iScience
·
2024
·
IF 4.6
Rufeng Jia,Yanyan He,Jia Liang,Lin Duan,Chi Ma,Taoyuan Lu,Wenbo Liu,Shikai Li,Haigang Wu,Huixia Cao,Tianxiao Li,Yingkun He
Magnesium alloy is an excellent material for biodegradable cerebrovascular stents. However, the rapid degradation rate of magnesium alloy will make stent unstable. To improve the biocompatibility of magnesium alloy, in this study, biodegradable sodium alginate and carboxymethyl chitosan (SA/CMCS) was used to coat onto hydrothermally treated the surface of magnesium alloy by a dipping coating method. The results show that the SA/CMCS coating facilitates the growth, proliferation, and migration of endothelial cells and promotes neovascularization. Moreover, the SA/CMCS coating suppresses macrophage activation while promoting their transformation into M2 type macrophages. Overall, the SA/CMCS coating demonstrates positive effects on the safety and biocompatibility of magnesium alloy after implantation, and provide a promising therapy for the treatment of intracranial atherosclerotic stenosis in the future.
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Food and Bioprocess Technology
·
2024
·
IF 5.3
Zhu Jianfei,Tian Dongling,Chen Xiaomei,Huang Tingting,Chen Xi
In this study, oleogels were produced with the emulsion template method utilizing seven phenolic aldehyde fragrances (PAFs) crosslinked with chitosan, and the physical and chemical characteristics of oleogels prepared by different crosslinking factors were comparatively investigated. XRD and ATR-FTIR results showed that chitosan was crosslinked with the PAFs to generate Schiff bases and that the Schiff base reaction was the main contributing factor to the construction of the oleogels. Macroscopic characterization showed that all the oleogels had good Oil binding capacity (> 90%) and high gel hardness (> 55.46 g). The rheological properties showed that all the oleogels had high thermal stability and gel strength (G’ > G” ), as well as good thixotropic recovery (among them, CS-ISA had the largest thixotropic recovery of 24.05%), which indicated the elasticity and structural stability of the gel network formed by crosslinking of PAF and chitosan.Additionally, lower oxidation rates were observed for the peroxide value (POV ) and thiobarbituric acid reactive substance (TBARS) values of all oleogels in accelerated oxidation experiments, all indicating good oxidative stability.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
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IF 8
Shuhan Wu,Huayong Luo,Shiyin Li,Zexin Zheng,Qingwu Long,Chunhai Wei,Hongwei Rong
A new facile route to decorate polyurethane foams (PUF) with dense and uniform silver nanoparticles (AgNPs) to ensure efficient and long-term water disinfection is proposed. The antibacterial sponge was fabricated by sequential treatment with chitosan hydrogels grafting, polydopamine (PDA) coating, and finally in situ growth of AgNPs on the surface of substrate. The morphologies, chemical composition, crystalline nature, mechanical property, and swelling capacity of the composite were characterized. Its silver release behavior and bactericidal performances against Escherichia coli ( E. coli ) were evaluated. Results show that the composite demonstrated higher mechanical strength (compression strength, 51.34 kPa) and a rapid swelling rate with an equilibrium swelling ratio of 18.2 g/g. It possessed a higher loading amount of AgNPs (35.87 mg/g) than that of PUF@Ag (8.21 mg/g) and restricted the cumulative silver release of below 0.05% after 24-h immersion in water. Besides, it presented efficient bactericidal activity with complete reduction of E. coli with 10 min of contact time. The strong bactericidal action was probably governed by strengthening the contact between AgNPs immobilized on the substrate and bacteria cells. Furthermore, the composite demonstrated exceptional reusability for five cycles and exhibited a superior processing capacity in the flow test. Finally, the composite could effectively disinfect the natural water sample like a river in 30 min under real conditions.
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FIBERS AND POLYMERS
·
2024
·Vol. 25
·期 7
·2403-2417
·
IF 2.2
Lei Juan,Chen Kunlin,Chen Yu,Qiu Hua
Most functional hydrogels have biocompatibility problems in the pursuit of high performance, and there is an urgent need to study the problem of maintaining good biocompatibility and making hydrogels both multifunctional. Here, this paper proposes polyvinyl alcohol (PVA), chitosan quaternary ammonium salt (HACC) and polyacrylamide (PAM) with good biocompatibility as hydrogel substrates and nano-ferric copper-zinc oxide (nFCZ) as the main antimicrobial source. The physicochemical double crosslinked network hydrogels were prepared using one-pot method. Finally, the conductive properties of the hydrogel were enhanced by soaking in CaCl 2 solution, and the PHP dual-network conductive antimicrobial composite hydrogel was prepared. The hydrogel was characterised, tested and analysed through various tests. The results showed that the obtained dual-network composite hydrogels had good mechanical properties, stable sensing properties, excellent swelling rate, biocompatibility and antimicrobial activity, and the bacterial inhibition rate against Escherichia coli and Staphylococcus aureus was higher than 99%. The stable electrical conductivity and sensing properties promote cell regeneration at the wound site, which broadens the scope of hydrogel applications in biomedical fields.
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FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Fengyan Liang,Xiaohong Li,Xinyi Li,Xianyou Liu,Rongkai Pan,Wenyi Su,Chengpeng Li,Kaidong Liu
Applications of chitosan (CS) are hindered by its weak antimicrobial ability, poor solubility in basic and neutral solutions, structural modification is needed to improve its functional properties. Herein, a new chitosan-gentamicin derivative (CS-GT) was successfully synthesized via protection, regioselective bromination, nucleophile substitution reaction, and deprotection. Characterization techniques confirmed the successful introduction of GT onto the C-6 position of CS with a grafting rate of 76.19%. The additional amino groups provided by GT decreased the crystallinity and thermal stability of CS-GT, while enhancing its solubility in neutral and alkaline solutions. Compared to CS, CS-GT exhibited 2.50 and 2.41 times higher antibacterial activities against Escherichia coli and Staphylococcus aureus , respectively. Besides, an active packaging coating was develop by incorporating glycerol into CS-GT. The hydrogen bond networks formed within coatings endowed them good thermal stability and tightly uniform morphology. Furthermore, increasing CS-GT from 1% to 3% improved the coating's ultraviolet resistance and flexibility, but reduced its waterproof performance, visual appearance, and water barrier properties. Preservation experiments with papaya and litchi showed that CS-GT coatings effectively inhibited microbial growth and maintained quality and appearance up to 16 and 8 days of storage, respectively. In conclusion, CS-GT show promising potential for applications in food packaging.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Dongsheng Ma,Xu Liao,Xiaofeng Li,Yang Liu,Xiumei Zhang
The development of degradable food packaging materials with hydrophobic and oleophobic properties is a key to focus in reducing plastic waste. Chitosan is gaining interest for its versatility and easy modification, but its application is limited by the poor hydrophobicity and oleophobicity. Using polymers to modify chitosan films has been shown as a promising approach to solve this issue. In this study, the modified films (CS/xmono-PDMS-E, where x = 0.25, 0.5, 1, 2, and 3 %) were prepared by utilizing mono-terminal epoxy-terminated polysiloxane (mono-PDMS) and chitosan (CS) through chemical grafting. The qualities of these films were characterized. CS/xmono-PDMS-E films were demonstrated to have enhanced hydrophobicity, oleophobicity, moisture resistance, and thermal stability in comparison to CS films. Furthermore, because Si O Si has a greater bonding energy in the PDMS chain segment, the CS/xmono-PDMS-E films showed superior UV shielding. The resistance to weathering of CS/xmono-PDMS-E films was also greatly enhanced by the low surface energy of PDMS, which moved to the surface during drying. By combining experimental design with result characterization, this work provides a new strategy for bio-based packaging materials featuring with green double sparse coatings, showing great potential for low-carbon recycling applications.
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ANALYST
·
2024
·
IF 3.6
Xiaomeng Hu,Shan Zhou,Xin Zhang,Hui Zeng,Yaxin Guo,Yeqing Xu,Qirui Liang,Jinqiang Wang,Lei Jiang,Biao Kong
Copper ions (Cu2+), as a crucial trace element, play a vital role in living organisms. Thus, the detection of Cu2+ is of great significance for disease prevention and diagnosis. Nanochannel devices with an excellent nanoconfinement effect show great potential in recognizing and detecting Cu2+ ions. However, these devices often require complicated modification and treatment, which not only damages the membrane structure, but also induces nonspecific, low-sensitivity and non-repeatable detection. Herein, a 2D MXene–carboxymethyl chitosan (MXene/CMC) freestanding membrane with ordered lamellar channels was developed by a super-assembly strategy. The introduction of CMC provides abundant space charges, improving the nanoconfinement effect of the nanochannel. Importantly, the CMC can chelate with Cu2+ ions, endowing the MXene/CMC with the ability to detect Cu2+. The formation of CMC–Cu2+ complexes decreases the space charges, leading to a discernible variation in the current signal. Therefore, MXene/CMC can achieve highly sensitive and stable Cu2+ detection based on the characteristics of nanochannel composition. The linear response range for Cu2+ detection is 10−9 to 10−5 M with a low detection limit of 0.095 nM. Notably, MXene/CMC was successfully applied for Cu2+ detection in real water and fetal bovine serum samples. This work provides a simple, highly sensitive and stable detection platform based on the properties of the nanochannel composition.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
Omer Ahmed M.,Eltaweil Abdelazeem S.,Abdelhamed Aly M.,Abd El-Monaem Eman M.,El-Subruiti Gehan M.
Worldwide industrialization has grown at a rapid pace, contaminating water resources, particularly with phenolic pollutants that pose a risk to aquatic systems and human health. The goal of this study is to create an inexpensive magnetic composite that can effectively remove nitrophenol (o-NP) using adsorptive means. In this instance, a nonanyl chitosan (N-Cs) derivative was synthesized and then combined with activated petroleum coke (AP-coke) and magnetic Fe 3 O 4 to boost its adsorbability towards o-NP and to facilitate its separation. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffractometer (XRD), Vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), and zeta potential were employed to characterize the magnetic composite. The experimental results indicated that the Fe 3 O 4 /AP-coke/N-Cs composite possesses a greater affinity toward o-NP with a maximal efficiency reached 88% compared to 22.8, 31.2, and 45.8% for Fe 3 O 4 , AP-coke and N-Cs, respectively. The equilibrium adsorption data coincided with the Langmuir, Freundlich, and Temkin isotherm models, with a maximum adsorption capacity of 291.55 mg/g at pH 6, whereas the pseudo second order kinetic model offered the best fit to the experimental data. Besides, the developed adsorbent preserved satisfactory adsorption characteristics after reuse for five successive cycles. The proposed adsorption mechanism involves the H-bonding, π-π interaction, hydrophobic interactions and electron donor-acceptor interactions. These findings hypothesize that the constructed magnetic composite could efficiently remove nitrophenols from polluted water with high performance and ease-separation.
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DRUG DELIVERY
·
2025
·
IF 8.1
Zheng Zhang,Jiaxing Wang,Xiaofang Li,Lingzhou Zhao,Junwei Zhao,Mengjiao Su,Xiangxiang Wu,Huahui Zeng
Celastrol (Cel) is a potential anticancer therapeutic candidate, but its limited practical applicability is due to its low solubility, poor tumor selectivity, and cytotoxicity. Clinically, ginsenoside Rg3 (RG3) is typically combined with chemotherapy to enhance antitumor effects and reduce side effects. Herein, we developed novel pH-sensitive prodrug nanoparticles (NPs) containing RG3 and Cel for the synergistic treatment of pancreatic cancer (PC). Amphiphilic prodrug, a PEGylated chitosan oligosaccharide coupled with RG3 via Schiff base bond, was self-assembled with hydrophobic Cel into NPs with drug loadings of 2.12% (Cel) and 1.63% (RG3). NPs exhibited a suitable particle size of 124.01 nm, zeta potential of −39.89 mV and good physical stability. In addition, NPs also showed a controlled drug release when the Schiff base bonds were hydrolyzed in the acidic environment. In Pan02 tumor-bearing mice, NPs exhibited a high accumulation in tumor tissues and prolonged blood circulation time. Furthermore, NPs could more effectively inhibit tumor growth and reduce systemic toxicity, compared with the free Cel, RG3, prodrug, and Cel + RG3. The results indicated that the NPs could provide a safe and promising nanoplatform for PC therapy.
CAS / MDL:
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Zeyu Qin,Wangyang Fang,Qinbo Jiang,Jiawen Li,Hui Zhang
Inspired by the natural antimicrobial effect of the topographical features of insect wings, this study prepared urchin-like gold nanoparticles (UGNPs) and deposited them on poly(ε-caprolactone) (PCL)/chitosan (P/C) electrospun nanofiber film to strengthen antibacterial activities of this active packaging. Results showed that L-Dopa was a suitable reducing agent to prepare UGNPs, and the spine length of UGNPs increased from 21.23 to 35.83 nm as the molar ratio of L-Dopa:HAuCl 4 increased from 1 to 3. As the nanofiber film was immersed in the nanoparticle solution for a longer time, the UGNP content in P/C nanofibers increased. As the spine length of UGNPs and depositing UGNP content increased, the inhibition rate against S. aureus and E. coli . of P/C nanofiber film increased. In addition, P/C nanofiber film deposited with UGNPs also exhibited good thermal stability , hydrophilicity, mechanical strength , and water vapor permeability, exhibiting its potential as an antibacterial active packaging.
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Wood Material Science & Engineering
·
2024
·
IF 2.2
Yanchun Fu,Jingyu Chen
The photochromic properties are highly desirable for advanced wood applications, but they have not been extensively studied. To incorporate photochromic capabilities into wood materials, composite coatings were developed on the wood surface using an electric field-assisted layer-by-layer (LBL) self-assembly technique. The composite coatings consist of cationic chitosan and anionic tungsten trioxide (WO3) nanoparticles. By applying a direct current voltage during the deposition process, a well-organized distribution of WO3 nanoparticles was achieved, resulting in a uniform coverage of the wood substrate. This assembly process facilitated the creation of structured photochromic coatings with minimal nanoparticle fillers, a straightforward and rapid procedure, and potential for large-scale production. Lab colorimetric results demonstrated that the wooden substrate changed color from its natural state to blue when exposed to UV light. UV-vis spectroscopy further confirmed the efficient absorption of WO3 and photochromic properties of the modified wood.
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Xiao-Ping Zheng,Xin-Yu Tian,Yu Chai,Ya-Peng Du,Yu-Cang Zhang,Yan-Zhen Zheng
This study explores an efficient catalytic system for the conversion of chitosan into 5-hydroxymethylfurfural (5-HMF) under hydrothermal conditions. The catalysts used are deep eutectic solvents (DESs) comprising choline chloride (ChCl) as the hydrogen bond acceptor (HBA) and various organic acids as the hydrogen bond donor (HBD). Among the DESs tested, the ChCl: oxalic acid (OA) combination exhibits the highest catalytic activity, resulting in a yield of 27.5% 5-HMF employed the optimized conditions. To elucidate the interaction between ChCl and OA, various analytical techniques were employed, including quantum chemical calculations, nuclear magnetic resonance (NMR), and Fourier transform infrared spectroscopy (FTIR). These investigations confirmed the formation of strong hydrogen-bonds between ChCl and OA. Furthermore, the solid residues obtained during the conversion process were characterized using FTIR, X-ray diffraction (XRD), and scanning electron microscopy (SEM). These analyses provide insights into the chemical structures and morphologies of the residues, revealing the gradual conversion of chitosan, along with the formation of humin by-products.
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