POLYMERS FOR ADVANCED TECHNOLOGIES
·
2018
·Vol. 29
·期 11
·2724-2734
·
IF 2.137
Wei Liu,Xiaolian Zhu,Xinlin Yang,Ke Li,Zupeng Yang
An effective polymerization system was developed for the synthesis of highly cross-linked hydrophilic monodispersed microspheres with both the micropores and mesopores inside. A series of poly( N , N ′-methylenebisacrylamide) (PMBA) microspheres with the diameters ranging from 100 to 300 nm were synthesized by distillation precipitation polymerization with N , N -dimethylacetamide (DMAC) as the porogen, acetonitrile as the solvent, and MBA as the cross-linker and monomer. The particle size, morphology, and porosity varied according to the variation of the DMAC content. The porosity was determined by physical adsorption of nitrogen, and reached the maximum at 7.5 vol% of DMAC with the specific surface area at 135.8 m 2 g −1 and the total pore volume at 0.43 cm 3 g −1 . The porous and hydrophilic microspheres showed excellent swelling property in water and adsorption property for the Cd(II) in aqueous solution. Meanwhile, carboxylic groups were incorporated into the porous microspheres to achieve porous poly( N , N ′-methylenebisacrylamide- co -acrylic acid) (P (MBA- co -AA)-P), which exhibited obvious synergies of the pores and functional groups on the adsorption and provided a perspective application of the Cd(II) removal.
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BIORESOURCE TECHNOLOGY
·
2023
·
IF 11.4
Zhaoyun Wang,Liyong Hu,Jiamei He,Gang Zhou,Zhenghui Chen,Zeyu Wang,Jun Chen,Kashif Hayat,Dzmitry Hrynsphan,Savitskaya Tatsiana
n -Hexane and N, N-dimethylacetamide (DMAC) are two major volatile organic compounds (VOCs) discharged from the pharmaceutical industry. To enhance DMAC-facilitated n -hexane removal, we investigated the simultaneous removal of multiple pollutants in a rotating drum biofilter packed with bamboo charcoal-polyurethane composite. After adding 800 mg·L −1 DMAC, the n -hexane removal efficiency increased from 59.4 % to 83.1 % under the optimized conditions. The maximum elimination capacity of 10.0 g·m −3 ·h −1 n -hexane and 157 g·m −3 ·h −1 DMAC were obtained. The biomass of bamboo charcoal-polyurethane and the ratio of protein-to-polysaccharide in extracellular polymeric substances were significantly increased compared with the non-DMAC stage, which is attributed to increased carbon utilization. In addition, Na + K + -ATPase was positively correlated with increasing electron transport system activity, which was 1.98 and 1.36 times greater. Hydrophilic DMAC improved the bioavailability of hydrophobic n -hexane and benefited bacterial metabolism. Co-degradation of n -hexane and DMAC system can be used for other volatile organic pollutants.
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JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Yuqian Sui,Huayuan Hu,Mitsuru Ueda,Lianjun Wang,Xuan Zhang
In this study, a novel poly[vinyl-(4-benzyl- N , N , N -trimethylammonium bromide) ketone] (QA-PVBK) homopolymer was synthesized by conventional free-radical polymerization, followed by benzyl bromination, and in-situ quaternization reaction, successively. Blend membranes were further constructed between QA-PVBK and commercially available polybenzimidazole (PBI), as novel anion exchange membrane materials. Owing to the short repeating unit of QA-PVBK, the ion-clusters for the ion transport were highly aggregated on the microscale, which significantly contributed to the excellent hydroxide conductivity of the blend membranes. The PBI was introduced as a physical reinforcement, strengthening the membranes’ robustness and suppressing excessive swelling. Membrane PBI/QA-PVBK-OH(70%), with the QA-PVBK-OH (hydroxide form) content of 70% over the entire membrane matrix, exhibited a high hydroxide conductivity of 50.8 mS cm −1 at 60 °C, and, consequently, a good peak power density of 170.6 mW cm −2 at 60 °C/100% relative humidity condition in a H 2 /O 2 single cell test. The blend membranes also demonstrated acceptable chemical stability towards the alkaline condition (1 M NaOH at 60 °C) with the residual conductivity over 59.4% after 168 h. In light of these promising results, the present study demonstrates a facile blending process for simultaneously addressing the ion conductivity and mechanical properties of anion exchange membranes.
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JOURNAL OF MOLECULAR LIQUIDS
·
2016
·
IF 2.74
Junzhi Li,Junqiang Wang,Wei Zhao,Xiaoliang Li
Isobaric vapor-liquid equilibrium (VLE) data for the four systems n -heptane + 2-methylthiophene, 2,2,4-trimethylpentane + 2-methylthiophene, n -nonane + 2-methylthiophene, n -decane + 2-methylthiophene were measured at 90.00 kPa with a modified Rose-Williams still. Gas chromatography equipped with a flame ionization detector was used to analyze composition of the samples from the vapor-liquid equilibrium systems. All the VLE measurements passed the thermodynamic consistent test using the Herington method and the Van Ness test. The azeotropic behavior was found in the 2,2,4-trimethylpentane + 2-methylthiophene system. The experimental data were correlated by the Wilson and NRTL activity coefficient models and also compared with the original UNIFAC predictive model. The corresponding parameters for the three models were obtained. The results exhibited that the measured data got agree well with the calculated values using the Wilson, NRTL and original UNIFAC models.
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INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Qi Zhang,Minghui Li,Zhuofan Zuo,Tianhang Zhan,Xiaoyan Li,Wei Zhang
Cotton, as one of the world’s most crucial economic crops, suffers from a markedly shortened service life of its fabrics due to microbial degradation. In this study, N-isopropylacrylamide (NIPAM) containing amide bonds was grafted onto cotton fibers via atom transfer radical polymerization (ATRP) to develop a heat-resistant and wash-durable N-halamine functionalized cotton fabric (PN@CF-Cl). The resulting material exhibited rapid and potent antibacterial activity, killing over 85 % of bacteria within 1 min of contact and achieving > 99.9 % inactivation of Staphylococcus aureus and Escherichia coli within 10 min. After 50 washing cycles at 75 °C, the antibacterial activity retention remained above 97 %. Following storage for 30 days, rechlorination restored the active chlorine content to its initial level. Even after 10 consecutive chlorination–reduction cycles, the active chlorine recovery reached 98.9 %. In addition, the fabric demonstrated high hydrophobicity, air permeability, and moisture vapor transmission. Molecular dynamics (MD) simulations further validated the dynamic interconversion between N–Cl and N–H in the material, elucidating the underlying mechanism for its regenerative performance. Functionalized cotton fabrics based on the N–Cl/N–H dynamic cycling mechanism can extend product lifespan and hold significant promise for applications in medical protective equipment and smart home textiles.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2018
·Vol. 29
·期 8
·1-14
·
IF 2.448
Liu Chundong,Wang Jianhua,Huang Sheng,Yu Lin,Wang Yan,Chen Hang,Wang Dong
Peptide nucleic acid (PNA) holds enormous potentials as antisense/antigenic drug due to its specific binding ability and biostability with DNA or RNA. However, the poor cellular delivery is the key obstacle in development of PNA therapy. To overcome this difficulty, we developed self-assembled nanoparticles (NPs) for delivery of PNA to living cells using amphiphilic CS derivatives. A series of N,N,N-trimethyl-O-alkyl chitosans (TMACs) with different lengths of alkyl chains were synthesized. The structures of these synthesized chemicals were characterized with FT-IR and 1 H NMR. We found that the TMACs were all able to self-assemble in aqueous condition to form nano-size NPs. These nano-size NPs are spherical shape with a size range of around 100 nm and a zeta potential above +30 mV. PNA was easily encapsulated into chitosan derivative NPs by an ultrasonic method with entrapment efficiency up to 75%. The PNA-loaded TMAC NPs released the drug in a sustained manner in PBS (pH 7.4) at 37 °C. N,N,N-trimethyl-O-cetyl chitosan (TMCC) showed the best in vitro hemocompatibility and cell viability. These TMCC based NPs were able to dramatically increase the cellular uptake of PNA, specifically, 66-fold higher compared to without using these nanoparticles. The results suggest that the designed TMCC NPs might be a promising solution for improving cellular delivery of PNA.
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Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 15
·3845-3853
·
IF 7.779
Yongqiang Li,Quan Wang,Yuhua Ju,Yarong Li,Yanbo Zhang,Ronggui Hu
The development of novel materials with dual functions of simultaneous detection and removal of heavy metal ions has been an important pursuit of environmental remediation. Herein, we demonstrate that two-dimensional covalent organic frameworks (COFs) with well-defined functional chelating sites can combine the inherent advantages of COF materials to prepare novel materials with the dual functions of selective detection and effective removal of Ni2+ from aqueous solutions. A new pyridine-based COF material (TAPA–PCBA) containing functional N,N,N-chelating sites has been designed and synthesized by the imine condensation reactions between tris(4-aminophenyl)amine and 2,6-pyridinedicarboxaldehyde under solvothermal conditions. The newly designed TAPA–PCBA possesses high crystallinity, moderate specific surface area and robust chemical and thermal stability. These excellent properties of TAPA–PCBA, together with its extended π-conjugated framework structure and the dense distribution of functional N,N,N chelating sites, enable TAPA–PCBA to selectively detect and effectively remove Ni2+ from aqueous solutions. This dual function can be attributed to the coordination interactions between Ni2+ and N,N,N-chelating sites embedded in the skeleton structure of TAPA–PCBA. These results reveal that COFs with reasonable design have great development prospects in heavy metal ion related environmental remediation.
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TOXICOLOGY LETTERS
·
2026
·
IF 2.9
Liya Fang,Chanlin Fang,Shanshan Di,Xinquan Wang,Yuanxiang Jin
This study examined the hepatic effects of parous exposure to the rubber-derived contaminant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), in C57BL/6 mice during gestation and lactation. Both compounds exhibited dose-dependent bioaccumulation in the liver of the F0 generation and lactated F1 offspring, with 6PPDQ accumulating more due to its greater stability. Lactational transmission of both compounds was observed, and the accumulation declined with age, disappearing by 8 weeks. Notably, 6PPDQ exposure resulted in reduced body weight in mature F1 female mice, which was associated with altered cholesterol metabolism and disrupted expression of the estrogen receptor gene. In these mice, molecular analysis revealed dysregulation of key cholesterol-related genes, such as HMGCR and PCSK9. In contrast, male offspring showed less pronounced effects. These results indicate that the toxicity of 6PPD and 6PPDQ can be transmitted through placental and lactational pathways, with 6PPDQ presenting a greater risk, particularly to female mice, through its impact on cholesterol metabolism and endocrine signalling. These findings offer valuable insights for assessing the environmental and health risks associated with these compounds.
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ACS Omega
·
2019
·
IF 2.584
Sherif M. Ibrahim,Yan Zhang,Yun Xue,Suliang Yang,Fuqiu Ma,Yang Gao,Yu Zhou,Guoxin Tian
The complexation and selectivity of N,N-di(2-ethylhexyl)-diglycolamic acid (HDEHDGA/kerosene, HA) toward the light lanthanides, La(III), Ce(III), Pr(III), and Nd(III), are presented for the extraction from chloride media. In the low pH region (pH 1.8–2.8), the obtained data reveal that the extraction of Ln(III) is governed by cation-exchange mechanism and is driven by the negative change in enthalpy. The results from the slope analysis method suggest the formation of LnA3·(HA)1or2 in the extraction process. As major extracted species with a core of LnA3 in the first coordination sphere, LnA3 might connect with one or two additional HA molecules in the second coordination sphere by hydrogen bonding. The LnA3 core might share similar coordination geometry to those of 1:3 Ln(III) complexes (LnA′3) with water-soluble N,N-dimethyl-diglycolamic acid (HDMDGA, HA′) formed in aqueous solutions or in solid-state compounds. The correlation between the extraction with HDEHDGA (HA) as an extractant and the complexation with HDMDGA (HA′) as a chelator has been explored by interpreting the separation factors for HA with the difference in the stability constants for HA′. Consequently, the ratios of the stability constants of the corresponding 1:3 complexes (LnA′3) with HDMDGA could be reasonably translated to the separation factors (SFs) with HDEHDGA, providing a valuable approach for understanding the origin of the extraction/separation mechanism. By comparing the extraction selectivity of HDEHDGA with that of the currently deployed extractants in the industry such as P204, P507, and Cyanex 272, HDEHDGA offers outstanding selectivity with considerable SFs (SFCe/La = 6.68, SFPr/Ce = 2.79, and SFNd/Pr = 2.65) for light Ln(III) pairs under conditions of low acid concentrations.
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COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
·
2025
·
IF 4.3
Hua Zhang,Chenglong Liu,Yulu sun,Shuqiong Tang,Yan Lei,Weixin Zhang,Bo Cheng,Yan Zhao,Qiang Luo
N, N-Diethyl-meta-toluamide (DEET) is a widely used insect repellent that can be detected in water and soil worldwide. Although adverse reactions have been reported following the use of DEET - containing products, there are few toxicity studies. In this study, zebrafish were exposed to 0, 0.2 mg/mL, 0.25 mg/mL, and 0.3 mg/mL of DEET. With increasing exposure concentrations, zebrafish mortality increased and body length development was reduced. At 72 hours post fertilization (hpf), zebrafish exhibited pericardial edema, decreased heart rate, and yolk sac edema. Significant abnormalities in the looping morphology of the heart were observed, with the atrium and ventricle positioned along the midline, resulting in cardiac linearization. The expression levels of genes related to cardiac development ( myh6 , nppa , nkx2.5 , gata4 , tbx5a , vmhc ) increased. On the other hand, the quantity of neutrophils and macrophages exhibited a decrease, and the expression level of genes related to mediating inflammatory response ( myd88 , ifn-γ , tlr4 ) and inflammatory factor genes ( il-6 , il-8 , il-10 ) increased. In addition, DEET exposure caused a reduction in newly generated neurons at 24 hpf. At 72 hpf, the activity of acetylcholinesterase (AChE) was inhibited, and motor behavior show that the total distance and average speed were significantly reduced. Further research found that oxidative stress was activated, and reactive oxygen species (ROS) content increased significantly. In summary, DEET cause multiple toxicities to the heart, immune system, and nervous system during early developmental stages of zebrafish embryos, and these toxicities may be induced by oxidative stress.
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International Journal of Ophthalmology
·
2026
·Vol. 19
·期 4
·655
·
IF 2
Xiao-Qing Cai,Ping Zhang,Zhou-Fan Zhang,Jing Gu,Ting-Ting Chen,Ai-Na Chen
AIM To investigate the therapeutic efficacy and underlying mechanisms of epigallocatechin gallate (EGCG), a major green tea catechin with potent antioxidant properties, in an N-methyl-N-nitrosourea (MNU)-induced mouse model of retinitis pigmentosa (RP). METHODS C57BL/6 mice were randomly divided into control (PBS), MNU-induced RP, and MNU+EGCG pretreatment groups. EGCG (50 mg/kg, intraperitoneal) was administered daily for 3 consecutive days prior to a single MNU injection (50 mg/kg). Retinal function was evaluated by scotopic electroretinography (ERG). Retinal structure was assessed using optical coherence tomography (OCT) and hematoxylin-eosin staining, with outer nuclear layer (ONL) thickness measurement. Mechanisms were explored via RNA sequencing, reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) validation of oxidative stress- and inflammation-related genes, and immunohistochemistry for microglial activation, astrocytic gliosis, and apoptosis markers. RESULTS Compared with the MNU group, EGCG pretreatment significantly preserved scotopic ERG a-wave and b-wave amplitudes ( P <0.001). OCT and histological analysis showed that EGCG markedly attenuated MNU-induced thinning of total retina and ONL ( P <0.005, P <0.001, respectively). RNA sequencing identified 1147 differentially expressed genes modulated by EGCG, with significant upregulation of antioxidant genes ( Nrf2 , Sod1 , Gpx4 , Cat1 , Ho-1 ) and downregulation of pro-inflammatory genes. Immunohistochemistry confirmed that EGCG significantly reduced microglial activation, glial fibrillary acidic protein (GFAP) expression, and cleaved caspase-3-positive cells ( P <0.01 to P <0.001). CONCLUSION EGCG exerts robust neuroprotective effects in MNU-induced RP through enhancement of antioxidant defenses, suppression of neuroinflammation, and preservation of retinal structure and function. These findings suggest EGCG as a promising candidate for adjuvant antioxidant therapy in RP.
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Materials
·
2023
·Vol. 16
·期 3
·1053
·
IF 3.4
Yanpei Dang,Tianhao Li,Yangzhong Zhao,Liantai Duan,Jianning Zhang,Ke Chen,Liu He,Qing Huang,Chuanzhuang Zhao,Yujie Song
Polyborosilazanes with controllable B/N ratio were synthesized using high-boron-contentm-carborane, dichloromethylsilane, and hexamethydisilazane. After high-temperature pyrolysis, Si–B–C–N quaternary ceramics with SiC and B4C as the main phases were obtained. The B/N ratio in the precursors corresponded to the change in the feeding ratio of carborane and dichloromethylsilane. The effects of boron content and B/N ratio on the ceramic precursors and microphase structure in Si–B–C–N quaternary ceramics were explored in detail through a series of analytical characterization methods. A high boron content results in a significant increase in the ceramic yield (up to 71 wt%) of polyborosilazanes, and at the same time, the B/N molar ratio was regulated from 28.4:1 to 1.62:1. The appearance of the B4C structure in the Si–B–C–N quaternary ceramics through the regulation of the B/N ratio, has rarely been reported.Keywords:polyborosilazane;SiBCN;carborane;polymer derived ceramics;B/N ratio;microphase evolution
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