SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Zhijiang Sun,Dahui Wang,Nailing Sun,Fen Ran
In recent years, a range of high-performance ultrafiltration membranes have been developed, but maintaining high retention without sacrificing high throughput remains a serious challenge. In this paper, functionalized halloysite nanotubes is constructed by copolymerization and by a one-step reaction of L -arginine and dopamine hydrochloride using halloysite nanotubes as carriers. Subsequently, modified polyethersulfone membranes are prepared by blending them as additives through non-solvent-induced phase transition separation. As the synthesized nanofillers is rich in functional groups, negative electronegativity, and unique structures, the study focuses on adding nanofillers’ effect on the membrane structure and physicochemical properties. The addition of appropriate nanofillers enhances the membrane surface wettability and negative electronegativity, and the enlarged internal pores and the dense layer that remains flat and homogeneous effectively promote the flux of small molecules, the retention of large molecules, and the cyclic stability of the membrane. The prepared polyethersulfone membranes demonstrate exceptional cycle stability, high separation efficiency (almost 100 % for Congo red), and significantly improved permeation performance (initial permeate flux up to 316.5 L m -2 h −1 ). The results demonstrate the high potential of the modified prepared polyethersulfone membranes for pertinent environmental separation processes.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Songlin Chen,Zhihao Shen,Shuming Wen,Guang Han,Qicheng Feng
Flotation separation of Cu–Fe sulfide minerals typically necessitate the addition of substantial quantities of lime to depress pyrite flotation. Because lime can harm the environment, there is an urgent need to develop novel environmentally friendly depressants that are non-toxic and biodegradable. In this study, we investigated an environmentally friendly pyrite depressant containing amino and carboxyl groups, namely D-arginine (DA). The effect of DA on the surface hydrophobicity of Cu–Fe sulfide minerals and thus collector adsorption was investigated by analyzing zeta potentials, adsorption capacities, and contact angles. Additionally, changes in the surface properties of the minerals induced by DA were examined using X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectroscopy (ToF-SIMS), and atomic force microscopy (AFM). Flotation tests revealed that 2 × 10 –4 mol/L DA reduced the flotation recovery of pyrite to 9.96 % at low alkalinity while leaving chalcopyrite recovery unchanged. The results of mineral surface analysis indicated that DA exhibited significantly stronger adsorption on the pyrite surface than on the chalcopyrite surface. Furthermore, DA effectively reduced the adsorption of the collector on the surface of pyrite, thereby weakening pyrite floatability at low alkalinity. Therefore, DA is a promising alternative depressant for the flotation separation of chalcopyrite from pyrite.
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Journal of Materials Chemistry C
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2024
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IF 5.7
Jiaxuan Pan,Jiazhen Lu,Yichen Shang,Ying Li,Bing Yan
Dopamine and arginine are both important substances in the body and are closely related to human health. Timely detection of their concentration abnormalities is of great significance to the prevention of disease. In this work, a Tb3+-functionalized Eu-MOF hybridized double network hydrogel film (Tb@Eu-MOF@PVA/SA) was prepared by a simple synthesis, which can accurately detect arginine (Arg) and dopamine hydrochloride (DH). Meanwhile, the hydrogel acquired good mechanical properties through crosslinking of Tb3+and freeze–thaw cycles. The free carboxyl groups on the surface of the Eu-MOF in this hydrogel film can bind to Tb3+ and sensitize it to emit light through the “antenna effect”, thus forming a fluorescent hydrogel film with dual emission centers. By testing two kinds of detectors and controlling different excitation wavelengths, we can realize the encryption and decryption of information and build an anti-counterfeiting platform to improve the level of information security. The present work not only provides a case study for the preparation of dual-emission Tb3+-functionalized Eu-MOF hybridized dual-network hydrogel films, but also provides ideas for the development of multifunctional luminescent materials.
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DYES AND PIGMENTS
·
2025
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IF 4.2
Xinlu Bao,Kebin Ye,Zhikang Song,Mingzhu Zhang,Shaohua Wei,Lin Zhou
Photodynamic therapy (PDT) utilizes reactive oxygen species (ROS) generated by photosensitizers under light to kill cancer cells. The phototoxic index (PI) indicates the safe therapeutic window of photosensitizers, and an ideal photosensitizer should have a high PI. Monosubstituted zinc phthalocyanine (ZnPc-COOH) exhibits excellent phototoxicity in bladder cancer cell (T24, IC 50 = 10.7 nM). However, its localization in mitochondria leads to high dark toxicity (IC 50 = 2.12 μM), resulting in a PI of less than 200. In this study, the binding ability of phthalocyanine to the cell membrane was significantly enhanced by side-chain modification with arginine. By taking advantage of the fluidity of the membrane structure, the drug was transported to the lysosome. After modification with Arg, the dark toxicity of ZnPc-COOH decreased by nearly 100 times, and the PI increased to 8979, which is 12 times that of the clinical photosensitizer Photosens®. In a mouse model of non-muscle-invasive bladder cancer (NMIBC), ZnPc-Arg demonstrated therapeutic effects comparable to those of the clinical drug mitomycin C (MMC). This study provides valuable references for the design of photosensitizers with high PI.
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Small
·
2021
·Vol. 18
·期 9
·2104120
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IF 13.281
Ziyu Wu,Rui Wu,Xiaoyun Li,Xingwen Wang,Xueting Tang,Kaiyuan Tan,Mimi Wan,Chun Mao,Xingquan Xu,Huiming Jiang,Jiawei Li,Min Zhou,Dongquan Shi
Most of the current non-pharmacological treatment strategies for atherosclerosis (AS) suffer from poor penetration into the plaque and only aim at a certain factor in its formation process, resulting in limited therapeutic effect. Herein, a kind of nanomotor with dual-mode propulsion is constructed, which is sensitive to higher reactive oxygen species (ROS) at the AS site and near-infrared (NIR) laser by the covalent binding and self-assembly of β-cyclodextrin (β-CD) and L-arginine (LA) with immobilization of Au nanoparticles. NIR laser irradiation can be used as a driving force and to ablate inflammatory macrophages through the photothermal effect. The nitric oxide (NO) released by the nanomotors can be used as another driving force and a therapeutic agent to promote endothelial repair in the plaque site. LA can eliminate ROS in the inflammatory site, and β-CD can promote the removal of cholesterol from foam cells. In particular, the two driving modes of nanomotors synergistically promote their aggregation and penetration in the plaque. This kind of nanomotor can regulate the microenvironment of AS in multiple ways, including combination therapy for endothelial repair, lipid clearance, and reducing ROS, which is expected to become a potential non-pharmacological strategy in the treatment of AS.
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DRUG DELIVERY
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2020
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IF 4.902
Pengcheng Zhang,He Tao,Liyang Yu,Lixiao Zhou,Chenggang Zhu
Injectable implants with the ability to form in situ are one of the most promising carriers for the delivery of chemotherapeutic drugs to tumor sites. We have reported a novel injectable in situ-forming implant system composed of n-butyl-2-cyanoacrylate (NBCA), ethyl oleate, along with the sol-gel phase transition. The chemotherapeutic drug-loaded injectable NBCA ethyl oleate implant (INEI) exhibited excellent therapeutic efficacy for local chemotherapy. Herein, we utilize this INEI to carry N, N′-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide) (TE-C-5003), which is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, to treat the lung cancer mice model. The in vitro experiment shows that TE-C-5003 has a good anti-tumor effect on lung cancer (IC50 = 0.7022 µM for A549; IC50 = 0.6844 µM for NCL-H1299) and breast cancer (IC50 = 0.4128 µM for MCF-7; IC50 = 0.5965 µM for MDA-MB-231). Anti-tumor experiments in animal models showed that the average growth inhibition rate of xenografted human lung cancer cells by the TE-C-5003-loaded INEI (40% NBCA) was 68.23%, which is far more than TC-E-5003 alone (31.76%). Our study further confirms that INEI is an effective technique to improve the anti-tumor effect. The druggability of small molecule compounds can be improved with the help of the mentioned technology. Also, TC-E-5003 may be developed as a broad spectrum anti-tumor drug.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
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IF 5.9
Ziyi Zhao,Xiaoxiao Huang,Lining Huang,Hui Xing,Yuhui Yang,Guanhai Wang,Yunfeng Hu,Xiaoxu Zhu,Dong Ma
L -Arginine ( L -Arg), a precursor of nitric oxide (NO), is efficiently delivered to the deeper layers of the skin via a hyaluronic acid-based liposomal transdermal delivery system (HL@ L -Arg), which enhanced cutaneous delivery and local retention of L -Arg. Through nitric oxide synthase (NOS)-mediated conversion, HL@ L -Arg promoted endogenous NO production and provided a sustained NO-related therapeutic effect. • Transcriptomic analysis indicated that HL@ L -Arg treatment in androgenetic alopecia (AGA) was associated with pathways related to Wnt signaling, inflammatory responses, and steroid hormone biosynthesis. Functional studies further showed that HL@ L -Arg reduced SRD5A1/5α-reductase activity and DHT production, while promoting β-catenin/IGF-1-associated follicular growth responses. • HL@ L -Arg improved the follicular microenvironment by suppressing inflammatory factors (TNF-α and IL-6) and androgen receptor (AR) expression, while enhancing Ki67 and VEGF expression, endothelial responses, and local blood perfusion, thereby promoting hair regeneration. Androgenetic alopecia (AGA) is a common hair loss disorder caused by genetic susceptibility and androgen-driven follicular miniaturization. Current FDA-approved therapies, including finasteride and minoxidil, are limited by adverse effects. Here, we developed a hyaluronic acid-based liposomal transdermal delivery system loaded with L -arginine (HL@ L -Arg) to enhance cutaneous delivery and promote endogenous nitric oxide (NO) production through nitric oxide synthase. Transcriptomic analysis indicated significant changes in pathways related to inflammatory responses, Wnt signaling, and steroid hormone biosynthesis. Mechanistically, HL@ L -Arg inhibited 5α-reductase activity and reduced dihydrotestosterone (DHT) production while promoting endogenous NO generation. In an AGA mouse model, HL@ L -Arg reduced TNF-α, IL-6, and androgen receptor (AR) expression, increased VEGF and Ki67 levels, and markedly promoted hair regeneration. Collectively, transdermal L -Arg delivery represents a promising endogenous NO-based therapeutic strategy for AGA through DHT suppression, regulation of the follicular microenvironment, and anti-inflammatory activity.
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Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Duo Xu,Xinyang Sun,Simiao Wu
Forward osmosis (FO) technology has been employed extensively in a multitude of fields. The primary impediment to the development of this technology is the phenomenon of bio-fouling. This study presented an innovative and straightforward approach to mitigating bio-fouling and simultaneously improving water drawing performance through the incorporation of arginine (Arg) and lysine (Lys) into the active layer of FO membranes. This was contributed from the hydrophilic groups (i.e. guanidine and amino groups) derived from Arg and Lys. The highest water fluxes were observed of 23.3 ± 0.4 and 20.7 ± 0.7 LMH, with Arg and Lys loading concentrations of 6 and 7 wt%, respectively (Arg-FO-6 and Lys-FO-7 membrane). The E. coli fouling test demonstrated that the modified FO membranes exhibited excellent and stable antibacterial activity. The normalized water fluxes of the Arg-FO-6 and Lys-FO-7 membranes remained at 0.50 and 0.59, respectively, after 120-hour dynamic fouling, whereas the flux of the pristine membrane declined to 0.32. The Arg-FO-6 and Lys-FO-7 membranes exhibited total membrane resistance ( R t ) of 3.6 × 10 8 and 4.9 × 10 8 m −1 , respectively, significantly lower than the pristine membrane (11.4 × 10 8 m −1 ). These findings demonstrate that the modification of FO membranes with Arg and Lys is an effective approach with significant potential for alleviating bio-fouling.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Fengxian Luo,Xinchuang Wang,Xinru Tang,Di Wu. Yinan Du,Jiangning Hu
Although chitosan (CS) is recognized as a promising material for food preservation, the performance of a single-component chitosan coating exhibits inherent limitation. Herein, novel epigallocatechin gallate (EGCG)-cinnamaldehyde-L-arginine nanoparticles (ECL NPs) were synthesized though self-assembly and mannich reaction by integrating EGCG, cinnamaldehyde (Cin), and L-arginine (L-Arg). ECL NPs displayed strong antioxidant and antibacterial activity. Additionally, ECL NPs have greater antioxidation stability than free EGCG. Furthermore, ECL NPs were dispersed into CS to prepare ECL/CS coatings that were applied to fresh strawberries. During six days of storage, the 0.2 %( w /w) ECL/CS coating suppressed visible spoilage, reduced weight loss to 28.49 ± 5.99 % and maintained fruit hardness at 95.05 ± 4.78 g. These results confirm that ECL/CS coating provides an effective strategy for extending the shelf life of perishable fruit and offers a multifunctional platform for antioxidant and antimicrobial applications in food preservation.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chang Liu,Sen Tan,Weili Xue,Wenkang Tu,Hengrui Liu,Meng Yuan,Yuchu He,Xuwu Zhang,Dawei Gao
Mechanistic Insight: Identified a NETs-mediated arginine depletion pathway that suppresses T cell infiltration and effector function in the tumor microenvironment (TME). • Biomimetic Design: Developed a neutrophil membrane-camouflaged piezoelectric nanodrug (gZn-PCN@NEM) for targeted delivery to tumor sites. • Targeted NETs Degradation: Piezoelectric catalysis enables efficient degradation and functional inactivation of NETs within the TME. • Barrier Breakdown: Elimination of NETs dismantles the physical barrier, significantly enhancing T cell infiltration into tumors. • Metabolic Restoration: NETs disruption restores local arginine levels in the TME, providing essential metabolic support for T cell proliferation and activation. • Enhanced Immunotherapy: Synergistic regulation of the physical barrier and arginine metabolism markedly enhances T cell-mediated antitumor immune responses. • Therapeutic Strategy: This work proposes a dual-function immunomodulatory strategy integrating NETs disruption with arginine rescue to overcome tumor immunosuppression. Arginine depletion in the tumor microenvironment (TME) directly deprives T cells of key metabolic substrates required for proliferation and differentiation, thereby inhibiting their antitumor effects. This process is closely associated with neutrophil extracellular traps (NETs). Under inflammatory stimulation, neutrophils generate hypochlorous acid (HClO) by intracellular enzymes and release chromatin and proteases to form NETs. Notably, arginase-1 (ARG1) within NETs accelerates arginine degradation, impairing the metabolic supply of T cells and forming the immunosuppressive TME. Herein, we construct a piezoelectric catalytic nanodrug gZn-PCN@NEM to degrade NETs by doping polymerized carbon nitride (PCN) nanosheets with gradient Zn 2+ and coating them with neutrophil membranes (NEM). This biomimetic camouflage enables neutrophils to rapidly internalize gZn-PCN@NEM and transport it to the tumor site. Under ultrasonic (US) stimulation, gZn-PCN@NEM decomposes HClO in NETs to produce chlorine radicals (Cl·), which induce DNA double-strand breaks of tumor cells, thereby efficiently killing them. The decomposition of HClO triggers the structural collapse of NETs and functional inactivation of ARG1, thereby restoring arginine levels in the TME and promoting T cell proliferation and activation. This work proposes a piezoelectric-catalytic “nets-breaking and source-rescuing” strategy to rescue arginine by degrading NETs, providing a promising approach for enhancing cancer immunotherapy.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Xiangfei Hu,Qiannan Jiang,Zongcai Tu,Yueming Hu,Hui Wang
Pulsed electric field accelerated oxidation of arginine and glutamic acid. • Arginine had higher susceptibility to electric field due to its charged guanidino. • Density functional theory revealed electric field-altered oxidation pathways. • Electric field reduced energy barriers of β-cleavage through electronic polarization. Pulsed electric field (PEF) processing promoted oxidation of charged residues of proteins, while its mechanism remained vague. In this study, polarization and oxidation of arginine (Arg) and glutamic acid (Glu) induced by PEF treatment (5–20 kV/cm for 4 h) was investigated through experimental characterization and density functional theory (DFT) computation. The results demonstrated that PEF treatment restrained the vibrational dipole moment of N H and C O within Arg and Glu side-chain, respectively. In Arg, H 4 -H 6 signals shifted to a lower magnetic field with pronounced broadening, while C 1 , C 4 , C 5 , and C 7 shifted to a higher magnetic field accompanied by the appearance of C=N-related resonances. In contrast, Glu's carbon skeleton shifted slightly to a lower magnetic field without structural conversion. Furthermore, residues were oxidatively degraded with electric field intensity extended, accompanied by impaired positive of Arg and negative charge of Glu. DFT revealed strong polarization of electron distribution within molecular framework, where 0.017 a.u. treatment partially detached the electrons from backbone of carbon-centered radicals. Thermodynamic calculations verified that electric-field alignment with molecular dipoles markedly reduced the energy barrier of β-cleavage, yielding distinct volatile profiles characterized by multi-site cleavage and N-heterocycle in Arg, and predominant aldehydes and acids in Glu. These findings clarified electric field-induced oxidation pathways and provided the theoretical guidance of PEF processing for improved quality stability. Download: Download high-res image (151KB) Download: Download full-size image
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Foods
·
2026
·Vol. 15
·期 13
·2266
·
IF 6
Xinyue Wang,Lianqun Wu,Xin Yang,Miao Yang,Yanping Wu,Lixia Pan,Kai Zhong,Hong Gao
Elucidating the interactions among microbial communities in the Sichuan paocai fermentation system is of great significance for ensuring the safety and quality of paocai. In this study, the interaction betweenBacillus subtilisY61 andWeissella paramesenteroides(CWP) was preliminarily verified through the culture of CWP using the cell-free supernatant derived from Y61. Building on this, a transwell chamber was employed to spatially isolate the two bacteria. Combined with transcriptomic and metabolomic profiling, the underlying interaction mechanism was revealed.Weissella paramesenteroides(CWP) exhibited enhanced growth in the cell-free supernatant ofBacillus subtilisY61, confirming a cross-feeding relationship between the two strains. In the transwell chamber, the promoting effect was most significant whenWeissella paramesenteroides(CWP) was in the upper compartment andBacillus subtilisY61 in the lower compartment. Transcriptomic analysis showed thatWeissella paramesenteroides(CWP) significantly upregulated genes involved in fatty acid synthesis and metabolism while downregulating those related to amino acid anabolism (p< 0.05). Metabolomic analysis further revealed that metabolites secreted byBacillus subtilisY61, including the key metabolites arginine and isovaleric acid, were markedly depleted during co-culture. Exogenous supplementation assays revealed that the combination of 0.1 g arginine and 2 mg isovaleric acid exhibited the strongest growth-promoting effect onWeissella paramesenteroides(CWP). Collectively, these results demonstrated thatBacillus subtilisY61 promoted the growth ofWeissella paramesenteroides(CWP) through cross-feedingviathe extracellular secretion of the key metabolites arginine and isovaleric acid.
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