MOLECULAR DIVERSITY
·
2024
·
IF 3.9
Ou Yuqin,Guo Xue,Zhang Qi,Zhang Wei,Gan Xiuhai
Plant-parasitic nematodes are seriously affecting agricultural production worldwide and there are few highly effective and low-risk nematicides to control nematode diseases. In order to discover new nematicides, a series of 1,2,4-oxadiazole derivatives containing amide fragments have been designed and synthesized with the principle of active substructure splicing. The nematicidal activity of the target compounds was evaluated in vitro and it indicated that compound C3 exhibited the most nematicidal activity against Bursaphelenchus xylophilus , Aphelenchoides bessey i, and Ditylenchus destructor with the LC 50 values of 37.2, 36.6, and 43.4 μg/mL, respectively, which were superior to positive agent tioxazafen. The preliminary mechanism results revealed that compound C3 not only inhibited the reproduction of B. xylophilus populations, but also affected the production of ROS and the accumulation of lipofuscin and lipids. Furthermore, compound C3 showed good inhibition of succinate dehydrogenase (SDH) with the IC 50 value of 45.5 µmol/L. Molecular docking indicated that compound C3 had excellent binding to amino acids around the SDH active pocket. This work indicated that 1,2,4-oxadiazole derivative containing amide fragment is a promising template for the discovery of new nematicides and compound C3 can be used as a potential nematicide candidate. Graphical abstract
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DOI
PubMed
高影响因子
Journal of Sustainable Metallurgy
·
2024
·
IF 2.5
Peng Miaomiao,Xi Chen,Shen Keyu,Tan Yangjing,Li Fei
A novel greenness and low-cost biosorbent was prepared by polyethylene polyamine-modified waste biomass of sugarcane bagasse in this study, which was used to remove molybdenum(VI) from aqueous solution. The structural properties and adsorption mechanism of this amine-functionalized sugarcane bagasse adsorbent (SCB-A) on Mo(VI) were investigated by SEM–EDS, BET, TG, FTIR, XPS, and batch adsorption experiments. The results show that the adsorption reaction between SCB-A and Mo(VI) was a spontaneous endothermic process, and its theoretical maximum adsorption capacity was about 231.48 mg/g. The adsorption capacity was 8.93-fold compared to that of pristine sugarcane bagasse. This adsorption process was more consistent with the Langmuir model and pseudo-second-order kinetics model, indicating that this process was monolayer adsorption on a homogeneous surface and the adsorption rate was controlled by the chemisorption process. SCB-A possessed great reusability, maintaining a stable adsorption capacity after five recycles. For the adsorption toward Mo(VI), SCB-A also exhibited superior selectivity in a multi-ion coexistence solution. Therefore, SCB-A has tremendous potential in the economically and feasible removal of Mo(VI) from wastewater. Graphical Abstract
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高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-18
·
IF 14.7
Zhang Yan,Shen Jiayi,Xie Famin,Liu Zhiwei,Yin Fangfang,Cheng Mingxiu,Wang Liang,Cai Meiting,Herzog Herbert,Wu Ping,Zhang Zhi,Zhan Cheng,Liu Tiemin
Resistance to stress is a key determinant for mammalian functioning. While many studies have revealed neural circuits and substrates responsible for initiating and mediating stress responses, little is known about how the brain resists to stress and prevents overreactions. Here, we identified a previously uncharacterized neuropeptide Y (NPY) neuronal population in the dorsal raphe nucleus and ventrolateral periaqueductal gray region (DRN/vlPAG) with anxiolytic effects in male mice. NPY DRN/vlPAG neurons are rapidly activated by various stressful stimuli. Inhibiting these neurons exacerbated hypophagic and anxiety responses during stress, while activation significantly ameliorates acute stress-induced hypophagia and anxiety levels and transmits positive valence. Furthermore, NPY DRN/vlPAG neurons exert differential but synergic anxiolytic effects via inhibitory projections to the paraventricular thalamic nucleus (PVT) and the lateral hypothalamic area (LH). Together, our findings reveal a feedforward inhibition neural mechanism underlying stress resistance and suggest NPY DRN/vlPAG neurons as a potential therapeutic target for stress-related disorders.
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DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2017
·Vol. 35
·期 11
·1428-1435
·
IF 1.692
Wei Xiao-yan,Zhao Bo-xuan,Shang Ya-zhuo,Cheng Yuan-rong
Biphenyl-contained monomer of 1,4-bis[2-(3,4-epoxy cyclohexyl ethyl) dimethylsilyl] biphenyl (BP-SiH-EP) was prepared via hydrosilylation reaction of 1,4-bis(dimethylsilyl) biphenyl (BP-SiH) and 1,2-epoxy-4-vinylcyclohexane in the presence of Karstedt’s catalyst. 1 H-NMR, 13 C-NMR and FTIR were used to characterize the structure of the obtained monomer. BP-SiH-EP was then cured by methyl hexahydrophthalic anhydride (MeHHPA) with 1-cyanoethyl-2-ethyl-4-methylimidazole as an accelerator. The polymerization behavior was studied by DSC. The results of DMA measurement demonstrate that the cured BP-SiH-EP/MeHHPA can maintain high storage modulus (> 1 GPa) in a wide range of temperature up to 176 °C. According to the damping factor curve of DMA, cured BP-SiH-EP/MeHHPA exhibits a high glass transition temperature ( T
g ) of 192 °C, which is 20 °C higher than that of cured 1,4-bis[2-(3,4-epoxy cyclohexyl ethyl) dimethylsilyl] benzene (DEDSB)/MeHHPA. TGA results show that cured BP-SiH-EP/MeHHPA has good thermal stability ( T
5% = 339 °C) due to the high heat-resistance of rigid biphenyl group. Moreover, the crosslinking density of cured BP-SiH-EP/MeHHPA should be lower than that of cured DEDSB/MeHHPA estimated from their chemical structures, which conflicts with the calculated results based on the rubber elasticity equation. The inconsistence indicates that the calculated crosslinking densities are not comparable, possibly owing to their differences in the rigidity of polymer chains and intermolecular interaction.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
·Vol. 332
·期 12
·5035-5043
·
IF 1.6
Li Lin,Qian Zhenghua,Zhang Hengrui,Duan Xilei,Liu Xueyang,Zhang Qiang,Qiao Yanbo
The porous compound generated from the reaction of 4-[tris(4-carboxyphenyl)methyl]benzoic acid (H4MTB) with actinide Th in simulated high-level radioactive waste can adsorb Ru, which can separate Th and Ru by more than 68.1 and 37.3%, respectively, in simulated high-level radioactive waste. The waste liquid before and after separation was vitrified with borosilicate glass and iron phosphate glass. The composition and morphology of the glasses were characterized by XRD, SEM and ICP‒OES, and the product consistency test was used to measure the chemical durability of the glasses. The chemical stability and waste loading of the glasses after the separation of actinide and noble metal elements was significantly improved. This work is of great significance for the recovery and utilization of actinide and noble metal elements in high-level radioactive waste and the optimization of the vitrification process of radioactive waste.
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高影响因子
Systems Microbiology and Biomanufacturing
·
2024
·
IF 0
Feng Yuanbang,Zhang Xin,Yang Hua,Feng Xue,Chen Ming
To achieve high production of arachidonic acid (ARA) through industrial fermentation of Mortierella alpina , the correlation between metal ions, mycelium pellet morphology and ARA production was investigated. By adding different metal ions to the culture medium, observing the morphological differences of mycelium pellet, total oil production and ARA content and established a correlation between them. The results showed that adding sodium ions increase the density of mycelium pellet, while reducing the diameter of mycelium pellet, resulting in a 41.59% increase in ARA production. Potassium ions, magnesium ions, calcium ions and iron ions slightly reduce the diameter of fungal hyphae and increase ARA production by 7.47%, 17.81%, 36.05% and 9.37%, respectively. At the same time, calcium ions promoted the branching growth of mycelium, which solve the problem of excessive free mycelium in fermentation broth within a certain concentration range. Zinc ions had a negative impact on bacterial growth, leading to the formation of mycelium clumps in the fermentation broth. Manganese ions and ferrous ions could transform the morphology of fungal mycelium into a smooth spherical surface, which was not conducive to the growth of M . alpina and the accumulation of oil. The comprehensive results showed that the optimal fermentation mycelium form for M . alpina was a dense central and loosely packed mycelium pellet. The yield of ARA was directly proportional to the density of mycelium pellet and inversely proportional to the diameter of mycelium pellet.
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DOI
Nanomanufacturing and Metrology
·
2018
·Vol. 1
·期 4
·225-235
·
IF 0
Geng Yanquan,Yan Yongda,Wang Jiqiang,Zhuang Yun
This study presents an atomic force microscope (AFM)-based scratching combined with reactive ion etching (RIE) method to fabricate nanopatterns on the silicon surface. All AFM-based scratching processes are performed on the polymethylmethacrylate (PMMA) film to create features in order to protect the AFM tip from wearing and enlarge its life time. Two types of resist films are selected for the RIE process. One is only PMMA thin-film resist, and the other one contains two-layer thin-film resist which are PMMA and aluminum thin films. The nanopatterns on the silicon after etching using RIE with these two types of resist film are compared. Results show that when using PMMA film, the width of the nanopattern on silicon is larger than on the PMMA film, and the material pile-ups formed during the scratching process cannot be considered as a resist. On the contrary, the aluminum thin films can improve the quality of the transfer. It indicates that the thin-film resist with bilayers can guarantee the transfer accuracy of the features, which can expand the application of the AFM tip-based scratching technique.
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DOI
Collagen and Leather
·
2024
·Vol. 6
·期 1
·1-12
·
IF 0
Yi Yudan,Fan Xinxin,Li Qijun,Wang Ya-nan
Hydrophobicity enhancement of metal-free leather, which is crucial for improving its comprehensive performance, can be achieved by using amphiphilic copolymer retanning agents. However, the relationship between the sequential structure and the hydrophobic modification effect of amphiphilic copolymers remains unclear. Herein, an amphiphilic block copolymer was synthesized using stearyl methacrylate and 2-(dimethylamino)ethyl methacrylate via atom transfer radical polymerization, and the corresponding random copolymer with similar monomer compositions and molecular weights was prepared for comparison. The aggregation behavior of block and random copolymers was investigated. DLS and TEM results indicate that the block copolymer exhibits a larger aggregate size than the corresponding random copolymer. Molecular dynamics simulations suggest that the block copolymer aggregate exhibit a thicker hydrophilic shell and more concentrated distribution of cationic DMA block than the random copolymer aggregate. Subsequently, the block and random copolymers were used for the hydrophobic modification of metal-free tanned collagen fibers (CFs). The block copolymer shows superior binding capacity to CFs than the random one because of its larger size and more concentrated charge distribution. Hence, the block copolymer can form a dense and uniform hydrophobic film on the surface of collagen fibrils and endow CFs with higher hydrophobicity than the random one. This work provides theoretical guidance for modulating the hydrophobicity of CFs by tailoring the sequential structure of amphiphilic copolymers, which is expected to inspire the manufacturing of high-performance metal-free leather. Graphical Abstract
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Systems Microbiology and Biomanufacturing
·
2022
·Vol. 3
·期 2
·262-272
·
IF 0
Niu Chengtuo,Xing Xianlei,Zheng Feiyun,Liu Chunfeng,Wang Jinjing,Li Qi
This study aimed to reveal the effect of salt reduction on the nutritional, functional and sensory aspects of doubanjiang through preparing three sets of doubanjiang fermentation (Sample H, Sample M and Sample L) with different salt concentrations. The results showed that fermentation with lower salt concentration led to significantly higher amino acids concentrations in doubanjiang, while the organic acids concentrations were also slightly increased. For biologically active compounds, the concentrations of total flavonoids, total phenols and five monomer isoflavones in Sample L were all significantly higher than those in Sample M and Sample H. Moreover, better anti-oxidant ability was observed in doubanjiang samples fermented with lower salt concentration. Bacillus and Millerozyma genus were found to be closely related to the formation of amino acids and biologically active compounds in doubanjiang, while organic acids were highly correlated with Cronobacter , Erwinia , Trabulsiella , Enterobacter and Millerozyma genus. Through sensory evaluation and electric tongue, unsatisfactory sensory characteristics, such as lighter color, strong acid taste and off-flavor, were found in lower salt fermented doubanjiang samples. This indicated that lower salt concentration favored the nutrition and function of doubanjiang while negatively influenced doubanjiang flavor. This study deepened our understanding of the roles of salt concentration on doubanjiang fermentation and provided guidance for the further development of low-salt doubanjiang .
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POLYMER BULLETIN
·
2022
·Vol. 80
·期 11
·12373-12392
·
IF 2.843
Jiang Yang,Wang Shifeng,Zhang Yong
Silica dispersion and silica–natural rubber (NR) interaction are two major issues in determining the performance of a NR/silica composite in tire industry. In our research, the reaction product of 3-isocyanatopropyltrimethoxysilane and a crosslinking agent, poly( tert -butylphenol) disulphide, was used to modify silica. Then, the modified silica was added into NR by mechanical blending. The modification of silica can promote the silica dispersion and enhance silica–NR interaction. At silica loading of 50 phr, compared with the NR/pure silica composite containing 5 phr bis -( γ -triethoxysilylpropyl)-tetrasulfide, the NR/modified silica composite exhibits 18% shorter curing time, 16% higher 300% modulus, 9% higher crosslink density and 6% lower rolling resistance with comparable abrasion resistance even reducing the amount of silane coupling agent to 2 phr. This modification of silica by using the derivative of poly( tert -butylphenol) disulphide provides a novel approach to the preparation of the high-performance NR/silica composites and the reduction of the amount of bis -( γ -triethoxysilylpropyl)-tetrasulfide in tire tread formulations.
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高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2023
·Vol. 49
·期 10
·4523-4539
·
IF 3.3
Guo Hui,Han Long,Baloch Humair Ahmed,Wang Zhonghui,Xia Jia,Zhang Chengkun,Yin Xuejian
Biomass-derived 5-Hydroxymethylfurfural (HMF) is a vital platform compound for synthesizing biofuel and various high-value chemicals. This work prepared carbonaceous solid acid catalysts with Brønsted acid and Lewis acid using pine biomass as raw materials through chloride salts impregnation, carbonization and sulfonation. The obtained catalysts were characterized by XRD, FTIR, SEM–EDS, BET, and Py-IR. The catalysts were applied to convert glucose into HMF in a biphasic system involving NaCl solution and γ-valerolactone. The results showed that the catalyst of PC-Al-SO 3 H exhibited larger microspheres and pore sizes compared with the sulfonated catalyst of PC-SO 3 H without AlCl 3 impregnation. Effects of key variables such as reaction temperature, reaction time on conversion of glucose into HMF were examined. By using PC-2Al-SO 3 H with stronger Lewis acid, glucose conversion and HMF yield achieved 86.53 mol% and 59.62 mol% at 160 °C and 6 h. The cyclic experiments revealed that PC-2Al-SO 3 H exhibited relatively stable activity.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 17
·1-12
·
IF 2.8
Liu Yang,Yang Jingdong,Wen Jiaxin,Ye Junliu,Liu Huan,Lu Liwei
Recently, rechargeable magnesium-ion batteries (MIBs) and rechargeable magnesium/lithium hybrid-ion batteries (MLHBs) have gained recognition as promising energy storage devices. However, the conventional CuS cathodes exhibit sluggish kinetics and poor cycle stability, thereby impeding the advancement and application of CuS. In this work, we have developed an economical and simple in-situ approach for synthesizing CuS@Cu foam (CSC) and evaluated its potential as a cathode material for both MIBs and MLHIBs. In both MIBs and MLHIBs, the CSC cathode demonstrates competitive performance. In MIBs, at a current density of 100 mA g −1 , the initial discharge specific capacity of the CSC is 150.94 mAh g −1 , which is higher than that of commercial CuS (3.99 mAh g −1 ). In MLHIBs, the CSC exhibits a discharge specific capacity of 502.95 mAh g −1 after 70 cycles at a current density of 100 mA g −1 , which significantly surpasses the discharge specific capacity of commercial CuS (229.52 mAh g −1 ). This performance improvement is attributed to the presence of Li + ions, which expedite the reaction kinetics, obviate the need for an activation process, and effectively facilitate the conversion reaction. In conclusion, by in-situ synthesis of CSC, the active material CuS firmly adheres to the Cu foam current collector. This approach is not only economical and simple but also significantly enhances the reactivity of the electrode material, thereby improving the electrochemical performance. This work provides valuable insights for the design, synthesis, and performance optimization of cathode materials of magnesium metal-based batteries.
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高影响因子
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