ONCOLOGY REPORTS
·
2024
·Vol. 52
·期 4
·1-8
·
IF 3.8
Tong Wang,Xu Ye,Hao Jiang,Yu Gao
B‑cell lymphoma is difficult to cure because of its biological and clinical heterogeneity, and due to native chemoresistance. Immunotherapies that overcome cancer‑induced immune evasion have been the center of recent developments in oncology. This is emphasized by the accomplishment of various agents that disrupt programmed cell death protein 1 (PD‑1)‑mediated immune suppression in diverse tumors. However, while PD‑1 blockade has been effective in numerous malignancies, a significant proportion of cancers, including B‑cell lymphoma, show certain rates of primary resistance to these therapeutic strategies. Histone deacetylase inhibitors (HDACis) have exhibited anticancer activity though suppressing cell proliferation, inducing differentiation and triggering apoptosis. The present study aimed to explore a therapeutic strategy combining a HDACi (romidepsin) and PD‑1 blockade (BMS‑1) in B‑cell lymphoma, utilizing a constructed mouse model of B‑cell lymphoma. The IC50 of the two inhibitors was confirmed by MTT assay, and their inhibitory effects were revealed to be dose‑ and time‑dependent. The data demonstrated that the combined treatment of romidepsin and BMS‑1 synergistically inhibited the growth of B‑cell lymphoma. Furthermore, it was revealed that romidepsin and BMS‑1 synergistically triggered apoptosis in mouse B‑cell lymphoma. The synergistic effect of these agents was capable of activating tumor‑infiltrating lymphocytes, particularly CD3+CD4+ and CD3+CD8+ T cells. The results of the present study underscore the potential of HDAC inhibition in conjunction with PD‑1 blockade as a novel therapeutic approach for B‑cell lymphoma, highlighting the synergistic effects of these two mechanisms in enhancing antitumor immunity.
研究领域:
肿瘤学
·
免疫学
·
分子生物学
·
癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Huifang Liu,Jianyu Han,Qitian Huang,Hongwei Shen,Lijun Lei,Zhipeng Huang,Zhixin Zhang,Zongbao K. Zhao,Feng Wang
Catalytic hydrotreating of renewable oils is a promising way to get diesel alkanes, with the use of microbial lipids further facilitating scalable production of green diesel. The core issue of triglyceride hydrodeoxygenation (HDO) research is still to develop efficient catalysts under mild reaction conditions. Herein, we demonstrate that the heteropolyacid (HPA)-modified SiO2 supported Pd catalysts showed high activity for the HDO reaction of methyl stearate and soybean oil to diesel alkanes (C15∼C18, >90 wt % at 200 °C). Characterizations show that the Brønsted acid sites introduced by grafting heteropolyacid on SiO2 and metal sites of small Pd particles contribute to the high HDO activity of this bifunctional catalyst. Additionally, lipids produced by Rhodosporidium toruloides Y4 from glucose or corn stover were also transformed to about 75 wt % of diesel-range alkane products. This integration of microbial lipid production with chemical catalysis should facilitate the engineering of green diesel production from lignocellulosic biomass.
研究领域:
化学工程
·
催化
·
生物能源
·
绿色化学
·
可再生能源
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2017
·
IF 3.012
Mingdang Li,Ping Wang,Fubin Pei,Haoxuan Yu,Peng Chen,Yunhui Dong,Yueyun Li,Qing Liu,Degang Li
In this work, a highly sensitive sandwich-type electrochemical immunosensor was fabricated by using the gold nanorods (Au NRs) as the substrate material and the mesoporous Au@Pd@Pt core-shell nanospheres (m-Au@Pd@Pt) as the label of the detection antibodies (Ab 2 , Ab 2 label) for detecting Hepatitis B surface antigen (HBs Ag). The Au NRs with excellent conductivity and biocompatibility can accelerate the electron transfer on the electrode interface and enhance the load capacity of capture antibodies (Ab 1 ). The m-Au@Pd@Pt with mesoporous structure can not only provide high specific surface area and abundant catalytically active sites, but also offer great pore accessibility of guest species from outside. The detection signal of the immunosensor was effectively improved by the novel Ab 2 label. With the good cooperation between Au NRs and Ab 2 label, a linear relationship between current signal and the logarithm of the HBs Ag concentration was obtained in the wide range of 20 fg/mL to 200 ng/mL and the detection limit of HBs Ag was 6.7 fg/mL (signal-to-noise ratio of 3). Besides, the designed immunosensor shows good reproducibility, long-term stability and high specificity. Crucially, the sensitive and selective response to HBs Ag in real human serum samples confirms that the designed immunosensor will be promising in the clinical diagnosis of biomarkers.
研究领域:
纳米技术
·
生物传感器
·
分析化学
·
医学诊断
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2024
·
IF 3.7
Junbo Feng,Junyan Wu,Dongdong Yan,Yadong Zhang
Porous silica nano-flowers (KCC-1) immobilized Pt-Pd alloy NPs (Pt-Pd/KCC-1) with different mass ratios of Pd and Pt were successfully prepared by a facile in situ one-step reduction, using hydrazinium hydroxide as a reducing agent. The as-synthesized silica nanospheres possess radial fibers with a distance of 15nm, exhibiting a high specific surface area (443.56 m 2 ·g –1 ). Meanwhile, the obtained Pt-Pd alloy NPs are uniformly dispersed on the silica surface with a metallic particle size of 4–6 nm, which exist as metallic Pd and Pt on the surface of monodisperse KCC-1, showing the transfer of electrons from Pd to Pt. The as-synthesized 2.5%Pt-2.5%Pd/KCC-1 exhibited excellent catalytic activity and stability for the continuous dehydrogenation of 2-methoxycyclohexanol to prepare guaiacol. Compared with Pt or Pd single metal supported catalysts, the obtained 2.5%Pt-2.5%Pd/KCC-1 shows 97.2% conversion rate of 2-methoxycyclohexanol and 76.8% selectivity for guaiacol, which attributed to the significant synergistic effect of bimetallic Pt-Pd alloy NPs. Furthermore, turn over frequency value of the obtained 2.5%Pt-2.5%Pd/KCC-1 NPs achieved 4.36 s –1 , showing higher catalytic efficiency than other two monometallic catalysts. Reaction pathways of dehydro-aromatization of 2-methoxycyclohexanol over the obtained catalyst are proposed. Consequently, the obtained 2.5%Pt-2.5%Pd/KCC-1 NPs prove their potential in the dehydrogenation of 2-methoxycyclohexanol, while the kinetics and mechanistic study of the dehydrogenation reaction over the catalyst in a continuous fixed-bed reactor may provide valuable information for the development of green, outstanding and powerful synthetic pathway of guaiacol.
研究领域:
催化
·
纳米技术
·
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Ruijie Chen,Baiqun Duan,Shize Li,Yixuan Zhu,Zihao Huang,Dingchao Shen,Zhanzheng Ye,Yuqi Yan,Chenyu Qiu,Haoxiong Guan,Yinsha Yao,Jie Dong,Fugen Wu,Xinyu Jiang,Xianbao Shi,Longfa Kou
Psoriasis, a prevalent immune-mediated chronic inflammatory skin ailment, has been linked to heightened oxidative stress and compromised immune tolerance. Immune checkpoint pathways, particularly the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signaling axis, are instrumental in establishing and sustaining self-tolerance and regulating immune responses. Augmenting PD-1/PD-L1 interaction holds promise for curtailing the proliferation and activation of infiltrating T cells and curbing the release of inflammatory cytokines, thereby mitigating psoriasis induced by impaired immune tolerance. Consequently, neutralizing the surplus reactive oxygen species (ROS) in the affected skin and revitalizing local immune tolerance could represent a beneficial approach to psoriasis treatment. In light of these insights, this study introduced a bilirubin-based nanoparticle cloaked in IFN-γ-stimulated macrophage membrane (designated as IMφm@GBn or "nano-brake"). Treatment with IFN-γ conferred the macrophage membrane with heightened expression of pro-inflammatory cytokine receptor and PD-L1. As a result, the engineered IMφm@GBn not only scavenged excessive ROS in psoriatic lesions but crucially also absorbed a wide spectrum of pro-inflammatory cytokines. Furthermore, it inhibited the proliferation and activation of infiltrating T cells through augmented PD-1/PD-L1 interactions, thereby rebalancing the Th17/Treg ratio. In an in vivo psoriasis mouse model, the "nano-brake" was locally and accurately delivered to the dermis via microneedle, orchestrating the immune microenvironment of psoriasis and mitigating autoimmune damage linked to impaired immune tolerance. This approach significantly enhanced the therapeutic efficacy in ameliorating psoriasis-associated symptoms. This study sets an illuminating precedent for cell membrane-based biomimetic nano-formulations, holding broad implications for psoriasis treatment through multi-pronged immunomodulation.
研究领域:
皮肤病学
·
免疫学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2023
·
IF 14
Yuquan Li,Junxu Yang,Xiaoming Chen,Hao Hu,Nihan Lan,Jinmin Zhao,Li Zheng
Mitochondrial reactive oxygen species (mROS) play a crucial role in the process of osteoarthritis (OA), which may be a promising target for therapy of OA. In this study, novel mitochondrial-targeting and SOD-mimic Mn 3 O 4 @PDA@Pd-SS31 nanozymes with near-infrared (NIR) responsiveness and synergistic cascade to scavenge mROS were designed for the therapy of OA. Results showed that the nanozymes accelerated the release of Pd and Mn 3 O 4 under NIR irradiation, exhibiting enhanced activities of SOD and CAT mimic enzymes with reversed mitochondrial dysfunction and promoted mitophagy to effectively scavenge mROS from chondrocytes, modulate the microenvironment of oxidative stress, and eventually inhibit the inflammatory response. Nanozymes were excreted in vivo through intestinal metabolic pathway and had good biocompatibility, effectively reducing the inflammatory response and relieving articular cartilage degeneration in OA joints, with a reduction of 93.7 % and 93.8 % in OARSCI scores for 4 and 8 weeks respectively. Thus, this study demonstrated that the mitochondria targeting and NIR responsive Mn 3 O 4 @PDA@Pd-SS31 nanozymes could efficiently scavenge mROS, repair damaged mitochondrial function and promote cartilage regeneration, which are promising for the treatment of OA in clinical applications.
研究领域:
生物医学工程
·
纳米技术
·
骨科
·
药学
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Kok Bing Tan,Pan Tian,Xinxin Zhang,Jian Tian,Guowu Zhan,Jiale Huang,Qingbiao Li
The present study developed bifunctional catalyst for CO 2 hydrogenation into dimethyl ether (DME), whereby it consists of Pd/In 2 O 3 for CO 2 hydrogenation into methanol, and H-ZSM-5 for methanol dehydration into DME. The catalyst development was focused on the synthesis of Pd/In 2 O 3 via a green and low-cost synthesis method of carbonized alginate templating. Thus, microspherical-confined nano-Pd/In 2 O 3 was formed, whereby the localized nucleation growth was coordinated by the chemically entrapped In 3+ via ionic bond in the well-distributed alginate structure. It was found that hydrothermal temperature plays a key role in the development of this catalyst structure. The optimum hydrothermal temperature is 160 °C, as it is able to produce the highest amount of methanol. This catalyst was further integrated with H-ZSM-5 via different integration manners. It was found that mortar mixed method produces the highest amount of DME, as the close proximity causes stronger ion-exchange mechanism between the catalyst components, which facilitates higher oxygen vacancy density in the bifunctional catalyst. Under the optimum Pd/In 2 O 3 : H-ZSM-5 (PdIn-160–12: H-ZSM-5) mass ratio of 4:1, the highest STY DME of 79.7 g DME kg cat -1 h −1 with CO 2 conversion of 9% and DME selectivity of 44.1% can be achieved. In addition, the STY DME can be maintained even in 60 h on stream, demonstrating the excellent stability and performance of microspherical-confined nano-Pd/In 2 O 3 /H-ZSM-5 bifunctional catalyst synthesized via carbonized alginate templating strategy.
研究领域:
催化
·
化学工程
·
材料科学
·
环境化学
·
能源科学
✓ 已验证
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 13
·2107809
·
IF 15.153
Qinyanqiu Xiang,Chao Yang,Yuanli Luo,Fan Liu,Jun Zheng,Weiwei Liu,Haitao Ran,Yang Sun,Jianli Ren,Zhigang Wang
The efficacy of immune checkpoint inhibition in inducing death of cancer cells is affected by the immunosuppressive “cold” tumor microenvironment, which results in a poor response by the patient's antitumor immune system. However, the immunomodulatory effects of immunogenic cell death in response to irritation by heat energy and reactive oxygen species (ROS) can switch the tumor microenvironment from “cold” to “hot.” This study has developed a nanoadjuvant for immune therapy using iron tungsten oxide (FeWOx)-based nanosheets with surface PEGylation (FeWOx-PEG). This FeWOx-PEG nanoadjuvant serves as a chemodynamic reagent via the Fenton reaction and acts as a photosensitizer for photodynamic and photothermal therapy under near-infrared II laser irradiation; however, it could also be used to augment tumor-infiltrating T-cells and provoke a systemic antitumor immune response by combining the immunogenic cell death triggered by ROS and photothermal therapy with the immune checkpoint blockade. This research demonstrates that application of the FeWOx-PEG nanoadjuvant under the guidance of magnetic resonance/computed tomography/photoacoustic imaging can eliminate the primary tumor and suppress the growth of distant tumors.
研究领域:
肿瘤学
·
免疫治疗
·
纳米技术
·
生物医学工程
·
癌症生物学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Fei Kong,Zhiqiang Zeng,Xiaorong Zhu,Qingqing Wu,Lu Zhou,Changwei Dou,Zhongbo Xie,Lidong Cao
The combination of photodynamic therapy and immunotherapy has emerged as a safe and effective cancer treatment strategy. However, traditional photodynamic therapy and precision anti-tumor immunotherapy still face challenges, such as weak light source penetration, poor targeting specificity, low response rates and immune-related adverse effects. Herein, a smart polymer nano-immunomodulator (SPNI) that can respond to the tumor microenvironment for precise photodynamic immunotherapy of cancer is reported. This SPNI is self-assembled from pH and glutathione (GSH) bi-responsive amphiphilic polymers, simultaneously loaded with photosensitive materials and oxygen-carrying molecules, subsequently is wrapped by hepatocellular carcinoma (HCC) cell membrane using a simple coextrusion method to generate biomimetic nanoparticles. Upon reaching the tumor site, the SPNI degrades in the tumor microenvironment, effectively releasing photosensitive substances with chemophotodynamic effects to directly eliminate tumors without an external light source. Additionally, the immunosuppressant blocks PD-1/PD-L1 signaling pathways to enhance the body’s endogenous anti-tumor immune response, inhibiting tumor growth and metastasis. Furthermore, the incorporated immunosuppressant effectively blocks PD-1/PD-L1 signaling pathways, thereby potentiating endogenous anti-tumor immune responses to suppress both primary tumor growth and metastatic progression. This innovative combination of tumor microenvironment-responsive photodynamic therapy and checkpoint blockade immunotherapy demonstrates remarkable efficacy in anti-HCC treatment and shows substantial potential for clinical translation. The SPNI platform represents a significant advancement in precision cancer therapy by simultaneously addressing multiple limitations of current treatment modalities.
研究领域:
医学
·
生物材料学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2021
·
IF 13.084
Tian-Wen Jiang,Ya-Wei Zhou,Xian-Yin Ma,Xianxian Qin,Hong Li,Chen Ding,Bei Jiang,Kun Jiang,Wen-Bin Cai
The electrochemical CO2 reduction reaction (CO2RR) on Pd-based electrodes to dissolved formate and/or gaseous CO is largely dependent on potential and the electrode material, yet there is a lack of molecular-level insights into this dependence. Herein, in situ attenuated total reflection surface enhanced infrared absorption spectroscopy (ATR-SEIRAS) in conjunction with differential electrochemical mass spectrometry (DEMS), gas chromatography (GC), and nuclear magnetic resonance (NMR) measurements is applied to investigate the CO2RR on Pd and Pd-B film electrodes, providing a direct observation of the role of surface CO as well as the B-doping effect at varied potentials. Comprehensive spectrometric results reveal that at lower overpotentials, CO gradually accumulates on both Pd electrode surfaces poisoning the dominant formate pathway, while at higher overpotentials, surface CO forms facilely with linearly bonded CO (the minor surface CO species) acting as an active precursor and bridge-bonded CO (the major surface CO species) as a spectator toward the gaseous CO product. Moreover, B-doping in Pd hinders CO formation and promotes formate production on the Pd-B electrode for the CO2RR as compared to that on the pristine Pd electrode at all of the overpotentials under investigation.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2017
·Vol. 27
·期 22
·1700016
·
IF 12.124
Xingzhong Zhu,Henglei Jia,Xiao-Ming Zhu,Si Cheng,Xiaolu Zhuo,Feng Qin,Zhi Yang,Jianfang Wang
The synthesis of anisotropic metal nanostructures is strongly desired for exploring plasmon-enabled applications. Herein, the preparation of anisotropic Au/SiO 2 and Au/SiO 2 /Pd nanostructures is realized through selective silica coating on Au nanobipyramids. For silica coating at the ends of Au nanobipyramids, the amount of coated silica and the overall shape of the coated nanostructures exhibit a bell-shaped dependence on the cationic surfactant concentration. For both end and side silica coating on Au nanobipyramids, the size of the silica component can be varied by changing the silica precursor amount. Silica can also be selectively deposited on the corners or facets of Au nanocubes, suggesting the generality of this method. The blockage of the predeposited silica component on Au nanobipyramids enables further selective Pd deposition. Suzuki coupling reactions carried out with the different bimetallic nanostructures functioning as plasmonic photocatalysts indicate that the plasmonic photocatalytic activity is dependent on the site of Pd nanoparticles on Au nanobipyramids. Taken together, these results suggest that plasmonic hot spots play an important role in hot-electron-driven plasmonic photocatalysis. This study opens up a promising route to the construction of anisotropic bimetallic nanostructures as well as to the design of bimetallic plasmonic-catalytic nanostructures as efficient plasmonic photocatalysts.
研究领域:
纳米材料
·
等离激元学
·
光催化
·
材料化学
·
纳米技术
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Zimo Lou,Jiasheng Zhou,Mei Sun,Jiang Xu,Kunlun Yang,Dan Lv,Yaping Zhao,Xinhua Xu
A Pd/MnO 2 /Ni foam electrode with hierarchical structure was synthesized via electrodeposition for efficient electrocatalytic hydrodechlorination. Compared with the ordinary Pd/Ni foam electrode, the introduction of MnO 2 greatly enhanced the catalytic reactivity and reduced the dose of precious metal Pd. Only a quarter of Pd was required for the Pd/MnO 2 /Ni foam compared to the Pd/Ni electrode to achieve complete dechlorination of 2,4-dichlorobenzoic acid (2,4-DCBA) within 120 min. Various characterizations suggested that MnO 2 covered the surface of the Ni foam and increased the specific surface area of the electrode, while Pd nanoparticles were subsequently deposited on MnO 2 . The atomic H ∗ -based indirect dechlorination was the dominant pathway while only approximately 13% of 2,4-DCBA was removed by direct electron transfer. Atomic H ∗ adsorbed on Pd acted as the key active species for the dechlorination of 2,4-DCBA by the Pd/MnO 2 /Ni foam electrode in this study. The introduction of MnO 2 would promote the water dissociation and the hydrogen evolution reaction, and provide Pd with more atomic H ∗ . Pd/MnO 2 /Ni foam exhibited good stability and reusability according to the XPS spectra and consecutive electrocatalytic experiments, which suggested its long-term potential for efficient removal of chlorinated contaminants. This work demonstrated a new strategy to design efficient electrocatalysts with less precious metal.
✓ 已验证
产品关联
DOI
高影响因子
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