International Journal of Nanomedicine
·
2025
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IF 6.5
Shiyan Lv,Yuechi Zhang,Xiongjie Liang,Wenbo Xu,Zhibin Geng,Weifeng Hu,Xiaoyan Wang,Helin Li,Wenhui Guo,Yongbin Jing,Xiaoqi Liu,Huichao Fu,Gongping Xu,Chunyang Xi,Jinglong Yan,Hui Chi
Background Bone, a natural piezoelectric material, converts mechanical stress to electrical signals; local bioelectric changes in defects affect repair. Current biomimetic bone materials focus on composition, bioactivity and structure, neglecting bioelectric effects. Piezoelectric materials reconstruct electrical microenvironments, simulating natural regulation and addressing traditional materials’ structural reliance, offering effective repair strategies.Methods In this study, barium titanate piezoelectric nanoceramic particles were embedded into thermoresponsive shape-memory polylactic acid via 4D printing to fabricate BT/PLA composite scaffolds. The scaffolds were characterized using scanning electron microscopy, X-ray diffraction, surface roughness analysis, water contact angle measurement, as well as mechanical and piezoelectric property tests. Cellular experiments were performed to verify the effects of these scaffolds on the proliferation, adhesion, and osteogenic capacity of bone marrow mesenchymal stem cells under low-intensity pulsed ultrasound stimulation. Additionally, a rat calvarial defect model was established to evaluate the in vivo bone repair efficacy of the scaffolds.Results A shape-memory piezoelectric BT/PLA scaffold was 4D-printed. The 20 wt% BT scaffold showed excellent mechanics (~25 MPa compressive strength) and shape memory (full recovery in 5s), meeting clinical needs. All scaffolds were non-cytotoxic; BT/PLA with LIPUS generated ~1 μA current, promoting BMSC proliferation and osteogenesis. BT/PLA + LIPUS showed superior in vivo bone formation in rats, validating clinical potential for critical defects.Conclusion The BT/PLA scaffold, combining shape-memory and piezoelectric effects, shows significant bone regeneration potential. Its degradability with 4D printing may facilitate translation of personalized bone repair implants from bench to bedside. Transcriptome sequencing suggests its osteogenic effect may involve the PI3K-Akt pathway, providing a basis for optimizing molecular targets in future bone regenerative materials and reinforcing the study’s scientific value in material design and mechanistic exploration.
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DOI
PubMed
高影响因子
Journal of Materials Research and Technology-JMR&T
·
2022
·
IF 6.267
Jiyuan Zhou,Baiwang Wang,Chang Xu,YiZhuo Xu,Haiyan Tan,Xianquan Zhang,Yanhua Zhang
Inspired by marine mussels, dopamine with a catechol structure was self-polymerized in a weak alkaline environment and deposited on the surface of wood fiber (WF) to enhance the interface between WF and polylactic acid (PLA). At the same time, silver nanoparticles (Ag NPs) were attached to the surface of WF under the reducibility of polydopamine (PDA), giving the composite antibacterial activity against Aspergillus niger . The results showed that PDA and Ag NPs were successfully generated and attached to the WF surface. The thermal stability of WF was improved after the modification, which the maximum decomposition rate temperature of WF/PDA/Ag was increased by 29.2 °C compared with WF. According to relevant analysis, the tensile properties of WF/PDA-PLA were significantly improved. Compared with PLA, the tensile strength and Young's modulus of WF/PDA-PLA were increased by 8.13% and 52.89%. The bacteriostatic circle method measurement showed WF/PDA/Ag-PLA had a particular antibacterial ability for Aspergillus niger .
研究领域:
材料科学
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纳米技术
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生物医学工程
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DOI
高影响因子
Gels
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2022
·Vol. 8
·期 9
·570
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IF 4.432
Qingrong Wu,Yu Fu,Wanying Yang,Shouxin Liu
Hydrogel is a good drug carrier, widely used in the sustained-release aspect of tumor drugs, which can achieve the continuous release of drugs to the tumor sites. In this study, diethylene glycol monomethyl ether methacrylate (MEO2MA) and poly (ethylene glycol) methyl ether methacrylate (OEGMA) are temperature-sensitive monomers. N-Methacryloyl-L-Histidine (Mist) is pH sensitive monomer and ligand for metal coordination bond. The temperature-sensitive monomers and pH sensitive monomer with stereocomplex of modified polylactic acid (HEMA-PLLA30/PDLA30) were mixed, under 2,2’-azobis (2-methylpropionitrile) (AIBN) as radical initiator, polymer was formed by free-radical polymerization. The polymer was then immersed in ZnSO4solution, the imidazole group of Mist monomer forms a tridentate metal coordination bond with Zn2+, temperature/pH double-responsive and physical double-crosslinked hydrogel was finally obtained. Comparing the hydrogen bond hydrogel, hydrogen bond and metal coordination bond double crosslinking hydrogel, metal coordination bond hydrogel, testing thermal stability, viscoelasticity, swelling, and morphology of three hydrogels. In addition, using UV-Visible spectroscopy (UV-Vis) to test the sustained release of the hydrophobic drug doxorubicin hydrochloride (DOX-HCl) in the human tumor environment (37 °C, pH = 5). We found that the temperature/pH double-responsive and physical double-crosslinked hydrogel had the most potential for the sustained drug release.
研究领域:
材料科学
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药学
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生物医学工程
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DOI
高影响因子
POLYMER COMPOSITES
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2024
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IF 4.8
Xiaolin Zhang,Xing Chang,Long Xu,Maocai Huang,Liyuan Zuo,Jing Cao,Yali Wu,Xin Li,Menghao Yang,Limin Gao,Xiangfeng Bo
As is well known, Laser print paper is usually produced with high-quality chemical wood pulp. The laser print waste paper fiber (LPWF) is a high-quality secondary fiber, and the research and development of high-value utilization technology for laser print waste paper has attracted much attention in the field of renewable resource recycling. In this study, LPWF was used to reinforce poly(lactic acid) (PLA) composites in the field, and the composites were modified with bioenzyme, cationic polyacrylamide (CPAM), and nano-silicon carbide (Nano-SiC) to enhance the interfacial compatibility of LPWF/PLA composites. The study systematically investigated the effects of various modification methods on the characteristics and degradability of composites made from laser print waste paper fiber reinforced PLA resin matrix. The results showed that the mechanical properties of the composites treated with CPAM and Nano-SiC were significantly improved, with tensile strengths of 54.3 and 59.5 MPa, and flexural strengths of 85.1 and 91.5 MPa, respectively, and the water absorption of the composites was reduced after the modification treatment, while the thermal stability was improved. The degradation performance of the composites in various water environments indicated that the inclusion of LPWF accelerated the water degradation rate of the composites, with the maximum degradation rate of the composite reaching 1.26% in 30 days. Highlights Laser print waste paper is an excellent quality recyclable fiber resource. Four modifiers were used to modify LPWF/PLA composites. Characteristics and degradability of the composites were investigated. Significantly improved properties of CPAM and Nano-SiC modified composites. The degradation rate of composites is increased by the addition of LPWF.
研究领域:
材料科学
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环境科学
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可再生资源利用
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
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IF 10.723
Weidong Niu,Yunfeng Guo,Wei Huang,Lili Song,Zefang Xiao,Yanjun Xie,Yonggui Wang
To promote the replacement of nondegradable petrochemical-based polymers with green polylactic acid (PLA) materials, aliphatic chains-grafted cellulose nanocrystals (ECNCs) were prepared and used as nanofillers to overcome the disadvantage of poor toughness of PLA. ECNCs with core-corona structures were obtained by modifying cellulose nanocrystals (CNC) with valeryl chloride, octanoyl chloride, dodecanoyl chloride, and stearoyl chloride. ECNCs consists of a cellulose crystalline core and a soft esterified corona layer with aliphatic chains. Among the diverse ECNCs, the obtained EOCNC by esterification of octanoyl chloride exhibited most efficient enhancement of the toughness of PLA. Specifically, PLA/EOCNC-1% film displayed the best elongation at breakage of 108%, which was 6.4 times that of pure PLA. The esterified outer layer of ECNCs, which improves the interfacial compatibility, is one of the key factors contributing to toughening of PLA. These ECNCs with core-corona structure open up new directions for the application of PLA advanced composites.
研究领域:
材料科学
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生物材料
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DOI
PubMed
高影响因子
Materials Today Sustainability
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2023
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IF 7.8
Y. Wang,X. Wu,L. Guo,Q. Li,S. Wang
In this study, polylactic acid (PLA) composites with a content of 1 wt% titanium dioxide (TiO 2 ) were prepared by melt extrusion and then annealed in order to further enhance their crystalline properties and barrier properties. It is found that α-crystals with tight packing and a more perfect structure were formed under annealing treatment at a higher temperature. The crystallinity of PLA/1T composites annealed at 115 °C for 60 min reached 34.08%. The mobility of molecular chains in the amorphous region was limited by the increase of the crystalline region and thus reduces the solubility and diffusion coefficient of water. The water vapor barrier properties of the PLA/1T composite annealed at 115°C for 60 min were improved by 22.34% compared with the unannealed one. The structure of the annealed PLA/1T composites is more compact, and the surface roughness decreases, which increases the surface hydrophobicity and water resistance of the composites. The increase in crystallinity leads to an increase in the stiffness of the PLA/1T composite. The tensile properties of the PLA/1T composite were further improved by the annealing treatment. The annealing treatment provides a technical method to balance the water vapor barrier properties and degradation properties of PLA.
研究领域:
材料科学
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土木工程
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DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
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2023
·Vol. 30
·期 5
·1-13
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IF 2.8
Yang Xiao-Mei,Yin Guang-Zhong,Amorós Olga Zafra,Hernández María Arroyo,de la Vega Jimena,Torralba José Manuel
The “catalytic degradation” of metal oxides limits the wide application of PLA when PLA needs to be modified by adding metal oxides to achieve desired properties. Zinc oxide (ZnO) is a common and widely used agent as it can be used for many properties, such as antioxidant, antibacterial, etc. However, detrimental effects often exist on the properties of polymers after introducing the ZnO, due to the catalytic degradation. In this study, we used polydopamine (PDA) to construct ZnO@PDA core-shell submicron particles via the self-polymerization of dopamine (DA) in alkaline solution, aimed to produce a surface functionalization that would be used to control the rate of degradation of PLA by ZnO during thermal processing, and promote the preservation of mechanical properties. PLA with different contents of ZnO and ZnO@PDA were prepared by a simple melt extrusion method. The degradation behavior, mechanical properties and antibacterial activity of ZnO/PLA and ZnO@PDA/PLA were investigated. It was found that the incorporation of ZnO@PDA in PLA at different contents exhibits a dramatic control over the degradation rate when compared to that of the ZnO/PLA with the same filler content. Notably, the T 5% and T 50% of 3%-ZnO@PDA/PLA increased by 36.4 o C and 31.9 o C. GPC results showed the molecular weight of 3%-ZnO@PDA/PLA was only reduced by 15.8% after thermal processing. In addition, 3%-ZnO@PDA/PLA can be 3D-printed smoothly. That is to say, the introduction of ZnO@PDA can increase the processing window of PLA/ZnO composites, providing the possibility for materials that need to be included in civil application. Accordingly, ZnO@PDA/PLA samples showed higher tensile strength and elongation at break than that of corresponding ZnO/PLA samples. Regarding the antibacterial behavior, the ZnO@PDA/PLA have more bacterial growth disability effect against Gram(+) bacteria than that of pure PLA.
研究领域:
材料科学
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生物医学工程
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高分子化学
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DOI
高影响因子
Polymers
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2023
·Vol. 15
·期 20
·4144
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IF 5
Yisu Wang,Yan Wang,Shuai Qiu,Chongyang Wang,Hong Zhang,Jing Guo,Shengfa Wang,Huixia Ma
Chitosan/Hydroxyapatite composites, enriched with relatively active -NH2and -OH groups, have emerged as promising adsorbents for heavy metal removal. In this study, we harnessed the potential of CS/HAP composites by developing monolithic PLA@CS/HAP filters utilizing 3D printing and freeze-drying techniques. These filters possess both macroscopic and microscopic porous structures, endowing them with exceptional capabilities for removing heavy metals from water. The adsorption properties of CS/HAP composites were explored by varying the dosage, duration, and initial concentrations of copper ions. The maximum adsorption capacity for Cu2+was determined to be approximately 119+/−1 mg/g at the natural pH and 298 K. Notably, the monolithic PLA@CS/HAP filters demonstrated remarkable efficiency in the removal of copper ions, with 90% of copper ions effectively removed within a mere 2-h period in a cyclic adsorption experiment. Furthermore, the PLA@CS/HAP filters exhibited a robust dynamic Cu2+removal capacity (80.8% or even better in less than 35 min) in a dynamic adsorption experiment. Importantly, all materials employed in this study were environmentally friendly. In summary, the PLA@CS/HAP filter offers advantages such as ease of preparation, eco-friendliness, versatility, and broad applicability in diverse wastewater treatment scenarios, thereby presenting a significant potential for practical implementation.Keywords:chitosan;hydroxyapatite;3D printing;adsorption
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
POLYMER
·
2025
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IF 4.5
Yanjun Sun,Haihao He,Xuehua Jia,Meiqiong Chen,Ning Chen,Yinghong Chen
In this study, the biaxially stretching and reactive blending strategies were combined to fabricate the high-performance antimicrobial biodegradable polybutylene adipate-terephthalate (PBAT)/polylactic acid (PLA) based composite film with polyhexamethylene guanidine hydrochloride (PHMG) being as the efficient antimicrobial agent. Various measurements, including scanning electron microscopy (SEM), Fourier transform infrared (FTIR) analysis, 2D-small angle X-ray scattering (2D-SAXS), gas barrier test, mechanical property test, antimicrobial activity test, etc., were employed to carefully characterize the obtained films. The experimental results showed that the biaxially stretching could induce the orientation of polymer molecular chains and formation of submicron-thick layered thin-lamella structures of PLA dispersed phases in PBAT matrix in the presence of initiator dicumyl peroxide (DCP) and PHMG, thus significantly enhancing the crystallinity and mechanical properties of the obtained film, as well as improving the gas barrier and hydrophilicity-oleophobicity characteristics. At a stretching ratio of 3.5 × 3.5, the tensile strength of the prepared film could reach 61.9 MPa, and meanwhile the oxygen and water vapor permeability rates were reduced to 3.1 × 10 −14 and 5.1 × 10 −14 g/(cm s Pa), respectively. In addition, the incorporation of PHMG endowed the film with highly efficient antibacterial properties, e.g. a film with 1.0–1.5 wt% PHMG content could achieve a 100 % inhibition rate against Escherichia coli (E. coli) and a 99.9 % inhibition rate against Staphylococcus aureus (S. aureus). The further lychee preservation experiments demonstrated that the PHMG incorporating PBAT/PLA composite film remarkably extended the preservation time of fruit (40 % longer). The prepared antimicrobial PBAT/PLA/PHMG film exhibited the high safety and economic benefits, thus showing the promising application prospects in the field of food packaging.
研究领域:
材料科学
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高分子科学
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食品包装
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抗菌技术
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可生物降解材料
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产品关联
DOI
高影响因子
Advanced Science
·
2023
·
IF 15.1
Wan Peng,Cheng Liu,Youjin Lai,Yanting Wang,Pingsheng Liu,Jian Shen
Most of the current bioadhesives cannot perform well on bleeding tissues while postoperative adhesion is a general but serious clinical issue. Here, a three-layer biodegradable Janus tissue patch (J-TP) that is able to simultaneously enable efficient closure of bleeding wounds with significantly promoted clotting ability and suppressed postoperative adhesion of tissues is reported. A dry adhesive hydrogel bottom layer of the J-TP can form rapid (within 15 s) and strong (tensile strength up to 98 kPa) adhesion to bleeding/wet tissues with high bursting pressure (about 312.5 mmHg on a sealed porcine skin) through hydrogen binding and covalent conjugation between the carboxyl & N -hydroxy succinimide (NHS) groups of hydrogel and the primary amine groups of tissues, while the phosphonic motifs can significantly reduce blood loss (by 81% on a rat bleeding liver model) of bleeding wounds. A thin polylactic acid (PLA) middle layer can improve the tensile strength (by 132%) of the J-TP in wet conditions while the grafted zwitterionic polymers can effectively prevent postoperative tissue adhesion and inflammatory reaction. This J-TP may be a promising tissue patch to assist the clinical treatment of injured bleeding tissues with inhibited postoperative adhesion.
研究领域:
生物医学工程
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材料科学
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组织工程
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DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Weiwei Ma,Jiehong He,Lanfang Han,Chuanxin Ma,Yanpeng Cai,Xiaoyu Guo,Zhifeng Yang
Dissolved organic matter (DOM) exists widely in natural water, which inevitably influences microplastic (MP) photoaging. Nevertheless, the impacts of DOM fractions with diverse molecular structures on MP photoaging remain to be elucidated. This study explored the photoaging mechanisms of polylactic acid (PLA)-MPs and polystyrene (PS)-MPs in the presence of DOM and its subfractions (hydrophobic acid (HPOA), hydrophobic neutral (HPON), and hydrophilic (HPI)). Across DOM fractions, HPI exhibited the highest electron accepting capacity (23 μmol e– (mg C)−1) due to its abundant tannin-like species (36.8%) with carboxylic groups, which facilitated more reactive oxygen species generation (particularly hydroxyl radical), leading to the strongest photoaging rate of two MPs by HPI. However, the sequences of bond cleavage during photoaging of each MPs were not clearly shifted as revealed by two-dimensional infrared correlation spectra. Inconspicuous effects on the extent of PS- and PLA-MPs photoaging were observed for HPOA and HPON, respectively. This was mainly ascribed to the occurrence of inhibitory mechanisms (e.g., light-shielding and quenching effect) counteracting the reactive oxygen species-promoting effects. The findings identified the HPI fraction of DOM for promoting PS- and PLA-MPs photoaging rate and first constructed a link among DOM molecular structures, redox properties, and effects on MP photoaging.
研究领域:
环境科学
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化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
·
IF 2.8
Changqing Peng,Dongmei Xie,Hongzhi Liu
Previous works have demonstrated that diisocyanate-induced dynamic vulcanization of difunctional fatty acid is an effective and promising strategy to highly toughen PLA. However, the effect of diisocyanate structure on the toughening of PLA remains unclear. For this sake, three diisocyanates with different molecular structures, that is, hexamethylene diisocyanate (HDI), 4,4-diphenylmethane diisocyanate (MDI), and dicyclohexylmethane 4,4′-diisocyanate (HMDI), were chosen to induce dynamic vulcanization of hydrogenated dimer acid (HDA) in the presence of PLA. The reaction rates of the diisocyanates with HDA were found to follow the following order: HDI > MDI > HMDI. The higher reactivity of diisocyanates resulted in better interfacial compatibility between the in situ formed polyamide elastomer and PLA components. PLA blends utilizing MDI or HMDI with cyclic structural units have superior tensile strength (TS) and tensile modulus (TM) but minimal improvement in tensile ductility. Among the three PLA blends, the PLA/(HDA + HDI) blend exhibited a bi-continuous morphology and the highest toughness, with an elongation at break of 283.4% and a notched impact strength of 80.1 kJ/m 2 . This work would offer guidance for the development of high-performance PLA blends prepared by dynamic vulcanization of reactive monomers.
研究领域:
高分子科学
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材料工程
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化学反应
·
纳米复合材料
·
力学性能
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）