Microbiome
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2025
·Vol. 13
·期 1
·1-26
·
IF 12.7
Li Daojie,Meng Kun,Liu Guohua,Wen Zhiguo,Han Yunsheng,Liu Weiwei,Xu Xin,Song Liye,Cai Hongying,Yang Peilong
Background Fatty liver hemorrhage syndrome (FLHS) has become one of the major factors leading to the death of laying hen in caged egg production. FLHS is commonly associated with lipid peroxidation, hepatocyte injury, decreased antioxidant capacity, and inflammation. However, there are limited evidences regarding the preventive effect of Lactiplantibacillus plantarum on FLHS in laying hens and its mechanisms. Our previous results showed that Lp. plantarum FRT4 alleviated FLHS by regulating lipid metabolism, but did not focus on its antioxidant and anti-inflammatory functions and mechanisms. Therefore, this study aimed to investigate the preventive mechanisms of Lp. plantarum FRT4 in alleviating FLHS, with a focus on its role in antioxidant activity and inflammation regulation. Results Supplementation with Lp. plantarum FRT4 enhanced the levels of T-AOC, T-SOD, and GSH-Px, while reducing the levels of TNF-α, IL-1β, IL-8, and NLRP3 in the liver and ovary of laying hens. Additionally, Lp. plantarum FRT4 upregulated the mRNA expressions of SOD1 , SOD2 , CAT , and GPX1 , downregulated the mRNA expressions of pro-inflammatory factors IL-1β , IL-6 , and NLRP3 , and upregulated the mRNA expressions of anti-inflammatory factors IL-4 and IL-10 . Lp. plantarum FRT4 improved the structure and metabolic functions of gut microbiota, and regulated the relative abundances of dominant phyla (Bacteroidetes, Firmicute, and Proteobacteria) and genera ( Prevotella and Alistipes ). Additionally, it influenced key KEGG pathways, including tryptophan metabolism, amino sugar and nucleotide sugar metabolism, insulin signaling pathway, FoxO signaling pathway. Spearman analysis revealed that the abundance of microbiota at different taxonomic levels was closely related to antioxidant enzymes and inflammatory factors. Furthermore, Lp. plantarum FRT4 modulated the mRNA expressions of related factors in the FoxO / TLR - 4 / NF-κB signaling pathway by regulating gut microbiota. Moreover, the levels of E 2 , FSH, and VTG were significantly increased in the ovary after Lp. plantarum FRT4 intervention. Conclusions Lp. plantarum FRT4 effectively ameliorates FLHS in laying hens. This efficacy is attributed to its antioxidant and anti-inflammatory properties, which are mediated by modulating the structure and function of gut microbiota, and further intervening in the FoxO / TLR - 4 / NF-κB signaling pathway. These actions enhance hepatic and ovarian function and increase estrogen levels.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Shihao Zhang,Shuo Zhang,Zhen Liu,Keping Yan
In this study, 3,4,3′,4′-Tetrachlorobiphenyl (PCB77) contaminated soil was treated by ball milling. Experimental results have demonstrated that reagent-to-soil ratio, revolution speed, milling ball size, ball-to-soil ratio, soil moisture and initial concentration of PCB77 all influenced the degradation of PCB77. The removal efficiency of PCB77 could reach 79.6 % after 12 h of ball milling (ball-soil ratio 8:1, revolution speed 250 rpm, reagent-soil ratio 1:12). After ball milling, the size of soil particles decreased significantly, while the specific surface area and pore size increased. Based on the degradation byproducts determined by GC–MS, the possible degradation pathway of PCB77 by ball milling was inferred. Momentously, we attempted to combine ball mill and non-thermal plasma (NTP) to treat PCB77-contaminated soil. The contaminated soil pretreated by ball milling exhibited a higher removal efficiency of PCB77 in subsequent Dielectric barrier discharges (DBD) treatment compared to untreated soil. Quantitative detection of total organic carbon and inorganic chlorine in soil revealed that plasma technology exhibits superior capabilities in degradation mineralization and dechlorination of PCB77 compared to ball milling. The innovative technology not only efficiently enhances the removal efficiency of PCB77 but also eliminates the risk of secondary pollution introduced by reagents used in ball milling, thereby presenting a novel and effective strategy for soil remediation.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Yuan Zhang,Kangping Cui,Xueyan Liu,Minshu Cui,Xing Chen,Yuchao Tang,Haiyang Li
Metal-based catalyst could be used for efficient peroxymonosulfate (PMS) activation, but inevitably suffered from metal ion leaching. Metal-free graphitic carbon nitride (g-C 3 N 4 ) materials that can activate PMS are more conducive for practical water treatment. In this study, g-C 3 N 4 with both N-defects and P-doping (CN-NP) was synthesized, which mainly produce singlet oxygen ( 1 O 2 ), and 97 % of 4-CP (4-Chlorophenol) was removed by CN-NP/PMS/Vis reaction system within 60 min. The active species was identified by quenching experiments and electron spin resonance (ESR) tests, and the origin of mainly active species was further verified by the concentration change of PMS during the reaction. It was verified by experiments and theoretical calculations that the introduction of N-defects led to the separation of photoinduced electron-hole pairs and improved photocatalytic activity. Notably, density functional theory (DFT) revealed that both N-defects and P-doping are electron-deficient sites, and P-doping acts as the main PMS adsorption site to promote the loss of electrons from PMS to generate 1 O 2 . In addition, the catalysts developed in this research were anticipated to be applied in real wastewater treatment, contributing to further comprehend the mechanisms of element doping and defect modification in g-C 3 N 4 activating PMS, and providing new insights for the design of PMS-activating catalysts.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2018
·
IF 11.698
Weiping Zhang,Guiying Li,Wanjun Wang,Yaxin Qin,Taicheng An,Xinyan Xiao,Wonyong Choi
A chemically modified Ag 3 PO 4 @MS 2 (M = Mo, W)/rGO composite was firstly synthesized via a liquid-exfoliation solvothermal method. The structure, morphology, optical properties and composition were characterized by X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, UV–vis diffuse reflectance spectra and X-ray photoelectron spectroscopy, respectively. The characterization results indicated that compact structure could be obtained by using this typical method due to in-situ chemical modification, which could also control the sizes of Ag 3 PO 4 nano-sheets by adding MS 2 /rGO hybrids. More importantly, the resultant Ag 3 PO 4 @MS 2 /rGO composite exhibited higher photocatalytic activity and stability toward the degradation of 4-nitrophenol than pure Ag 3 PO 4 under sunlight irradiation. The stable structure of Ag 3 PO 4 @MS 2 /rGO was closely related with Z-scheme electronic structure and electrical conductivity of MS 2 /rGO hybrids, leading to a higher consumption and transfer of photogenerated electrons. However, by controlling the amounts of MS 2 /rGO hybrids, more stable but lower photocatalytic activity composites could be obtained. Further analysis found that the holes and O 2 − were the main reactive species involved in the photocatalytic degradation of 4-nitrophenol. In addition, possible photocatalytic degradation pathways of 4-nitrophenol were also proposed based on the identified intermediates. The findings of this work may provide a new method to design efficient composites for photocatalytic degradation of organic pollutants .
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ACS Applied Energy Materials
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2018
·
IF 0
Junjie Fu,Jie Fu,Qingwen Tian,Houlin Wang,Fengming Zhao,Jun Kong,Xiangyun Zhao,Sixin Wu
The Se content in a Cu2ZnSn(S, Se)4 absorber layer has a significant impact on the electronic properties, but it is rather challenging to control the Se/(S + Se) ratio due to a complicated selenization process. Here, a low-toxicity thiol/amine-based solution process was developed to tune the Se content in a Cu2ZnSn(S, Se)4 absorber layer to an optimal value by ingeniously controlling the SeO2 in the precursor solution. We demonstrated that the crystal growth and the band gap of Cu2ZnSn(S, Se)4 thin films are affected by the Se/(S + Se) ratio. By this approach, the open-circuit voltage deficit (Voc,def) of the device was effectively decreased, and the short-circuit density (Jsc) and fill factor (FF) were remarkably improved; thus, the power conversion efficiency of the Cu2ZnSn(S, Se)4 solar cells was successfully increased from 5.6% to 9.7% for the optimal band gap (Eg = 1.13 eV).
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ELECTROCHIMICA ACTA
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2011
·
IF 3.65
Zhe Sun,Ren-Kai Zhang,Huan-Huan Xie,Mao Liang,Rui-Hong Du,Song Xue
4- N , N -Dimethylaminopyridine (DMAP) was introduced into poly(ethyleneoxide)/oligo(ethylene glycol) (PEO/PEG) electrolytes for dye-sensitized solar cells (DSCs). The improved photovoltaic performance of DMAP-doped DSCs was attributed to the integrated effects of the upward displacement of the TiO 2 band edge and the decrease in the electron recombination rate. Remarkably, the presence of DMAP suppresses electron recombination via two combined pathways involving the dissociation of triiodide to iodide by a complexation reaction and a modification of the surface state distribution in the band gap of TiO 2 . With the addition of DMAP, the open-circuit voltage enhances dramatically. The short-circuit photocurrent density has a small increase at low DMAP concentration and drops afterwards. The power conversion efficiency is 4.07%, which corresponds to a 63% increase over that of the DSC without DMAP.
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CHEMOSPHERE
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2009
·
IF 3.054
Shuang Song,Zhiwu Liu,Zhiqiao He,Yu Li,Jianmeng Chen,Chaolin Li
Biocides usually persist during municipal sewage treatment and are subsequently distributed into aquatic environments. To explore the capability of advanced oxidation processes for the rapid removal of biocides, we examined the total organic carbon (TOC) reduction of 4-chloro-3,5-dimethylphenol (PCMX) with a combination of UV/O 3 . Moreover, the related important parameters, including the mass transfer coefficient and light utilization efficiency, in PCMX degradation were determined. The UV/O 3 experimental results showed a pronounced synergistic effect, leading to the nearly complete elimination of TOC within 75 min. Thus, the effect of operating variables was investigated as a function of pH, ozone dosage, bulk temperature and the initial concentration of PCMX. The efficiency of PCMX mineralization increased with an increase in ozone dose up to 3.1 g h −1 , and a decrease in the initial concentration from 250 to 100 mg L −1 . The optimal pH value was 4.0, and the preferred bulk temperature was 20 °C on the basis of the influence of temperature on reaction rate and ozone solubility. The major aromatic intermediates identified by gas chromatography/mass spectrometry were 2,6-dimethylbenzene-1,4-diol, 2,6-dimethylbenzo-1,4-quinone, 2,6-bis(hydroxymethyl)benzo-1,4-quinone, and 2,6-dimethylbenzo-1,4-aldehyde. Quantitative determination of related carboxylic acid and inorganic anions was done by ion chromatography . On the basis of the identified reaction products, a possible degradation pathway for the UV/O 3 oxidation of PCMX in aqueous media is proposed.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2012
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IF 2.905
Xiaohua Zhu,Qifang Jiao,Chuyi Zhang,Xiaoxi Zuo,Xin Xiao,Yong Liang,Junmin Nan
The graphene and 5-[ o -(4-Bromine amyloxy) phenyl]-10,15,20-triphenylporphrin ( o -BrPETPP) composite (GR- o -BrPETPP) film is prepared on the glassy carbon electrode (GCE) with graphene oxide (GO) modifier through a consecutive cyclic voltammetry process, and then its electrocatalytic oxidation to indirubin is investigated. The as-prepared GR- o -BrPETPP film exhibits wrinkling paper-like structure and lower electron transfer resistance. In comparison with the o -BrPETPP/GCE and GCE, the GR- o -BrPETPP film electrode prepared for five cycles indicates an excellent electrocatalytic oxidation activity toward indirubin with about 2.2 and 13.3 times higher current response, respectively. In addition, in the 0.1 mol L −1 acetate buffer solution (pH = 4.6), the film electrode displays a linear relationship between the oxidation current and the indirubin concentration in the range from 5.0 × 10 −7 mol L −1 to 2.4 × 10 −5 mol L −1 , and presents a detection limit of 1.0 × 10 −7 mol L −1 ( S / N = 3) by differential pulse voltammetry (DPV) with 220 s accumulation. Especially, this film electrode also shows a comparative sensitivity with high-performance liquid chromatography (HPLC) for the determination of the indirubin extractive of herbal medicines, showing its practical prospect in the electrochemical determination of indirubin.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2010
·Vol. 119
·期 4
·1923-1930
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IF 1.203
Pengqing Liu,Ting Wu,Meiwu Shi,Guangdou Ye,Jianjun Xu
A series easily soluble polyarylates were synthesized from either 1,1-bis(4-hydroxyphenyl)-1-phenylethane or tetramethylbisphenol A with various aromatic diacid chlorides by the two-phase interfacial polycondensation. These polyarylates have the inherent viscositiesin the range of 0.36–0.97 dL/g, and their number-average and weight-average molecular weights determined by gel permeation chromatography are 14,200–43,200 and 31,900–102,500, respectively. All these polyarylates are readily soluble in a wide range of organic solvents, thus these polymers can be convenient to process into heat resistance films by cast, spin- or dip-coating. The polyarylates have the glass transition temperatures in the range of 165.0–201.6°C. The pendent phenyl-containing polyarylates reveal excellent thermal stability, and their initial degradation temperatures are all above 480°C and char yields at 700°C are 37.97–40.53% in nitrogen atmosphere. However, the polymers prepared from tetramethylbisphenol A have a large decrease in thermal stability, and their initial degradation temperatures in nitrogen are only about 440°C. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2012
·
IF 3.07
Shaohua Zhang,Han Yan,Mingwei Zhao,Liqiang Zheng
Three gemini pyrrolidine-based ionic liquids, 1,1′-(butane-1,4-diyl)bis(1-alkylpyrrolidinium) bromide ([C n py-4-C n py][Br 2 ], n = 10, 12, 14), were synthesized. Their aggregation behavior in aqueous solution was systematically investigated by surface tension, electrical conductivity, and steady-state fluorescence. Compared with their corresponding monomers, N -alkyl- N -methylpyrrolidinium bromide (C n MPB), [C n py-4-C n py][Br 2 ], have higher surface activity. The special structure of [C n py-4-C n py][Br 2 ] that has a spacer in their hydrophilic head groups results in a lower surface excess concentration ( Γ max ) and a larger molecular cross-sectional area ( A min ). Electrical conductivity studies show a lower degree of counter-ion binding to the aggregates. A smaller aggregation number ( N agg ) is observed by the pyrene fluorescence quenching method. A series of thermodynamic parameters ( Δ G agg 0 , Δ H agg 0 , - T Δ S agg 0 ) of aggregation derived from electrical conductivity indicate that the aggregation of [C n py-4-C n py][Br 2 ] is enthalpy-driven, while aggregation of C n MPB is entropy-driven at low temperatures but enthalpy-driven at high temperatures.
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JOURNAL OF MEMBRANE SCIENCE
·
2017
·
IF 6.035
Ruijun Zhang,Shuili Yu,Wenxin Shi,Wei Wang,Xiaoying Wang,Zhiqiang Zhang,Li Li,Bing Zhang,Xian Bao
In order to integrate the advantages of polyamide thin film composite (TFC) nanofiltration (NF) membranes and that of polyester TFC NF membranes, a novel polyesteramide (PEA) TFC NF membrane was prepared by interfacial polymerization between serinol and trimesoyl chloride (TMC) and catalyzed by 4-dimethylaminopyridine (DMAP) on a flat-sheet polyethersulfone (PES) substrate membrane. The membrane performance was maximized by optimizing different preparation parameters. The reaction process was divided into four basic patterns. X-ray photoelectron spectroscopy (XPS) and infrared spectroscopy confirmed the membrane had a partially cross-linked active layer that contained ester bonds, amide bonds and residual hydroxyl groups. Morphology analysis showed the surface of the PEA-TFC-NF membrane was grainy, which was different from the typical polyamide membranes. The contact angle and zeta potential measurements confirmed the PEA-TFC-NF membrane was highly hydrophilic and negatively charged across the entire pH range tested. The optimized PEA-TFC-NF membrane had a MWCO of 474 Da and water permeability of 6.0 L m −2 h −1 bar −1 at 0.5 MPa and 25 °C. The membrane salt rejections followed the order of Na 2 SO 4 > MgSO 4 > NaCl > MgCl 2 , which were 96.27%, 83.92%, 58.68% and 28.76%, respectively. Moreover, the PEA-TFC-NF membrane displayed good antifouling ability.
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
·
2025
·
IF 3.8
Jin Feng,Qian Yang,Ming Chen,Long Ning,Yan Wang,Dan Luo,Dongxiong Hu,Qing Lin,Fangyan He
Background The active ingredient of Gastrodia elata , 4-hydroxybenzaldehyde (4-HBd), can rapidly enter the brain and undergo massive oxidation to produce the metabolite 4-hydroxybenzoic acid (4-HBA), which has no significant activity after equal dose gavage. It is crucial to clarify the metabolic pathway of 4-HBd and its correlation with the anti IS mechanism. Objective To explore the possible mechanism of 4-HBd in clearing ROS and protecting BBB from oxidative stress damage during brain metabolism from the perspective of ROS response. Method A rat model of cerebral ischemia-reperfusion injury and a cellular oxidative stress response model were replicated to simulate the accumulation process of ROS in the brain. The changes in ROS and peroxidation products before and after 4-HBd intervention were detected, and the changes in oxidative metabolism were also measured to confirm the correlation between antioxidant stress damage and ROS capture/clearance in oxidative metabolism. Result 4-HBd has significant antioxidant stress resistance both in vitro and in vivo, and can reduce the levels of MDA and 4-HNE in ischemic brain tissue. It can capture O2·- and ·OH in vitro and use the captured ROS to oxidize and metabolize 4-HBA. Conclusion The oxidative metabolism process of 4-HBd in the brain is one of its mechanisms for exerting antioxidant stress damage and protecting BBB.
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