MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 7
·1-10
·
IF 6.232
Zhang Xue,Shen Yan-Feng,Li Xin-Xin,Yang Jin-Rong,Liu Zhao-Sheng,Huang Yan-Ping
An organic-inorganic hybrid monolithic column doped with gold nanorods (AuNRs) was prepared and evaluated for solid phase extraction (SPE) of polycyclic aromatic hydrocarbons (PAHs). Excellent dispersibility of AuNRs in binary green porogen system consisting of 1-hexyl-3-methylimidazolium tetrafluoroborate and deep eutectic solvents (DESs) was confirmed by energy dispersive spectrometry (EDS). The particle size of the resulting AuNRs (70–90 nm) was thoroughly examined by a transmission electron microscopy (TEM). The redox system including ammonium persulfate (APS) and tetramethylethylenediamine (TEMED) was used to initiate in situ polymerization at 4 °C to prepare the hybrid monolith. The mesoporous structure of the AuNR hybrid monoliths was confirmed by scanning electron microscopy (SEM) and nitrogen adsorption. With enrichment factors (EFs) of 150- to 292-fold, the developed method was successfully applied to the determination of 10 PAHs in wastewater samples. The recoveries at a spiked level were in the range 84.9 to 99.5% with limit of detections (LODs) and relative standard deviations (RSDs) ranging from 0.02 to 0.10 μg L −1 and 1.5 to 4.2%, respectively. The correlation coefficients ( R 2 ) for the calibration function obtained were better 0.9991 for the target compounds. Compared to the AuNR-free monolith, the extraction efficiency of the AuNR-incorporated monolith is more than two times higher. The results indicated that the doping of AuNRs is an effective approach to obtain the hybrid monolithic column with good separation ability for PAHs.
Graphical abstract
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BIODEGRADATION
·
2021
·Vol. 32
·期 1
·99-112
·
IF 3.909
Qiao Weichuan,Miao Jiahui,Jiang Hongmei,Yang Qiwen
Perfluoroalkyl carboxylates (PFCAs) is toxic to the environment and human health. However, the degradation characteristics of fluorotelomer alcohols (FTOHs), precursors of PFACAs biodegradation, in the sludge during aerobic composting remain unclear. In this study, the degradation characteristics of 6:2 FTOH in sewage sludge by composting were researched and the influences of 6:2 FTOH on the composting process and microbial communities of the sludge were evaluated. After 52 days of composting, 6:2 FTOH retained only 0.73% of its original concentration, and its half-life was less than 1 d; 6:2 FTOH was degraded finally to perfluorohex unsaturated acid, perfluoropentanoic acid, 5:3 polyfluorinated acid (FTCA), 4:3 FTCA, and perfluorobutanoic acid through two pathways; and 6:2 FTCA and 6:2 fluorotel unsaturated acid were the intermediate products. Notably, dosing with 6:2 FTOH affected the composting process of sewage sludge. Additionally, 50 mg/kg 6:2 FTOH resulted in a decrease in the microbial richness and diversity of sludge compost. When compared with the compost without 6:2 FTOH, the proportion of Proteobacteria had increased, and the proportion of Firmicutes had decreased as the concentration of 6:2 FTOH increased. The negative effect of a dosage of 50 mg/kg 6:2 FTOH was more obvious than the effect of other treatments. This study expanded our understanding of the risk of sludge contaminated by 6:2 FTOH being used as a fertilizer after composting.
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MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 10
·3747-3753
·
IF 4.58
Jia Haiyan,Yang Taotao,Zuo Yinxiu,Wang Wenmin,Xu Jingkun,Lu Limin,Li Ping
The authors describe a voltammetric immunosensor with antibody immobilized on a glassy carbon electrode (GCE) modified with N-doped graphene (N-GS), electrodeposited gold nanoparticles (AuNPs) and chitosan (Chit). The preparation is simple and the thickness of the electrodeposited films can be well controlled. Due to the specific advantages of N-GS, AuNPs and Chit, the electrode has a large specific surface, improved conductivity, high stability. A new label-free immunosensor for the model antigen (alpha fetoprotein, AFP) detection was then designed by employing N-GS-AuNP-Chit as the antibody immobilization and signal amplification platform. Differential pulse voltammetry and electrochemical impedance spectroscopy were used for the characterization of the stepwise assembly process. Under the optimized conditions, at a typical working potential of +0.20 V (vs. SCE), and by using hexacyanoferrate as an electrochemical probe, the immunosensor has a detection limit as low as 1.6 pg mL −1 and a linear analytical range that extends from 5 pg mL −1 to 50 ng mL −1 . AFP was quantified in spiked human serum samples with acceptable precision.
Schematic of sensitive and effective label-free electrochemical immunosensor for the detection of AFP based on N-GS-AuNP-Chit as signal amplification matrix.
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Forensic Toxicology
·
2023
·Vol. 41
·期 2
·241-248
·
IF 2.2
Guo Caixia,Yan Hui,Liu Wei,Xiang Ping,Di Bin,Shen Min
Purpose An analytical method using liquid chromatography with tandem mass spectrometry (LC–MS/MS) was established and validated for screening 425 drugs and poisons in dried blood spots (DBSs). Methods Blood (20 μL) was spotted on Whatman FTA™ classic card to prepare DBS sample, then extracted with 150 μL methanol and analyzed by LC–MS/MS using a multiple reaction monitoring method. Results The limit of detection of the compounds were 0.1–10 ng/mL. The values for recovery and matrix effect were 40.3–114.9% and 40.2–118.4%, respectively. This method was successfully applied to DBS samples from 105 humans suspected of drug poisoning, which was stored for 3–5 years at room temperature. Thirty-three kinds of drugs, including benzodiazepines, antipsychotics, antidepressants, antipyretic analgesics, non-steroidal anti-inflammatory drugs, antibiotics, antiepileptic drugs, new psychoactive drugs were confirmed in 102 cases, while no compound was detected in the other 3 cases. Estazolam, a benzodiazepine widely used in clinical practice as a sedative, hypnotic, and anti-anxiety drug, was the most frequently detected substance, occurring in 34.2% of the cases. Conclusions Most drugs in DBS could still be detected after storage for 3–5 years, but ambroxol, zopiclone, carbofuran, chlorpyrifos, and valproic acid were not detectable after 3–5 years of storage at room temperature. The components measured in DBS were consistent with those measured in whole blood at the collection time, thereby confirming that DBS samples have the advantage of stable storage at room temperature.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Zhu Bin,He Shanshan,Yang Yan,Li Songwei,Lau Cher Hon,Liu Shaomin,Shao Lu
Advances in membrane technologies are significant for mitigating global climate change because of their low cost and easy operation. Although mixed-matrix membranes (MMMs) obtained via the combination of metal-organic frameworks (MOFs) and a polymer matrix are promising for energy-efficient gas separation, the achievement of a desirable match between polymers and MOFs for the development of advanced MMMs is challenging, especially when emerging highly permeable materials such as polymers of intrinsic microporosity (PIMs) are deployed. Here, we report a molecular soldering strategy featuring multifunctional polyphenols in tailored polymer chains, well-designed hollow MOF structures, and defect-free interfaces. The exceptional adhesion nature of polyphenols results in dense packing and visible stiffness of PIM-1 chains with strengthened selectivity. The architecture of the hollow MOFs leads to free mass transfer and substantially improves permeability. These structural advantages act synergistically to break the permeability-selectivity trade-off limit in MMMs and surpass the conventional upper bound. This polyphenol molecular soldering method has been validated for various polymers, providing a universal pathway to prepare advanced MMMs with desirable performance for diverse applications beyond carbon capture.
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Bio-Design and Manufacturing
·
2021
·Vol. 4
·期 4
·902-911
·
IF 6.302
Zeng Zhiyong,Jiang Guohua,Liu Tianqi,Song Gao,Sun Yanfang,Zhang Xueya,Jing Yanting,Feng Mingjia,Shi Yufei
Abstract Injection therapy for diabetes has poor patient compliance, and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients. In this work, to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues, methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats. Gelatin methacryloyl microneedles (GelMA-MNs) with different degrees of substitution were successfully prepared by a micro-molding method. The resultant GelMA-MNs exhibited excellent mechanical properties and moisture resistance. Metformin, an anti-diabetic drug, was further encapsulated into the GelMA-MNs, and its release rate could be controlled by the three-dimensional cross-linked network of microneedles, thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic rats. The drug release period could be significantly prolonged by improving the cross-link density of GelMA-MNs. The results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 6
·1387-1393
·
IF 2.726
Wu Zhifang,Liang Zhishan,He Ziqian,Wang Tianqi,Xiao Ren,Han Fangjie,Zhao Zhengzheng,Han Dongfang,Han Dongxue,Niu Li
We report a photoelectrochemical(PEC) sensor for selective detection of ascorbic(AA) by introducing Z-scheme Bi 2 S 3 @nitrogen doped graphene quantum dots(Bi 2 S 3 @NGQDs) heterojunctions as efficient photoactive species. The Bi 2 S 3 @NGQDs were successfully prepared by a simple hydrothermal process, and the microstructures and components were investigated by various characterized techniques. The photocurrent of the Bi 2 S 3 @NGQDs-based sensor increased significantly in the presence of AA and showed excellent selectivity and stability for AA detection in the presence of some other antioxidants and small molecules. A wide linear range of 0.1–5 µmol/L and 5–1380 µmol/L was achieved for the AA detection with a detection limit of 36 nmol/L( S / N =3). Moreover, the proposed PEC sensor achieved the determination of AA in real red peppers and commercially available vitamin C tablets samples.
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EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2017
·Vol. 244
·期 5
·851-860
·
IF 1.664
Xu Dan,Liu Hong,Jin Cheng-yu,Cao Chun-mei,Li Wen-gang,Zeng Fan-kui,Zhao Yu-ci,Liu Gang
Hongmei is a new potato variety developed in recent year, which is suitable for raw eating as a kind of fruit. In this study, sensory evaluations, nutritional components, morphology characteristics of starch granules, phenolic compounds, sugars, glycoalkaloids, and amino acid composition of potato Hongmei were investigated. The results show that Hongmei be suitable for raw eating mainly based on three reasons: (1) possess a juicy characteristic and lower earthy smell, with a distinctive fruity flavor of fresh cucumber; (2) the average particle size of starch from Hongmei is 18.31 ± 7.71 μm, which is smaller than the commercial potato starch significant ( p < 0.01); (3) with a content of 653.64 ± 83.25 mg/100 g of fructose, which is similar to the sweet potato be suitable for raw eating. The results also show that Hongmei had high concentrations of crude protein, total ascorbic acid, but lower starch content. The total glycoalkaloids content in the flesh is only 5.52 mg/kg, which implied that it is safe for raw eating. However, due to the total glycoalkaloids in the Hongmei peel is 358.88 mg/kg, which is higher than the safe standard of 200 mg/kg, it is recommended to peel when eating raw.
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Food Analytical Methods
·
2018
·Vol. 12
·期 2
·544-557
·
IF 2.245
Al-Dalali Sam,Zheng Fuping,Sun Baoguo,Chen Feng
Zhenjiang aromatic vinegar is one of the most popular vinegars in China, which can be produced by either traditional or modern techniques. Aroma profiles of the traditional Zhenjiang aromatic vinegar (TZAV) and the modern Zhenjiang aromatic vinegar (MZAV) at different stages of their aging were analyzed by headspace solid-phase microextraction (HS-SPME) with an aid of DVB/CAR/PDMS fiber combined with gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O). A total of 53 volatile compounds were identified. Among them, 43 aromas were positively identified after comparison with their corresponding authentic compounds. Two volatiles, including isopentyl alcohol and butyl benzoate, were only identified in TZAV, while propiophenone was only identified in MZAV. In addition, some volatiles were found to be generated during the aging period, which included isopentyl alcohol, 3-(methylthio)propyl acetate, and 2-acetoxy-3-butanone in the TZAV samples, and 2-ethyl-1-hexanol, octanoic acid, propiophenone, and dimethyl trisulfide in the MZAV samples. The total amount of volatile compounds in the MZAV was greater than its counterpart TZAV. Moreover, 29 odor-active compounds were recognized by GC-O analysis, while 25 of them were confirmed by their authentic compounds, and their perceived odors included sweet, acid, buttery, floral, herbal, fruit, fresh, pungent, almond, and geraniol notes.
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CHROMATOGRAPHIA
·
2016
·Vol. 79
·期 19
·1263-1269
·
IF 1.332
Wang Liang,Wu Minghuo,Wang Qixue,Zhan Jingjing,Chen Hongbo
Polyethylenimine (PEI) and 2,4,6,8-tetramethyl-2,4,6,8-tetrakis(propyl glycidyl ether)cyclotetrasiloxane (POSS–epoxy) were used as precursors for the preparation of organic-silica hybrid monolithic columns (PEI–POSS monolith) via epoxy–amine ring-opening polymerization (ROP). The high density of amine groups in PEI provides rich chromatographic interaction sites for the polar or acidic analytes in hydrophilic interaction (HILIC) and weak anion exchange (WAX) mechanisms. The column preparation conditions, such as the porogens, solvent and reaction temperature, were systematically investigated according to the morphology, permeability and column efficiency. The separation mechanisms of HILIC and WAX were evaluated with neutral polar compounds and halogen benzoic acids. Owing to the existence of reactive amine groups on the matrix surface, the PEI–POSS monolith is also an ideal starting material for the preparation of HILIC or strong anionic exchange (SAX) stationary phases by modification. The modification of PEI–POSS monoliths with iodomethane or bromoacetic acid via the nucleophilic substitution reaction could achieve the retention mechanisms of SAX or zwitterionic HILIC, respectively.
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WATER AIR AND SOIL POLLUTION
·
2016
·Vol. 227
·期 8
·1-9
·
IF 1.551
Yu Yanghai,Zhou Shiqing,Bu Lingjun,Shi Zhou,Zhu Shumin
An electrochemically activated persulfate (EC/PS) system was proposed for the degradation of herbicide diuron in this study. In the EC/PS system, the ferrous ions (Fe 2+ ) produced from iron electrode can activate persulfate to generate sulfate radical (SO 4
·- ) as well as hydroxyl radical (OH • ). The results showed that the degradation of diuron was significantly enhanced in the EC/PS system, compared to electrocoagulation, persulfate, and Fe 2+ /PS process. Both of SO 4
·- and OH · contributed to the degradation of diuron in the EC/PS system according to the radical scavenging studies. The pseudo first-order rate constants of diuron increased with increasing the applied currents and dosages of persulfate. pH affected the degradation of diuron indirectly through the speciation of iron and resulted in higher removal efficiency in acidic condition than in alkaline condition. Chloride, carbonate, and bicarbonate in real water inhibited the degradation of diuron dramatically through consuming SO 4
·- and OH · and abided by the order of CO 3
2− >HCO 3
− >Cl − . This study demonstrates that the EC/PS system is a novel, efficient, promising, and environmental-friendly method to treat diuron contamination.
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-15
·
IF 14.919
Xiong Pan,Zhang Fan,Zhang Xiuyun,Liu Yifan,Wu Yunyan,Wang Shijian,Safaei Javad,Sun Bing,Ma Renzhi,Liu Zongwen,Bando Yoshio,Sasaki Takayoshi,Wang Xin,Zhu Junwu,Wang Guoxiu
The regulation of anions and cations at the atomic scale is of great significance in membrane-based separation technologies. Ionic transport regulation techniques could also play a crucial role in developing high-performance alkali metal batteries such as alkali metal-sulfur and alkali metal-selenium batteries, which suffer from the non-uniform transport of alkali metal ions (e.g., Li + or Na + ) and detrimental shuttling effect of polysulfide/polyselenide anions. These drawbacks could cause unfavourable growth of alkali metal depositions at the metal electrode and irreversible consumption of cathode active materials, leading to capacity decay and short cycling life. Herein, we propose the use of a polypropylene separator coated with negatively charged Ti 0.87 O 2 nanosheets with Ti atomic vacancies to tackle these issues. In particular, we demonstrate that the electrostatic interactions between the negatively charged Ti 0.87 O 2 nanosheets and polysulfide/polyselenide anions reduce the shuttling effect. Moreover, the Ti 0.87 O 2 -coated separator regulates the migration of alkali ions ensuring a homogeneous ion flux and the Ti vacancies, acting as sub-nanometric pores, promote fast alkali-ion diffusion.
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