Scientific Reports
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2026
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IF 3.9
Zou Yufeng,Xiao Shunli,Wang Jiayi,Chen Qiru,Shu Liangyin,Chen Yifan,Hu Dingli,Tan Yuhua,Yang Sixuan,Liu Lianghong,He Qingjiao,Liu LH.,He QJ.
Finger millet ( Eleusine coracana L., EC) is a nutritionally dense and medicinally valuable cereal crop with a long history of use in traditional health practices. Contemporary pharmacological studies have demonstrated that extracts from EC and its individual chemical constituents exhibit a wide range of health benefits and therapeutic properties. For instance, they possess antioxidant activity, can reduce blood glucose levels, and enhance gastrointestinal health. However, the full spectrum of their chemical constituents remains to be fully elucidated. In this study, we established a state-of-the-art analytical workflow integrating Ultra-High-Performance Liquid Chromatography coupled with Quadrupole-Orbitrap Mass Spectrometry (UHPLC-Q-Exactive Orbitrap MS) with Feature-Based Molecular Networking (FBMN) and Parallel Reaction Monitoring (PRM) for comprehensive chemical profiling of EC. A total of 126 compounds were unambiguously identified, including 64 flavonoids, 24 phenylpropanoids, 21 organic acids, and 22 other metabolites. Notably, 44 of these represent novel reports in EC, significantly expanding its known chemical repertoire. Further verification via Western Blot (WB) showed that the ethanol extract of EC (1 ~ 100 µg/mL) could concentration-dependently inhibit the overexpression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-induced RAW264.7 macrophages, which initially confirms its in vitro anti-inflammatory activity. The analytical method established in this study enables rapid and efficient identification of the major chemical constituents of EC, laying a foundation for its quality control, exploration of bioactive components, and mechanism research.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 3
·242
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IF 2.8
Zhang Jianhua,Li Lu,Hao Rong,Lei Zhipeng,Ma Yun,Li Yuanyuan,Kang Ailiang
CaCu 3 Ti 4 O 12 (CCTO) has been widely studied for capacitor applications due to its excellent giant dielectric constant and frequency stability, but its development is limited by its low breakdown field strength ( E b ). To promote E b and primarily clarify the intrinsic mechanism, a synergistic strategy combining Sr substitution for Ca in CCTO ceramics with the polymer pyrolysis method was adopted. With the increase of Sr substitution, the average grain size of the ceramics gradually decreased and E b was remarkably enhanced. In particular, an E b of 106.0 kV/cm at a current density of 0.05 mA/cm 2 was achieved for Ca 0.4 Sr 0.6 Cu 3 Ti 4 O 12 ceramics, which is mainly attributed to the tremendous increase in grain boundary resistance induced by the increase of grain boundary density and formation of the insulating secondary phase SrO resulting from Sr substitution. We hope this study will provide a potential solution for the fabrication of CCTO-based dielectric ceramics with excellent E b .
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 12.6
Jingya Xiu,Lin Liu,Lingao Yin,Yihong Peng,Ziqi Li,Ziyun Lin,Yilin Song,Degong Yang,Jiulong Zhang,Chunrong Yang
Immunogenic cell death (ICD), instigated by reactive oxygen species (ROS), has emerged as an efficacious strategy for augmenting the immunogenicity of tumor cells. However, the effects of ICD are severely diminished by elevated levels of glutathione (GSH) within tumor cells to maintaining intracellular redox homeostasis. To address this, the novel carrier-free self-assembled nanoparticles are designed to aggravating redox dyshomeostasis by reducing GSH and increasing ROS levels. The nanoparticles (ZDS NPs) were established by the self-assembly of zinc ions (Zn 2+ ), doxorubicin (DOX) and Nrf2 siRNA. The ZDS NPs exhibited the ultra-high entrapment efficiency of DOX (99%) and siRNA (89%), and the releases of DOX and siRNA were both pH-dependent owing to the cleavage of coordinate and hydrogen bonds under acidic conditions. Following the endocytosis of ZDS NPs by tumor cells, redox homeostasis was significantly disrupted, DOX and Zn 2+ enhanced the production of ROS via activating cGAS/STING pathway, whereas siRNA reduced GSH levels by decreasing the expression of Nrf2 protein. This further promoted a stronger ICD effect with elevated secretion of ATP, HMGB1, CRT, thereby inducing the maturation of DCs and activating a more robust anti-tumor immunity. This study presents a novel approach for the synergistic enhancement of ICD in cancer immunotherapy.
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高影响因子
Nature Protocols
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2026
·
IF 16
Gong Zhenggang,Yang Guangxu,Wu Tong,Wang Mengyao,Yang Jiarui,Lei Zhendong,Shuai Li
Practical lignin valorization strategies have the potential to enhance the profitability of lignocellulosic biorefineries. Leveraging the phenolic structure of lignin, commercially available lignins (for example, kraft, soda or biorefinery lignin) have been extensively studied as renewable substitutes for phenol in the synthesis of lignin–phenol–formaldehyde resin adhesives. However, the large-scale production and adoption of lignin–phenol–formaldehyde resin adhesives remain limited owing to challenges related to appearance, performance and cost. To address these limitations, this protocol outlines a comprehensive process for producing lignin adhesives with light colors, high adhesion properties and superior water and weather resistance. The procedure encompasses: (1) isolation of lignin from various types of biomass pretreatment liquors; (2) screening of high-quality lignins from the isolated lignins; and (3) performance assessment of lignin adhesives prepared directly from high-quality lignins without the need for chemical modification or additional processing. Additionally, this protocol provides a rapid and quantitative method for determining the condensation degree of lignin using a small amount of the isolated lignin sample (~50 mg) within a relatively short experimental time (5 h 20 min). This enables efficient quality evaluation and screening of high-quality lignins derived from different extraction methods and biomass sources. The entire process, from biomass to lignin adhesive fabrication, requires a total of 8 h 10 min and is designed for users with prior experience in biomass fractionation, chromatographic analysis and wood-based panel production.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2026
·Vol. 28
·期 2
·29
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IF 2.6
Xu Yujie,Ling Ping,Huang Nafei,Ma Xian
Photothermal therapy (PTT) demonstrates significant potential as a cancer treatment; however, the protective autophagy triggered by PTT limits its effectiveness. This study fabricated multifunctional nanoplatforms, BM/GNPs@ZIF8 (BGZ), by concurrently coating the autophagy inhibitor bafilomycin (BM) and the photothermal agent gold nanoparticles (GNPs) in the ZIF8 using the "one-pot method." Subsequently, a targeted alteration was performed using folic acid (FA) to develop FA-BM/GNPs@ZIF8 (FA-BGZ). The co-delivery of BM and GNPs aims to integrate autophagy regulation with PTT in a synergistic manner. The final NPs, FA-BGZ, integrate pH responsiveness, PTT, and tumor-target abilities. The stability is markedly enhanced after coating with ZIF8 (GNPs@ZIF8), with minimal effect on photothermal performance. The FA-BGZ exhibits a photothermal significant impact of approximately 32.74%. Concurrent coating of BM can inhibit autophagy and interfere with cancer cells' defensive mechanisms. Additional in vitro biological experiments further validate that FA-BGZ exhibits a significant cytotoxic effect on cervical cancer SiHa cells under near-infrared (NIR) exposure (IC 50 : 16.52 ± 3.48 μg/mL), decreasing mitochondrial membrane potential (MMP), and increasing reactive oxygen species (ROS), which subsequently leads to cell apoptosis. These findings suggest that FA-BGZ is a promising nanodrug delivery system (NDDS) that could enhance synergistic treatment approaches in cervical cancer cells.
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Science China-Technological Sciences
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2026
·Vol. 69
·期 3
·1320201
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IF 4.9
Yan Tao,Zhu Yehan,Wu Yuting,Zhang Xin,Pan Zhijuan
The development of multifunctional intelligent textiles has become an important innovation direction in the field of textile engineering, under the dual demands of intelligent health monitoring and environmental protection. Although single-functional textiles with antibacterial, photochromic, and strain-sensing properties have been developed, they are unable to meet the demand for multifunctional textiles. In this respect, this study developed a poly(lactic acid) and poly(3-hydroxybutyrate)/ thermoplastic polyurethane/carbon black nanoparticle composite nanofiber yarn (PPTCY) with a hollow-core-sheath structure using a simple conjugate electrospinning technology. PPTCY possessed excellent mechanical strength and could be effectively woven. More importantly, it not only enabled real-time visual monitoring of ultraviolet (UV) intensity in the environment but also possessed excellent antibacterial properties and strain-sensing performance. Its ΔE value was up to 58.24, and its antibacterial rates against Escherichia coli and Staphylococcus aureus were both 99.99%. This fabric had excellent strain-sensing performance, high linearity, and durability under both pressure and stretching deformations. This research provides favorable technical support for the application of intelligent textiles in the field of UV protection and traffic safety.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 12.6
Song Wanli,Zhao Chuanyi,Mai Youqing,Zhang Guangrong,Kang Wenyue,Zheng Xuanjun,Yuan Qingpeng,Chen Zeyang,Zhong Chengxun,Tang Junbao,Fu Duoyi,Zhai Tiantian,Ling Kai,Jiang Hongyan
Low-dose X-ray-activated radiodynamic therapy (RDT) is a promising strategy for precision oncology. However, its therapeutic efficacy is limited by tumor radioresistance and insufficient generation of reactive oxygen species (ROS). Here, we describe a biomimetic lutetium-coordinated black phosphorus nanosheet platform (BPNS@Lu 3+ /Lap-CMV) capable of initiating a tripartite synthetic lethality cascade upon low-dose irradiation. Through a single coordination strategy utilizing high atomic number (high-Z) Lu 3+ ions, the nanoplatform simultaneously stabilizes the black phosphorus scaffold, functions as an efficient X-ray antenna, and integrates a pH-responsive gate for the controlled release of β-lapachone (Lap). Additionally, surface camouflage using cancer cell membrane vesicles (CMV) enables homologous tumor targeting and reduces clearance by the reticuloendothelial system. A multi-pathway therapeutic cascade is initiated upon exposure to low-dose X-ray. First, Lu 3+ -amplified RDT generates a burst of ROS. Second, tumor-overexpressed NAD(P)H: quinone oxidoreductase 1 (NQO1) bioactivates Lap, intensifying redox stress (GSH depletion and H 2 O 2 overproduction) and promoting ferroptosis. Third, co-administration of the PARP inhibitor olaparib (Ola) functionally impairs PARP-mediated DNA repair, thereby converting RDT-induced DNA lesions into lethal damage and promoting apoptosis. Guided by its intrinsic computed tomography-mediated visibility, which revealed peak tumor accumulation at 12 h post-administration, the triple‑combination regimen achieved 85.5% tumor suppression in an orthotopic triple-negative breast cancer model without evident toxicity. This study presents a strategic framework for an intelligent nanoplatform capable of converting low-dose physical energy into biological cascades, thereby systematically disrupting parallel tumor defense mechanisms and broadening the therapeutic scope of radiotherapy. Graphical abstract
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Nature Communications
·
2026
·
IF 15.7
Ren Qingtan,Sheng Jie,Li Jie,Liu Bin,Xing Changsheng,Wu Yunzhong,Chen Wanxiaonan,Zhang Linsen,Zhang Tong,Bai Xueping,Shi Zhendong,Wang Lidong,Fei Weidong
Hundreds of thousands of tons of epoxy-containing carbon fibre (CF) wastes are generated from the manufacture of CF reinforced epoxy composites to their end-of-use. Today, most recycling strategies of these CF wastes aim at recovering CFs to the ones as virgin as possible, while techniques for efficiently converting CF wastes to materials of higher value, i.e., upcycling of CF wastes, are underexplored. Here, we develop a solid-flames upcycling technique using Mg and CaCO 3 powders as reactants to convert CF wastes into graphene-grafted CFs (GCFs) and graphene powders within a few seconds. In Mg/CaCO 3 solid-flames, Mg accelerates disconnection of C-O bonds in epoxy resins, promoting interconnection of C-C bonds that lead to the graphene-CF grafting microstructures. This solid-flames upcycling technique, with its superior sustainability metrics and attractiveness in commercial applications including reinforced graphite composites and electromagnetic interference shielding, presents a viable strategy for long-term management of accumulating CF wastes.
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POLYMER BULLETIN
·
2026
·Vol. 83
·期 5
·214
·
IF 4
Bai Shihao,Pei Jingke,Li Fei,Song Haotian,He Xu,Hu Ran,Jiang Weijiao,Kang Jian,Li Yuanjie,Xiang Ming
Global water shortage and water pollution are severe. Nanofiltration membranes are used in the field of water treatment, but traditional nanofiltration membranes have problems such as low permeability flux and serious membrane pollution. This paper selects a kind of ionic liquid called 1-aminepropyl-3-methylimidazole bromine salt (AMIB) as an aqueous additive to prepare a modified nanofiltration membrane. The chemical structure of the film was characterized by ATR-FTIR, XPS and other means, and it was found that the crosslinking degree of the modified film was smaller than that of the initial film, and AMIB was successfully introduced; SEM and AFM observations showed that the modified film was looser, the polyamide layer was thinner, and the surface roughness was reduced; the water contact angle test showed that the surface hydrophilicity of the film was improved; the Zeta potential test showed that the modified film was negatively charged in a larger pH range. The separation performance test results show that while the modified membrane maintains a high retention rate for Na₂SO₄, the water flux is greatly increased, The water flux of the NF-AMIB-0.2 membrane reaches 75.96 L·m⁻²·h⁻¹, which is 1.48 times higher than that of the unmodified membrane (51.24 L·m⁻²·h⁻¹). The retention rate of Na₂SO₄ exceeds 98%, and the retention rate of salt follows the Na₂SO₄ > MgSO₄ > MgCl₂ > NaCl, and has excellent long-term stability.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
·
IF 3.8
Wang Li,Li Lei,Chen Wei,Zhang Mingcui
Acute myocardial infarction (AMI) poses a severe threat to human health, making its rapid and sensitive diagnosis crucial. Cardiac troponin I (cTnI) has been established as the gold standard biomarker for AMI diagnosis. Herein, a dual-mode immunosensor was constructed by integrating manganese dioxide (MnO 2 ) nanozyme and fluorescence carbon dot (B-CDs) in silica (SiO 2 ), termed B-CDs@SiO 2 @MnO 2 , for the colorimetric and fluorescent detection of cTnI. The sensing signal mainly included two parts: B-CDs@SiO 2 @MnO 2 -based catalytic color reaction and B-CDs@SiO 2 fluorescence recovery after etching MnO 2 . The MnO 2 nanozyme catalyzes the oxidation of TMB to generate blue-colored TMBox, which turns yellow upon acid addition, enabling colorimetric detection. Concurrently, the MnO 2 nanosheets quench the fluorescence of B-CDs@SiO 2 . In the presence of ascorbic acid (AA), MnO 2 is reduced to Mn 2+ , leading to fluorescence recovery and thus enabling fluorescent detection. Profiting from the superior self-correction features of B-CDs@SiO 2 @MnO 2 dual-mode sensor, this method exhibits good linearity and sensitivity toward cTnI among 0.05–50 ng/mL, with detection limits of 0.0074 ng/mL for the colorimetric mode and 0.0063 ng/mL for the fluorescent mode. In addition, the human serum samples’ recoveries show good agreement between the colorimetric mode (90.0–117.8%) and the fluorescent mode (90.2–115.8%). Furthermore, we employ this platform to monitor cTnI levels in both cellular and blood samples from AMI patients, indicating the promising clinical application potential of this platform.
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Science China-Materials
·
2018
·Vol. 61
·期 5
·728-736
·
IF 4.318
Li Kaikai,Jiao Tifeng,Xing Ruirui,Zou Guodong,Zhou Jingxin,Zhang Lexin,Peng Qiuming
MXene, a new type of two-dimensional layered transition metal carbide material differing from graphene, demonstrates intriguing chemical/physical properties and wide applications in recent years. Here, the preparation of the self-assembled MXene-gold nanoparticles (MXene@AuNPs) nanocomposites with tunable sizes is reported. The nanocomposites are obtained via the self-reduction reactions of MXene material in a HAuCl 4 solution at room temperature. The sizes of the Au particles can be well-controlled by regulating the self-reduction reaction time. They can greatly influence the catalytic behaviors of the MXene@AuNPs composites. MXene@AuNPs composites with optimized reduction time show high catalytic performances and good cycle stability for model catalytic reactions of nitro-compounds, such as 2-nitrophenol and 4-nitrophenol. This work demonstrates a new approach for the preparation of tunable MXene-based self-assembled composites.
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IONICS
·
2020
·Vol. 26
·期 10
·4937-4948
·
IF 2.394
Tian Leiwu,Yuan Haifeng,Shao Qinjun,Zaidi Syed Danish Ali,Wang Chong,Chen Jian
Surface modification plays a vital role in improving the rate performance and cycling stability of layered Ni-rich LiNi 0.6 Co 0.2 Mn 0.2 O 2 (NCM622) cathode materials for Li-ion batteries. In this study, Li 2 MgTi 3 O 8 (LMTO)-coated NCM622 was successfully synthesized by wet coating combined with sintering process. The results of morphological analysis showed a uniform LMTO layer coated on the surface of NCM622 materials. The dual ions of Ti 4+ and Mg 2+ on surface structure of NCM622 were identified by X-ray diffraction and X-ray photoelectron spectroscopy. The surface coating layer prevented the direct contact between the active cathode material and the electrolyte which significantly reduced the side reactions, and the doping of Ti 4+ and Mg 2+ improved the structural stability of the NCM622 materials. The electrochemical performance indicates that NCM622 cathode with a coating layer of 0.5 wt% LMTO exhibited excellent cycle stability and maintained a capacity retention up to 76% after 200 cycles at 25 °C at 1 C-rate, which was higher than the value of 52% for the NCM622.
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