Nature Communications
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2024
·Vol. 15
·期 1
·1-15
·
IF 14.7
He Pei,Yue Junyu,Qiu Zhennan,Meng Zijie,He Jiankang,Li Dichen
Electric eel is an excellent example to harness ion-concentration gradients for sustainable power generation. However, current strategies to create electric-eel-inspired power sources commonly involve manual stacking of multiple salinity-gradient power source units, resulting in low efficiency, unstable contact, and poor flexibility. Here we propose a consecutive multimaterial printing strategy to efficiently fabricate biomimetic ionic hydrogel power sources with a maximum stretchability of 137%. The consecutively-printed ionic hydrogel power source filaments showed seamless bonding interface and can maintain stable voltage outputs for 1000 stretching cycles at 100% strain. With arrayed multi-channel printhead, power sources with a maximum voltage of 208 V can be automatically printed and assembled in parallel within 30 min. The as-printed flexible power source filaments can be woven into a wristband to power a digital wristwatch. The presented strategy provides a tool to efficiently produce electric-eel-inspired ionic hydrogel power sources with great stretchability for various flexible power source applications.
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Science China-Materials
·
2025
·
IF 7.4
Zhao Weidong,Zheng Mengfei,Chu Hongyu,Zhang Jingxuan,Wang Kun,Yang Chenguang,Shen Na,Tang Zhaohui
β-Lapachone (β-Lap) is a promising ortho -naphthoquinone drug for cancer treatment and has been in clinical trials. Its application is constrained by the low aqueous solubility, and severe side effects. Even prodrug designation is an effective approach to render it with tumor selectivity, it is limited by the lack of modifiable groups on β-Lap. Herein, a novel azo bond primary cleavage and carbon–carbon (C–C) bond secondary cleavage-based polymeric β-Lap prodrug (Azo-Lap NP) is designed, in which the self-immolated para -aminobenzyl linker is connected to poly( l -glutamic acid) (PGlu) via azo linkage and the responsive drug release of β-Lap against tumors can be achieved under high NAD(P)H:quinone oxidoreductase 1 (NQO1) expression and low pH environment in tumors. The effective covalent loading of β-Lap by Azo-Lap NPs permitted a high administration dose of β-Lap and enabled significant tumor retention time. Moreover, Azo-Lap NPs markedly reduced the side effects of β-Lap by avoiding hemolysis and the production of methemoglobin. The safety of Azo-Lap NPs administration is validated in the antitumor experiment of mice. In the 4T1 model, Azo-Lap NPs exhibited a markedly higher tumor suppression rate than β-Lap. This work provides an effective and safe polymeric prodrug for tumor selective delivery of β-Lap.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-16
·
IF 14.7
Lin Peihua,Zhang Bo,Yang Hongli,Yang Shengfei,Xue Pengpeng,Chen Ying,Yu Shiyi,Zhang Jichao,Zhang Yixiao,Chen Liwei,Fan Chunhai,Li Fangyuan,Ling Daishun
Reversible protein phosphorylation, regulated by protein phosphatases, fine-tunes target protein function and plays a vital role in biological processes. Dysregulation of this process leads to aberrant post-translational modifications (PTMs) and contributes to disease development. Despite the widespread use of artificial catalysts as enzyme mimetics, their direct modulation of proteins remains largely unexplored. To address this gap and enable the reversal of aberrant PTMs for disease therapy, we present the development of artificial protein modulators (APROMs). Through atomic-level engineering of heterogeneous catalysts with asymmetric catalytic centers, these modulators bear structural similarities to protein phosphatases and exhibit remarkable ability to destabilize the bridging μ 3 -hydroxide. This activation of catalytic centers enables spontaneous hydrolysis of phospho-substrates, providing precise control over PTMs. Notably, APROMs, with protein phosphatase-like characteristics, catalytically reprogram the biological function of α-synuclein by directly hydrolyzing hyperphosphorylated α-synuclein. Consequently, synaptic function is reinforced in Parkinson’s disease. Our findings offer a promising avenue for reprogramming protein function through de novo PTMs strategy.
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Waste and Biomass Valorization
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2025
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IF 2.8
Zhou Caixue,Dai Shuxia,Yin Li,Zhuo Yu,Zhao Nannan,Li Dehai,Sun Changyan
Purpose In this paper, we use Pinus pumila (Pall.) Pinecone to extract essential oil and improve its utilization. Methods The study used hydrodistillation to extract essential oil from Pinus pumila (Pall.) pinecone. Inhibition analysis of E. coli using extracted essential oils was evaluated to reveal the inhibitory activity by assessing growth curves, conductivity, nucleic acids, proteins, enzyme activities, and protein synthesis. Results The primary constituents, as shown by GC-MS chemical composition study, were α-pinitol, β-pinene and limonene. The results of the bacteriostatic activity indicated that the inhibitory zone (DIZ) had a diameter of 14.93 ± 0.14 mm, the minimum bactericidal concentration (MBC) was 16.0 µL/mL, and the minimum inhibitory concentration (MIC) was 8.0 µL/mL. Sweeping electron microscopy and laser confocal also demonstrated the disruption of cell wall and cellular enzymes, analyzed by CATase and ATPase activities, which showed a decrease in enzyme activity, and SDS-PAGE analysis showed its ability to inhibit protein synthesis, which leads to cellular damage. Conclusion The present study emphasizes the sustainable use of Pinus pumila (Pall.) Pinecone for economic opening of food preservation in addition to inhibition of spoilage bacteria.
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Nano Research
·
2024
·
IF 9.5
Zhang Guiru,Ji Ning,Lyu Shiheng,Ni Baoxin,Shen Peng,Ye Ke,Wang Yuting,Jiang Xuheng,Zhang Hai,Liu Xi,Wang Yongcheng,Jiang Kun
Electrochemically converting CO 2 into value-added chemicals is a promising approach to mitigate anthropogenic carbon emissions, yet largely limited to short-chained C 1 –C 3 products. Herein, we demonstrate a tandem artificial synthesis of biodegradable polyhydroxybutyrate (PHB) plastic from CO 2 building blocks. Batch synthesis of defects-enriched Bi catalyst is firstly demonstrated by plasma bombardment and following in situ electrochemical reduction, which delivers a HCOOH Faradaic efficiency above 80% at tunable concentration from 2 to 250 mM, an energy efficiency up to 41%, and a single-pass carbon conversion efficiency up to 60%. Annular dark field and second electron microscopic analysis, density functional theory (DFT) calcualtions, coupled with H-type and solid-state electrolyzer assessments, point out the vital role of defective and/or stepped Bi surface sites in promoting CO 2 -to-HCOOH conversion. Thereafter, as-synthesized high-purity HCOOH is used as the sole carbon source for C-chain growth within microbial fermentation reactor with Ralstonia eutropha , where activated formate dehydrogenase and increased metabolites related to Calvin–Benson–Bassham cycle are found to be responsible for the enhanced polyester accumulation.
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BioNanoScience
·
2024
·
IF 3
Tahamtan Salman,Shamsabadipour Amin,Pourmadadi Mehrab,Khodabandehloo Amir Hossein,Ghadami Azam,Fathi-karkan Sonia,Rahdar Abbas,Pandey Sadanand
Quercetin (QC), a naturally occurring antioxidant, has demonstrated potential in the prophylaxis and therapy of various cancer types. Despite its biocompatibility and minimal side effects, its therapeutic efficacy is limited by its low physicochemical stability, poor solubility, and suboptimal bioavailability. This study proposes a novel approach to address these limitations and augment the pharmacokinetics of QC, specifically its half-life and overall delivery efficacy. The W/O/W was employed to load QC into a chitosan (CS)/Starch/graphene quantum dots (GQDs)/titanium dioxide (TiO 2 ) nanocomposite, serving as a stimuli-responsive nanocarrier. The CS/Starch hydrogel was synthesized via a physical crosslinking process to optimize biocompatibility. Subsequently, GQDs and TiO 2 were incorporated to induce porosity within the system. The porosity was examined pre and post QC integration using Brunauer–Emmett–Teller (BET) analysis. The successful incorporation of QC and the crystalline properties of the resultant drug-loaded nanocomposite, CS/Starch/GQDs/TiO 2 @QC, were confirmed through Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses, respectively. Morphological evaluations were conducted using zeta potential, dynamic light scattering (DLS), and field emission scanning electron microscopy (FESEM) to ascertain the size, stability, and homogeneity of the nanoparticles. The encapsulation and loading efficiencies, along with release kinetics, were assessed under varying pH (5.4 and 7.4) and temperature (37 °C and 42 °C) conditions. The results indicated Fickian diffusion as the primary QC release mechanism, exhibiting stimuli-responsive behavior. The cytotoxicity of the CS/Starch/GQDs/TiO 2 @QC nanocomposite was evaluated against the A549 cell line using the MTT assay, demonstrating enhanced cytotoxicity compared to QC alone. In light of these findings, the study advocates for the use of the CS/Starch/GQDs/TiO 2 nanocomposite as a biocompatible, porous, and stimuli-responsive nanocarrier for the sustainable delivery of QC in lung cancer therapy.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-11
·
IF 5.3
Wang Xueyu,Wei Xin,Tong Runze,Yi Chunhui,Wang Yidi,Fu Yang,Yan Fanyong
Novel boron-doped carbon dots (BCDs) with extended afterglow characteristics were synthesized via a one-step solvothermal method using acrylamide, sulfosalicylic acid, and sodium tetraborate as protective matrices. The presence of boron from sodium tetraborate introduced an empty orbital, allowing it to form a more extended conjugated system with adjacent oxygen atoms, thereby lowering the energy level of the lowest unoccupied molecular orbital in the system. The phosphorescence emission of these BCDs exhibits a red shift over time from 450 to 500 nm. These BCDs have been effectively utilized to produce anti-counterfeit phosphorescent powder. Additionally, the BCDs display optimal fluorescence excitation at 330 nm and optimal emission at 420 nm. They demonstrate a detection limit for ciprofloxacin hydrochloride of 37 nM in the 1-100 µM concentration range and 26 nM in the 100-210 µM range. This fluorescence detection is governed by an inner filter effect. Real sample testing further confirms that these BCDs serve as excellent sensors for ciprofloxacin hydrochloride. Graphical Abstract
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Friction
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2024
·Vol. 12
·期 9
·1991-2003
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IF 6.3
Ao Dong,Fan Xiaoqiang,Zhu Minhao
Efficient cooperative lubrication can be achieved via the introduction of core-shell structure lubricant additives with hard core and soft shell, for obtaining the expected anti-wear performance from the structural changes in the friction process. In this study, C@Ag microspheres with a core-shell structure were prepared by the redox method with carbon spheres as the core and Ag nanoparticles as the shell. Their tribological behaviors as base oil (G1830) additive with different concentrations were investigated in detail. Compared with base oil, the addition of C@Ag particles at 0.5 wt% can reduce the coefficient of friction (COF) and wear volume (Wv) up to 15.5% and 88%, respectively. More importantly, C@Ag particles provide superior lubrication performance to single additive (like carbon sphere (CS) and Ag nanoparticle). C@Ag core-shell particles contribute to the formation of tribo-film by melt bonding of flexible Ag and carbon sphere (CS) toward excellent self-repair performance and high-efficiency lubrication. Hence, core-shell structural nanoparticles with hard-core and soft-shell hold bright future for high-performance lubrication application.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 9
·1-12
·
IF 5.3
Yu Xifeng,Shen Qirui,Yu Miaomiao,Zhang Wei,Kang Qi,Shen Dazhong
An intense cathodic electrochemiluminescence (ECL) is reported from a polarized glassy carbon electrode (GCE) in peroxydisulfate solution. After the polarization in 1 M Na 2 SO 4 at the potential of − 3.7 V for 3 s, carbon nanosheets (C-NSs) were in situ grown on the surface of the GCE. Measured in 100 mM K 2 S 2 O 8 solution, the ECL intensity of the GCE/C-NSs is 112-fold that of a bare GCE. The ECL spectrum revealed that the true ECL luminophore in the GCE/C-NSs-peroxydisulfate system is O 2 /S 2 O 8 2− which is promoted by C-NSs. When Cu 2+ was electrochemically enriched and reduced to Cu(0) on the catalytic sites of C-NSs, the ECL from GCE/C-NSs/Cu in K 2 S 2 O 8 solution was decreased with increasing logarithmic concentration of Cu 2+ in the range from 10 pM to 1 μM, with a limit of detection (LOD) of 3 pM. An immunoanalysis method is proposed via a biometallization strategy using CuS nanoparticles as the tags and carcinoembryonic antigen (CEA) as the model analyte. After the immune recognition in the microplate, the CuS tags in the immunocomplex were dissolved and the resultant Cu 2+ was electrochemically enriched and reduced on the catalytic sites of C-NSs, quenching the ECL intensity of GCE/C-NSs-O 2 /S 2 O 8 2− system. The proposed ECL immunoanalysis method was used to quantify CEA in actual serum samples with an LOD of 1.0 fg mL −1 , possessing the advantages of simple electrode modification, high sensitivity and good reproducibility. Graphical Abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 12
·1-10
·
IF 5.3
Ye Tai,Luo Zheng,Che Yueyue,Yuan Min,Cao Hui,Hao Liling,Zhang Qian,Xie Yongxin,Zhang Kaisen,Xu Fei
An inverted DNA tetrahedron–mediated modular DNA walker was developed for the determination of sulfadimethoxine. The inverted DNA tetrahedron scaffold raises several advantages of recognition module including appropriate lateral space, multiple recognition domains, and cost-effectiveness. The proposed inverted DNA tetrahedron-based recognition module exhibited better binding affinity and kinetics toward target antibiotic than that of other DNA tetrahedron counterparts. Upon specific binding with target, the released bipedal DNA walking strand hops to the signal amplification module and moves stochastically with assistant of nicking enzyme. By coupling these two modules, a good linear relationship between the fluorescence intensity of supernatant and the concentration of sulfadimethoxine was achieved in the range 0.1–100 nM, and the limit of detection was 64.7 pM. Furthermore, this modular DNA walker had also successfully applied to spiked honey and milk samples with satisfactory recoveries from 91.5 to 108.8%, demonstrating its practical sensing capability. Graphical
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2024
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IF 4.7
Zhao Yanna,Bai Xiaowei,Zhang Yingying,Wang Yuqi,Li Yiqing,Yang Shuai
The preparation of high-performance recyclable epoxy vitrimer from bio-based feedstocks is of great industrial significance. Based on the above considerations, in this paper, we report a reaction of curing a bio-based epoxy monomer, propanetriol triglycidyl ether (GTE), with vanillin-derived diphenol monomer (VD) and 3-aminophenylboronic acid (M-APBA) as a curing agent, which resulted in the preparation of epoxy vitrimer films (EVB-X) with acylhydrazone bonds and cyclic boroxine dual dynamic response. Among them, the diphenol monomer VD supplies the flexible structure of the film, while the film showed a gradual increase in the boroxine six-membered ring structure with the gradual increase in the ratio of M-APBA, and the thermal and mechanical properties of the films are also gradually improving. By varying the ratio of VD to M-APBA in the material, EVB-3 was the most thermally stable, while T g was measured at 45 °C, the highest tensile strength (57.40 MPa), and the largest cross-linking density (3271 mol/m 3 ) among the four groups of films obtained from EVB-X films. In addition, the EVB films had excellent triple memory and could be largely degraded in acidic DMF and DMSO, with a gel content of 86.74% measured with EVB-3. Notably, the EVB scratches were completely healed at 100 °C for 1 h, indicating that EVB have excellent self-repairing properties, while the tensile strength could be recovered up to 28.98 MPa after heat treatment, and the strain repair rate could reach up to 89.42%, which provides good reprocessability.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Guo Jun,Duan Yulong,Jia Yunling,Zhao Zelong,Gao Xiaoqing,Liu Pai,Li Fangfang,Chen Hongli,Ye Yutong,Liu Yujiao,Zhao Meiting,Tang Zhiyong,Liu Yi
Assembly ubiquitously occurs in nature and gives birth to numerous functional biomaterials and sophisticated organisms. In this work, chiral hydrogen-bonded organic-inorganic frameworks (HOIFs) are synthesized via biomimicking the self-assembly process from amino acids to proteins. Enjoying the homohelical configurations analogous to α -helix, the HOIFs exhibit remarkable chiroptical activity including the chiral fluorescence ( g lum = 1.7 × 10 −3 ) that is untouched among the previously reported hydrogen-bonded frameworks. Benefitting from the dynamic feature of hydrogen bonding, HOIFs enable enantio-discrimination of chiral aliphatic substrates with imperceivable steric discrepancy based on fluorescent change. Moreover, the disassembled HOIFs after recognition applications are capable of being facilely regenerated and self-purified via aprotic solvent-induced reassembly, leading to at least three consecutive cycles without losing the enantioselectivity. The underlying mechanism of chirality bias is decoded by the experimental isothermal titration calorimetry together with theoretic simulation.
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