DIAMOND AND RELATED MATERIALS
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2023
·
IF 4.1
Yuhao Han,Jin Lin,Huajun Zhou,Li Guo,Yanzhong Wang
Developing an efficient non-noble metal catalyst for water splitting is very important for large-scale production of green hydrogen , but it is still a challenge due to the slow kinetics of hydrogen evolution in alkaline media . Herein, the self-standing Co 2 P 2 O 7 encapsulated N doped carbon anchoring onto the skeletons of carbon foams (Co 2 P 2 O 7 @NC/CF) was synthesized via the phosphating and carbonization of zeolitic imidazolate framework cross-shaped nanosheets at different temperatures. Co 2 P 2 O 7 @NC/CF-700 showed the highest HER activity, with an overpotential of 145.7 mV and a Tafel slope of 92.6 mV dec −1 at a current density of 10 mA cm −2 . Such an excellent performance is attributed to the three-dimensional interconnected, conductive carbon foams (CF) and uniformly distributed cross-shaped Co 2 P 2 O 7 @NC nanosheets, resulting in exposing more active sites and facilitating the mass and electron transfer .
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JOURNAL OF MEDICINAL CHEMISTRY
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2014
·
IF 5.48
Yuanchao Xie,Dongqing Xu,Bing Huang,Xiuli Ma,Wenbao Qi,Fangyuan Shi,Xinyong Liu,Yingjie Zhang,Wenfang Xu
To discover group-1-specific neuraminidase (NA) inhibitors that are especially involved in combating the H5N1 virus, two series of oseltamivir derivatives were designed and synthesized by targeting the 150-cavity. Among these, compound 20l was the most potent N1-selective inhibitor, with IC50 values of 0.0019, 0.0038, and 0.0067 μM against NAs from three H5N1 viruses. These values are better than those of oseltamivir carboxylate. Compound 32 was another potent N1-selective inhibitor that exhibited a 12-fold increase in activity against the H274Y mutant relative to oseltamivir carboxylate. Molecular docking studies revealed that the 150-cavity was an auxiliary binding site that may contribute to the high selectivity of these compounds. The present work is a significant breakthrough in the discovery of potent group-1-specific neuraminidase inhibitors, which may be further investigated for the treatment of infection by the H5N1 virus.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2023
·
IF 3
Haiyan Chen,Xinyu Wang,Meijin Lv,Yongxin She,Ziping Zhang,Xiaolin Cao
In this paper, the novel metal-organic framework @molecularly imprinted polymers were prepared and applied in extracting N-nitrosamines from salted vegetables. The imprinted polymers were coated on the surface of MIL-101 using multi-dummy template molecules (5-nonanol, benzhydrol and N-formylpyrrolidine). The characterization and adsorbing experiments showed that the hybrid imprinted polymers presented spherical particles with typically core-shell structure, and exhibited high adsorption capacity (maximum capacity: 46.85 mg/g) and fast equilibrium rate (only 5 min) for N-nitrosamines. Various parameters (sample loading solvent, pH, washing solvent, elution solvent and elution volume) affecting solid-phase extraction were optimized. Under the optimum conditions, the solid-phase extraction process based on the hybrid polymers combined with high performance liquid chromatography-ultraviolet detection method was established and applied to analyze N-nitrosamines in different salted vegetables. The results showed that the developed method produced the linear relationship between the peak areas versus the N-nitrosamines concentrations of 0.2–10 µg/g with limit of detections from 20.6 to 76.1 ng/g. The spiked recovery of N-nitrosamines in the salted vegetable samples was in the range of 66–100.5 % with relative standard deviation from 0.1 to 3.4 %. Those results demonstrated that the established method was sensitive and efficient for directly enriching and analyzing trace N-nitrosamines in salted vegetables.
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APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Yanzhong Wang,Sha Li,You Chen,Xiaofeng Shi,Chao Wang,Li Guo
Developing efficient Pt-free electrochemical catalysts for hydrogen evolution reaction (HER) is crucial for an energy source with low pollutant emissions. Herein, zeolitic imidazolate framework-67 (ZIF-67) polyhedrons are first in situ grown on the fibrils of commercial melamine foam at room temperature, and then phosphided and carbonized to obtain the free-standing 3D hierarchical CoP@N-doped carbon composite foam (CoP@NC/CF) with interconnected architecture. The 3D interconnected carbon networks provide efficient and fast channels for the rapid transfer of ions and electrons, and inhibit the agglomeration of CoP nanoparticles . The unique structure of CoP@NC/CF thus allows for delivering the remarkable HER performance with a low overpotential of 151.3 mV at 10 mA cm −2 , small Tafel slope of 64.8 mV dec −1 , and excellent long-term stability. This research provides a new strategy for the rational design and facile synthesis of the free-standing 3D CoP-based catalysts for high-performance HER.
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Materials Horizons
·
2023
·Vol. 11
·期 4
·1023-1031
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IF 13.3
Weichen Song,Jiankun Sun,Qian Wang,Han Wu,Kunpeng Zheng,Binbin Wang,Zhong Wang,Xiaojing Long
Organic semiconductor (OSC) gas sensors with good mechanical flexibility have received considerable attention as commercial and wearable devices. However, due to poor resistance to moisture and low conductivity, the improvement in the sensing capability of individual OSCs is limited. Reported here is a promising pathway to construct a series of conjugated organic polymers (COPs) with well-defined pyrimidine (Py-COP) or boron β-diketone (BF-COP) units. Unlike traditional metal- or carbon-based hybrid materials, the developed COPs can provide abundant absorption sites for gaseous analytes. As a result, the as-prepared BF-COP results in an excellent sensing response of over 1500 (Ra/Rg) toward 40 ppm of NH3 at room temperature, which is the highest value among those of pristine COPs as n-type sensing materials. Notably, they can maintain their initial sensing responses for two months and 90% relative humidity resistance. Combining the results of in situ Fourier transform infrared spectroscopy and theoretical calculations, the β-diketone skeleton is found to activate the surface electronic environment, verifying that the electron-deficient B ← O groups are adsorption centers. The B/N-heterocyclic decoration effectively modulates the redox properties and electronic interactions, as well as perturbs charge transfer in typical π-conjugated COPs. These results offer insight into developing highly efficient OSC gas sensors, which potentially have broadened sensing applications in the areas of organoboron chemistry.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2023
·
IF 4.3
Qi Guo,Xiaorong Huang,Yajuan Huang,Zhaowei Zhang,Peiwu Li,Li Yu
Aflatoxin B 1 (AFB 1 ) is a prominent food contaminant known for its high toxicity. Rapid, low-cost, and sensitive detection of AFB 1 is an urgent demand for food safety risk control. In the traditional enzyme-linked immunosorbent assay (ELISA) method for AFB 1 detection, horseradish peroxide (HRP) is high-cost and possesses poor environmental stability. In this study, a direct competitive single-atom nanozymes (SAzymes) -linked immunosorbent assay was developed based on Fe-N-C SAzymes. The proposed methods exhibited excellent sensitivity, rapid detection, fabrication, and low cost. Under the optimal conditions, the limit of detection of the new assay was 3.3 pg mL −1 , with a quantitative relationship between 0.0084 and 0.358 ng mL −1 . In addition, the developed method presented good recoveries in spiked samples, ranging from 84.50% and 103.75%, with coefficients of variation below 10%. Furthermore, the developed detection method showed good consistency (R 2 = 0.9852) with the reference method, liquid chromatography/mass spectrometry (LC-MS/MS). To our knowledge, this is the first report about single-atom nanozymes-based ELISA for AFB 1 determination. This work provides a feasible strategy for the rapid and sensitive detection of food contaminants using SAzymes.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2023
·
IF 6.1
Renjie Xie,Jianbin Lu,Jian Wang
The detection of dissolved gases in the oil of oil-immersed transformers is essential to evaluate the operating status of oil-immersed transformers. In this study, a CuO/TiO 2 /N-MWCNTs composites-based sensor was fabricated by hydrothermal method for the detection of dissolved CO gas in oil. The introduction of N-MWCNTs with high specific surface area, high electrical conductivity and multiple adsorption sites effectively improved the response value and response/recovery performance for CO. The response can reach 4.33 at a CO concentration of 50 ppm, which is 1.74 times higher than that of the CuO/TiO 2 sensor. In addition, the prepared sensor presents a fast response/recovery time (230 s/60 s) to CO, and has excellent selectivity and long-term stability. Finally, a multi-concentration CO alarm system was constructed through a reasonable circuit design. It is shown that the CuO/TiO 2 /N-MWCNTs-based sensor can achieve high-precision CO detection, which can provide a new idea for the detection of dissolved CO gas in the oil of oil-immersed transformers.
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ELECTROCHIMICA ACTA
·
2023
·
IF 6.6
Haoqiang Ma,Chenxin Jin,Guojun Xu,Lijun Wen,Chuanbin Tu,Fugen Sun,Yong Li,Lang Zhou,Zhihao Yue
Silicon-carbon composites are considered as the most promising anode materials for lithium ion batteries . Currently, most silicon-carbon composites were prepared by solid nano‑silicon particles as the silicon source, which suffers from high price and uneven dispersion. Here, we used tetraethyl orthosilicate as the liquid silicon source and polyvinylpyrrolidone as the carbon source. Both were homogeneously mixed in the liquid phase, and then processed through electrospinning, carbonization and nitrogen-doped processes to obtain free-standing nitrogen-doped carbon coated silicon monoxide (N-doped C/SiO x ). When served as anode material, N-doped C/SiO x can possess a reversible capacity of 488 mAh g −1 at 0.5 C (0.6 A g −1 ) and 377 mAh g −1 at a high current density of 2 C (2.4 A g −1 ). In addition, copper foil is not used as a collector for free-standing electrode structure, and eliminates the coating process of traditional electrodes, which reduces production costs. It is proposed that a facile strategy to fabricate silicon-carbon composites with good electrochemical properties and cost-effective way for lithium ion batteries.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2023
·
IF 5
Min Fang,Hongling Hou,Bo Feng,Tianzhu Zhang,Xiaomei Zhu,Zhen Liu
Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, nevertheless specific treatments with conclusive clinical benefit in improving outcomes of ICH remain lacking. The present study applied dl-3-n-butylphthalide (NBP), a compound approved for the treatment of ischemic stroke and rarely studied in ICH, to an experimental animal model of ICH, aiming to evaluate the therapeutic effects of NBP on ICH and the potential mechanisms. The results showed that rats receiving NBP administration exhibited a structural and functional restoration of brain after ICH mainly manifested as alleviation of neuronal apoptosis , suppression of neuroinflammation and oxidative stress , neurovascular remodeling, and eventually improvement of neurological deficits. In addition, several protein targets of NBP were revealed, which mainly play molecular functions of ribonucleoside triphosphate phosphatase activity, pyrophosphatase activity, hydrolase activity and GTPase activity, and participate in the biological process of brain development by regulating the formation of cellular components such as spindles, polymeric cytoskeletal fibers, microtubules and synapses, through mediating pathways such as VEGF signaling pathway, Fc epsilon RI signaling pathway, ECM-receptor interaction, Fc gamma R-mediated phagocytosis , peroxisome and so on, guiding the mechanism exploration of NBP therapy to some extent. Taken together, the study added some new evidence to the application of NBP in ICH treatment.
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CARBON
·
2023
·
IF 10.9
Haiqin Zhou,Xiangwei Zhang,Xinchao Zhang,Fang Yuan,Xinlin Wang,Shunlong Yan,Jianbing Wang,Chunquan Li,Zhiming Sun
With the excellent electrical conductivity and unique structure, carbonaceous materials are expected to prepare green catalysts used in sulfate radical based advanced oxidation processes. Nevertheless, most of researches are focusing on artificial synthetic material to date, thus the studies on natural carbon materials call for attention and development. Herein, impregnation-pyrolysis method was employed by adopting the urea as an extrinsic N-dopant under 850 °C to favor C–N configuration for natural microcrystalline graphite (MG). And N element presented as pyridinic N (27.42 %), pyrrolic N (40.08 %), graphitic N (25.86 %) and nitric oxide (6.65 %) in N-doped microcrystalline graphite (NMG). In addition, the catalysis performance of MG, NMG and calcined microcrystalline graphite (CMG) was examined by the degradation of bisphenol A (BPA). The NMG system exhibited high activity in a broad pH range, and acidic conditions promote the reaction rate greatly. Based on quenching tests and electron paramagnetic resonance, the degradation mechanisms comprised radical and nonradical pathway, in which 1 O 2 was the dominant reactive oxidative species (ROS). This study suggested that pyridinic N, pyrrolic N, graphitic N, sp (2)-hybridized carbon structure as well as defects in NMG promoted the generation of ROS, and provides a new insight in natural carbon materials for the fabrication of new eco-friendly and highly efficient PMS activation catalysts.
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Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 44
·24351-24358
·
IF 11.9
Dunren He,Wanyi Nie,Huihui Huang
Hydrovoltaic technology is a promising approach for clean and renewable energy generation, owing to its unique ability to generate electricity from the interactions between nanomaterials and abundant water. However, the output current of hydroelectric generators, which is usually below 1 mA, needs improvement. Here, we demonstrate a large-scale integration of water-graphite hydroelectric generators that can produce an output current of up to 58 mA, surpassing the performance of existing hydroelectric generators, and capable of powering commercial electronics, such as electric fans and full-color liquid crystal display screens. Our results show that this low-cost and scalable hydroelectric generator has the potential to significantly expand the application domain and facilitate the development of clean and renewable energy sources.
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MOLECULES
·
2023
·Vol. 28
·期 18
·6443
·
IF 4.6
Chaoyan Zhang,Xiaoyu Zhou,Fei Yan,Jing Lin
Herein, we describe a fast and highly sensitive electrochemical sensor for doxorubicin (DOX) detection based on the indium tin oxide (ITO) modified with a binary material consisting of vertically-ordered mesoporous silica films (VMSFs) and N-doped graphene quantum dots (NGQDs). VMSFs, with high permeability and efficient molecular transport capacity, is attached to the ITO electrode via a rapid and controllable electrochemical method, which can serve as a solid template for the confinement of numerous NGQDs through facile electrophoresis. By virtue of the excellent charge transfer capacity, π-π and electrostatic preconcentration effects of NGQDs, as well as the electrostatic enrichment ability of VMSF, the presented NGQDs@VMSF/ITO shows amplified electrochemical signal towards DOX with a positive charge, resulting in good analytical performance in terms of a wide linear range (5 nM~0.1 μM and 0.1~1 μM), high sensitivity (30.4 μA μM−1), and a low limit of detection (0.5 nM). Moreover, due to the molecular sieving property of VMSF, the developed NGQDs@VMSF/ITO sensor has good selectivity and works well in human serum and urine samples, with recoveries of 97.0~109%, thus providing a simple and reliable method for the direct electrochemical analysis of DOX without complex sample pretreatment procedures.
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