JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Hu Jingde,Mei Shaoxun,Song Qixiang,Wang Xinru,Yang Shuaiqi,Wu Guohuo,Wang Zhen,Zhang Xiangchun,Ji Yuntao,Jiang Xiasen,Qu Changqing
Bacterial resistance, recurrent infections, and impaired wound healing pose significant challenges in clinical wound management. Natural biomass-derived carbon dots (CDs) have attracted considerable attention due to their synergistic antibacterial, anti-inflammatory, and biosafety, which facilitate the healing of infected wounds. In this study, carbon dots derived from Toona sinensis gum polysaccharide (TGP-CDs) were integrated into a gelatin-chitosan hydrogel to construct TGP-CDs@Gel. Experimental results demonstrated that TGP-CDs@Gel exhibits strong light-activated ROS generation capability, effectively disrupting bacterial biofilms and compromising membrane integrity through photodynamic antibacterial mechanisms. The composite also significantly promoted L929 fibroblast migration and protected RAW264.7 macrophages and N2 nematodes from oxidative stress. Importantly, TGP-CDs@Gel exhibited potent photodynamic antibacterial activity, as well as the regulation of pro-inflammatory cytokines and angiogenesis-related proteins (i.e., CD31, VEGF) in MRSA-infected wound, thereby significantly accelerating wound healing. Moreover, comprehensive biosafety evaluation confirmed its excellent biocompatibility across multiple models, including in vitro cell cultures, zebrafish, and nematodes. Collectively, TGP-CDs@Gel demonstrates promising photodynamic antibacterial and anti-inflammatory functions, providing a novel strategy for tissue regeneration and extending the application of Toona sinensis gum in biomaterials. Graphical abstract
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Chong Li,Yi Zhang,Guixiang Yang,Qian Jin,Wang Chen,Ruihua Zhang,Tong Shi,Jingchen Wei,Xuejun Chen,Liqin Li
The rapid aging kinetics of soman (< 2 min) necessitate the development of effective prophylactic countermeasures, as conventional post-exposure therapies are often inadequate. To address this challenge, we engineered a novel separable microneedle (MN) system based on silk fibroin (SF) for sustained transdermal delivery of huperzine A (Hup A)—a reversible acetylcholinesterase inhibitor with demonstrated blood - brain barrier penetration capabilities. The optimized SFMNs design featured a distinctive tip-separation mechanism that facilitated reliable detachment of drug-loaded needle tips within 2 min after dermal application. The characterization results showed that the MN patch exhibited robust mechanical strength (155.49±11.18 N/patch), uniform morphology, effective skin penetration and homogeneous distribution of Hup A within the needle tips. Notably, the SFMNs platform provided controlled release kinetics, achieving sustained in vitro release of Hup A over 12 h, with an initial burst phase conducive to rapid drug onset. Pharmacokinetic evaluations in mice revealed that transdermal delivery via SFMNs (4 mg/kg Hup A) maintained therapeutic plasma concentrations for up to 12 h, significantly prolonging the mean residence time (11.87 ± 0.88 h) compared to oral administration (2.39 ± 0.31 h). This sustained-release profile markedly reduced systemic toxicity; whereas oral Hup A elicited severe cholinergic adverse effects (e.g., sweating, tremors), SFMNs-mediated delivery circumvented these toxic responses. In a prophylactic efficacy study, Hup A-loaded SFMNs (4 mg/kg) conferred complete protection (100% survival) for 12 h against a 95% lethal dose soman challenge, substantially extending the protective window compared to both oral Hup A (2 h) and intramuscular pyridostigmine bromide (45 min). These findings demonstrate that the SFMNs platform represents a promising, convenient, and well-tolerated strategy for long-acting prophylaxis against soman intoxication.
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Cell Reports Medicine
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2026
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IF 14
Zifan Pei,Yifan Yin,Nailin Yang,Shumin Sun,Nan Jiang,Fangyi Yu,Xiaofen Zhang,Jihu Nie,Youdong Chen,Longxiao Li,Jie Wu,Fei Gong,Minming Chen,Wei Liu,Liang Cheng
Clinical evidence has suggested that persistent STAT3 activation and alteration in lipid metabolism correlate with pathological progression in patients with breast cancer, driving resistance to chemotherapy. Herein, we show that H 2 S, an endogenous gas signaling molecule, sensitizes breast cancer to chemotherapy by suppressing STAT3 signaling-mediated lipid metabolism and improves tumor immunogenicity. Moreover, we further identify Ni 2+ as immune agonist for potent metalloimmunotherapy. The construction of an activable nanoplatform enables the controllable delivery of metal ions and H 2 S gas, which triggers pyroptosis and mobilizes multiple immune cells to elicit systemic anti-tumor immunity in combination with chemotherapy. Moreover, the synergy with αPD-1 inhibits the progression of both primary and metastatic tumors. Our work highlights the potential of bioactive gas transmitters and nutrient metal ions for reversing the dual dilemmas of chemoresistance and low immunogenicity in breast cancer and thus provides a nanosensitization strategy to synergize with multiple clinical treatment modalities.
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Discover Oncology
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2026
·Vol. 17
·期 1
·720
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IF 2.8
Duan He,Li Ning,Song Dingming,Li Yongzhuo,Liang Xin,Ding Yongxue,Tong Ming
Introduction Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy of the kidney, known for its aggressive growth and tendency to metastasize. Cellular senescence (CS), regarded as a characteristic feature of the natural aging process, is strongly linked to the initiation and advancement of several diseases. This research seeks to develop an integrated prognostic model utilizing senescence markers in ccRCC, with the goal of evaluating clinical outcomes and clarifying the tumor’s immune microenvironment. Methods The transcriptome profiles from ccRCC patients were acquired from TCGA database, and the senescence-related genetic model (SRGM) was developed through Cox proportional hazards analysis integrated with multiple machine learning approaches. In addition, immune microenvironment and drug sensitivity analysis were performed. EIF4EBP1 expression and its role in epithelial cell senescence were analyzed using single-cell RNA sequencing, spatial transcriptomics, and trajectory analysis. Finally, cellular experiments were conducted to confirm the role of silencing EIF4EBP1 in the biological behavior of ccRCC cells. Results Through a comprehensive framework incorporating 117 machine learning algorithm combinations, we established an SRGM consisting of 9 genes. The optimal model was constructed using CoxBoost + StepCox[forward] and achieved a concordance index (C-index) of 0.743, demonstrating robust prognostic predictive capacity across independent datasets. EIF4EBP1 is a central gene in the model. Silencing EIF4EBP1 reduced cell migration, proliferation, and invasion, while inducing senescence-associated phenotypes and apoptosis in ccRCC cells. Additionally, it significantly enhanced the responsiveness of ccRCC cells to sunitinib treatment. Conclusions In summary, we developed a novel SRGM that effectively stratifies prognosis in ccRCC. Furthermore, EIF4EBP1 has been validated at the cellular level as a promising therapeutic target, providing innovative insights into the personalized treatment of ccRCC.
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IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
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2026
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IF 7
Chen Liu,Xue Zhou,Hanyu Bai,Yana Zhang,Yong Zhao,Xuegang Li
Beta-actin (ACTB), a highly conserved cytoskeletal protein, is frequently dysregulated in early-stage malignancies, making its sensitive and specific detection crucial for cancer screening. Here, we develop a reflective fiber-optic SPR biosensor functionalized with copper–glycine engineered WS₂ nanosheets for label-free ACTB detection. The Cu–glycine modification not only enables WS₂ surface amination for efficient antibody conjugation, but also introduces Cu²⁺-mediated near-infrared absorption to amplify the plasmonic resonance response. Combined with the intrinsically large surface area and high refractive index sensitivity of WS₂, this synergistic design markedly enhances both molecular binding and signal transduction. The resulting WS₂-NH₂-based sensor achieves a refractive index sensitivity of 1467.5 nm/RIU, representing a 1.67-fold enhancement over unmodified fiber probes. For ACTB detection, it delivers an ultralow detection limit down to 9.766 pM, a broadened linear range of 2.4–120 pM (5×expansion), and a biosensing sensitivity of 84.477 nm/nM (1.4× improvement). Furthermore, at 1 ng/mL, a rapid response time of 20 min is achieved, demonstrating applicability for trace-level biomarker screening. Integrating high sensitivity, broad dynamic range, amplified spectral response, and strong anti-interference capability, this plasmonic WS₂-NH₂-modified fiber platform enables highly selective, label-free ACTB quantification. These findings highlight its strong potential for early cancer diagnosis, biomarker monitoring, and precision medical applications.
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JOURNAL OF BIOLOGICAL CHEMISTRY
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2026
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IF 4.1
Chengmeng Jin,Siying Zeng,Hao Wu,Xun Hu
Intracellular lactic acidosis, a metabolic state newly defined in this study, is characterized by a coupled increase in intracellular lactate and proton concentrations, resulting in higher levels inside cancer cells than outside. This finding expands the Warburg paradigm: lactic acidosis is not merely extracellular but intracellular, reshaping metabolism through direct biochemical mechanisms. Acidic pH and elevated lactate jointly suppress glycolysis by inhibiting HK, PFK1 and GAPDH, enforcing a low-flux, energy-efficient state. Meanwhile, pyruvate enters the TCA cycle through a pyruvate – lactate –export – reimport – lactate – pyruvate cycle that both fuels mitochondrial metabolism and maintains lactic acidosis intracellularly and extracellularly. Lactic acidosis also reprograms anaplerosis by promoting lactate-derived oxaloacetate formation and reducing glutamine dependence. Together, these findings establish lactic acidosis as an active regulator of cancer metabolism, revealing a distinct metabolic state. This coupled lactate–proton state drives coordinated metabolic reprogramming across glycolysis and mitochondrial metabolism. representing a fundamental tumor adaptation that may be exploited to disrupt cancer metabolic resilience.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Wang Weilin,Hu Qiaoying,Wu Chunyan,Ding Jiayue,Zhu Chuanxiu,Wen Jiayao,Li Yingchao,Yang Menghan,Wang Yujie,Sun Deqing,Zhai Guangxi,Zhang Yanan
Ferroptosis and sonodynamic therapy (SDT) have both been recognized as powerful weapons in cancer treatment, especially in non-small-cell lung carcinoma (NSCLC) recently. However, the lack of effective sono-sensitizer and ferroptosis regulator limited their usage. In order to overcome the limitation, a novel nanoplatform of DTX-CS/ART/PFCA@RGD (cRCAPD) was fabricated based on SDT and ferroptosis. Nanoparticles, under the action of c(RGDfk) cyclic peptides and their skeleton chondroitin sulfate (CS), could specifically target αvβ3 and CD44 receptors, respectively, thereby targeting tumor sites. Meanwhile, the peroxy-bridge structure of ART disrupted the intracellular iron homeostasis while generating highly toxic reactive oxygen species (ROS) under the SDT. Docetaxel (DTX) in nanoparticles led to the excellent apoptosis of A549 cells. Oxygen carried by PFCA alleviated the tumor hypoxic microenvironment, downregulated HIF-1α, and provided substrates for SDT. Further, the nanoparticles showed a strong immunogenic cell death (ICD) effect, modulating the number of T cells and dendritic cells in tumor-bearing mice. In summary, the proposed therapeutic strategy based on SDT and ferroptosis holds promising potential for synergistic treatment of lung cancer in future clinical applications. Graphical The alternative text for this image may have been generated using AI.
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DESALINATION
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2026
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IF 9.9
Qiang Xian,Xingrui Tang,Shibing Zuo,Di Wu,Lei Xie,Hao Li,Jun Wen
Adsorbents with same grafting ratio but varied chain densities were obtained. • Different grafting densities yield distinct conformations and uptake abilities. • High-density, short-chain materials show better salt tolerance; • High-density adsorbent reaches 9.6 mg/g in seawater-twice that of low-density one. Polymers with distinct chain conformations exhibit pronounced performance differences across various applications, and the grafting density as a critical parameter that governs both chain conformation and the overall performance of polymeric materials. However, existing seawater uranium extraction materials rely exclusively on grafting ratio as the sole criterion for functionalization, but neglecting the critical role of grafting density, resulting in insufficiently extended chain conformations and limited accessibility of adsorption sites, which ultimately constrains uranium extraction efficiency. Herein, a series of materials with identical degrees of functionalization but varying grafting densities and chain lengths of the polymers were obtained, and their uranium adsorption behavior were systematically investigated. In aqueous systems, the adsorption capacities of these adsorbents are comparable. However, in saline environments (including simulated, U-spiked and natural seawater) the adsorbent with high grafting density and short chains architecture exhibits the highest uranium adsorption performances. To gain deeper insight into the underlying mechanisms, the conformational behaviors of polymer chains were monitored by Quartz Crystal Microbalance with Dissipation (QCM-D). The results reveal that high grafting density and short chains display a significantly stronger anti-polyelectrolyte effect compared to that low grafting density and long chains. Consequently, the high grafting density and short of polymer chain adsorbent demonstrates superior resistance to salt-shrinkage and achieves higher uranium extraction capacity (9.6 mg/g) in natural seawater, substantially outperforming the low grafting density long chain (4.9 mg/g). This study provides critical design principles for developing polymeric adsorbents tailored for high-salinity environment applications, such as uranium extraction from seawater.
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Current Research in Food Science
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2026
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IF 7.7
Ruya Guo,Zhuorui Li,Jingjiang Qiu,Zhongwei Guo,Wuzhen Qi,Li Xue,Xiangyang Gao,Ronghan Wei,Jianhan Lin
Colorimetric immunoassays based on nanozyme labelling offer promising solution to rapid detect pathogenic bacteria for ensuring food safety. However, sluggish electron transfer kinetics and finite active sites of nanozyme result in unsatisfactory catalytic activity, achieving sensitive detection remains a challenge. Here, we report a Cu 2 O@CeO 2 heterostructure nanozyme with synergistic amplification effect integrating rapid charge transfer kinetics and abundant active sites to enhance the colorimetric immunoassay for sensitive detection of pathogenic bacteria. Highly active CeO 2 nanoparticles (NPs) are uniformly and firmly anchored onto stable Cu 2 O nanocubes to form Cu 2 O@CeO 2 core-shell heterostructure, which effectively alleviates the aggregation of NPs and achieves extremely exposure of catalytic active sites. Density functional theory (DFT) calculations reveal that electron transfer at the heterointerface induces a strong built-in electric field, along with abundant density and high affinity for H 2 O 2 , thus enhancing the reaction kinetics and catalytic activity of the nanozyme. Benefiting from these advantages, the Cu 2 O@CeO 2 heterostructure nanozyme exhibits excellent peroxidase-like activity, which could effectively catalyze the substrate 3,3′,5,5′-tetramethylbenzidine (TMB) to generate blue oxidized TMB. More importantly, the colorimetric immunoassay utilizing Cu 2 O@CeO 2 nanozyme as labeling probe achieves sensitive detection of Salmonella with a low limit of detection (LOD) of 26 CFU/mL and presents high specificity and stable applicability in spiked food samples. This work provides scientific insights for developing high-activity heterostructure nanozyme and advancing the exploitation of fast bacteria detection technologies to ensure food safety.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Cheng Han,Zhe Zhang,Yin Wei,Lanlan Liang,Xinao Zhao,Danna Yang,Zhongze Cui,Chuanliang Zhao,Liwei Yang
PVP-assisted synthesis enabled in-situ δ-MnO 2 -to-MnOOH reconstruction. • MnOOH/δ-MnO 2 interfaces enhanced PMS adsorption and electron transfer. • Surface-bound PMS* species enabled selective ETP-dominated TC oxidation. • The system maintained high TC removal in real lake water and groundwater. • The catalytic membrane achieved stable TC removal at low PMS dosage. Developing non-radical peroxymonosulfate (PMS) activation pathways that resist interference from complex water matrices remains challenging for the treatment of emerging contaminants in practical applications. A polyvinyl pyrrolidone-assisted hydrothermal strategy was therefore developed to induce the partial in - situ reconstruction of δ-MnO 2 into MnOOH. The resulting MnOOH/δ-MnO 2 interface directed PMS activation toward an electron transfer process (ETP) for tetracycline (TC) removal. The catalyst achieved nearly complete TC removal within 30 min and maintained high activity under complex water matrix conditions. Experimental results and density functional theory (DFT) analysis revealed that the MnOOH/δ-MnO 2 composite interface strengthened PMS adsorption and promoted interfacial charge redistribution. These effects facilitated electron transfer during TC oxidation. Surface-bound PMS* species on the MnOOH/δ-MnO 2 interface acted as electron-accepting centers, steering TC oxidation toward an ETP-dominated non-radical pathway. The MnOOH/δ-MnO 2 catalytic membrane maintained above 98% TC removal in real water matrices under continuous-flow conditions at only 0.2 mM PMS. These results demonstrate the promising practical applicability of the system. Life cycle assessment further indicated a comparatively low environmental burden for the MnOOH/δ-MnO 2 /PMS system. These findings provide a mechanistic basis for designing manganese oxide/oxyhydroxide catalysts through polymer-induced interfacial reconstruction and offer a practical strategy for ETP-dominated PMS activation in complex water treatment Download: Download high-res image (222KB) Download: Download full-size image
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Lixin Wang,Renjie Ji,Chunge Wang,Fanbo Meng,Zhongwu Luo,Mengran Wang,Hui Jin,Shijie Yang,Shi’an Zhao,Dahao Han,Yongjie Cheng,Tianyu Liu,Jianmin Ma,Yonghong Liu
To address the limited activity and durability of oxygen evolution reaction (OER) electrocatalysts, we present an integrated in situ strategy for constructing a three-dimensional Ni-Co dendritic electrode matrix coupled with a surface amorphous Ni-Co-Fe layered double hydroxide (LDH) catalytic layer. A Ni-Co dendritic matrix (NCDEM) with enhanced electrolyte accessibility and mass transport properties is first fabricated via jet electrodeposition, followed by the in situ hydrothermal growth of Ni-Co-Fe LDH nanosheets to construct a Ni-Co-Fe dendritic electrode (NCFDE). The introduction of NaBO₂ during the hydrothermal process regulates surface etching kinetics and the Fe³ ⁺ coordination environment, promoting uniform nanosheet growth and triggering the crystalline-to-amorphous transition of the LDH structure. The amorphous LDH layer increases the accessible active surface area, facilitates the formation of reconstructed NiOOH active species during OER, and enhances structural stability during prolonged electrochemical operation. The optimized B2-NCFDE exhibits outstanding OER performance in 1 M KOH, requiring an overpotential of only 215.34 mV to achieve 100 mA cm⁻², with a Tafel slope of 38.29 mV dec⁻¹ and stable operation at 500 mA cm⁻² for 2000 h. Furthermore, the B2-NCFDE||B2-NCFDE electrolyzer achieves 100 mA cm⁻² at a cell voltage of 1.822 V and demonstrates excellent durability for overall water splitting. This work provides a scalable strategy that integrates electrode architecture engineering with amorphous LDH regulation for efficient and durable hydrogen production.
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Environmental Technology & Innovation
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2026
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IF 7.3
Siyao Wang,Lei Wen,Zhimin Xu,Gang Chu,Kexin Chang,Hongbo Peng,Dandan Zhou,Peng Gao,Yang Liu,Bo Pan
Biochar (BC)-mediated aerobic oxidation of arsenite (As(III)) has been reported, but the coupling among phenol-quinone redox cycling, O 2 activation, and pH-regulated H 2 O 2 formation remains insufficiently resolved. In this study, pine-sawdust-derived BC and molecular analogues of phenolic/quinoid moieties, hydroquinone (HQ) and 1,4-benzoquinone (BQ), were used to examine As(III) oxidation at pH 3.0, 7.0, and 9.5 under oxic and oxygen (O 2 )-limited conditions. Under oxic conditions, BC oxidized 42.4%, 21.6%, and 74.7% of As(III) after 24 h at pH 3.0, 7.0, and 9.5, respectively, whereas arsenate (As(V)) formation was negligible under O 2 -limited conditions. BC generated hydrogen peroxide (H 2 O 2 ) in air-equilibrated suspensions, with maximum concentrations of 88.5, 38.8, and 204.2 μM at pH 3.0, 7.0, and 9.5, respectively·H 2 O 2 -associated pathways contributed an estimated 69.2%, 77.2%, and 67.4% to As(III) oxidation at pH 3.0, 7.0, and 9.5, respectively. Superoxide dismutase suppressed O 2 •- generation without affecting H 2 O 2 accumulation or As(III) oxidation, indicating that O 2 •- primarily served as an intermediate in H 2 O 2 formation. Tert-butanol negligibly altered As(V) formation, consistent with the absence of detectable •OH. The BQ/HQ model system confirmed the chemical feasibility of quinone reduction, HQ re-oxidation by O 2 , and associated H 2 O 2 generation, but it should be interpreted as a molecular analogue rather than direct proof of the heterogeneous BC surface mechanism. Overall, BC mediates As(III) oxidation mainly via O 2 -dependent H 2 O 2 production promoted by phenol-quinone-like redox cycling, while the non-monotonic pH trend (pH 9.5 > pH 3.0 > pH 7.0) reflecting the combined effects of As(III) speciation, surface redox behavior, and H 2 O 2 availability.
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