Biomedical Materials
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2024
·Vol. 19
·期 3
·035011
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IF 3.9
Piaoyi Chen,Qinglin Xiao,Zhaoxiong Guo,Wei Liang,Ou Liu,Liteng Lin,Yugang Huang,Kangshun Zhu,Guodong Ye
Transcatheter arterial embolization plays a pivotal role in treating various diseases. However, the efficacy of embolization therapy in cancer treatment can be limited by several factors, such as inevitable incomplete or non-target embolization, and the tumor recurrence and metastasis caused by the hypoxic microenvironment. Moreover, it is essential to explore simpler, more economical, and efficient methods for microsphere synthesis. Herein, we achieved one-step photocatalytic synthesis of lipiodol-doped Fe3O4@Poly (diallyl iso-phthalate) multifunctional microspheres (IFeD MS) for arterial embolization, chemotherapy, and imaging. The prepared microspheres are in the shape of dried plums, with a particle size of 100–300 μm. Lipiodol demonstrates a certain degree of chemotherapeutic activity, and the incorporation of Fe3O4 enables the microspheres to exhibit magnetothermal response and magnetic resonance imaging capabilities. Furthermore, the radiopaque characteristics of both agents provide the microspheres with promising potential for computed tomography and digital radiography imaging. The renal embolization experiment in rabbits demonstrated that IFeD MS achieved significant embolization and chemotherapeutic effects. Biocompatibility experiments revealed that this embolic agent did not induce tissue damage or inflammation beyond the treatment area. Additionally, IFeD MS exhibited promising imaging potential. The results of this study imply that the developed multifunctional embolic agent IFeD MS may have significant potential in transforming tumors previously only suitable for palliative cares into resectable radical treatments.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Gang Huang,Chenggong Wang,Danil Bukhvalov,Yingchun Yang,Jialu Gao,Fengyan Han,Xiaofei Yang,Caiqin Wang
Urea-assisted water electrolysis is a significant and sustainable strategy to optimize electrolyte system to promote the efficiency of hydrogen producing in overall water splitting. Here we construct excellent catalysts (NiCoRu-X) by introducing Ru into reduced dual metal-organic frameworks (MOFs) via a mild chemical reduction method, which preserves multi hetero-interfaces that are spontaneously formed. Interestingly, excellent performances in urea oxidation reaction (UOR) can be observed on all NiCoRu-X samples but without obvious difference in the activity, while the optimal catalyst can be distinguished by testing their catalytic activity in hydrogen evolution reaction (HER). Dependent density functional theory (DFT) calculations are applied to identify the potential activity sites of different heterostructure in NiCoRu-X, and reveal that the hetero-interface promotes the formation of dynamic Ni 3+ actives like NiOOH, which benefit for UOR. In the urea-assisted electrolytes, the reaction potential difference by coupling the LSV curves of HER and UOR is 155 mV lower than that in the electrolyte without urea at 20 mA cm −2 , and 70 mV lower than that in overall water splitting. It reaches a high faraday efficiency (FE) of 98.5 % at 2.0 V in urea-assistant water electrolysers, higher than that without urea assistant (92.9 %). This work highlights the possibility of using urea oxidation to decrease the reaction overpotential and to further improve the efficiency of producing hydrogen in overall water splitting by introducing urea in electrolyte system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xunda Hu,Shiyan Sun,Yunxuan Weng,Caili Zhang
The advancement of high-performance poly(3-hydroxybutyrate- co -4-hydroxybutyrate) (P34HB) bioplastics is limited by their inherent brittleness and narrow processing window. In this study, a novel class of reactive citrate-based plasticizers was developed by combining short-chain butyl esters with long-chain polyethylene glycol diglycidyl ether (PEGDE). Three derivatives—TE1B2, TE2B1, and TE3—were synthesized, with TE3 containing three epoxy groups for covalent network formation. Comprehensive characterization showed that TE3 significantly outperforms commercial tributyl citrate (TBC) in thermal stability ( T d- 10% = 275.3 °C vs. 179.2 °C), migration resistance (<1 % mass loss in petroleum ether), and mechanical performance (elongation at break, ε b = 51.2 %; tensile strength, σ = 15.8 MPa). The PEGDE segments of TE3 enable (1) covalent crosslinking with P34HB terminals via epoxy–carboxyl and epoxy–hydroxyl reactions and (2) topological entanglement maintaining the storage modulus of neat P34HB. This molecular architecture suppressed spherulite formation and established a stress-dissipating network, as evidenced by SEM. Rheological analysis further revealed TE3's shear-thinning behavior with high-frequency elasticity retention, enabling reliable fused deposition modeling (FDM). By overcoming the traditional strength–ductility trade-off, this work introduces a synergistic strategy combining chemical crosslinking and physical entanglement, offering new insights into covalently anchored plasticization and network dynamics in biopolymer design.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Renfan Chen,Kaile Zhao,Weilong Wu,Kunxi Huang,Mengyao Zhou,Xiaolong Huang,Bing Deng,Zhen Wang,Wenpu Zhang
Efficient flotation separation of pentlandite from pyrite is central to improving the utilization efficiency of nickel-cobalt sulfide resources. In this work, 3-mercapto-1-propanol (3-MP) was employed as a selective pyrite depressant in Ni-Co sulfide flotation. The selective depression mechanism was elucidated through single-mineral, artificial mixed-mineral and real ore flotation tests, combined with contact angle measurements, adsorption measurements, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy characterizations. Single-mineral flotation results demonstrated that 3-MP reduced pyrite recovery to 19% while maintaining pentlandite recovery steadily at 75%. In artificial mixed-mineral flotation, 3-MP significantly upgraded the nickel concentrate grade, with a nickel recovery of 85.42%. Open-circuit flotation (one rougher, one scavenger and two cleaner stages) on a real ore yielded a nickel concentrate assaying 3.40% Ni and 1.73% Co, corresponding to enrichment ratios of 5.7-fold and 5.6-fold, respectively, and the sulfur recovery to the concentrate was merely 10.07%, indicating favorable practical application potential of this reagent. Surface analyses confirmed that 3-MP chemically bonds with Fe sites on the pyrite surface via its thiol group (–SH), while exhibiting negligible interaction with Ni sites on pentlandite, thereby leaving the surface properties and collector adsorption behavior of pentlandite unaffected and ensuring its excellent floatability. This work provides a theoretical basis and technical support for the efficient separation and utilization of nickel-cobalt sulfide resources. Download: Download high-res image (176KB) Download: Download full-size image
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Frontiers in Cell and Developmental Biology
·
2026
·
IF 5.3
Wenting Song,Xiao Kang,Xueyan Li,Yuyan Yang,Xinke Wu
Polycyclic aromatic hydrocarbon derivatives, as a class of environmental pollutants, often exhibit higher toxicity than their parent polycyclic aromatic hydrocarbons, posing potential health risks. This study selected the potentially estrogenic derivative 3-hydroxybenz[a]anthracene as the research subject. Using the estrogen receptor-positive breast cancer cell line T47D as a model, the effects of this compound on cell proliferation, migration, invasion, and apoptosis were evaluated through EdU staining, colony formation, scratch healing, Transwell invasion, and apoptosis assays to evaluate its effects on cell proliferation, migration, invasion, and apoptosis. Western blot analysis was employed to detect the expression of relevant signaling proteins. Results indicate that 3-hydroxybenz[a]anthracene promotes T47D cell proliferation by activating the PI3K/AKT signaling pathway, thereby upregulating AKT, p-AKT, and c-Myc protein expression. It enhances cell migration and invasion by downregulating E-Cadherin and MMP9 while simultaneously upregulating Vimentin and MMP2 protein expression. Furthermore, this compound simultaneously upregulates Bax and Bcl-2 expression, ultimately inducing apoptosis in T47D cells. This study confirms that 3-hydroxybenz[a]anthracene exhibits estrogen-like activity in vitro and can influence malignant biological behaviors of breast cancer cells by regulating relevant signaling pathways. These findings provide experimental evidence for further evaluating the endocrine-disrupting effects and breast cancer risks associated with such environmental pollutants.
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BIOCATALYSIS AND BIOTRANSFORMATION
·
2021
·
IF 2.181
Hongqian Dai,Yuan Lu,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou
Fe3O4 magnetic nanoparticles were prepared by chemical co-precipitation and modified with 3-aminopropyltriethoxysilane (APTES) and CS2 to form Fe3O4-APTES-CS2 magnetic carriers. Magnetically immobilized enzymes are attractive owing to their potential applications in many biological fields. When an alternating magnetic field is applied, the magnetic nanoparticles experience a force in the direction of the field, and the magnetic moments of the magnetic nanoparticles are apt to align in the direction of the field. Thus, magnetic nanoparticles behave like microscopic stirrers. The optimal reaction conditions of the acylation reaction using Fe3O4-APTES-CS2-lipase were 200 mmol/L 1-methyl-3-amphetamine, 100 mg immobilized lipase, 200 μL ethyl acetate, 12.6 × g rotating speed, 40 °C, and 5 days in the shaker. The conversion and enantiomeric excess of R-2a reached a maximum of 36.8% and 98.5%, respectively. 1-Methyl-3-phenylpropylamine was resolved using Fe3O4-APTES-CS2-lipase in an alternating magnetic field. The optimal magnetic field frequency and magnetic field intensity were determined to be 500 Hz and 12 Gs, respectively. The conversion and enantiomeric excess of R-2a reached a maximum of 40.3% and 98.5%, respectively. The results revealed that conversion under a magnetic field was significantly higher than that without a magnetic field. Highly optically active (R)-N-acetyl-1-methyl-3-amphetamine can be obtained via an efficient resolution of racemic 1-methyl-3-phenylpropylamine with immobilized lipase magnetic nanoparticles as a catalyst and ethyl acetate as an acyl donor in organic solvents in an alternating magnetic field.
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JOURNAL OF LUMINESCENCE
·
2017
·
IF 2.686
Haoyue Hao,Hongyu Lu,Guanghong Ao,Yinglin Song,Yuxiao Wang,Xueru Zhang
The nearly pure green and red emissions of Ho 3+ /Yb 3+ co-doped Gd 2 (MoO 4 ) 3 were realized by tri-doping Eu 3+ and Ce 3+ , respectively. The Ho 3+ /Yb 3+ co-doped Gd 2 (MoO 4 ) 3 powder, radiating intense green and red emissions, was prepared by a typical sol-gel method. Under the excitation of 980 nm laser, the red-to-green ratio was tuned from 0.2 to 4 as the concentration of Eu 3+ changed from 6 to 0 mol%, attributed to the energy transfer processes between Ho 3+ and Eu 3+ . Meanwhile, the red-to-green ratio altered from 4 to 20 as the concentration of Ce 3+ changed from 0 to 20 mol% via the cross relaxing processes between Ho 3+ and Ce 3+ . The prepared phosphors, possessing large tuning range of red-to-green ratio and resisting high temperature, can be potentially applied to colorful display and solid-state lighting.
研究领域:
材料科学
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光学材料
·
光子学
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固态照明
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显示技术
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MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 11
·1-15
·
IF 6.408
Qin Dongmiao,Meng Shuo,Wu Yusheng,Luo Zhi,Deng Biyang
An efficient electrochemiluminescence resonance energy transfer (ECL-RET) method is proposed which combines the luminescent materials of tris(4,4′-dicarboxylicacid-2,2′-bipyridyl) ruthenium(II) (energy donor) and tin dioxide and tin disulfide quantum dots (SnO 2 /SnS 2 QDs) (energy acceptor) into the isoreticular metal − organic framework-3 (IRMOF-3) material to form a composite. In this mode, the distance between the energy donor and the acceptor was greatly shortened, reducing the energy loss, and thereby effectively improving RET efficiency and further significantly improving the ECL signal. The obtained composite (SnO 2 /SnS 2 QDs-Ru@IRMOF-3) was combined with sandwich immunoreaction to construct an ECL immunosensor for the sensitive detection of procalcitonin (PCT). Under the optimized experimental conditions with a working potential of − 1.48 V (vs Ag/AgCl), the proposed PCT biosensor exhibited a linear concentration range of 1 × 10 −4 –200 ng mL −1 , with a detection limit of 0.029 pg mL −1 ( S / N = 3). The biosensor was used to detect PCT in actual samples. The biosensor has broad application prospects in biological analysis and clinical diagnosis due to its high sensitivity, good selectivity, and good stability. Graphical abstract
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Metabolomics
·
2023
·Vol. 19
·期 2
·1-13
·
IF 3.6
Zhang Rong,Zhang Zijia,Wu Wenyong,Shi Jingying,Berk Entezar,Li Wei,Deng Yanping,Wang Zhaojun,Hou Jinjun,Long Huali,Lei Min,Wu Wanying
Introduction Lipid metabolism participates in various biological processes such as proliferation, apoptosis, migration, invasion, and maintenance of membrane homeostasis of prostate tumor cells. Bufadienolides, the active ingredients of Chansu, show a robust anti-proliferative effect against prostate cancer cells in vitro, but whether bufadienolides could regulate the lipid metabolism in prostate cancer has not been evaluated. Objectives Our study explored the regulatory effects of bufadienolides on lipid metabolism in human prostate carcinoma cells (PC-3). Methods Untargeted lipidomics and transcriptomics were combined to study the effect of different bufadienolides interventions on lipid and gene changes of PC-3 cells. The key genes related to lipid metabolism and prostate cancer development were verified by qPCR and western blotting. Results Lipidomic analysis showed that the active bufadienolides significantly downregulated the content of long-chain lipids of PC-3 cells. Based on transcriptomic and qPCR analyses, many genes related to lipid metabolism were significantly regulated by active bufadienolides, such as ELOVL6 , CYP2E1 , GAL3ST1 , CERS1 , PLA2G10 , PLD1 , SPTLC3, and GPX2 . Bioinformatics analysis of the Cancer Genome Atlas database and literature retrieval showed that elongation of very long-chain fatty acids protein 6 ( ELOVL6 ) and phospholipase D1 ( PLD1 ) might be important regulatory genes. Western blot analysis revealed that active bufadienolides could downregulate PLD1 protein levels which might promote anti-prostate cancer effect. Conclusions All these findings support that bufadienolides might induce lipid metabolic remodeling by regulating long-chain lipids synthesis and phospholipid hydrolysis to achieve an anti-prostate cancer effect, and PLD1 would probably be the key protein.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Linjing Liu,Bin Yang,Rui Lv,Qiangwei Kou,Shuai Yang,Hang Xie,Yuan Sun,Yunfei Chang,Shan-Tao Zhang,Fei Li
Piezoceramics with high and fatigue-resisted piezoelectric properties are strongly desired for actuator applications. In this work, textured Pb(Mg 1/3 Nb 2/3 )O 3 -Pb(Zr, Ti)O 3 ceramics with Lotgering factor F 001 ∼98% were fabricated by templated grain growth technique. Strong [001] c -grain orientation ( f ∼90% and r ∼0.22) of the textured ceramics effectively produced about 230% enhanced piezoelectric coefficient d 33 * (i.e., S max / E max ) and substantially improved unipolar electrical fatigue resistance. Unipolar polarization P max and d 33 * of the textured ceramics were nearly maintained up to 10 6 unipolar cycles, while 19% and 14% degradations were respectively observed from randomly oriented counterparts. Especially, normalized d 33 * of the textured ceramics shows better unipolar fatigue resistance than those of piezoceramics reported previously. Much lower bipolar strain asymmetry γ s (∼4%) was observed from the textured samples fatigued after 10 6 unipolar cycles as compared to γ s ∼23% for randomly oriented counterparts. While charged defect accumulation model described the serious fatigue deteriorations in randomly oriented ceramics, the current work revealed that substantially enhanced unipolar fatigue resistance of the textured ceramics is mainly associated with the inherent fatigue anisotropy, weakened local bias fields owing to both enhanced domain mobility and lower defect density near grain boundaries/interfaces, and increased intrinsic contribution due to more tetragonal content. These superior characteristics suggest the great potential of textured ceramics for high-performance and robust actuator applications.
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Journal of Integrative Agriculture
·
2023
·
IF 4.8
Yang-yang XIAO,Jia-jia QIAN,Xing-liang HOU,Lan-ting ZENG,Xu LIU,Guo-guo MEI,Yin-yin LIAO
The sweet potato weevil ( Cylas formicarius (Fab.) (Coleoptera: Brentidae)) is a pest that feeds on sweet potato ( Ipomoea batatas (L.) Lam. (Solanales: Convolvulaceae)), causing substantial economic losses annually. However, no safe and effective methods have been found to protect sweet potato from this pest. Herbivore-induced plant volatiles (HIPVs) promote various defensive bioactivities, but their formation and the defense mechanisms in sweet potato have not been investigated. To identify the defensive HIPVs in sweet potato, the release dynamics of volatiles was monitored. The biosynthetic pathways and regulatory factors of the candidate HIPVs were revealed via stable isotope tracing and analyses at the transcriptional and metabolic levels. Finally, the anti-insect activities and the defense mechanisms of the gaseous candidates were evaluated. The production of ( Z )-3-hexenyl acetate ( z 3HAC) and allo -ocimene was induced by sweet potato weevil feeding, with a distinct circadian rhythm. Ipomoea batatas ocimene synthase (IbOS) is first reported here as a key gene in allo -ocimene synthesis. Insect-induced wounding promoted the production of the substrate, ( Z )-3-hexenol, and upregulated the expression of IbOS , which resulted in higher contents of z 3HAC and allo -ocimene, respectively. Gaseous z 3HAC and allo -ocimene primed nearby plants to defend themselves against sweet potato weevils. These results provide important data regarding the formation, regulation, and signal transduction mechanisms of defensive volatiles in sweet potato, with potential implications for improving sweet potato weevil management strategies.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2023
·
IF 5.4
Xiaowei Zhang,Liang Zhao,Shixie Xiang,Yiran Sun,Pan Wang,Jenny Jie Chen,Brian Sheng-Xian Teo,Zhishen Xie,Zhenqiang Zhang,Jiangyan Xu
Ethnopharmacological relevance Yishen Tongluo formula (YSTLF) is formulated based on traditional Chinese medicine theory for the treatment of Diabetic kidney disease (DKD) and has been shown to be effective in improving the symptoms of DKD according to the clinical observation. Aim of the study To explore the effect of YSTLF on DKD and figure out whether its effects were due to the regulation Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1. Materials and methods The extract of YSTLF at 1, 2.5 and 5 g/kg was orally administered to C57BLKS/J ( db/db ) mice for 8 weeks and db/db mice were given valsartan as a positive control. The littermate db/m and db/db mice were given vehicle as the control and model group, respectively. Blood urea nitrogen and serum creatinine were detected and the urinary albumin excretion, urea albumin creatinine ratio was calculated. The histopathological change of renal tissues in each group was determined. Simultaneously, the levels of fibrosis-related proteins and messenger RNA (mRNA) in kidney and high glucose (HG)-induced SV40-MES-13 cells were detected. The roles of YSTLF in regulating of Sirt6/TGF-β1/Smad2/3 signaling pathway were investigated in HG-stimulated SV40-MES-13 cells and validated in db/db mice. Furthermore, the effect of YSTLF on TGF-β1 degradation was investigated in HG-stimulated SV40-MES-13 cells. Results YSTLF significantly improved the renal function in DKD mice. YSTLF dose-dependently attenuated pathological changes and suppressed the expression of type I collagen , alpha smooth muscle actin , type IV collagen , and fibronectin in vitro and in vivo , resulting in ameliorating of renal fibrosis . YSTLF positively regulated Sirt6 expression, while inhibited the activating of TGF-β1/Smad2/3 signaling pathway. TGF-β1 was steady expressed in HG-stimulated SV40-MES-13 cells, whereas was continuously degraded under YSTLF treatment. Conclusions YSTLF significantly ameliorates renal damages and fibrosis may via regulating Sirt6/TGF-β1/Smad2/3 signaling pathway as well as promoting the degradation of TGF-β1.
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危险品化学品经营许可证（带存储）