ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Jinzhi Shi,Kai Shi,Qi Dong,Junfeng Yang,Yingshan Zhou,Peng Ma,Sha She,Fan Yang,Zuojiong Gong
Enriching erythrocytes and platelets in seconds and providing a fast seal in bleeding sites is vital to fatal hemorrhage control. Herein, hydrophilic chitosan fibrous mats (CECS-D mats) are fabricated by introducing hydrophilic carboxyethyl groups and subsequent catechol groups onto chitosan fibers. Due to strong hydrophilicity, CECS-D mats exhibit rapid liquid-absorption capacity, especially instantaneous absorptivity to the rabbit blood, which can achieve erythrocyte and platelet aggregations quickly by concentrating blood, thus promoting the formation of blood clots. Furthermore, the mats are self-oxidated to form quinone-amine adducts or quinone multimers by adjusting pH conditions, which not only provides tissue adhesion but also induces erythrocyte aggregation and platelet adhesion, further enhancing the seal and triggering quick closure to achieve fast hemostasis. Therefore, the mats reveal superior hemostatic performance in rabbit liver and spleen models over CECS mats and gauze. Especially in the fatal femoral artery injury model of rabbits, the mats reduce the blood loss by ∼75% and shortened the bleeding time by ∼50% compared with CECS mats, which have been reported to have the same hemostatic effect as commercialized Celox products in a swine femoral artery injury model. Besides, the mats are cytocompatible and degradable as well as antibacterial. This chitosan mat is a promising hemostatic material for fatal hemorrhage control.
研究领域:
生物材料
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止血
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组织工程
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生物医学工程
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shuang Cai,Linlin Wang,Xilong Cui,Xinshu Zou,Sidi Zheng,Fanhui Liu,Chun Shi,Yanhua Li,Zhiyun Zhang
The multi-drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) and complex wound microenvironment challenge the repair of MRSA infected wound. Herein, in this study, α-tocopherol modified glycol chitosan (TG) nanoparticles encapsulated with phytochemical rhein (Rhein@TG NPs) were prepared for comprehensive anti-infection and promotion of MRSA infected wound healing. Rhein@TG NPs could not only specifically release rhein in the infection site in response to low pH and lipase of infectious microenvironment, but also up-regulated M1 macrophage polarization in the infection stage, thus achieving synergistically bacterial elimination with low possibility of developing resistance. Additionally, the NPs reduced the levels of pro-inflammatory factors in the post-infection stage, scavenged the ROS, promoted cell migration and angiogenesis, which significantly improved the microenvironment of infected wound healing. Therefore, this antibiotic-free NPs enabling anti-infection and promotion of wound healing provides a new and long-term strategy for the treatment of MRSA infected wound.
研究领域:
纳米技术
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药学
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伤口愈合
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微生物学
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免疫学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Zhiwei Wen,Shuiling Qin,Huajie Huang,Xingle Xia,Wei Zhang,Wei Wu
Anthracyclines belong to a class of anti-tumor antibiotics, and their severe cardiotoxicity significantly limits their clinical use. Exosomes play key roles in intercellular communication, characterized by high biocompatibility and specific tissue and organ homing effects. In this study, doxorubicin, an anthracycline anticancer drug widely used in clinical chemotherapy, was selected as a model drug. To address the significant cardiotoxicity associated with doxorubicin, tumor exosomes are utilized as drug carriers. The homing effect of autologous exosomes enhances drug uptake by tumor cells and reduces cardiotoxicity. To enhance the stability of exosomes, improve therapeutic effectiveness, and reduce toxic side effects, chitosan was utilized to modify the surface of exosomes. Chitosan has a specific anti-tumor effect because it can target the CD44 receptor of tumor stem cells and interact with tumor cells through charge adsorption. Through in vitro cell experiments, in vivo pharmacokinetic experiments, and an in situ ectopic nude mouse tumor model, the study demonstrated that chitosan-modified tumor exosomes significantly alleviated the severe cardiotoxicity of doxorubicin, while also showing remarkable anti-tumor efficacy. This study introduces a novel approach to reduce the adverse side effects of anthracycline chemotherapeutic drugs and presents a highly promising nanocarrier delivery system.
研究领域:
药理学
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肿瘤学
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纳米技术
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药物递送系统
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DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
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2024
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IF 5.4
Shasha Zhou,Jibing He,Quan Liu,Ting Chen,Xiangheng Guan,Haihan Gao,Jia Jiang,Jiaxing Wang,Xiaochun Peng,Jinglei Wu
Itaconic acid and its derivative 4-octyl itaconate (OI) represent a novel anti-inflammatory medication that has demonstrated efficacy in multiple inflammation models because of its minimal side effects. Recently, natural polymers conjugated with small molecule drugs, known as polymer-drug conjugates (PDCs), have emerged as a promising approach to sustained drug release. In this work, we reported an approach to prepare a PDC containing an OI and make it into an injectable hydrogel. Chitosan (CS) was selected for PDC synthesis because of its abundant free amino groups that can be conjugated with molecules containing carboxyl groups by carbodiimide chemistry. We used an ethanol/water cosolvent system to synthesize a CS-OI conjugate via EDC/NHS catalysis. The CS-OI conjugate had improved water solubility and unique anti-inflammatory activity and did not show compromised antibacterial activity compared with unmodified CS. Beta-glycerophosphate (β-GP) cross-linked CS-OI hydrogel exhibited good injectability with sustainable OI release and effectively modulated inflammatory response in a rat model. Therefore, this study provides valuable insights into the design of PDC hydrogels with inflammatory modulatory properties.
研究领域:
生物材料学
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药剂学
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炎症研究
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DOI
PubMed
高影响因子
ACS Applied Nano Materials
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2024
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IF 5.3
Huawei Zhuo,Yaoyao Chen,Hongtao Xie,Xueli Huang,Vitaliy P. Guro,Kamil Tadjiev,Yizhao Li
The significant accumulation of fly ash has resulted in serious environmental issues. It is imperative to find a safe and high-value method for reusing fly ash to effectively address this problem. Additionally, silica aerogels have gained attention as a promising material for energy conservation and thermal management. However, producing a silica aerogel with low production costs and superior overall properties is still a major challenge. In this study, silica–chitosan composite aerogels (SCA) were prepared from fly ash and chitosan. Amorphous silica is polymerized in situ on chitosan by hydrogen bonding and silyl-oxygen condensation. The resulting aerogels exhibited a fully formed block structure, extremely low density, exceptional flame retardancy, and notable mechanical properties (able to withstand 24,000 times the stress of its own mass). It is noteworthy that the nanopores and three-dimensional network structure endow SCA with excellent thermal insulation performance (with a thermal conductivity of 0.0474–0.0521 W m–1 K–1). The strategy presented here provides a cost-effective and straightforward approach to prepare SCA. The results demonstrate its considerable potential for practical use in energy-efficient and thermally insulated structures. Moreover, this approach offers a direct and high value-added solution to the problem of fly ash.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-13
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IF 3.8
Mu Dehong,Zhou Li,Shi Lingyu,Liu Ting,Guo Ying,Chen Hao,Luo Hongping,Ma Junhao,Zhang Hui,Xiong Peizheng,Tian Li
Allergic rhinitis (AR) remains a major health problem worldwide. Compared with traditional oral drugs, nasal administration avoids first-pass metabolism and achieve faster and more effective efficacy. In this study, we used the ion crosslinking method to prepare quercetin–chitosan nasal adaptive nanomedicine (QCS) delivery system and evaluated in the treatment of allergic rhinitis mice models. The obtained positively charged nanoparticles with a particle size of 229.2 ± 0.2 nm have excellent characteristics in encapsulation efficiency (79.604%), drug loading rate (14.068%), drug release (673.068 μg) and stability(> 7 days). Excitingly, QCS treatment significantly reduced the number of sneezing and nasal rubbing events in AR mice, while reducing the levels of inflammatory factors such as immunoglobulin E (IgE), interleukin (IL)-17, tumor necrosis factor (TNF)-α, and (IL)-6 to alleviate AR symptoms. Hematoxylin–eosin (HE) staining also showed the damaged nasal mucosa was improved. These experimental results suggest that QCS can effectively suppress allergic inflammation in a mouse model and hold promise as a therapeutic option for allergic rhinitis.
研究领域:
药剂学
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免疫学
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生物医学工程
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DOI
PubMed
高影响因子
Bioactive Materials
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2024
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IF 18
Zhenhua Huang,Dong Zhang,Laiqiang Tong,Fan Gao,Shaozan Zhang,Xinqing Wang,Yina Xie,Fangping Chen,Changsheng Liu
Hemostatic materials are essential for managing acute bleeding in medical settings. Chitosan (CS) shows promise in hemostasis but its underlying mechanism remains incompletely understood. We unexpectedly discovered that certain protonated-chitosan (PCS) rapidly assembled plasma proteins to form protein membrane (PM) upon contact with platelet-poor plasma (PPP). We hypothesized that the novel observation was intricately related to the procoagulant effect of chitosan. Herein, the study aimed to elucidate the conditions necessary and mechanism for PM formation, identify the proteins within the PM and PCS's procoagulant action at the molecule levels. We confirmed that the amount of –NH 3 + groups (>4.9 mmol/g) on PCS molecules played a crucial role in promoting coagulation. The –NH 3 + group interacted with blood's multiple active components to exert hemostatic effects: assembling plasma proteins including coagulation factors such as FII, FV, FX, activating blood cells and promoting the secretion of coagulation-related substances (FV, ADP, etc) by platelets. Notably, the hemostatic mechanism can be extended to protonated-chitosan derivatives like quaternized, alkylated, and catechol-chitosan. In the blood clotting index (BCI) experiment, compared to other groups, PCS95 achieved the lowest BCI value (∼6 %) within 30 s. Protonated-chitosan exhibited excellent biocompatibility and antibacterial properties, with PCS95 demonstrating inhibition effectiveness of over 95 % against Escherichia coli ( E.coil ) and Staphylococcus aureus ( S. aureus ). Moreover, PCS performed enhanced hemostatic effectiveness over chitosan-based commercially agents (Celox™ and ChitoGauze®XR) in diverse bleeding models. In particular, PCS95 reduced bleeding time by 70 % in rabbit models of coagulopathy. Overall, this study investigated the coagulation mechanism of materials at the molecular level, paving the way for innovative approaches in designing new hemostatic materials.
研究领域:
生物材料
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止血
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凝血
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生物医学工程
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药理学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
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2024
·
IF 4.6
Shuang Sun,Yongyao Tan,Qikuan Cheng,Yuchen Cai,Jiaqi Zheng,Wei Wang,Lingjuan Xu,Guigang Li,Dong Wang,Lu Zhang,Yunming Wang
Flexible and wearable pressure sensors have attracted significant attention in the fields of smart medicine and human health monitoring. Nevertheless, the design and fabrication of degradable disposable pressure sensors still face urgent challenges. Herein, we fabricated poly(3-hydroxybutyrate) (PHB)-reinforced chitosan (CS) piezoelectric films for intelligent sensors through a simple, low-cost, and environmentally friendly roll-forming method. The results show that PHB doping successfully increased the effective piezoelectric coefficient of the chitosan-based film from 40.12 to 49.38 pm/V (a 23% increase). Simultaneously, the pressure sensor based on the CS/PHB film exhibited excellent response sensitivity (484 mV/kPa) and a wide linear response range (0–130 kPa), which could be used as haptic sensors and motion monitoring sensors for the fast response to human motion signals. Additionally, the CS/PHB film could be completely degraded within 18 days in a natural soil environment, demonstrating outstanding degradability. Therefore, chitosan-based piezoelectric films with excellent biodegradability and piezoelectric characteristics have been successfully fabricated in this work, which will promote the innovative development of green chitosan-based electronic devices and disposable pressure sensors.
研究领域:
材料科学
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生物医学工程
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环境科学
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传感器与执行器
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yi Li,Tian Tu,Shasha Zhou,Aixia Jiang,Jinglei Wu
Hydrogels with anti-inflammatory and antibacterial capacity have gained increasing attention in regenerative medicine. Dimethyl itaconate (DMI), a derivative of itaconic acid, exhibits powerful anti-inflammatory activity. Herein, we report a green synthesis of a chitosan-dimethyl itaconate (CS-DMI) conjugate through a nucleophilic substitution reaction, where primary amines of chitosan attack the ester carbonyl groups of DMI to form conjugation under mild alkaline conditions. The resulting conjugate was subsequently crosslinked with genipin into a hydrogel. Our findings indicate that this reaction fundamentally changed the nature of CS, converting it from acidic aqueous solution into a nearly neutral aqueous CS-DMI solution. It improved the efficiency of genipin crosslinking while maintaining the robust antibacterial activity of CS. The CS-DMI hydrogel showed sustained drug release of DMI and greater compression strength over the CS hydrogel. The CS-DMI conjugate showed good cytocompatibility, significantly promoted macrophage polarization toward an M2-like phenotype, reducing reactive oxygen species and nitric oxide production in lipopolysaccharide-stimulated macrophages. In a murine subcutaneous implantation model, the CS-DMI hydrogel significantly reduced immune cell infiltration, primarily by suppressing neutrophil recruitment and promoting a shift in macrophage polarization toward the pro-healing M2 phenotype. These findings confirm a viable strategy for developing multifunctional hydrogels that simultaneously address anti-inflammatory and antibacterial needs for modulating inflammation in regenerative medicine.
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Yang Yang,Sizhi Wu,Kailin Li,Xiao Wang,Haoling Huo,Peng Zhang,Qiwei Wang,Zhidan Lin,Lin Cao
Food spoilage, particularly in perishable meats, leads to significant economic loss and food safety concerns, while synthetic preservatives face increasing consumer scrutiny. To address the need for effective and biocompatible alternatives, this study developed a novel chlorogenic acid-grafted chitosan/acrylamide (CCAM) antibacterial hydrogel film. The film was synthesized through carbodiimide-mediated grafting followed by UV-initiated polymerization. Incorporation of chlorogenic acid produced a denser polymeric network in CCAM-1, lowering its equilibrium swelling ratio approximately 44% relative to CA‑free CCAM‑0 and elevating tensile strength to 411 kPa. The resulting CCAM‑1 exhibited potent broad‑spectrum antibacterial efficacy, inhibiting 97.97% of E. coli and 98.24% of S. aureus . The antibacterial effect was further enhanced by the pro‑oxidant activity of chlorogenic acid, which elevated intracellular ROS levels and disrupted bacterial redox homeostasis. In practical application, chicken breast wrapped with CCAM film and stored at 4 °C maintained acceptable microbial counts (< 7.0 log CFU/g) and sensory quality for up to 10 days, extending the shelf life by approximately 6 days compared to unpackaged samples. These findings demonstrate that the CCAM hydrogel film is a promising active packaging material, offering a green and efficient strategy for prolonging the shelf life of high-protein foods.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Siquan Wu,Xuan He,Xianjiao Wang,Liheng Chen,Jianglin Liu,Shuai Zhao,Xuliang Lin
Solar-driven interfacial evaporation requires photothermal materials that combine efficient solar absorption, continuous water transport, and resistance to salt accumulation. Herein, a lignin nanoparticle-reinforced chitosan hydrogel evaporator (LPCH) was constructed by integrating alkali lignin nanoparticles into a chemically cross-linked chitosan network. The uniformly dispersed lignin nanoparticles functioned as photothermal and nanoreinforcing domains, enhancing light harvesting and increasing the surface temperature to 39.5 °C under 1 sun irradiation. Interactions between the hydroxyl-rich lignin nanoparticles and chitosan regulated the water state within the hydrogel network, increasing the intermediate-water-to-free-water ratio from 0.35 for the chitosan hydrogel (CS) to 1.24 for LPCH and lowering the equivalent evaporation enthalpy to 2085 J g −1 . The optimized LPCH evaporator achieved an evaporation rate of 2.77 kg m −2 h −1 under 1 sun irradiation, together with an apparent solar-to-vapor efficiency of 152.4%. It retained an evaporation rate of 2.29 kg m −2 h −1 in 10 wt% saline water and maintained continuous operation over 10 h in simulated seawater. Outdoor tests using real seawater produced a peak evaporation rate of 3.47 kg m −2 h −1 and a daytime average rate of 2.38 kg m −2 h −1 . These results demonstrate a sustainable strategy for combining lignin-derived photothermal conversion, water-state regulation, and structural reinforcement in biomass-based solar evaporators.
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jing Jin,Yu Ren,Hua Zhou,Yujie Hou,Peng Jin,Yonghua Zheng,Zhengguo Wu
Berries, being juicy and thin-skinned, are prone to mechanical damage and microbial contamination during transportation. Therefore, developing functional cushioning packaging becomes crucial to minimize product losses. Herein, modified MXene was used to immobilize silver nanoparticles (AgNPs) and graft trans -2-hexenal (E2H), synthesizing MXene-NH 2 /AgNPs/E2H preservative. Subsequently, the CPMAE aerogel buffer packaging was obtained by MXene-NH 2 /AgNPs/E2H, chitosan and polyvinyl alcohol, and then using to the strawberry preservation. The physical entangling, electrostatic and hydrogen bonding between chitosan and polyvinyl alcohol, as well as the interaction with MXene-NH 2 /AgNPs/E2H endow CPMAE aerogel excellent buffering properties. Besides, only about 67.40 % of E2H and 5.80 % of AgNPs were released from the CPMAE aerogel after 7 days. Although the immobilization of MXene-NH 2 significantly reduced the release rate of AgNPs and E2H, the CPMAE aerogel still had excellent antioxidant (36.5 μg FeSO 4 /5 mg) and antimicrobial (reaches 99 %) capabilities. Moreover, these features enable the CPMAE aerogel buffer packaging to have an efficient fresh-keeping effect on strawberries and extend the storage time at 4 ℃ to 12 days. This study offers a novel approach for applying chitosan aerogel in buffer and antimicrobial packaging for berries.
研究领域:
食品科学
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材料科学
·
生物工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）