POLYMER
·
2021
·
IF 4.43
Bing-Zi Yang,Shu-Ya Zhang,Ping-Hua Wang,Chun-Hua Liu,Yuan-Yuan Zhu
Hydrogel actuators belong to a type of smart soft materials which can take place anisotropic thrust and/or displacement under various environmental stimuli including thermal, light, pH, humidity etc . Robust strength and rapid response are of critical importance to high-performance hydrogel actuators. Here we report the syntheses and investigations of mechanical properties for series novel organic-inorganic hydrogels by using vinyl functionalized silicon nanoparticles (SiNPs) as the cross-linker. The doped SiNPs significantly enhance the mechanical strength of polyacrylamide (PAAm) hydrogels. Furthermore, the SiNPs composite poly- N -isopropylacrylamide (PNIPAm) hydrogels exhibit rapid response in deswelling and swelling behaviours. The excellent mechanical and responsive properties are attributed to the enhanced rigidity via SiNPs doping into the hydrogel network and the improved water diffusion through mPEG branch chains on the surface of nanoparticles , respectively. As a proof of concept, a bilayer PNIPAm@PAAm hydrogel actuator is facilely synthesized via an in-situ polymerization process. This composite hydrogel actuator shows extremely fast response rate of directional bending in hot water, about 6 times faster than the control without doping of SiNPs. This work demonstrates that these SiNPs composite hydrogels provide enhanced mechanical and responsive performances and may expand the future applications in smart hydrogel materials.
研究领域:
材料科学
·
纳米技术
·
智能材料
·
高分子化学
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DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 21
·11489-11496
·
IF 6.895
Yiming Wang,Jinjin Zeng,Lingwei Wang,Yuanmin Yuan,Qingbiao Li,Jianning He,Ling Lin,Ning He
Oil pollution is one of the main environmental problems that is attracting increasing attention from people. In this study, a new composite, namely a PNIPAm-Clay-γPGA-SiO2 (PCPS) nanomaterial, was prepared through chemical modification. The material exhibited excellent separation efficiencies for both oil-in-water (O/W) and water-in-oil (W/O) emulsions. The maximum separation efficiency of the W/O emulsion reached 98.70%, while that of the O/W emulsion was 99.23%, and the average separation fluxes were 107.44 L m−2 h−1 and 1529.34 L m−2 h−1, respectively. The superhydrophobicity of the PCPS nanoparticles could be maintained under strong acid/alkali conditions for over 30 days. The high separation efficiency could be maintained even after 7 cycles, indicating the long-term availability of the material. Furthermore, the PCPS nanoparticles showed excellent biocompatibility due to the presence of γ-polyglutamic acid (γPGA) and poly(N-isopropylacrylamide) (PNIPAm). The properties of strong acid/alkali and thermal stabilities, recyclability, and biocompatibility gave the material great potential for applications.
研究领域:
环境科学
·
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
Colloid and Interface Science Communications
·
2020
·
IF 2.831
Hui Xue,Ziqing Zhao,Siqi Chen,Hui Du,Rui Chen,John L. Brash,Hong Chen
The availability of biocompatible, anti-bacterial coatings is of extreme importance for the development of biomedical devices. However, it has proven to be difficult to achieve both biocompatibility and bactericidal properties simultaneously. In the present work, as a novel, alternative approach, a quaternary ammonium salt-based poly(N-isopropylacrylamide) (QAS-PNIPAM) microgel was used both as the bactericidal agent and as an anchor system for the attachment of a cyto-compatibility-enhancing component. QAS-PNIPAM microgels were first prepared as thin films on silicon wafer. The QAS component of the film, as well as having strong inherent bactericidal properties, also provided binding sites for attachment of a glycopolymer containing sulfonate groups via attractive electrostatic interactions . It was shown that introduction of the sugar units improved the cytocompatibility of the microgel film without compromising its bactericidal efficacy. It is proposed that such microgel coatings may serve more generally as intermediates for the attachment of biofunctional components to biomaterial surfaces.
研究领域:
材料科学
·
生物材料
·
生物医学工程
·
聚合物化学
·
表面科学
✓ 已验证
产品关联
DOI
高影响因子
Molecular Catalysis
·
2026
·
IF 4.3
Wenhui Li,Jiajia Chen,Jiaolong Fu,Zhi Chen,Xin Ju,Liangzhi Li
Design and fabrication of multifunctional charge-tunable hydrogel carriers. • Molecular docking reveals hydrogen bonding mechanisms in charge-assisted non-covalent immobilization. • PASP/PNIPAM-immobilized enzymes retain 89.7% initial activity after six cycles. • A novel biocatalytic pathway for D-xylose enables efficient rare sugar production. Immobilization of enzymatic cascades is an important tool for the efficient production of value added products, such as rare sugars from biomass monosaccharides. However, there is a lack of biocompatible and inexpensive immobilization carriers with high reusability in immobilizing multiple enzyme proteins currently. In this study, poly-N-isopropylacrylamide (PNIPAM) hydrogels were fabricated and employed to immobilize the enzymatic cascade of glucose isomerase (GI) and D-tagatose-3epimerase (DTE) for the conversion of D-xylose to rare sugar products, D-xylulose and D-ribulose. To attain stable protein attachment and high reusability, PNIPAM microspheres were further grafted by polyaspartic acid (PASP), polyethylene glycol (PEG), polylysine (PL), and anionic polyacrylamide (APAM), obtaining composite hydrogels with tailored surface charges to achieve effective non-covalent immobilization. The enzymatic cascades immobilized by modified PNIPAM hydrogels demonstrated improved thermal stability in the range of 40–70 °C with prolonged enzyme half-lives, and higher conversion of D-xylose. After 6 recycles, PASP/PNIPAM-GI-DTE retained 89.7% initial activity which was superior in enzyme immobilization by PNIPAM. Molecular simulation studies revealed that PASP/PNIPAM formed stable hydrogen bonds with GI and DTE, rationalizing its superior performance. This work proved charge aided immobilization of proteins as a feasible strategy for the production of biomass derived high value chemicals, and provided a practical protocol for industrial scale biomanufacturing. Download: Download high-res image (204KB) Download: Download full-size image
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DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2019
·Vol. 304
·期 7
·1900087
·
IF 3.038
Sirui Jiang,Kang Wang,Yu Dai,Xiaojin Zhang,Fan Xia
Gold nanorod (AuNR)-embedded poly( N -isopropylacrylamide) (PNIPAM) hydrogels offer the possibility of achieving near-infrared (NIR) light-triggered drug release. In addition, using nanoparticles as a crosslinker can enhance the mechanical properties of PNIPAM hydrogels, and nanoparticle-crosslinked hydrogels provide an important approach for dual drug release. Here, NIR light-triggered dual drug release using AuNR-embedded thermosensitive nanogel-crosslinked hydrogels is reported for the first time. Two kinds of drugs are encapsulated, one in the nanogel and the other in the hydrogel. The volume phase transition of the PNIPAM hydrogels is induced by NIR light by utilizing the photothermal effect of AuNRs. By changing the number of embedded AuNRs and the intensity of NIR light, the release rate and drug quantity can be adjusted for on-demand release. Because of its NIR light-triggering and nanoparticle-crosslinking capabilities, AuNR-embedded thermosensitive nanogel-crosslinked hydrogels may expand the application scope of hydrogels and provide enhanced properties in their applications.
研究领域:
材料科学
·
纳米技术
·
药学
·
生物医学工程
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产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Huimin Li,Huanhuan Dong,Xudong Wu,Lei Li,Wenli Zhou,Zhaoyang Li,Qing Wang,Ke Chen,Tao Chen,Wenkun Zhu
Atmospheric Water Harvesting (AWH) is considered a promising approach aimed at addressing global water scarcity by extracting water from the air, which is particularly suitable for arid and water scarce regions. Here, we report an ultrahygroscopic polymer hydrogel bead (SC-LiCl/PNIPAM, SCLP) composed of renewable biomasses, hygroscopic salt, and temperature sensitive materials to extract water vapor from arid climates. Sodium alginate and carboxymethyl cellulose endow a 3D porous structure with enlarged polymer–air interfaces, enabling efficient water capture and vapor transport. Thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) can achieve phase transition under daylight conditions to assist the release water collected by hydrogels via hydrophobic interactions. Impressively, SCLP hydrogel beads display a maximum water uptake of up to 9.93 g/g–1 at a relative humidity of 90% and also demonstrate excellent water absorption and release properties in natural conditions. By virtue of plant cultivation experiments and 16S rRNA (16S rRNA), the introduction of SCLP hydrogel beads can effectively capture water from the atmosphere to alter the distribution of dominant populations of soil communities and enhance the activity of defensive enzymes, thereby alleviating the wide impact of drought stress on plant growth. This work provides a feasible prospect for large-scale manufacturing of hygroscopic hydrogels and the ecological restoration of barren slope areas.
研究领域:
环境科学
·
材料科学
·
高分子科学
·
农业工程
·
生态修复
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Ling Zhou,Xue-feng Tao,Li-sheng Tang,Ming-Bo Yang,Wei Yang
The incorporation of porous supporting materials to prepare shape-stable phase change materials (PCMs) is of great interest in recent years. However, extensive reported composite PCMs are shape-stable in the air atmosphere but neglected in the water environment. To develop shape-stable and waterproof PCMs is important for their outdoor applications but challenging. Herein, we report a novel cellulose nanocrystal/poly(N-isopropylacrylamide) (CNC/PNIPAM) gel-supported hexadecanol (H-anol) PCM with good thermal storage properties and excellent shape stability in both air and water environments. The CNC/PNIPAM hydrogel is prepared through an ultraviolet-induced C═C cross-linking reaction, and its physical structure and mechanical properties are well characterized. H-anol is then directly immerged into the CNC/PNIPAM alcogel by a facile and low-cost solvent-exchange strategy. The mechanism of the solvent-exchange strategy has been established. Because of the temperature-sensitive hydrophilic/hydrophobic transform behavior of the CNC/PNIPAM network, the CNC/PNIPAM/H-anol PCM displays excellent shape stability in a water environment by forming a dense hydrophobic surface, providing it with great potential in all-weather thermal energy storage applications.
研究领域:
材料科学
·
能量存储
·
复合材料
·
高分子化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATHEMATICAL PROBLEMS IN ENGINEERING
·
2022
·
IF 1.43
Shi Yifang,Lingling Huang,Xiao Wang,Yanru Li,Runqing Shen
It is critical to develop drug carriers for intelligent drug delivery systems. Normally, the drug carriers of the intelligent drug delivery system are stimulus-responsive polymers. However, as drug carriers, the biocompatibility of the materials should be the primary consideration. In this work, two smart drug systems were prepared using natural protein materials (silk and wool) as drug carriers and poly(N-isopropylacrylamide) (PNIPAM) as a functional additive material. (1) Silk fibroin (SF)/wool keratin (WK) composite films: the differences in drug release efficiency of composite films are based on the different crystallinity of composite films. Analysis of the XRD results showed that the content of the β-crystallite structure in different proportions of the composite films changed from 38.3% to 19.5%. The percentage of drugs released of the mixed films with different proportions ranged from 28% to 58% after eight hours of release, showing a gradient release. (2) SF/WK and PNIPAM composite films: the particle size of the PNIPAM microspheres changed with the temperature. The particles’ size of the prepared PNIPAM microspheres was reduced from 700 nm to 300 nm from 25°C to 35°C. After eight hours of release, the composite films with temperature-sensitive microspheres increased the percentage of drug released by up to 20% compared with the composite films without microspheres when the temperature was ranged from 25°C to 37°C. The result of drug release showed the amount of drug released could be changed with temperature stimulation, which could satisfy people’s controllable requirements for the time, location, and dose of drug release.
研究领域:
药学
·
材料科学
·
生物技术
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产品关联
DOI
高影响因子
Materials Today Bio
·
2022
·
IF 10.761
Xueqing Hao,Jielong Zhou,Juning Xie,Xianrui Zou,Baoe Li,Chunyong Liang,Yu Zhang,Feng Peng,Donghui Wang
Preferable antibacterial property and osteogenesis are the permanent pursuit for metallic implants. However, it is difficult to satisfy both the properties. In fact, implants may be contaminated with bacteria during storage and surgery, leading to inflammation. Therefore, the antibacterial property of biomaterial surfaces is required not only in the human environment but also at room temperature. In this study, porous structures loaded with a thermosensitive poly ( N -isopropylacrylamide) (PNIPAM) hydrogel on a nitinol (NiTi) substrate were constructed. When the temperature is 25 °C, almost all bacteria cannot adhere to the sample surface due to the abundant hydration layer of the PNIPAM hydrogel. Meanwhile, when the temperature is 37 °C, the structure of the PNIPAM hydrogel collapses and the hydration layer disappears due to the temperature change. However, the porous structures lock water in the pores, which results in a high-hydration-rate sample surface. This surface has few bacterial adhesion sites; nevertheless, the adhesion of larger cells to the surface is not impeded by the porous structure. In addition, the PNIPAM hydrogel is soft and biocompatible, so the sample can have better cell adhesion and proliferation than a bare NiTi alloy. Based on these results, it can be concluded that the porous NiTi sample loaded with the thermosensitive PNIPAM hydrogel has the antibacterial property before implantation and the dual function of inhibiting bacterial adhesion and promoting cell adhesion and proliferation after implantation, which shows promising applications in the biomedical field such as orthopedic implantation.
研究领域:
生物材料
·
生物医学工程
·
骨科
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2013
·Vol. 57
·期 3
·417-425
·
IF 1.327
Yin Jun,He YaGuang,Li Wei,Wu ZongQuan,Ding YunSheng
We report on the fabrication of a class of surface-enhanced Raman scattering (SERS) active thermometers, which consists of 60 nm gold nanoparticles, encoded with Raman-active dyes, and a layer of thermoresponsive poly( N -isopropylacrylamide) (PNIPAM) brush with different chain lengths. These SERS-active nanoparticles can be optimized to maintain spectrally silent when staying as single particles in dispersion. Increasing temperature in a wide range from 25 °C to 55 °C can reversibly induce the interparticle self-aggregation and turn on the SERS fingerprint signals with up to 58-fold of enhancement by taking advantage of the interparticle plasmonic coupling generated in the process of thermo-induced nanoparticles self-aggregation. Moreover, the most significative point is that these SERS probes could maintain their response to temperature and present all fingerprint signals in the presence of a colored complex. However, the UV-vis spectra can distinguish the differences faintly and the solution color shows little change in such complex mixture. This proof-of-concept and Raman technique applied here allow for dynamic SERS platform for onsite temperature detection in a wide temperature range and offer unique advantages over other detection schemes.
研究领域:
纳米技术
·
材料科学
·
分析化学
·
温度传感
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产品关联
DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2016
·
IF 2.624
Jian Qin Zhou,Ting He,Jian Wen Wang
Microbial transglutaminase (mTG) is widely utilized in the PEGylation of pharmaceutical proteins. mTG immobilization can be achieved via covalent bonding on solid supports. However, the catalytic efficiency of mTG immobilized on solid supports was significantly reduced by mass transfer limitation. To overcome this limitation, mTG was covalently immobilized on the thermo-responsive carboxylated poly( N -isopropylacrylamide) (pNIPAM). The pNIPAM-mTG conjugate exhibited reversibly solubility in aqueous solution with a low critical solution temperature (LCST) at 39 °C, i.e., it was insoluble above 39 °C and soluble below 39 °C. The pH dependence of the pNIPAM-mTG conjugate was similar with that of the native mTG. Upon conjugation to pNIPAM, the optimal temperature of mTG shifted down from 50–55 °C to 40–45 °C, and the thermal stability of the conjugate was elevated. The easy separation of the pNIPAM-mTG conjugate with its substrate and the catalytic efficiency of the pNIPAM-mTG conjugate were demonstrated by employing the pNIPAM-mTG conjugate to cross-link bovine serum albumin (BSA) and catalyze PEGylation of therapeutic protein, cytochrome c (Cyt C), respectively. The thermo-responsive mTG is suitable to modify proteins in food processing and biomedical engineering.
研究领域:
生物技术
·
生物化学
·
食品加工
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2011
·
IF 3.603
Jiucun Chen,Mingzhu Liu,Honghong Gong,Yinjuan Huang,Chen Chen
A well-defined thermoresponsive poly(ethylene glycol)-block-poly(N-isopropylacrylamide)-block-poly(ε-caprolactone) (PEG43-b-PNIPAM82-b-PCL87) triblock copolymer was synthesized by combination of atom transfer radical polymerization (ATRP), ring-opening polymerization (ROP), and click chemistry. The synthesis included the four steps, and all the structures of the polymers were determined. The thermoresponsive triblock copolymer can disperse in water at room temperature to form core–shell–corona micelles with the hydrophobic PCL block as core, the thermoresponsive PNIPAM block as shell, and the hydrophilic PEG block as corona. At temperatures above the lower critical solution temperature (LCST) of the PNIPAM block, the PNIPAM chains gradually collapse on the PCL core to shrink the size and change the structure of the resultant core–shell–corona micelles with temperature increasing.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）