Nature Communications
·
2026
·
IF 18.1
Yu Hongwei,Xin Xing,Ge Jiawen,Luo Yunyun,Cui Yanming,Zang Xu-Feng,Xu Tonghui,Zheng Tianle,Mandic Zoran,Xia Yongyao,Zhou Mingjiong
Lithium metal batteries offer a pathway toward next-generation energy storage due to their high specific energy. However, their implementation remains challenging, particularly under lean electrolyte conditions, where unstable interfaces and inefficient ion transport severely limit cycling stability. Here, we show a bifunctional ligand-bridged electrolyte by integrating ethyl difluoroacetate into a lithium nitrate/triethyl phosphate matrix. Incorporating ethyl difluoroacetate as a dynamic bridging agent drives the formation of interconnected ionic aggregates through synergistic H δ+ − O δ− hydrogen bonding with anions and coordination interactions with Li⁺, thereby accelerating interfacial kinetics and suppressing parasitic reactions. The electrolyte further enables weakly coordinating solvents to engage in the solvation sheath via non-classical hydrogen bonding, facilitating the formation of a robust, inorganic-rich solid electrolyte interphase. This design enables the realization of high-capacity (14 Ah) Li ‖ Ni95 pouch cells, which achieve a specific energy of 606.8 Wh kg −1 while maintaining 92.9% capacity retention after 75 cycles at rates of 0.1 C/0.2 C. These findings demonstrate a viable electrolyte strategy for enabling high-performance lithium metal batteries under practical conditions.
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高影响因子
Marine Drugs
·
2023
·Vol. 21
·期 2
·133
·
IF 5.4
Congling Liu,Gong Chen,Hailian Rao,Xun Xiao,Yidan Chen,Cuiling Wu,Fei Bian,Hailun He
Crude enzymes produced by a marine bacteriumPseudoalteromonassp. JS4-1 were used to hydrolyze phycobiliprotein. Enzymatic productions showed good performance on DPPH radical and hydroxyl radical scavenging activities (45.14 ± 0.43% and 65.11 ± 2.64%, respectively), especially small peptides with MWCO <3 kDa. Small peptides were fractioned to four fractions using size-exclusion chromatography and the second fraction (F2) had the highest activity in hydroxyl radical scavenging ability (62.61 ± 5.80%). The fraction F1 and F2 both exhibited good antioxidant activities in oxidative stress models in HUVECs and HaCaT cells. Among them, F2 could upregulate the activities of SOD and GSH-Px and reduce the lipid peroxidation degree to scavenge the ROS to protectCaenorhabditis elegansunder adversity. Then, 25 peptides total were identified from F2 by LC-MS/MS, and the peptide with the new sequence of INSSDVQGKY as the most significant component was synthetized and the ORAC assay and cellular ROS scavenging assay both illustrated its excellent antioxidant property.Keywords:phycobiliprotein;antioxidant peptide;bacterial extracellular protease;enzymatic hydrolyzation;C. elegans
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RSC Advances
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2023
·Vol. 13
·期 17
·11432-11440
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IF 3.9
Yang Hu,Huazhang Zhang,Jing Zhou,Jie Shen,Binbin Chen,Ang Li,Wen Chen
The ferroelectric behavior of Bi1/2(Na0.8K0.2)1/2TiO3 has been tailored by Eu3+ doping and the intermediate relaxor state is utilized for tristate ferroelectric memory effect. As Eu3+ content increases, the local structural disorder tends to get enhanced and the stability of ferroelectric order gets weakened. The disruption effect of Eu3+ is manifested structurally in XRD and PL spectra, and electrically in the ferroelectric, dielectric and piezoelectric properties. We found that the BNKT:3.0%Eu which owns a relaxor state under electrical cycle would be suitable for tristate ferroelectric memory, where two ferroelectric states and the relaxor state are respectively served as the “±1” and “0” memory states. We designed the verification experiments, and the results show good feasibility and stability. Moreover, it is innovative using PL spectra of Eu3+ to understand the structural changes related to different memory states, owning to its sensitivity to local structural symmetry. It also implies the possibility for non-destructive optical readout.
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CNS Neuroscience & Therapeutics
·
2023
·Vol. 29
·期 6
·1667-1677
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IF 5.5
Yuhua Chen,Wei He,Hong Wei,Cuicui Chang,Lingjian Yang,Jiao Meng,Tianlin Long,Quanhua Xu,Chi Zhang
Aim Ferroptosis is increasingly becoming to be considered as an important mechanism of pathological cell death during stroke, and specific exogenous ferroptosis inhibitors have the ability to reverse cerebral ischemia/reperfusion injury. However, research on Srs11-92 (AA9), a ferrostatin-1 (Fer-1) analog, in preclinical studies is limited. Methods In the middle cerebral artery occlusion-reperfusion (MCAO/R) mice model or oxygen–glucose deprivation/reperfusion (OGD/R) cell model, Fer-1, AA9, and/or ML385 were administered, and brain infarct size, neurological deficits, neuronal damage, oxidative stress, and neuroinflammation were determined after the damage, in vitro and in vivo. Results Fer-1 and AA9 improved brain infarct size, neuronal damage, and neurological deficits in mice model of MCAO/R, and inhibited the overloaded iron deposition, ROS accumulation, and neuroinflammation response: it also increased the expression of GPx4, Nrf2, and HO-1 and suppressed the expression of HMGB1 and NF-κB p65 in the epicenter of injured hippocampal formation. However, Nrf2 inhibitor ML385 reversed the neuroprotective effect of AA9, including the oxidative stress and neuroinflammation. In vitro studies showed that AA9 relieved OGD/R-induced neuronal oxidative stress and neuroinflammation via the Nrf2 pathway, which was impaired by ML385 in primary neurons. Conclusion The findings imply that Fer-1 analog AA9 may be suitable for further translational studies for the protection of neuronal damage via Nrf2 signal pathway-mediated oxidative stress and neuroinflammation in stroke and others neurological diseases.
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Small
·
2023
·Vol. 19
·期 29
·2207436
·
IF 13.3
Qing Yu Liu,Ying Wu,Zhen Qi Bu,Min Xia Quan,Jiao Yang Lu,Wei Tao Huang
Bimetallic nanomaterials (BNMs) have been used in sensing, biomedicine, and environmental remediation, but their multipurpose and comprehensive applications in molecular logic computing and information security protection have received little attention. Herein, This synthesis method is achieved by sequentially adding reactants under ice bath conditions. Interestingly, Ag-Cr NPs can dynamically selectively sense anions and reductants in multiple channels. Especially, ClO − can be quantitatively detected by oxidizing Ag-Cr NPs with detection limits of 98.37 nM (at 270 nm) and 31.83 nM (at 394 nm). Based on sequential-dependent synthesis process of Ag-Cr NPs, Boolean logic gates and customizable molecular keypad locks are constructed by setting the reactants as the inputs, the states of the resulting solutions as the outputs. Furthermore, dynamically selective response patterns of the Ag-Cr NPs can be converted into binary strings to exploit molecular crypto-steganography to encode, store, and hide information. By integrating the three dimensions of authorization, encryption, and steganography, 3 in 1 advanced information protection based on Ag-Cr nanosensing system can be achieved, which can enhance the anti-cracking ability of information. This research will promote the development and application of nanocomposites in the field of information security and deepen the connection between molecular sensing and the information world.
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BIOCHEMICAL PHARMACOLOGY
·
2023
·
IF 5.8
Lin Zhao,Bingling Zhong,Yanyan Zhu,Haoyi Zheng,Xumei Wang,Ying Hou,Jin-Jian Lu,Nana Ai,Xiuli Guo,Wei Ge,Yan-Yan Ma,Xiuping Chen
Glioblastoma multiforme (GBM) is one of the most lethal malignant tumors in the human brain, with only a few chemotherapeutic drugs available after surgery. Nitrovin (difurazone) is widely used as an antibacterial growth promoter in livestock. Here, we reported that nitrovin might be a potential anticancer lead. Nitrovin showed significant cytotoxicity to a panel of cancer cell lines. Nitrovin induced cytoplasmic vacuolation, reactive oxygen species (ROS) generation, MAPK activation, and Alix inhibition but had no effect on caspase-3 cleavage and activity, suggesting paraptosis activation. Nitrovin-induced cell death of GBM cells was significantly reversed by cycloheximide (CHX), N-acetyl-l-cysteine (NAC), glutathione (GSH), and thioredoxin reductase 1 (TrxR1) overexpression. Vitamins C and E, inhibitors of pan-caspase, MAPKs, and endoplasmic reticulum (ER) stress failed to do so. Nitrovin-triggered cytoplasmic vacuolation was reversed by CHX, NAC, GSH, and TrxR1 overexpression but not by Alix overexpression. Furthermore, nitrovin interacted with TrxR1 and significantly inhibited its activity. In addition, nitrovin showed a significant anticancer effect in a zebrafish xenograft model, which was reversed by NAC. In conclusion, our results showed that nitrovin induced non-apoptotic and paraptosis-like cell death mediated by ROS through targeting TrxR1. Nitrovin might be a promising anticancer lead for further development.
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International Journal of Nanomedicine
·
2023
·
IF 8
Wenshu Cheng,Xinyue Xu,Yuanyuan Lang,Zugen Cheng,Mohammad Rizwan,Xiaomin Tang,Lixin Xie,Yanling Liu,Hengyi Xu,Yang Liu
Purpose To evaluate the effects of anatase and rutile TiO2 nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms.Methods Three-week-old male rats were orally administered anatase TiO2 NPs and rutile TiO2 NPs for 28 days. The indicators of rat growth and development, liver function, bone metabolism, and insulin-like growth factor-1 (IGF-1) levels were evaluated. Micro-computed tomography (micro-CT) and immunohistochemistry were used to evaluate the tibia.Results No significant differences were observed among growth and development indicators in young rats. Significant differences were found in IGF-1 levels, phosphorus levels, and liver function. Micro-CT revealed osteoporosis in the bones. The micro-CT data supported the same result. Bone immunohistochemistry results showed that the expression of osteoprotegerin (OPG) was decreased and the expression of receptor activator of nuclear factor-κB ligand (RANKL) and cathepsin K (CTSK) was increased.Conclusion This study demonstrated that TiO2 NPs can damage bones via the IGF-1/OPG/RANKL/CTSK pathway in young rats. Furthermore, rutile TiO2 NPs damaged the bones more seriously than anatase TiO2 NPs.
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JOURNAL OF CATALYSIS
·
2023
·
IF 7.3
Yuexia Wang,Qibin Yao,Bowen Xu,Kehang Lin,Mengshan Deng,Xinqing Lu,Rui Ma,Yanghe Fu,Weidong Zhu
Although the oxidative hydration of ethylene with hydrogen peroxide (H 2 O 2 ) to ethylene glycol (EG) over Ti-MWW zeolites take advantages of step-saving and facile operation, both H 2 O 2 utilization efficiency and EG yield are relatively low, because some extra-framework octahedral Ti species are usually formed in the Ti-MWW zeolites synthesized by prevailing methods, which are detrimental to selective oxidation . In the present work, an acid-modulated isomorphous substitution method, i.e. , layered borosilicate MWW-type zeolite (ERB-1) treated with HNO 3 aqueous solution containing tetrabutyl orthotitanate (TBOT), is developed to synthesize a Ti-MWW zeolite without extra-framework octahedral Ti species under the optimized synthesis conditions. In combination with the results from extensive characterizations for the synthesized zeolites, it is found that in the zeolite prepared by the currently developed synthesis method there are more open Ti(OSi) 3 OH sites formed, resulting in the stronger Lewis acidity that is very helpful to EG production from the oxidative hydration of ethylene with H 2 O 2 , compared to the one synthesized by the prevailing method. Moreover, the developed catalyst is recyclable after the regeneration of the deactivated zeolite by calcination at high temperatures. Therefore, it is anticipated that the currently developed Ti-MWW might be industrially applicable in the one-pot synthesis of EG from ethylene with H 2 O 2 .
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Biochemistry and Biophysics Reports
·
2023
·
IF 2.7
Ke Zhang,Youyang Liu,Yunlu Zhao,Qi Guo,Shengjun An,Shuhui Wu
Many chronic inflammatory diseases, such as autoimmune inflammation, are associated with M1 macrophages, and the key to their treatment is blocking inflammation. Oxymatrine (OMT), a traditional Chinese medicine, has a marked anti-inflammatory effect. However, its anti-inflammatory target and mechanism in M1 cells remain unclear, which limits its clinical application. In this study, we investigated the anti-inflammatory effects of oxymatrine (OMT) on the M1 inflammatory response. We also determined the relationship between OMT treatment and the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) pathway with OMT treatment. To this end, we induced the differentiation of human peripheral blood monocytes (THP-1) into M1 cells. THP-1 cells were induced with a phorbol ester (phorbol-12-myristate-13-acetate (PMA)) and differentiated into naïve M0 macrophages. M0 cells were induced into M1 cells using lipopolysaccharide (LPS). The experimental groups were divided into the M0 macrophage group (NC), M1 inflammatory response group (LPS group), and M1 group treated with different concentrations of OMT (LPS + OMT-L, LPS + OMT-M, LPS + OMT-H). The cells in the OMT-treated groups were treated with OMT for 6 h, followed by LPS for 24 h, and the LPS group was treated with LPS only. The resulting supernatants and cells were collected. The secretion levels of NO were detected by the Griess method and the secretion levels of TNF-α and IL-1β in the supernatants were detected by the ELISA method. The secretion levels of these inflammatory factors were reduced in every OMT-treated group compared to the LPS group (P < 0.01), and the most significant reductions were found in the OMT-H group (P < 0.0001). By western blotting, the protein expression levels of TLR4, NF-κB, NLRP3, and Caspase-1 were all found to be downregulated in the cells of OMT-treated groups compared to the LPS group (P < 0.0001). In situ changes in NLRP3 expression were observed using immunofluorescence. The fluorescence intensity of NLRP3 in M1 cells was weaker in all OMT intervention groups than in the LPS group (P < 0.001). In conclusion, OMT has significant anti-inflammatory effects on the M1 inflammatory responses, and the TLR4/NF-κB/NLRP3 pathway was blocked proportional to the concentration of OMT.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2023
·
IF 6.1
Lei Jin,Zhao-Yun Wang,Zhuan-Yun Cai,Jia-Qiang Yang,An-Ni Zheng,Fang-Zu Yang,De-Yin Wu,Dongping Zhan
In this work, we develop a novel 1-(2-Pyridylazo)-2-naphthol (PAN)-based acidic sulfate copper electronic electroplating process for compact, homogeneous and conformal copper thickening of through hole (TH). The adsorption characteristics, electrochemical properties and the interaction mechanisms of three additives (PEG, SPS and PAN) are studied in detail. Scanning electron microscope (SEM) and optical microscope (OM) reveal that PAN can make the copper coating in fine grains and high throwing power of 90.35% in TH without an overhang phenomenon. Theoretical calculations illustrate that the binding energies between additive molecules and copper surface decrease in the order: PAN > SPS > PEG . Cyclic voltammetry experiments at rotating rates of 1200 and 200 r/min prove that PAN itself can accelerate and weakly suppress copper electrodeposition at the center and mouth of TH, respectively. PAN behaves respectively the synergistic and antagonistic effects with PEG at the mouth and center of TH, and the weakly synergistic effects with SPS both at the mouth and center of TH. The addition of PAN to the virgin make-up solution (VMS) containing PEG and SPS causes decreasing the relative electric charge (Δ Q ) at high and low rotating rates from 18.52 ± 0.08% to 8.25 ± 0.05%, which satisfies the closer copper electronic electroplating rate at the center and mouth of TH. The effective and complicated synergistic effects of the additives PEG, SPS and PAN can achieve compact, homogeneous and conformal copper thickening of TH.
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Catalysis Science & Technology
·
2023
·Vol. 13
·期 10
·3060-3068
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IF 5
Guanghua Liang,Jianyi Chen,Tao Dou,Zhijie Wu,Xiaofeng Li,Yuanshuai Liu
EU-1 zeolite is employed as an active component of a catalyst for isomerization or hydroisomerization of C8 aromatics (i.e., xylenes, ethylbenzene) in petrochemical processes to increase the para-xylene yield. However, conventional manufacturing of EU-1-based catalysts involves the production of mother liquors for zeolite synthesis which usually contain plentiful unreacted raw materials, or the negative impact of incorporated binders in mass transfer during reactions over shaped catalysts. Herein, we developed a novel route to prepare the monolithic EU-1 zeolite, and used it as an active component of a catalyst for hydroisomerization of ethylbenzene with meta-xylene. Recrystallization of the shaped zeolite precursors composed of incompletely crystallized zeolites with amorphous silica and alumina powders as binders in recycled mother liquor led to formation of the monolithic EU-1 zeolite. Transformation of binder species to a full-zeolitic phase was corroborated comprehensively by characterization methods. Compared with the conventionally fabricated counterpart, the monolithic EU-1 zeolite possessed similar mechanical strength, high crystallinity, and high acidity and, in particular, enhanced mesoporosity, which led to improved catalytic performances in hydroisomerization reactions. Our developed synthetic strategy provides an effective way to produce the monolithic EU-1 zeolite, but is also a reference for the sustainable production of other types of zeolitic materials for energy-related applications.
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Pharmaceuticals
·
2023
·Vol. 16
·期 4
·542
·
IF 4.6
Jia He,Jing Fang,Yuxin Wang,Chengyu Ge,Shao Liu,Yueping Jiang
Insomnia is an important public health problem. The currently available treatments for insomnia can cause some adverse effects. Orexin receptors 1 (OX1R) and 2 (OX2R) are burgeoning targets for insomnia treatment. It is an effective approach to screening OX1R and OX2R antagonists from traditional Chinese medicine, which contains abundant and diverse chemical components. This study established an in-home ligand library of small-molecule compounds from medicinal plants with a definite hypnotic effect, as described in the Chinese Pharmacopoeia. Molecular docking was applied to virtually screen potential orexin receptor antagonists using molecular operating environment software, and surface plasmon resonance (SPR) technology was used to detect the binding affinity between potential active compounds and orexin receptors. Finally, the results of virtual screening and SPR analysis were verified through in vitro assays. We successfully screened one potential lead compound (neferine) as an orexin receptor antagonist from the in-home ligand library, which contained more than 1000 compounds. The screened compound was validated as a potential agent for insomnia treatment through comprehensive biological assays. This research enabled the discovery of a potential small-molecule antagonist of orexin receptors for the treatment of insomnia, providing a novel screening approach for the detection of potential candidate compounds for corresponding targets.Keywords:traditional Chinese medicine (TCM);orexin receptors;in-home ligand library;neferine;screening and verification
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