JOURNAL OF MATERIALS RESEARCH
·
2024
·
IF 2.7
Deng Jianhua,Li Daosheng,Wang Yifei,Chen Rui,Liu Denghui,Peng Jindi
We constructed an iron (Fe 2+ ) metal–organic framework (MOF) in this study. We loaded SN-38 into the MOF before coating the MOF's surface with hyaluronic acid (SN-38@HA@MOF) to improve its ability to target cancer cells. SN-38@HA@MOF can specifically target cancer tissues, has a high loading efficiency, is biocompatible, has a good monodispersity, has a robust cell absorption capacity, and produces significant intracellular reactive oxygen species levels. The in vitro cytotoxicity of the nanocomposites was investigated in different neuroblastoma cancer cells (SH-SY5Y and IMR 32). Even at a 200 µg/mL dosage, the IC 50 range was as high as 85%, indicating that MOF and HA@MOF are non-cytotoxic to non-cancerous cells and have outstanding biocompatibility and low toxicity. Flow cytometric analyses investigated the cell death morphological investigation and mechanism. The adaptive multifunctional SN-38@HA@MOF has the potential to treat targeted neuroblastoma cancer. Graphical abstract
研究领域:
药学
·
纳米技术
·
癌症生物学
·
材料科学
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产品关联
DOI
高影响因子
Materials Today Chemistry
·
2025
·
IF 6.7
Meng Wu,Yucheng Zhou,Sichao Huang,Bixin Jiang,Peng Huang,Nan Liang,Laijun Xu
Preserving the vital pulp poses significant challenges in clinical pulp injury repair. Tricalcium silicate (C3S)-based cement has emerged as a successful pulp capping biomaterial. However, its efficacy in inducing pulp-dentin complex regeneration requires enhancement, and handling difficulties, poor anti-collapsible ability and inadequate self-setting performance remain significant obstacles, restricting its broader application in endodontics. In this study, a multifunctional SrCO 3 -doped C3S biocement (C3S-Sr/F127-nHA) reinforced by Pluronic® F127 thermoreversible hydrogel and nano hydroxyapatite (nHA) was developed to overcome the limitations of C3S-based cements. The thermoresponsive characteristic of F127 conferred the C3S pastes smart response behavior, allowing for optimal operability at room temperature and maintaining excellent anti-collapse properties at body temperature. C3S-Sr/F127-nHA exhibited an injectability rate of up to 93 %. nHA facilitated the hydration kinetics of C3S, resulting in reduced setting time and enhanced compressive strength. Furthermore, C3S-Sr/F127-nHA demonstrated excellent apatite mineralization ability, cytocompatibility, and potential for osteo/odontogenic induction. The inclusion of Sr 2+ ions and nHA promoted osteo/odontogenic differentiation of stem cells isolated from human exfoliated deciduous teeth (SHED). In vivo findings indicated that C3S-Sr/F127-nHA could stimulate the formation of a homogeneous dentin bridge. Consequently, C3S-Sr/F127-nHA is a promising biocement for use in regenerative endodontics.
研究领域:
牙科
·
材料科学
·
再生医学
·
生物材料
·
牙髓病学
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产品关联
DOI
高影响因子
Pharmaceuticals
·
2026
·Vol. 19
·期 2
·275
·
IF 5.7
Zhongnan Hu,Hui Liu,Weihua Wu,Tayyab Ali,Adam Junka,Farukh S. Sharopov,Xuan Zou,Shisong Fang,Yanfang Sun
Background: Influenza A virus is an acute respiratory virus that spreads quickly, affects a broad range of populations, and can lead to many complications and mortality.ArtemisiaL. species are widely used in traditional medicine, but their antiviral potential against H1N1 remains uncertain.Methodology: Network pharmacology and molecular docking were used to computationally explore their potential function in this domain, and to investigate how their invasion mechanisms and adsorption occur. UPLC-MS/MS analysis identified the main components of the extracts. The anti-H1N1 mechanism ofArtemisiaL. extracts was studied in vitro.Results: Network pharmacology identified 95 key targets betweenArtemisiaL. and IAV, with quercetin and luteolin as core active compounds. Molecular docking predicted strong binding affinities between these compounds and influenza virus proteins. UPLC-MS/MS analysis identified 75, 100, and 64 chemical components inACBE,AALE, andACTE, respectively, mainly flavonoids and terpenoids.ArtemisiaL. extracts exhibited both preventive and therapeutic effects against H1N1, reducing progeny virus NP mRNA and protein levels. In vitro experiments showed that higher concentrations of the extracts prevent virus attachment to MDCK cells by denaturing the HA protein. NA plays an essential role in progeny virus release. We found that a high concentration of ACTE can inhibit NA up to 85%, and ACBE showed a low inhibitory effect on NA.Conclusions: In terms of therapeutic effects,ArtemisiaL. extracts can regulate intracellular inflammatory factors via the TLR4/NF-κB/MyD88 signaling pathways and reduce the expression of IL-1β, IL-6, TNF-α, TLR4, NF-κB, p65, and MyD88 at the mRNA level, thereby inhibiting H1N1 virus replication. These results suggest that bioactive components inArtemisiaL. extracts may inhibit H1N1, potentially leading to the development of natural-product-based anti-influenza agents.
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DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2024
·
IF 3.8
Wei Jia,Jingyuan Qiao,Guangchao Shi,Lingzi Zhao,Wen Zhao,Feipeng Liu,Yiyun Fang,Jingzhi Shang,Zi-Qiang Rong
Hybrid quasi-two-dimensional (quasi-2D) perovskites have attracted great interest due to their excellent photovoltaic and light-emitting properties, which enable the rapid development of high-performance perovskite-based solar cells, light-emitting diodes, and lasers. Although many efforts have been made to improve the quality and stability of organic-inorganic perovskites, the controlled synthesis of high-quality layered perovskites remains challenging. Here, single-crystalline quasi-2D (HA) 2 (MA) n-1 Pb n I 3n+1 perovskites with layer numbers of n from 1 to 3 have been synthesized in a controllable manner, exhibiting stable lattice structures and tunable optical emission. Structurally, hexylamine (HA) with longer alkyl chains was used as an organic spacer in Ruddlesden-Popper (RP) phase perovskites to improve the chemical stability of perovskites. Various ratios of precursor materials were adopted for separating pure and large-scale quasi-2D (HA) 2 (MA) n-1 Pb n I 3n+1 perovskites, in which different layer-number perovskites with tunable band gaps were obtained with the modulated fluorescence lifetimes . Our lattice structural and fluorescence-lifetime characterizations of RP-phase perovskites provide critical information on the emerging quasi-2D perovskite-crystal systems and their fluorescence relaxation dynamics. The employed strategy to synthesize high-quality perovskites (HA) 2 (MA) n-1 Pb n I 3n+1 is technically essential to develop the rising perovskite-based photovoltaic and light-emitting applications.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Guofu Huang,Mianmian Wang,Yongyou Hu,Jianhua Cheng,Sihao Lv,Kui Yang
As a typical congener of Polybrominated diphenyl ethers (PBDEs), 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) has attracted more and more attention due to its high biological toxicity and environmental abundance. In this study, a novel polyanionic cellulose stabilized Pd/Fe (PAC-Pd/Fe) nanoparticle was successfully synthesized for BDE47 degradation under ambient condition. Batch experiments showed that BDE47 degradation followed pseudo first-order kinetic model. Pd loading played a crucial role as it affected the formation of activated hydrogen species H ∗ and accelerated electron transfer. At Pd loading of 0.3 wt%, nearly 100% BDE47 was degraded completely within 10 min by 0.4 g L −1 PAC-Pd/Fe nanoparticles. When compared with strong acidic (pH 3) and alkaline (pH 9 and 11) conditions, weak acidic condition (pH 5) was more favorable for BDE47 degradation, with nearly 100% BDE47 was removed within 7.5 min. In the presence of HA inhibited the degradation of BDE47, and the degradation efficiencies within 15 min decreased from 100%, 88.6%, 79.5% to 73.1% as HA concentration increased from 0, 10, 40 to 70 mg L −1 . The degradation of BDE47 by PAC-Pd/Fe nanoparticles was a reductive debromination process, and a stepwise debromination from n-Br to (n-1)-Br BDEs was the dominant reaction, in which the para -Br was more susceptible to remove than ortho -Br. This study suggests PAC-Pd/Fe nanoparticle can be utilized as a promising remediation technology for PBDEs contaminated wastewater.
研究领域:
环境科学
·
污染治理
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Shan Zhang,Ruiqi Liang,Kun Xu,Shurong Zheng,Somnath Mukherjee,Peng Liu,Changhao Wang,Yashao Chen
In recent years, magnesium alloys (MgA) have been reckoned as the most promising material of biomedical importance on account of its excellent degradable properties and mechanical properties mimicking natural bone tissues. However, MgA are prone to rapid corrosion under physiological conditions, causing toxicity around the neighboring tissues. In addition, they are susceptible to bacterial colonization, a detrimental factor for medical causes. In this study, antibacterial material coated hydrogel-based micro-patterns were developed on MgA to achieve long-term antibacterial, antifouling, osteogenic, and cell-compatible properties. First, the Mg(OH) 2 nanosheet coating was prepared on the surface of MgA as a physical barrier to prevent the corrosion of MgA. Then the hydrogel micropatterns of poly(alendronate sodium methacrylate)/poly(dimethyldiallylammonium chloride)/poly(ethylene glycol) diacrylate (PALNMA/PDADMAC/PEGDA) of different sizes were constructed on the surface of the Mg(OH) 2 coating using the photomask method. Finally, an intelligently responsive antibacterial material hyaluronic acid/berberine (HA/BBR) was coated on MgA-Mg(OH) 2 -PALNMA/PDADMAC/PEGDA patterns via layer-by-layer self-assembly. The excellent antifouling performance of the samples is attributed to the topological structure of the pattern. Interestingly, as the pattern size of PALNMA/PDADMAC/PEGDA decreases, the antibacterial, antifouling, and cell compatibility properties of the samples gradually improve. UV–Vis spectra and bacterial plate count indicate that HA/BBR coating provide a pH and hyaluronidase (HAase) dual-responsive surface to kill the attached bacteria quickly. Finally, the in vitro experiments demonstrate excellent blood compatibility, cell compatibility and osteogenic properties of the modified MgA samples. Therefore, the intelligent multifunctional assembly of MgA presented here has a promising future in the field of metal implant materials.
研究领域:
材料科学
·
生物医学工程
·
骨科
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2019
·Vol. 93
·期 2
·332-340
·
IF 1.986
Chen Yunyun,Zhao Yanbao,Sun Lei,Zou Xueyan
A multifunctional nanoplatform (pSiO 2 –Au/HA) combining porous silica (pSiO 2 ) carriers and gold nanoparticles (Au NPs) was synthesized for chemophotothermal synergistic therapy. The pSiO 2 carrier has the diameter size of 70 nm and high specific surface area (510.8 m 2 ·g −1 ). Au NPs as photothermal agents and gatekeepers were linked to pSiO 2 carriers by Au–S bonds for redox-responsive drug release and photothermal effect. Hyaluronic acid (HA) molecules were conjugated by the amide bonds on the surface of porous silica (pSiO 2 ) to seal the drug-loaded pores and endow it pH-and enzyme-responsive property. The results demonstrated that pSiO 2 –Au/HA carriers displayed good pH/redox/enzyme-responsive release behavior and photothermal effect, which may be a good promising targeted delivery systems for chemophotothermal therapy.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2025
·Vol. 36
·期 1
·1-17
·
IF 4.5
Chen Shaoqing,Liang Caiqin,Li Pengyin,Liu Chun,Zeng Xierong,Xiong Xinbo,Ni Xinye
Hydroxyapatite (HA) coatings on carbon fiber-reinforced carbon (C f /C) composites hold promise for orthopedic implants. However, the interface between HA and C f /C is prone to delamination, limiting its application. To address this, a polydopamine (PDA)-polyvinyl alcohol (PVA)-graphene oxide (GO) transition layer was introduced to reinforce and toughen HA coatings on C f /C composites (PDA-PVA-GO/C f /C) via hydrothermal electro-deposition/post-hydrothermal treatment. For comparison, the PDA and PDA/PVA transition layers were also prepared on C f /C, designated as PDA/C f /C and PDA-PVA/C f /C, respectively. The precursor and transformed coatings obtained were monetite and HA. XRD analyses revealed that PDA and PVA infiltrated the monetite lattice without affecting the HA lattice parameters. Remarkably, scratch tests demonstrated that the HA/PVD-PVA-GO coating on C f /C exhibited a dense configuration and compact interfacial structure, achieving a maximum critical load of 51.5 N, surpassing other reported electrochemically prepared HA coatings. Moreover, scratch tests indicated a more homogeneous scratch pattern with no sudden delamination of the coating from the matrix. In vitro assessments revealed that all HA coatings with the transition layer exhibited enhanced bioactivity and cell compatibility compared with HA alone. In particular, PDA/PVA/GO-C f /C exhibited the best superior efficacy in promoting the proliferation of mouse embryonic osteoblast precursor (MC3T3-E1) cells and significantly increased Alkaline phosphatase (ALP) production in rat bone marrow mesenchymal stem cells (BMSCs). These findings underscore the potential of PDA-PVA-GO/C f /C as a promising biomaterial for bone regeneration. Graphical
研究领域:
生物医学工程
·
材料科学
·
表面工程
·
生物材料
·
骨科
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Dongdong Guo,Wenjie Wang,Dongyang Zhao,Tianyu Chen,Xingyu Ma,Yixiao Li,Xiaojun Zhang
Repairing large bone defects effectively requires concurrent osteogenesis and angiogenesis, a significant challenge for conventional biomaterials often limited by suboptimal structural design and an inability to provide spatiotemporally controlled bioactive cues. Here, we report a novel chemophysical dual-responsive system rationally designed to address this osteogenic-angiogenic coupling challenge. This system integrates a structurally engineered bimetallic FeCu-metal-organic framework (FeCu-MOF) within a poly(lactic acid)/hydroxyapatite (PLA/HA) scaffold. The engineered FeCu-MOF architecture enables the programmed and sustained co-release of Fe 3+ and Cu 2+ ions, providing tailored chemical signals. Synergistic pulsed electromagnetic field (PEMF) stimulation was introduced as a physical cue to further enhance the scaffold's bioactivity. The composite scaffolds, featuring interconnected hierarchical porosity and enhanced hydrophilicity due to FeCu-MOF incorporation, demonstrated distinct Fe 3+ /Cu 2+ release profiles. In vitro , these scaffolds exhibited excellent biocompatibility and significantly promoted bone marrow mesenchymal stem cells (BMSCs) proliferation and osteogenic differentiation. Notably, this structure-derived dual-ion release also indicated pro-angiogenic potential. Crucially, daily PEMF treatment synergistically amplified these cellular responses. In vivo evaluation in a rat cranial defect model confirmed the system's efficacy. While FeCu-MOF/PLA/HA scaffolds alone enhanced bone regeneration, their combination with PEMF yielded the most robust outcomes, characterized by markedly superior vascularized bone formation. Comprehensive analysis, including micro-CT, histology, and immunohistochemistry, confirmed these findings by demonstrating improved bone volume, density, and architecture, mature integrated tissue, and enhanced coupled expression of CD31 and osteogenic markers. In summary, the study validates a powerful synergistic strategy for enhanced bone regeneration. This strategy, integrating programmable, structure-derived bimetallic ion release with PEMF stimulation, successfully achieved synergistic angiogenic-osteogenic coupling, offering a promising approach for complex defect scenarios.
研究领域:
生物医学工程
·
组织工程
·
再生医学
·
生物材料
·
骨生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Biomaterials and Tissue Engineering
·
2017
·Vol. 7
·期 4
·283-290
·
IF 1.383
Meng Zengdong,Liu Wei,Zhang Yuqin,Zhang Lei,Tang Xu,Lian XingYe,Xie Hui,Li Lei,Wang Chengjian
Hydroxyapatite bioceramics as a kind of bone defect repair and replacement material has been in clinical application for years. In order to further clarify the role of the addition of Sr on the physicochemical properties of these materials, a series of Sr-substituted hydroxyapatites
(Sr-HA) were synthesized by high temperature solid state methods and characterized extensively. The proliferation and osteogenesis reactivity of these materials in BMSCs was evaluated, and the behavior towards MG-63 osteoblast cells (in terms of cytotoxicity, proliferation and differentiation
assays) was studied. Our results indicated that the addition of Sr does influence the structure of HA, and the crystallinity degree of the materials decreased with Sr addition. The increasing amounts of Sr in the HA composition causes a decrease in the specific surface area and an enrichment
of Sr-apatite phase at the surface of the samples. Bioactivity tests show that the presence of Sr did not produce any cytotoxic effect. Moreover, Sr-HA increased the proliferation of BMSCs and MG-63 osteoblast cells and enhanced BMSCs differentiation to osteoblast cells. Thus the Sr-HA is
an optimal scaffold material for bone tissue engineering, which can be potentially applied in clinical practice for bone defect repair by compounding with osteoblasts.
研究领域:
材料科学
·
生物材料
·
组织工程
·
细胞生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2018
·
IF 7.877
Xiao Zhao,Xinfang Li,Peng Zhang,Jianwei Du,Youxiang Wang
5-Aminolevulinic acid (ALA) based photodynamic therapy (PDT) is a modality for the treatment of cancers. However, due to its hydrophilicity and zwitterionic nature, the transdermal delivery of ALA is limited for the PDT of subcutaneous tumor. To address this problem, tip-loaded fast-dissolving microneedles made of sodium hyaluronate (HA) were fabricated by two casting method. 122 μg of ALA was loaded per microneedle patch and mainly distributed in the tips, which could improve the utilization of drug and avoid the waste of drug residue in the base of microneedle patch after use. The HA microneedles could pierce stratum corneum with insertion depth about 200 μm in isolated skin. After insertion, HA microneedles were rapidly dissolved to release the encapsulated drug to improve patients' convenience and compliance. Importantly, in a subcutaneous mouse tumor model established in BALB/c nude mice, the PDT efficacy of ALA-loaded HA microneedle group was much better than ALA injection group in spite of a relatively lower ALA dose with HA microneedles. The tumor inhibition rate of ALA-loaded HA microneedle group (containing 0.61 mg of ALA) was up to 97%, while the tumor inhibition rate of ALA injection group (containing 1.65 mg of ALA) was just 66%. In addition, microchannels created by microneedle patch were quickly recovered within 3 h after insertion. Overall, the tip-loaded fast-dissolving HA microneedle patch with ALA as drug was promising and might improve topical PDT efficacy of subcutaneous tumor in an efficient and safe manner.
研究领域:
药学
·
肿瘤学
·
生物医学工程
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2022
·
IF 5.763
Wu Hao,Gao Yuan,Ma Jia,Hu Maosong,Xia Jing,Bao Shuting,Liu Yuxi,Feng Kai
Acute myelogenous leukemia (AML) remains a serious fatal disease for the patients and effective treatment strategies are urgently needed. Based on the characteristics of the AML, we developed the CD44 and bone targeting liposomes delivery system decorated with the redox-cleavable polymer. First, ALN-HA was obtained by amination between alendronate (ALN) and hyaluronic acid (HA), and cholesterol (Chol) was coupled by a disulfide linker (-SS-) with biological reducibility to obtain the goal polymer, ALN-HA-SS-Chol, decorated the liposomes loaded with the Cytarabine (AraC). ALN-HA-SS-AraC-Lip exhibited a spherical morphology with the diameter of 117.5 nm and expanded at the environment of 10 mM dithiothreitol. Besides, compared with other groups, ALN-HA-SS-AraC-Lip showed benign hydroxyapatite affinity in vitro and bone targeting in C57/BL6 mice, also, ALN-HA-SS-AraC-Lip exhibited encouraging antitumor which significantly reduced the white blood cell amount in bone marrow and blood smear caused by AML model, besides, the dual targeting liposomes also prolong the survival time of mice. In conclusion, the bone and CD44 dual targeting liposomes with redox sensitivity could target to the leukemia stem cells regions and then uptake by the tumor cells, which would be a valuable target for the treatment of the AML.
研究领域:
药理学
·
肿瘤学
·
纳米技术
·
血液学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）