JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 15
·e53719
·
IF 3
Liangjie Shi,Yong Jin,Long Bai,Xiang Shang,Yupeng Li,Rong Zhou
Polymer micelles have attracted much attention in the field of controlled drug release because of their excellent hydrophobic drug solubility and fewer drug side effects. However, insufficient sensitivity, insufficient dilution resistance, and ordinary therapeutic effect severely restrict the further development of current drug-loaded polymer micelles. Here, the ditelluride group was introduced for the first time into fluorinated Gemini amphiphilic polymer (FnH12DiTeFnH12) to fabricate polymeric micelles used for controlled release. Camptothecin (CPT) loaded in the FnH12DiTeFnH12 micelles can be rapidly released in a controlled manner through the cleavage of ditelluride bonds by mild H 2 O 2 and glutathione. Meanwhile, the synergism effect of the superhydrophobicity of the fluorocarbon chain and the special Gemini structure endows the drug-loaded polymer micelles with excellent stability and drug-loading content. Moreover, the in vitro studies revealed that the CPT@FnH12DiTeFnH12 micelles exhibited efficient uptake in Hela cells. Notably, about five times lower dosage of loaded CPT had a higher tumor cells growth inhibition than the free CPT, and cell membrane permeability became better with the increase of the fluorocarbon chain length. The CPT@FnH12DiTeFnH12 micelles exhibit excellent physical and chemical properties and good therapeutic effects, indicating their excellent potential for drug delivery and providing a novel avenue for chemotherapy.
研究领域:
药学
·
高分子化学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Weihua Su,Yan Qin,Jianning Wu,Guihua Meng,Shengchao Yang,Lin Cui,Zhiyong Liu,Xuhong Guo
After cotton is invaded by cotton aphids and other pests, the function of its defense system decreases, and it is more vulnerable to infection by bacteria. When plants are invaded by external bacteria, they quickly produce reactive oxygen species (ROS). In this paper, ROS-responsive pesticide release carrier materials are designed and prepared for solving bacterial infections in plants by ring-opening polymerization of ε-caprolactone (ε-CL) and β-cyclodextrin (β-CD) to obtain a hydrophobic guest (β-CD-PCL). Thioketal (TK) was modified by adamantane (Ad) and poly(ethylene glycol) monomethyl ether (mPEG5000-OH) to form a hydrophilic guest (mPEG5000-TK-Ad). β-CD-PCL and mPEG5000-TK-Ad interact with each other to form an amphiphilic polymer (mPEG5000-TK-Ad@β-CD-PCL), which is loaded with carbendazim (MBC) by self-assembly (MBC-mPEG5000-TK-Ad@β-CD-PCL). The polymer had ROS response characteristics, and the release rate of C increased from 30 to 57% after 120 h of ROS stimulation. The inhibition rate of Rhizoctonia S. was 92.23% when the effective concentration of MBC was 30 mg/L. The critical micelle concentration (CMC) of the polymer is 8.30 mg/L, and the micelle had storage stability for at least 14 days, showing good storage stability. Therefore, this ROS-responsive polymer carrier has great potential as a carrier for antimicrobial pesticides.
研究领域:
植物病理学
·
材料科学
·
农业科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2024
·
IF 4.6
He Ren,Minchao Hao,Gengqi Liu,Jiexin Li,Zhen Jiang,Wenlu Meng,Yumiao Zhang
Photodynamic therapy (PDT) and ferroptosis show significant potential in tumor treatment. However, their therapeutic efficacy is often hindered by the oxygen-deficient tumor microenvironment and the challenges associated with efficient intracellular drug delivery into tumor cells. Toward this end, this work synthesized perfluorocarbon (PFC)-modified Pluronic F127 (PFC-F127), and then exploits it as a carrier for codelivery of photosensitizer Chlorin e6 (Ce6) and the ferroptosis promoter sorafenib (Sor), yielding an oxygen self-supplying nanoplatform denoted as Ce6-Sor@PFC-F127. The PFCs on the surface of the micelle play a crucial role in efficiently solubilizing and delivering oxygen as well as increasing the hydrophobicity of the micelle surface, giving rise to enhanced endocytosis by cancer cells. The incorporation of an oxygen-carrying moiety into the micelles enhances the therapeutic impact of PDT and ferroptosis, leading to amplified endocytosis and cytotoxicity of tumor cells. Hypotonic saline technology was developed to enhance the cargo encapsulation efficiency. Notably, in a murine tumor model, Ce6-Sor@PFC-F127 effectively inhibited tumor growth through the combined use of oxygen-enhanced PDT and ferroptosis. Taken together, this work underscores the promising potential of Ce6-Sor@PFC-F127 as a multifunctional therapeutic nanoplatform for the codelivery of multiple cargos such as oxygen, photosensitizers, and ferroptosis inducers.
研究领域:
肿瘤学
·
纳米医学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomedicine
·
2025
·
IF 3.9
Jingmei Zhou,Min Lin,Yan Mo,Ruiyue Dang,Jin Zhou,Chengmin Li,Xin Deng,Alaa Aldeen Alsaeedi,Yingqi Zhao,Juan Huang,Lijuan Ma,Xueping Feng,Yong Liu,Yunyun Wang
Aim To develop docetaxel (DTX) and triptolide (TPL) polymer micelles (DTX/TPL-PMs) with synergistic anti-cancer effect and to evaluate their anti-cancer activity.Methods DTX/TPL-PMs were prepared by thin-film hydration. The drug loading (DL%), encapsulation efficiency (EE%), and cumulative release rate (CR%) were determined using HPLC. The anti-cancer activity was assessed using CCK-8, inverted microscopy, and laser scanning confocal microscope (LSCM).Results DTX/TPL-PMs exhibited the average particle size of 178.58 ± 1.66 nm with a polydispersity index (PDI) of 0.102 ± 0.018 and a zeta potential of 1.19 ± 0.12 mV. These micelles showed a high EE% (89.43%) and a DL% (5.21%). In vitro release studies of DTX/TPL-PMs revealed that the loaded drug exhibited a slow-release phase in physiological fluids and a rapid-release phase under acidic conditions. Compared with the free DTX/TPL drugs, DTX/TPL-PMs were more readily taken up by cancer cells. The cytotoxicity of DTX/TPL-PMs was significantly higher than that of the free drugs, which showed stronger growth inhibitory effects and higher apoptosis rates in cancer cells.Conclusion The research results demonstrate that DTX/TPL-PMs enhance the therapeutic efficacy against malignancies, while reducing adverse effects. It holds potential as an effective nanotherapeutic for combination chemotherapy and represents a promising clinical strategy.
研究领域:
药剂学
·
纳米医学
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Chunpeng Yang,Huiling Ma,Ze Liang,Ying Zhuang,Litao Hu,Kexin Zhang,Leixiao Huang,Min Li,Shubiao Zhang,Yuhong Zhen
Quercetin is a natural flavonoid found in many plants which has various pharmacological activities including antitumor effect. However, the poor water solubility and bioavailability limit the potential benefits of quercetin for patients. Thus, modifying quercetin structure and developing actively targeted drug delivery systems are extremely important for tumor precision therapy. Herein, polymer-drug conjugates dextran-quercetin (D-Q) and cRGD-dextran (R-D) were synthesized by grafting quercetin and polypeptide cRGDfk (Arg-Gly-Asp-(D-Phe)-Lys) to dextran. Then cRGD-modified dextran-quercetin polymer micelles (R-D-Q) were constructed by self-assembling of D-Q and R-D. R-D-Q micelles possessed appropriate particle size (133.4 nm), nearly neutral potential (8.14 mV) and excellent drug-loading efficiency (13.1 %) and achieved higher cytotoxicity, apoptosis induction and penetration to human breast cancer MCF-7 cells than the micelles unmodified with cRGD, which were ascribed to cRGD-integrin mediated transcytosis. R-D-Q micelles effectively suppressed tumor growth in tumor-bearing mice by delivering more quercetin throughout the tumor tissue. And R-D-Q micelles could promote the apoptosis of tumor cells by activating p38 and JNK signal pathways and suppressing ERK signal pathway. In addition, R-D-Q micelles had no damage to normal tissues of mice at therapeutic dose. These results indicate promising prospects for R-D-Q micelles as an effective drug delivery system against tumor.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Suzhen Liu,Li Zhang,Xiaohong Chen,Tingting Chu,Yanzhu Guo,Meihong Niu
A novel kind of cationic cellulose- g -oligo(ε-caprolactone) amphiphilic polymer (QC- g -OCL) was obtained by homogeneous ring-opening polymerization of ε-caprolactone (ε-CL) from quaternized cellulose (QC) in 1-butyl-3-methylimidazolium chloride (BmimCl) ionic liquids. Chemical structures and properties of the copolymers were characterized by FT-IR, 1 H NMR, 13 C NMR, XRD and TGA techniques. The grafting ratios of OCL chain onto QC- g -OCL were adjusted by changing the molar ratio of CL to QC. The micelles self-assembled from QC- g -OCL were prepared by ultrasonic-assisted dissolution method, and comprehensively analyzed by dynamic light scattering (DLS), TEM and fluorescence spectroscopy techniques. The micelles were in spherical shape with average hydrodynamic radiuses (R h ) in the range of 170–237 nm. Moreover, their critical micelle concentration (CMC) values were decreased from 0.302 mg/mL to 0.089 mg/mL with increasing the degree substitution values of OCL (DS OCL ) from 0.16 to 0.60. The ζ-potentials of micelles in water were ranged from 37.2 mV to 48.3 mV, indicating that the shells of micelles were constituted by ationic quaternary ammonium group. All of these findings established that the cationic cellulose-based micelles would be a promising aqueous carrier for hydrophobic drug.
研究领域:
材料科学
·
药物传递系统
✓ 已验证
DOI
高影响因子
MATERIALS RESEARCH INNOVATIONS
·
2024
·
IF 0
Shuai Li,Hongzhu Lai,Li Jiang,Wenyan Huang,Hongjun Yang,Qimin Jiang,Bibiao Jiang
Polymeric patchy micelles (PPMs) are nanostructures with distinct regions on their surfaces, offering unique properties for various applications. Herein, we present a straightforward method for monitoring the structure of PPMs formed via non-covalent post-assembly modification (NCPAM). By employing 1-pyrenemethylamine, a pyrene-based molecule, as both a modifier and fluorescent probe, we demonstrate that the formation of PPMs with a higher order aggregation state of pyrene induces a stronger pyrene excimer emission. This leads to variations in the excimer-to-monomer emission ratio, serving as a parameter for studying structural changes in PPMs during NCPAM. In situ monitoring of PPM formation and temperature-dependent transformations is achieved using fluorescent analytical method, providing valuable insights into their structural evolution and dynamic behaviour. This study offers a straightforward approach to understanding and controlling PPM structures, facilitating the design of advanced nanomaterials for diverse applications.
研究领域:
材料科学
·
化学
·
纳米技术
✓ 已验证
DOI
ACS Biomaterials Science & Engineering
·
2020
·
IF 4.152
Yanzhe Qin,Xinwen Peng
Patients with cancer suffer from severe side effects and reduced life quality, as chemotherapeutic drugs are cytotoxic toward normal cells as well as toward cancer cells. In recent years, nanoparticles have been explored as targeted drug delivery systems; however, problems such as toxicity and instability prevent their practical application. Here, we report the synthesis of cholesteryl–carboxymethyl xylan (CCMX) via an esterification reaction between the carboxyl group of carboxymethyl xylan and the hydroxyl group of cholesterol to form biocompatible micelles as a vehicle for targeted drugs. With its critical micelle concentration (CMC) depending on the degree of substitution (DS) of cholesteryl and ranging from 0.0024 to 0.017 mg/mL, CCMX could self-assemble and form nanoscale micelles in aqueous media. Taking doxorubicin (DOX) as a model drug, the drug encapsulation efficiency (EE%) of CCMX-3 (DS of 0.35 for cholesteryl) reached 91.3%, and this system exhibited excellent internalization ability, as verified by tumor cellular uptake tests. The results of in vitro cytotoxicity and in vivo antitumor activity tests of nude mice demonstrated that CCMX-3/DOX micelles effectively suppressed the growth of tumor cells by maintaining the cytotoxicity of commercial DOX injection while reducing the toxicity against normal cells and increasing the survival time.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2019
·Vol. 19
·期 9
·5456-5462
·
IF 1.093
Jie Liyong,Lang Dan,Kang Xuqi,Yang Zhixin,Du Yongzhong,Ying Xiaoying
The magnetic resonance imaging diagnosis and high-efficiency tumor targeting treatment are of notable importance for cancer therapy. In this study, starch-octanoic acid (ST-OA) micelles were successfully prepared to co-encapsulate the anti-tumor drug doxorubicin (DOX) and superparamagnetic
iron oxide nanoparticles (SPIONs), taking advantage of the hydrophobic core of the core–shell micellar structure. Size distribution, morphology and in vitro release behaviors of micelles were investigated. In addition, magnetic properties and the anti-tumor theranostic performance
were confirmed by conducting the cellular uptake, in vivo imaging and anti-tumor activity experiments. Therefore, co-encapsulation and specific delivery of the chemotherapeutic drug and contrast agent into tumor cells can realize the diagnosis and treatment of malignant tumor at the
same time.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2018
·
IF 4.556
Yun Zhu,Tingting Meng,Yanan Tan,Xiqin Yang,Yupeng Liu,Xuan Liu,Fangying Yu,Lijuan Wen,Suhuan Dai,Hong Yuan,Fuqiang Hu
The critical process and step in achieving effective antitumor therapies is facilitating endosomal escape, which can enhance the intracellular target delivery of therapeutics. However, the normally adopted approaches tend to result in colloidal instability as a result of the inevitable interactions between the resulting positively charged surfaces of micelles and proteins in vivo. Herein, negatively charged surface shielded polymeric micelles, consisting of polymethylacrylamide derivatives and hydrophilic chitosan (Mw = 18.8 kDa) linked by 3,3′-dithiodipropionic, are constructed. Until the pH decreases to less than 4.5, the DOX-loaded polymeric micelles (CSO-SS-PDPA/DOX) retain a negative surface charge as a result of the abundant amide groups, which could resist formation of the protein “corona” as visualized by transmission electron microscopy. Robust endosomal escape within tens of minutes due to protonated amine groups and specific redox-responsive drug release is visualized by confocal microscopy. The superior therapeutic efficacy in both 3D tumor spheroids and MCF-7 bearing mice further suggested that the prepared CSO-SS-PDPA/DOX is a promising approach for maintaining colloidal stability while achieving intracellular endosomal/lysosomal escape, which opens new opportunities for drug delivery.
研究领域:
药剂学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2017
·
IF 5.246
Kun Zhang,Yong-Guang Jia,I-Huang Tsai,Satu Strandman,Li Ren,Liangzhi Hong,Guangzhao Zhang,Ying Guan,Yongjun Zhang,X. X. Zhu
Natural compounds glucosamine and cholic acid have been used to make acrylic monomers which are subsequently used to prepare amphiphilic block copolymers by reversible addition–fragmentation chain transfer (RAFT) polymerization. Despite the striking difference in polarity and solubility, three diblock copolymers consisting of glucosamine and cholic acid pendants with different hydrophilic and hydrophobic chain lengths have been synthesized without the use of protecting groups. They are shown to self-assemble into polymeric micelles with a “bitter” bile acid core and “sweet” sugar shell in aqueous solutions, as evidenced by dynamic light scattering and transmission electron microscopy. The critical micelle concentration varies with the hydrophobic/hydrophilic ratio, ranging from 0.62 to 1.31 mg/L. Longer chains of polymers induced the formation of larger micelles in range of 50–70 nm. These micelles can solubilize hydrophobic compounds such as Nile Red in aqueous solutions. Their loading capacity mainly depends upon the hydrophobic/hydrophilic ratio of the polymers, and may be also related to the length of the hydrophilic block. These polymeric micelles allowed for a 10-fold increase in the aqueous solubility of paclitaxel and showed no cytotoxicity below the concentration of 500 mg/L. Such properties make these polymeric micelles interesting reservoirs for hydrophobic molecules and drugs for biomedical applications.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2016
·
IF 5.583
Weifeng Lin,Guanglong Ma,Nir Kampf,Zhefan Yuan,Shengfu Chen
Blood stability, active targeting, and controlled drug release are the most important features to design desirable drug carriers. Here, we demonstrate a zwitterionic biodegradable cross-linked micelle based on a penta-block copolymer, which utilizes poly(carboxybetaine methacrylate) as hydrophilic segment, poly(ε-caprolactone) as biodegradable hydrophobic segment, poly(S-2-hydroxyethyl-O-ethyl dithiocarbonate methacrylate) (PSODMA) block as thiol protecting segment for cross-linking, and cyclic Arg-Gly-Asp-d-Tyr-Lys [c(RGDyK)] as targeting ligand. As a result, this micelle possessed excellent colloidal stability at high dilution and in 50% fetal bovine serum. In vitro drug release experiment showed no burst release under physiological conditions but accelerated drug release in mimicking tumor tissue environment. In vivo tests showed that the drug-loaded micelles had prolonged half-life in bloodstream, enhanced therapeutic efficiency, and reduced cardiac toxicity and biotoxicity compared with free drug formulation. Taken together, the reported c(RGDyK)-modified zwitterionic interfacially cross-linked micelle has emerged as an appealing platform for cancer therapy.
研究领域:
药剂学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）