JOURNAL OF ELECTRONIC MATERIALS
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2024
·
IF 2.2
Hou Guangya,Wu Yitao,Chen Qiang,Zhang Jianli,Tang Yiping
Constructing low-cost, high-catalytic-performance anode electrocatalysts is a significant challenge for methanol oxidation (MOR) and urea oxidation (UOR) reactions. Using paper templates with abundant pores to prepare thin porous metal materials helps to obtain high-performance electrode materials. The nano amorphous B-doped Ni/crystalline Ni (nanoam Ni-B/Ni) foil composite electrodes were derived from paper templates prepared by impregnation, high-temperature reduction, and electrodeposition methods. Porous Ni foils (Nip) derived thinnest rice (“Xuan”) paper, initially used for Chinese calligraphy and painting, exhibits the best performance due to its strong adsorption and wettability. Compared to direct current electrodeposition, pulse electrodeposition yields finer amorphous B-doped Ni nanoparticles with good catalytic performance. Under a current density of 100 mA·cm −2 , the nanoam Ni-B/Ni composite electrode prepared under a duty cycle of 0.5–1.0 s achieved current densities of 290.4 mA·cm −2 (MOR) and 340.4 mA·cm −2 (UOR) at 0.8 V, which are improved by 37.1% and 55.1%, respectively, compared to those of Nip. After 2000 cycles, with solution replacement, the current densities maintained 99.2% (MOR) and 81.6% (UOR) of the original values, showing excellent electrocatalytic stability. This research provided a new use for Chinese rice paper, and the prepared Nip-based electrode, with a thickness of about 60 μm and a low area quality, had a simple preparation process and good electrochemical properties, and can be used as a potential substitute for commercial Ni foam for portable or small electrochemical devices. Graphical Abstract
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Junli Li,Guoqiang Xiang,Lijun He,Xiuming Jiang,Renyong Zhao
B, N-co-doped carbon dots (B, N-CDs) were prepared using hydrothermal method with 3-amino phenylboronic acid (3-APBA) as a precursor, yielding 82.5 %. The as-prepared B, N-CDs demonstrated highly stable fluorescence emission with a fluorescence quantum yield (FQY) of 51.4 % under various experimental conditions including 4 M NaCl solution, 120 days of storage, and solution temperature of 100 °C. Based on the boronate affinity between boric acid groups on the surface of B, N-CDs, and the cis -diol structure of ascorbic acid (AA), a novel fluorescence assay for AA was established with a detection limit of 41 nM. Additionally, based on the redox reaction between hydroperoxide (H 2 O 2 ) and boric acid groups on B, N-CDs, a fluorescence assay for H 2 O 2 with a detection limit of 4.5 nM was developed. The proposed fluorescent assay methods were successfully applied for the determination of AA and H 2 O 2 traces in food samples, and the spiking recoveries were in the range of 82.5 % −115.75 %.
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JOURNAL OF CELLULAR PHYSIOLOGY
·
2018
·Vol. 234
·期 4
·3555-3569
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IF 3.923
Yang Chen,Zhen-Xian Zhao,Fei Huang,Xiao-Wei Yuan,Liang Deng,Di Tang
Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proliferation, migration, invasion, and apoptosis in HBV-associated HCC through the Adenosine monophosphate–activated protein kinase (AMPK) signaling pathway via targeting CCNA1 . HBV-associated HCC and adjacent normal tissues were collected to identify the expression of miR-1271 and CCNA1. To verify the relationship between miR-1271 and CCNA1 , we used bioinformatics prediction and the dual-luciferase reporter gene assay. The effects of miR-1271 on HBV-associated HCC cell behaviors were investigated by treatment of the miR-1271 mimic, the miR-1271 inhibitor, or small interfering RNA against CCNA1. The HBV-DNA quantitative assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromid assay, scratch test, transwell assay, and flow cytometry were used to detect HBV-DNA replication, cell proliferation, invasion, migration, and apoptosis. MiR-1271 showed a low expression, whereas CCNA1 showed a high expression in HBV-associated HCC tissues. We identified that miR-1271 targeted and negatively regulated CCNA1 . Upregulated miR-1271 and downregulated CCNA1 inhibited the HBV-associated HCC cell HBV-DNA replication, proliferation, migration, and invasion, while accelerating apoptosis by activating the AMPK signaling pathway. MiR-1271 promotes the activation of the AMPK signaling pathway by binding to CCNA1 , whereby miR-1271 suppresses HBV-associated HCC progression. This study points to a potential therapeutic approach of downregulation of miR-1271 in HBV-associated HCC treatment.
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PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2020
·Vol. 27
·期 3
·1-11
·
IF 2.426
Du Chunhui,Zhang Xinyi,Ma Xumin
In order to obtain the tunable and charged surface of the membranes, polymerized ionic liquid(PIL) block copolymers poly (methyl methacrylate) (PMMA)-b-poly(1-[(2-methacryloyloxy)ethyl]-3-butylimidazoliumbromide) (PMEBIm-Br) with different poly(ionic liquid) brush lengths were synthesized by RAFT polymerization method and used in the fabrication of poly(vinylidene fluoride) blend membranes. Chemistry analysis confirmed the successful copolymerization of P(MMA-b-MEBIm-Br) with different chain lengths of PMEBIm-Br blocks, and the PIL groups was also detected on the surface of the blend membranes, which contributes to the hydrophilic and positively charged surface of the membrane. These properties were further enhanced by the chain length of PMEBIm-Br blocks in the copolymer. The surface wettability of the membranes can be regulated from hydrophilicity to hydrophobicity by anion exchange, and the water flux changes also confirmed these phenomena. In addition, the effects of PMEBIm-Br blocks on the separation properties of the membranes were investigated using two dyes, namely, orange G and rhodamine 6G. Results indicated that the blend membranes with long length of PMEBIm-Br blocks had high rejection and good antifouling property to rhodamine 6G. Furthermore, the adsorption experiment of the blend membranes to the two dyes also indicated that blend membranes with long length of PMEBIm-Br blocks would have good dye adsorption-separation property.
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高影响因子
Advanced Industrial and Engineering Polymer Research
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2019
·
IF 0
Han Hu,Ruoyu Zhang,Zhengyang Kong,Kai Wang,Wu Bin Ying,Jinggang Wang,Jin Zhu
Poly (butylene furandicarboxylate) based poly (ether ester), with poly (ethylene glycol) (PEG) molecular weight from 600 to 20 K g mol −1 and mass fraction of hard segments fixed at 50%, are synthesized through transesterification and melt polycondensation. When M n (PEG) is less than 1500 g mol −1 , the copolymers tend to be homogeneous. The tendency of microphase separation is facilitated by the increasing M n (PEG). The mechanical properties and water swelling are influenced by M n (PEG), equilibrium water-uptake and PEG crystals. Elastic modulus of samples with no PEG crystals vary from 34 to 64 MPa, with elongation at break exceeding 1000%. The hydrolytic degradation is strongly affected by M n (PEG), degradation medium and alkalinity. The degradation of copolymers with short PEG (<1500 g mol −1 ) could be accelerated by ions and increasing alkalinity in medium. For copolymers with M n (PEG) from 2 K to 6 K g mol −1 , the degradation rate is relatively slow, due to relatively long PBF segments and improved PBF crystals hindering the hydrolysis of ester bond. For copolyesters of PBF50-PEG10K and 20 K, the oxidation of PEG dominates the degradation behavior while the PBF segments can hardly be damaged. The drastic degradation of these samples takes place in the solutions of pH = 12, suggesting the high alkalinity can break the long PBF segments. The distinct degradation behavior of the copolymers conduces to realize tuned hydrolysis for different biomedical applications.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Haiyang Wang,Lin Cai,Yuwei Wang,Chang Liu,Guozhen Fang,Shuo Wang
A molecularly imprinted electrochemical sensor (MIES) modified with Cu-MOF and Ti 3 C 2 Tx was successfully prepared for the detection of hygromycin B in food. According to the pH sensitive property of reversible borate ester bonds, a molecularly imprinted polymers (MIP) were constructed on the modified gold electrode (GE) surface by electropolymerization to realize the controllable elution and adsorption of template molecules. Cu-MOF with large specific surface area and Ti 3 C 2 Tx with excellent electrical conductivity cooperate to improve the overall analytical performance of MIES. The morphology and electrochemical performance of the sensor were evaluated. Under the optimal experimental conditions, the method showed superior selectivity to hygromycin B with a linear range of 5 × 10 −9 –5 × 10 −6 M and a detection limit of 1.92 × 10 −9 M (S/N = 3). The detection results of this method are in good agreement with HPLC-MS/MS, which proves that the method has reliable practicability and accuracy.
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高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Siyuan Tang,Da Chen,Xiameng Li,Changxing Wang,Tingting Li,Jiaxing Ma,Guoqiang Guo,Qinglei Guo
A novel sensor based on dual emissive fluorescent graphene quantum dots is developed for a rapid, selective, sensitive and visual detection of doxycycline (DOX). The ratiometric fluorescent probe is designed by grafting fluorescent group (Rhodamine B, RhB) on F, N -doped graphene quantum dots (FNGQDs). In the presence of DOX, the fluorescence at 466 nm is remarkably quenched due to inner filter effect and fluorescence resonance energy transfer, whereas the peak at 592 nm is attenuated slightly due to the energy transfer in the emission peaks of FNGQDs and RhB functional group. The sensor shows good linear relationship from 0.04 to 100 µM with a low detection limit of 40 nM. Furthermore, the flexible solid-state fluorescent sensing platform is used for detecting DOX in milk, pork and water samples. Therefore, this dual-emission FGQD-RhB can be used as a high-performance fluorescent and visual sensor for food safety and environmental monitoring.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Guohao Xu,Jiaqi Liu,Xin Gao,Xuedong Zhu
Hollow b-oriented ZSM-5 with a thickness of approximately 80 nm was synthesized for methane co-aromatization with propane (MCP) through the desilication–recrystallization of b-oriented ZSM-5 using tetrapropylammonium hydroxide (TPAOH) as a template. A hollow structure was introduced into b-oriented ZSM-5 via desilication with OH− and a thin intact shell was formed during recrystallization of leached Si species under TPA+ template application. By regulating the recrystallization time, shell thicknesses could be controlled from 120 nm to 60 nm. Under a recrystallization time of 24 h, the hollow b-oriented ZSM-5 possessed suitable acidity as well as the largest SBET and daver. When the hollow b-oriented ZSM-5 zeolite was used as the support for a zinc-based catalyst, aromatic selectivity and the conversion of methane and propane were improved. A maximum aromatic selectivity of 87.5% was achieved, with methane and propane conversion of 10.7% and 77.9%, respectively.
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CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Changqing Yuan,Xiaorong Meng,Han Shen,HaoHao Wei
To address the shortcomings of VO 2 (B) when utilized as cathode materials for aqueous zinc ion batteries (AZIB), this study prepared a fluorine and manganese co-doped VO 2 (B) with a nanorod-like structure, formed from convoluted multilayered nanosheets, was synthesized via a solvothermal method. It was established that F and Mn doping effectively broadens the lattice structure and tunneling space of VO 2 (B) and induces lattice distortion of VO 2 (B) through the high electronegativity of F element, leading to the ductile growth of FMVO into a nanorod-like structure made of multilayered ultrathin nanosheets curled. The increased tunneling space and active sites of FMVO, compared to pure VO 2 (B), significantly enhanced the de-embedding rate of Zn 2+ and reduced diffusion resistance. The specific capacity of F 0.06 M 0.02 VO is 523.92 mAh/g (0.2 A/g) with 88.64 % capacity retention after 2,000 cycles (5 A/g). This research provides a novel approach to the development of cathode materials for AZIB.
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高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2018
·Vol. 28
·期 2
·133-142
·
IF 1.607
Feng Yu,Teng Xingxing,Gu Jinhua,Yu Bangwei,Luo Yan,Ye Lianbao
In the previous research, our group designed and synthesized 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b] indoles, which showed high anti-tumor activity. In this study, a series of novel 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b] indole derivatives were designed by introducing an alkyl or aralkyl and a sulfonyl group, which are considered as the pharmacophores of some antitumor drugs based on the combination principles, and synthesized. The antiproliferative activity of all the target compounds were evaluated against Hela, A549, HepG2, and MCF-7 cell lines using the MTT assay in vitro. The results were represented by IC 50 values. All compounds showed moderate to excellent antiproliferative activity with IC 50 values between 0 μM and 100 μM against cancer cells. The proliferations of Hela, A549, HepG2, and MCF-7 cell lines were inhibited in a dose-dependent manner, and the cytolytic activity was markedly inhibited at the same time. The IC 50 values of intermediate 3 inhibited against Hela, A549, HepG2, and MCF-7 cell lines were 52.75, 50.30, 60.31, and 54.39 μM, respectively, which were higher than the new compounds that we expected. The compounds 4a – 4d bearing sulfonyl, substituted by electron donating group, showed moderate to significant antiproliferative activity, in which compound 4c was the best with the IC 50 values of 13.71, 9.42, 15.06, and 14.77 μM, and these results suggested that the introduction of sulfonyl could increase the antiproliferative activity of 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b]indole. Compounds 4e – 4g bearing alkyl, phenyl, and arylated alkyl produced good antiproliferative activity and the IC 50 value of 4 g was lower than 30 μM. The target compounds were more potent against A549 compared to the other three cell lines. Molecular docking studies revealed the binding orientations of all the synthesized compounds in the active site of c-Met. Moreover, molecular dynamics simulations have been performed to evaluate the binding stabilities between the synthesized compounds and their receptors.
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高影响因子
Cancers
·
2022
·Vol. 14
·期 5
·1333
·
IF 6.575
Jichen Sha,Rongrong Zhang,Jiteng Fan,Yong Gu,Yiqing Pan,Jing Han,Xiaoyan Xu,Shifang Ren,Jianxin Gu
Simple SummaryAs serum IgG glycosylation is associated with various cancers, our goal is to explore whether serum IgG galactosylation and its associated glycans could be used as tumor markers associated with hepatocellular carcinoma (HCC). At the same time, we explore the effect of the B-cell-specific ablation of B4GALT1 on HCC and finally analyze whether the low incidence of female cancer was related to the findings from the above perspective. The results demonstrate that the tumor marker of serum IgG glycosylation is galactosylation and its associated glycans and that the B-cell-specific ablation of B4GALT1 reduces HCC formation by reducing serum IgG galactosylation levels and by modulating the associated glycans, meaning that the lower incidence of cancer in women may be related to minor changes in the B-cell B4GALT1 and unchanged serum IgG galactosylation levels. This study aims to provide a theoretical basis for the early diagnosis and prevention of HCC and to determine why it has such a high incidence in males.AbstractSerum immunoglobulin G (IgG) glycosylation, especially galactosylation, has been found to be related to a variety of tumors, including hepatocellular carcinoma (HCC). However, whether IgG glycan changes occur in the early stages of HCC formation remains unclear. We found that the galactosylation level increased and that the related individual glycans showed regular changes over the course of HCC induction. Then, the effect of the B-cell-specific ablation of β1,4galactosyltransferase 1 (CKO B4GALT1) and B4GALT1 defects on the IgG glycans that were modified during the model induction process and HCC formation is investigated in this study. CKO B4GALT1 reduces serum IgG galactosylation levels and reduces cancer formation. Furthermore, insignificant changes in the B-cell B4GALT1 and unchanged serum IgG galactosylation levels were found during cancer induction in female mice, which might contribute to the lower cancer incidence in female mice than in male mice. The gender differences observed during glycan and B4GALT1 modification also add more evidence that the B4GALT1 in B cells and in serum IgG galactosylation may play an important role in HCC. Therefore, the findings of the present research can be used to determine the methods for the early detection of HCC as well as for prevention.Keywords:hepatocellular carcinoma;immunoglobulin G;glycan;β1,4-galactosyltransferase 1;mouse
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Ying Liu,Jiao Jiao,Qing-Yan Gai,Yu-Jie Fu,Yi-Bo Qiu,Yuan Wang
The extensive use of refractory organic dyes in the textile, printing, paper, food, and pharmaceutical industries is a significant source of water pollution. In this study, a novel magnetic hollow porous copper-based Fenton-like catalyst using cattail sporopollenin as a skeleton support (CSp/Fe 3 O 4 -Cu 2 O) was developed for the first time for the adsorption and efficient degradation of two refractory organic dyes rhodamine B and methylene blue in aqueous environments. Under the optimal conditions, CSp/Fe 3 O 4 -Cu 2 O showed complete ability to degrade the mixed dyes. The degradation kinetic constant of CSp/Fe 3 O 4 -Cu 2 O increased by 10.57 times compared to the control Fe 3 O 4 -Cu 2 O. The hollow porous structure of cattail sporopollenin (CSp) in CSp/Fe 3 O 4 -Cu 2 O not only adsorbed the dyes, but also promoted the continuous generation of active species by facilitating the redox cycling of Cu 2+ /Cu + through the adsorption of Cu 2+ , which synergistically realized the efficient degradation of mixed dyes. Furthermore, CSp/Fe 3 O 4 -Cu 2 O showed promising application potentials as follows: degradation rates of over 96 % for mixed dyes in a wide pH range of 3.0–11.0; complete degradation of mixed dyes in various water matrices including ultrapure water, tap water, and Songhua River water; and degradation rates of over 98 % for mixed dyes after six consecutive cycles. Overall, the novel Fenton-like catalyst CSp/Fe 3 O 4 -Cu 2 O developed in this study was found to be highly promising for the treatment of organic dye-contaminated water in chemical industries. This study also provided new insight into using the excellent adsorption properties of natural sporopollenin for the Fenton-like catalytic degradation of organic pollutants.
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