnosis, demonstrating its practical application in smart healthcare. This study highlights the potential of Pt/CrVN2 sensor as a promising platform for real-time, sensitive biomarker detection, contributing to the advancement of next-generation medical diagnostics.
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DOI
PubMed
高影响因子
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