JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
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2024
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IF 3.6
Kainan Yu,YaChao Wang,Shuqi Zhang,JiangPing Zhao
Titanium powder easily accumulates during industrial processes, and its high reactivity poses unavoidable hazards to both industrial operations and human safety. To suppress the explosion of titanium powder, zinc phytate (Zn-PA) and chitosan (CS) are mixed and prepared into a new bio-inhibitor using hydrothermal-solvothermal synthesis. The suppression effects of Zn-PA@CS bio-powder on the explosion pressure and temperature of titanium powder under different inerting ratios (α) are investigated using a 20 L spherical explosion testing system. The results show that when the α of Zn-PA@CS bio-powder is 0.8, the maximum explosion pressure ( P max ) and the maximum rate of pressure rise (( dP / dt ) max ) of titanium powder decrease by 82.8% and 91.2%, respectively. Moreover, the maximum flame temperature ( T p ) drops from the initial 647 °C–38 °C. Combined with TG-DSC analysis, Zn-PA@CS bio-powder produces phosphorus-containing substances during high-temperature thermal decomposition, which consume a large number of free radicals essential for the explosion. Furthermore, Zn-PA@CS bio-powder generates solid and gaseous substances, leading to the formation of a dense carbonaceous residue that covers the titanium powder, acts as an effective barrier, and dilutes oxygen concentration, thereby further inhibiting the explosion reaction. The Zn-PA@CS bio-powder exhibits a synergistic effect in both physical and chemical suppression. This study provides technical support for developing biomass explosion suppression powder and for preventing and controlling explosion accidents in industrial production.
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Xiaojia Wang,Hongyu Zhu,Yina Yang,Guoqiao Lai,Xiongfa Yang
Food safety and food freshness issues have become important concerns for consumers and hydrogels with high antibacterial efficiency, low toxicity and pH−sensitive colorimetric intelligence are one of candidates to meet the requirement of food package and food spoilage monitoring. Nevertheless, hydrogels prepared only by assembling the ingredients with non−covalent interactions through time−consuming molding process usually encounter drawbacks such as relatively poor mechanical properties, stability and thermal stability, which always restrict their further applications. To overwhelm these shortcomings, UV−curable choline chloride (ChCl) and bromophenol red (BR) covalent functionalized antibacterial and pH−sensitive cross−linked hydrogels (UV−hydrogels) were developed in this paper. The UV−hydrogels possessed good thermal stability because the initiated thermal decomposition temperature (T d5 ) is in the range of 135.8–184.7 °C. The DMA analysis revealed that the UV−hydrogels are with good mechanical properties because the elongation at break is in the range of 117–525% and the tensile strength is in the range of 0.8–2.7 MPa. The UV−hydrogels with BR groups exhibited naked eye visible color variation from yellow to dark blue-green with the variation of the pH values from 2 to 14. The antibacterial efficiency of the UV−hydrogels against S . aureus , E . coli and M . albican increased with the increment of covalent−grafted ChCl amount. Cytotoxicity assay demonstrated that the UV−hydrogels are low toxicity against L929 cells. The experiment of monitoring freshness of beef denoted the UV−hydrogels have potential application in animal–derived high protein food packaging and freshness monitoring.
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DRUG DELIVERY
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2025
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IF 8.1
Zheng Zhang,Jiaxing Wang,Xiaofang Li,Lingzhou Zhao,Junwei Zhao,Mengjiao Su,Xiangxiang Wu,Huahui Zeng
Celastrol (Cel) is a potential anticancer therapeutic candidate, but its limited practical applicability is due to its low solubility, poor tumor selectivity, and cytotoxicity. Clinically, ginsenoside Rg3 (RG3) is typically combined with chemotherapy to enhance antitumor effects and reduce side effects. Herein, we developed novel pH-sensitive prodrug nanoparticles (NPs) containing RG3 and Cel for the synergistic treatment of pancreatic cancer (PC). Amphiphilic prodrug, a PEGylated chitosan oligosaccharide coupled with RG3 via Schiff base bond, was self-assembled with hydrophobic Cel into NPs with drug loadings of 2.12% (Cel) and 1.63% (RG3). NPs exhibited a suitable particle size of 124.01 nm, zeta potential of −39.89 mV and good physical stability. In addition, NPs also showed a controlled drug release when the Schiff base bonds were hydrolyzed in the acidic environment. In Pan02 tumor-bearing mice, NPs exhibited a high accumulation in tumor tissues and prolonged blood circulation time. Furthermore, NPs could more effectively inhibit tumor growth and reduce systemic toxicity, compared with the free Cel, RG3, prodrug, and Cel + RG3. The results indicated that the NPs could provide a safe and promising nanoplatform for PC therapy.
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EUROPEAN POLYMER JOURNAL
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2025
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IF 6.3
Yanfei Liu,Juan Li,Shengnan Huang,Xiaokai Wu,Shaowen Huang,Dingbo Shu,Chi Zhang,Xiaogang Yin
In this study, a novel three-dimensional bio-based superabsorbent hydrogel, SL-P(AA-AMPS)/CMCS, was synthesized via freeze-drying using sodium lignosulfonate (SL) with rigid phenylpropane structures as the bio-based framework, carboxymethyl chitosan (CMCS) enriched with hydrophilic groups (–OH, –COOH, and –NH 2 ) as the hydrophilic modifier, and acrylic acid (AA) and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) as monomers. Polymerization was initiated by ammonium persulfate (AP) and crosslinked with N,N’-methylenebisacrylamide (MB). The hydrogel’s structure, morphology, and absorption properties were systematically characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Results revealed a uniform porous structure with an average pore size of 5.8 μm. Absorption capacities in deionized water and 0.9 % NaCl solution reached 1132.9 g/g and 127.9 g/g, respectively, surpassing commercial diaper fillers (273.3 g/g and 61.5 g/g) and feminine hygiene products (223.5 g/g and 45.8 g/g). Under pressurized conditions (2068 Pa), absorption values remained high at 125.7 g/g (deionized water) and 24.0 g/g (0.9 % NaCl solution). The hydrogel exhibited exceptional water retention, retaining 88.8 % and 85.8 % of absorbed water after 8 h at 40 °C and 60 °C, respectively. Swelling kinetics followed a pseudo-first-order model (R 2 > 0.99), achieving equilibrium within 600 s (deionized water) and 60 s (0.9 % NaCl solution). Biodegradation tests demonstrated a 47.5 % degradation rate in soil after 28 days, significantly exceeding that of non-bio-based P(AA-AMPS) (3.7 %). Application tests highlighted superior absorption capacities for artificial urine (82.4 g/g) and blood (179.2 g/g), outperforming conventional hydrogels by 3.3- and 7-fold, respectively.
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CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Zuhan Chen,Huanjing Bi,Jingwen Wang,Ruiyang Ma,Ying Wang,Boqing Dong,Cuinan Lu,Jiale Wang,Yang Li,Jin Zheng,Fang Xie,Xiaoming Ding
Islet transplantation offers a promising therapeutic strategy for type 1 diabetes patients with inadequate glycemic control or severe complications. Islet encapsulation using biocompatible materials presents a potential solution to reduce immune rejection. This study fabricated and characterized Schiff base hydrogels (CMOCs) composed of varying ratios of carboxymethyl chitosan (CMCS) and oxidized carboxymethyl starch (OCMS). CMOCs exhibited desirable mechanical properties, injectability, self-healing properties, antibacterial properties, biocompatibility, and controlled-release capabilities. CMOC3, with the highest CMCS content, was selected for loading Fasudil and further islet encapsulation experiments. In vitro studies demonstrated that CMOC3 and CMOC3-Fasudil hydrogel (CMOC3-Fas) not only supported islet survival and insulin secretion but also increased insulin bioavailability through chelating the zinc ions from the insulin hexamers. CMOC3-Fas exhibited pro-angiogenic and anti-inflammatory properties, and effectively reduced islet cell death under hypoxic conditions. Finally, transplantation of islets encapsulated within CMOC3-Fas achieved prolonged normoglycemia and increased body weight in diabetic mice. This study demonstrates the synergistic protective effect of Schiff-base hydrogel co-delivering fasudil for islet encapsulation, potentially paving the way for improved islet transplantation therapy in type 1 diabetes.
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FOOD HYDROCOLLOIDS
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2025
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IF 12.4
Zi-Quan Wang,Hui-Xian Chen,Yu-Cang Zhang,Yan-Zhen Zheng
In this study, to enhance the water resistance, mechanical properties and functional properties of the chitosan (CS) film, the deep eutectic solvents-based propolis extract (DPE) containing polyphenols was directly incorporated into the chitosan-based films. The total polyphenol and the total flavonoid content in the DPE achieved increases of 289.9% and 216.6% compared to conventional ethanol–water propolis extract for polyphenol and flavonoid content, respectively. Effect of incorporating DPE into a chitosan matrix on the structural, physicochemical, and functional properties of the resulting composite films was comprehensively investigated. SEM, FTIR, XRD, and TGA analyses confirmed the uniform dispersion of DPE within the CS matrix via hydrogen bonding, resulting in improved structural homogeneity, modified crystallinity, and enhanced thermal stability. Optical analyses revealed an increase in film coloration and excellent UV-blocking ability due to the aromatic structures of polyphenols. Mechanical tests demonstrated that DPE incorporation significantly increased film flexibility (62.3% for CS/DPE60 (the adding of DPE was 60% dry weight of the chitosan)) while moderately reducing tensile strength (36.6 MPa for CS/DPE60) compared to pure chitosan film, indicating suitability for flexible packaging applications. Additionally, the CS/DPE films exhibited improved water barrier properties, antioxidant capacity, and antibacterial activity. A practical application in strawberry preservation showed that the CS/DPE film effectively reduced spoilage, minimized moisture loss, and delayed texture deterioration during storage. These findings highlighted the potential of CS/DPE composite films as multifunctional active packaging materials for food preservation.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yuemei Zhang,Xueyu Cheng,Chenghao Guo,Lijing Lu,Lixin Lu,Yongjin Qiao
Stimuli-responsive active packaging materials represent a promising frontier in food preservation by combining controlled-release functionality with environmental adaptability. Herein, a novel pH-responsive antibacterial bioactive packaging film based on a chitosan/gelatin (CS/GA) composite was developed by incorporating nanocomposites (NP) prepared through layer-by-layer assembly of natural polyelectrolytes onto modified halloysite nanotube (HNT), with carvacrol (Car) as the encapsulated active agent. The results showed that the developed composite films exhibited pH-responsive behavior under different pH conditions (4.0, 7.0, and 9.0), with a preferential release under alkaline conditions. The release rate was governed by the synergistic effects of carrier structural relaxation/dissolution within the NP, film diffusion, and structural relaxation/dissolution. In addition, hydrogen bonding and electrostatic interactions among CS, GA, and the NP improved the dispersion of the NP within the film matrix, thereby enhancing the film's mechanical strength, gas barrier performance, and thermal stability. The resulting active film effectively inhibited the growth of E. coli and S. aureus , and markedly prolonged the shelf life of pork. Overall, the developed pH-responsive active packaging films have great potential for application in future smart food preservation systems and lay a foundation for designing stimuli-responsive materials for different food environments.
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CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Lu Qin,Zhixiang Cui,Ziwei Zhang,Qiyao Zhai,Yu Wu,Jian Guan,Enyu Xu,Xin Zhang,Shirui Mao
Inspired by the structural and functional attributes of Cell-penetrating peptides (CPPs), in this study, diverse cationic and hydrophobic amino acids (AAs), which are regarded as the essential sequence of CPPs, were adopted to functionally modify chitosan (CS) to further enhance drug absorption across lung epithelial cells, and explore the absorption enhancing mechanism of different AA categories. Here, taking octreotide as a drug model, multifarious amino acids decorated chitosan copolymers (AA-CSs) were synthesized to investigate the influence of biomimetic AA-CSs structure on drug transmembrane absorption utilizing both 3D Transwell cell models and Sprague Dawley rats. It was demonstrated that indeed the absorption enhancing action of AA-CSs was AA categories-dependent. In comparison to native CS, hydrophobic AA-CSs induced no obvious enhancement in transmembrane permeation, while cationic AA-CSs improved drug absorption across pulmonary epithelium to varying degrees, with the highest enhancement ratio observed for arginine-CS (Arg-CS) group. Mechanism studies indicated paracellular pathway-mediated drug transport of AA-CSs. The in vivo pharmacokinetic data from microparticle groups revealed the AA categories-dependent absorption enhancing effect. In conclusion, the absorption enhancing activity of AA-CS copolymers depends on their AA categories, the enhancement extent of cationic AAs, particularly arginine, is preferable than that of hydrophobic AAs.
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NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Fang Wang,Ziqi Xu,Lingqi Deng,Jiaqi Liu
In this study, chitosan (CS) microspheres incorporated with polyacrylamide (PAM)/gelatin (Gel) hydrogel were fabricated using sodium tripolyphosphate (TPP) as cross-linking agent. The addition of TPP based on the optimal CS microsphere concentration, significantly enhanced hydrogel mechanical properties. Specifically, the composite hydrogel exhibited an elongation at break and tensile strength of 900% and 268.26 kPa, respectively, compared to 135.56 kPa and 419.03% for the PAM/Gel hydrogel. Furthermore, compressive strength at 70% strain was 2.1 times greater than that of the unmodified hydrogel. The composite hydrogel's network structure, rich in non-covalent bonds such as electrostatic interactions, hydrogen bonds, π-π interactions, and metal coordination bonds, exhibits excellent self-healing and self-adhesion properties. Following 18 hours of self-healing at room temperature, 92.2% of the original tensile strength was recovered. Additionally, the PAM/Gel/CS hydrogels exhibited powerful self-adhesive ability. Even after five bonding cycles to porcine skin, a substantial adhesion strength of 36.43 kPa was maintained, corresponding to 54% of the initial strength. Finally, in vitro studies revealed a controlled and sustained release profile for both 5-Fluorouracil (5-FU) and Tetracycline hydrochloride (TH) from the composite hydrogel. The observed increase in water uptake under acidic conditions of PAM and chitosan further accelerate drug release. Therefore, this dual-drug delivery hydrogel system, exhibiting excellent mechanical properties, suggests promise for pH-responsive therapeutic applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jingru Zhao,Hong Xiang,Yurong Liu,Xiaoqing Miao
An imbalance of androgens and changes in the follicular microenvironment are the hallmarks of androgenetic alopecia (AGA), a complex disorder that causes follicular shrinkage and progressive hair loss. Although the main goal of finasteride (FIN) monotherapy is androgen control, it has systemic drawbacks such as psychiatric side effects and sexual dysfunction. FIN nanocrystals (NCs) stabilized by cationic chitosan (CS) were added to dissolving microneedles (MNs) to improve follicle targeting while reducing systemic exposure. When CS was applied to the 167.20 ± 0.01 nm FIN-NCs, which had a zeta potential of −49.70 ± 2.00 mV, the outcome was positively charged CS-FIN-NCs that ranged in size from 200 to 300 nm. This alteration resulted in improved accumulation in hair follicles (2.65-fold fluorescence enhancement) and an enlarged passive diffusion area (1.48-fold increase). CS-FIN-NCs markedly enhanced folliculogenesis and hair regrowth in a mouse model of AGA. This formulation mechanistically enhances the migration of human umbilical vein endothelial cells by inhibiting TGF-β1, upregulating β-catenin, and promoting angiogenesis. These results demonstrate that CS-FIN-NCs delivered transcutaneously via MNs produce dual therapeutic benefits for the treatment of localized AGA by modulating follicular niches and acting pharmacologically.
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FOOD CHEMISTRY
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2025
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IF 9.8
Simin Fan,Wenxin Wang,Qingfeng Yang,Chaoqiao Zhu,Ming Tian,Aurore Richel,Marie-Laure Fauconnier,Chengli Hou,Dequan Zhang
The development of sustainable and functional food packaging is essential for mitigating food waste. In this study, quercetin nanocrystals (QNs) are synthesized and utilized to improve functionality of chitosan/ polyvinyl alcohol (PC) films. Molecular dynamics simulations and experimental characterizations reveal that the self-assembly of QNs is primarily driven by supramolecular interactions. QNs exhibit good compatibility with PC films, acting both as a nanofiller to improve mechanical properties (tensile strength of 49.68 MPa and elongation at break of 176.02 %) and as an active agent to impart antioxidant properties (fourfold increase compared to plain PC film). Additionally, QNs enhance the thermal stability, UV-blocking capability, and water vapor barrier properties of the PC films. More importantly, the QNs-reinforced PC films significantly extend the shelf life of fresh meat to 11 days. This work provides an effective strategy for fabricating eco-friendly and functional food packaging materials, demonstrating great potential for application in food preservation.
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Materials Today Communications
·
2025
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IF 4.5
Yuanyuan Wang,Yingjing Xia,Xingshen Dong,Peng Qiao,Wenyi Wang,Hua Song
A series of mixed biomass-derived porous carbon materials were successfully synthesized using chitosan and hydroxypropyl cellulose (CSHPC) as precursors through K 2 CO 3 activation. Among the synthesized materials, CSHPC-3–700 demonstrated a superior hierarchical pore structure and abundant nitrogen/oxygen functional groups, exhibiting exceptional electrochemical performance: a high specific capacitance of 371.8 F·g −1 at 1 A·g −1 and an outstanding rate capability (235.2 F·g −1 at 100 A·g −1 ). In symmetric supercapacitors, CSHPC-3–700 achieved a high energy density of 10.17 Wh·kg −1 with 91.3 % capacitance retention after 20,000 cycles, significantly outperforming porous carbons derived from individual chitosan (CS-3–700) or hydroxypropyl cellulose (HPC-3–700) precursors. This study provides a viable strategy for developing high-performance supercapacitor electrodes through rational hybridization of biomass precursors.
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危险品化学品经营许可证（带存储）