ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Fa-Ting Xie,Xiao-Lan Zhao,Kuan-Neng Chi,Tong Yang,Rong Hu,Yun-Hui Yang
A ratiometric electrochemical aptasensor is proposed for the detection of thrombin. In the sensor, the iron metal-organic frameworks (Fe MOFs)-labeled aptamer as signal tags was used as signal probe (SP), and the electrolyte solution [Fe(CN) 6 ] 3-/4- was utilized as an inner reference probe (IR). In the presence of thrombin, the signal of Fe-MOFs can be detected. Meanwhile, the signal of [Fe(CN) 6 ] 3-/4 -IR almost remains stable. Accordingly, thrombin concentration can be monitored with the ratio response of I Fe-MOFs-SP /I [Fe(CN)6] 3-/4- -IR . The proposed ratiometric biosensor owns a strong ability to eliminate the disturbance that arises from different DNA loading densities, environmental impact and instrumental efficiency. DNA nanotetrahedron (NTH) with three-dimensional (3D) scaffold can effectively eliminate nonspecific adsorption of DNA and protein. The accessibility of target molecules and loading amounts of signal substances could be increased because of the enhanced mechanical rigidity of well-designed 3D NTH. Thus, detection reproducibility and sensitivity can be further improved. Moreover, the biosensor only requires conjugation with one electroactive substance. The modification procedure can be greatly simplified. The biosensor owns high sensitivity with the detection limit of 59.6 fM. We expect that it will emerge as a generalized ratiometric sensor that may be useful for detecting target analytes .
研究领域:
分析化学
·
生物化学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2025
·Vol. 39
·期 9
·e70363
·
IF 0
Zi-hang Yuan,Si-ya Zheng,Yu-mei Dai,En Tang
The escalating global challenges posed by antibiotic resistance and oxidative stress demand the urgent development of dual-functional materials integrating both antimicrobial and antioxidant capacities to address these intertwined biological threats. This raises a pivotal question: Why not engineer a material capable of simultaneously delivering antioxidant and antibacterial functionalities? To bridge this critical gap, we strategically designed two novel Co and Zn metal–organic frameworks (MOFs) through supramolecular interactions to achieve synergistic antimicrobial–antioxidant performance, rigorously validated via multimodal characterization. Different from traditional antibiotics, these MOFs exert antibacterial effects by controlling the release of metal ions and other mechanisms. Co and Zn-MOFs demonstrated robust antimicrobial efficacy against both Gram-negative and Gram-positive bacteria, coupled with potent antioxidant properties. Zn-MOFs exhibited enhanced antibacterial activity by intensifying membrane disruption via strengthened hydrophobic interactions with bacterial surfaces, whereas Co-MOFs showcased superior antioxidant capacity derived from their redox-active nature. This study unravels the critical mechanistic interplay between metal-bacteria interfacial dynamics and the preservation of cell wall structural integrity. These MOFs redefine multifunctional material paradigms for combating drug-resistant pathogens and oxidative damage, offering transformative potential for biomedical innovations and beyond.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
药物化学
·
微生物学
·
生物化学
✓ 已验证
产品关联
DOI
Chemical Engineering and Processing-Process Intensification
·
2018
·
IF 2.826
Ding Chen,Peng-fei Feng,Fu-hua Wei
Fe-based metal-organic frameworks(Fe(III)-MOFs)were synthesized by Fe 2 (SO 4 ) 3 and trimesic acid using microwave-assisted ball milling method. The structure of the Fe(III)-MOFs was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR). The thermostability of the MOFs was analyzed by thermogravimetric analysis (TGA). Fe(III)-MOFs were added in aqueous solutions to remove organic dyes. The removal efficiencies of Orange II, CR and MB reached 95.9%, 98.7%, 95.7% respectively at 10℃ and reached 97.7%, 99.7%, 97.5% respectively at 35℃ in 300 min.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jinshan Xie,Xiaoxiang He,Kexin Liu,Wulong Li,Zhanxiong Li
In this paper, carboxylated cotton fabric (CF-Ph-COOH) were obtained as active substrate by diazonium radical polymerization modification of cotton fibers. Then the MOF fabric composites were prepared by in situ growth of metal zirconium ions (Zr) and organic ligands on the surface of carboxylated cotton fabrics under carboxylic acid modifier. MOF fabric composites with controllable morphologies structures were achieved by regulating organic ligands, reaction time the type and dosage of regulator (formic acid and acetic acid). The prepared acetic acid regulated MOF fabric composites were designated as CF-HAc1-UiO-66, CF-HAc2-UiO-66, CF-HAc1-UiO-66-NH 2 , and CF-HAc2-UiO-66-NH 2 , respectively, and the formic acid regulated as CF-FA-UiO-66 and CF-FA-UiO-66-NH 2 . The fabricated carboxylic acid modulated MOF fabric composites were well characterized using SEM, TGA, XRD, FTIR, and XPS spectra. The adsorption experiment results show that carboxylic acid modulated Zr based MOF fabric composites can serve as adsorbent for effective removal of Cr(VI) from water, in which the CF-FA-UiO-66-NH 2 was prepared under the ratio of ZrCl 4 and BDC-NH 2 is 1.006 and with 5.47 M formic acid regulator exhibits that the optimal adsorption efficiency and the removal efficiency is 79.5 %. In addition, the adsorption of Cr(VI) in water by CFA-UiO-66-NH 2 showed a quasi-secondary kinetic model following the Langmuir adsorption model, showing a a typical of chemisorption. What’s more, the Cr(VI) removal efficiency and saturated adsorption capacity of CF-FA-UiO-66-NH 2 was up to 80 % and 318.85 mg/g, respectively. The prepared CF-FA-UiO-66-NH 2 MOF fabric composite was recyclable for removal of Cr(VI), and could be used as the potential adsorbent membrane for waste water treatment.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Junying Wu,Ruijie Guo,Houting Kang,Yanming Wang,Jingyuan Tian,Jierong Wang,Hong Yan
Metal–organic frameworks (MOFs) have great potential in improving the fire safety of polymer materials. To improve the fire resistance and smoke suppression of polypropylene (PP), a flame-retardant system ZIF-67@γ-CD-MOFs@APP incorporating multiple flame-retardant elements was designed and applied to PP. The coated PP passed UL-94 V-0 level with the LOI up to 36.2% and char residue of 12.47%. The PHRR, PSPR, COP, and CO 2 P of coated PP were reduced by 52.65%, 24.72%, 36.49%, and 52.29%, respectively, compared to neat PP. In addition, the tPHRR, tPSPR, tCOP, and tCO 2 P were prolonged by 405.3%, 345.4%, 427.8%, and 405.3% compared to pure PP, allowing more escape time when facing a real fire. Integrating the hierarchical porous structure provided by ZIF-67 and γ-CD-MOFs, catalytic carbonization of transition metal Co and the nitrogen-containing ligand, ZIF-67@γ-CD-MOFs@APP played a flame-retardant role both in the condensed and gas phase, endowing PP with enhanced flame retardancy and smoke suppression. The “all-in-one” strategy provides helpful insights for constructing fire retardant system with multi-level nanostructure.
研究领域:
材料科学
·
高分子科学
·
消防安全工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Fuhua Wei,Jie Gong,Qinhui Ren,Xiang Yu,Yan Wang,Hongliang Chen,Zhao Liang
The Zn/Zr-MOFs were synthesized via microwave-assisted ball milling and subsequently characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The thermal stability of the Zn/Zr-MOFs was evaluated through thermogravimetry (TGA). The results demonstrated the exceptional adsorption properties of the Zn/Zr-MOFs towards Lomefloxacin hydrochloride and Levofloxacin hydrochloride. At a concentration of 30 ppm for Lomefloxacin hydrochloride, the addition of 30 mg of Zn/Zr-MOFs material resulted in an adsorption capacity of 179.2 mg•g−1. Similarly, at a concentration of 40 ppm for Levofloxacin hydrochloride, the addition of 30 mg Zn/Zr-MOFs material led to an adsorption capacity of 187.1 mg•g−1. Kinetic analysis revealed that the experimental data aligned well with a pseudo-second order kinetic model. Overall, these findings highlight the significant potential application of Zn/Zr-MOF materials in wastewater treatment.
研究领域:
材料科学
·
环境工程
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2016
·
IF 4.035
Meng Chen,Ning Gan,You Zhou,Tianhua Li,Qing Xu,Yuting Cao,Yinji Chen
An ultrasensitive electrochemical aptasensor for simultaneous detection of oxytetracycline (OTC) and kanamycin (KAN) has been developed based on metal ions doped metal organic frame materials (MOFs) as signal tracers and RecJ f exonuclease-catalyzed targets recycling amplification. The aptasensor consists of capture beads (the anti-single-stranded DNA Antibody, as anti-ssDNA Ab, labeled on Dynabeads) and nanoscale MOF (NMOF) based signal tracers (simplified as Apts-MNM, the NMOF labeled with metal ions and the aptamers). Particularly, the MOF (UiO-66-NH 2 ), with large internal surface areas, ultrahigh porosity and abundant amine groups in the pores, was employed as substrates to carry plenty of metal ions (Pb 2+ or Cd 2+ ) and label aptamers of OTC or KAN. Thus, the aptasensor is formed by the specific recognition between anti-ssDNA Ab and aptamers. In the presence of targets (OTC and KAN), aptamers prefer to form targets-Apts-MNM complexes in lieu of anti-ssDNA Ab-aptamer complexes, which results in the dissociation of Apts-MNM from capture beads. With the employment of RecJ f exonuclease, targets-Apts-MNM in supernatant was digested into mononucleotides and liberated the target, which can further participate in the next reaction cycling to produce more signal tracers. After magnetic separation, the enhanced square wave voltammetry (SWV) signals were produced from signal tracers. The aptasensor exhibited a linear correlation in the range from 0.5 pM to 50 nM, with detection limits of 0.18 pM and 0.15 pM (S/N=3) toward OTC and KAN respectively. This strategy provides specificity and sensitive approach for multiplex antibiotics detection and has promising applications in food analysis.
研究领域:
分析化学
·
环境科学
·
食品安全
·
生物传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yi Shao,Hao Suo,Shuting Wang,Yaou Peng,Xiaoying Chu,Ziyue Long,Kanghui Du,Lili Su,Xinyue Sun,Xinyi Wang,Qingying Wang,Renlong Li,Bailiang Wang
Eye trauma, ophthalmic surgery and contact lens (CL) wearing cause corneal infection and bacterial biofilms formation, which further lead to corneal ulcer and perforation. In view of the low bioavailability of antibiotic eye drops and the clinical problems that cause bacterial resistance, we used pH sensitive zeolitic imidazolate framework-8 metal–organic frameworks (ZIF-8 MOFs) to load broad-spectrum antibacterial drugs levofloxacin (LEVO). After the surface modification by hyaluronic acid (HA), the nanomaterial surface was negatively charged. A simple amination treatment was used to endow CL surface with amino groups to combine the negatively charged nano drug loading system through electrostatic forces. The bacteriostatic ring of ZIF-8@LEVO@HA-PEI modified CL (ZLHP-CL) was 34 mm, which could be owing to the high drug loading capacity of ZIF-8 (0.65 mg/cm 2 ). The bactericidal function was further confirmed by shake flask method and live/dead bacterial staining assay against S. aureus , S. epidermidis and E. coli . It is worth mentioning that ZLHP-CL showed significant pH sensitivity to the bacterial infection, which released drug rapidly at pH 5.5 and hardly released drug at pH 7.4. In the bacterial biofilm’s formation experiment, it was found that ZLHP-CL obviously inhibited bacterial adhesion and biofilms formation. Furthermore, it was proved in infectious keratitis animal that ZLHP-CL could kill the bacteria and reduce the inflammation reaction, which showed advantages in corneal tissue repair and light transmittance maintenance. In this work, based on nanotechnology, a facile CL drug loading technology is developed, which can be used to sustained release of various drugs for ophthalmic diseases treatment.
研究领域:
纳米技术
·
药学
·
眼科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of the American Chemical Society
·
2016
·
IF 13.038
Hai-Qun Xu,Kecheng Wang,Meili Ding,Dawei Feng,Hai-Long Jiang,Hong-Cai Zhou
The synthesis of phase-pure metal–organic frameworks (MOFs) is of prime importance but remains a significant challenge because of the flexible and diversified coordination modes between metal ions and organic linkers. In this work, we report the synthesis of phase-pure MOFs via a facile seed-mediated approach. For several “accompanying” pairs of Zr–porphyrinic MOFs that are prone to yield mixtures, by fixing all reaction parameters except introducing seed crystals, MOFs in phase-pure forms have been obtained because the stage of MOF nucleation, which generates mixed nuclei, is bypassed. In addition, phase-pure MOF isomers with distinct pore structures have also been prepared through such an approach, revealing its versatility. To the best of our knowledge, this is an initial report on seed-assisted synthesis of phase-pure MOFs.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2025
·
IF 10.5
Tayyaba Iftikhar,Tahir Imran,Jinhua He,Chuangjie Zhang,Yuanting Xie,Haitao Ye,Lei Su
Conventional UA detection relies on invasive blood or urine tests, limiting convenience and real-time monitoring. In this study, we have designed a novel microneedle array-based wearable electrochemical sensor to detect UA in skin interstitial fluid (ISF), which consists of a bi-metal-organic framework (bi-MOF) modified screen-printed electrode (SPE) and 3D-printed hollow microneedle array patch (HMNsAP). To this end, a “MOFs on MOFs” strategy was applied by combining HKUST-1 and Eu-MOF nanocomposites on an SPE, enhancing electrode surface area, electrode material porosity, and electron transfer efficiency. The HMNsAP was equipped with a microvalve and connected to a vacuum tube to facilitate efficient ISF extraction while preventing backflow to mitigate biosafety risk. The sensor showed outstanding analytical performance, with a low limit of detection of 20 nM and high recovery rates ranging from 98.6% to 100.4% across various UA concentrations in ex-vivo rat skin tests, along with strong selectivity and reproducibility, indicated by a relative standard deviation (RSD = 1.68%). These findings underscore the synergistic advantages of combining advanced MOF materials with an innovative microneedle system for precise UA monitoring in ISF, enhancing its role in personalized diagnostics and beyond.
研究领域:
生物传感器
·
可穿戴电子设备
·
电化学
·
即时检测
·
纳米材料
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2024
·
IF 4.3
Mohan Huang,Kun Zhao,Shuangyan Liu,Ang Bian,Lu Jiang,Dawei He,Jiaqi He,Yongsheng Wang
The design and development of microwave-absorbing materials with excellent performance hold significant importance in both civil and military fields. The combination of magnetic loss materials and dielectric loss materials can achieve complementary performance effects and regulate impedance matching. In this paper, spindle-like α-Fe 2 O 3 was synthesized using MIL-88A as a template, which was then composited with Ti 3 C 2 T x phase possessing excellent electrical conductivity to obtain Fe 2 O 3 /Ti 3 C 2 T x composites. Ti 3 C 2 T x can provide good conductance loss and dipole polarization relaxation, while the incorporation of Fe 2 O 3 between the layers of Ti 3 C 2 T x not only triggers the interfacial polarization effect but also increases layer spacing, thereby enhancing multiple reflection effects. Furthermore, the magnetic-dielectric synergies further optimize the impedance matching. Through the combined action of multiple mechanisms, the Fe 2 O 3 /Ti 3 C 2 T x composites (with a mass ratio of 1:3 for Fe 2 O 3 and Ti 3 C 2 T x ) exhibit a minimum reflection loss of −34 dB and an effective absorption bandwidth of 1.53 GHz at a thickness of 3 mm, as well as an effective absorption bandwidth of 2.805 GHz at a thickness of 1.5 mm. This paper presents a reference strategy for constructing highly efficient microwave absorbers derived from Metal-organic frameworks (MOFs) and MXene based on their outstanding properties.
研究领域:
材料科学
·
电磁学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Crystals
·
2018
·Vol. 8
·期 6
·250
·
IF 2.144
Xue-Qing Zhan,Xiao-Yan Yu,Fang-Chang Tsai,Ning Ma,Huan-Li Liu,Yu Han,Lei Xie,Tao Jiang,Dean Shi,Yan Xiong
Owing to their high surface area and porosity, metal-organic frameworks (MOFs) have been gradually employed for a myriad of applications ranging from sensing, pollutant adsorption, and drug delivery to environmental remediation and catalysis. Magnetic nanoparticles-metal-organic frameworks (MMOFs) hybrid materials can facilitate facile removal of MOFs from solutions. In this report, we report the synthesis of Fe3O4@UiO-66 by encapsulation and simulated the drug loading and release by studying the adsorption and release of AO7. Thus, we loaded these MMOFs with AO7 and found that they were able to trigger and control its release by simply applying an external magnetic field. The magnetic field heats the magnets in the MOF, which causes the load to burst from the framework.Keywords:magnetic MOFs;triggered release;targeted delivery;AO7
研究领域:
环境科学
·
材料科学
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）