APPLIED ORGANOMETALLIC CHEMISTRY
·
2017
·Vol. 32
·期 3
·e4201
·
IF 2.319
Mengqiu Huang,Jiasheng Fang,Yiwei Zhang,Chao Zhang,Yuming Zhou,Shuo Zhao,Yan Gao,Xiaoli Sheng
A novel magnetic binary-metal-oxide-coated nanocataly composing of a hollow Fe 3 O 4 core and CeO 2 -La 2 O 3 shells with Au nanoparticles encapsulated has been created in this work. The structural features of catalysts were characterized by several techniques, including SEM, TEM, UV-vis, FTIR, XRD, XPS and TGA analyses. After the coating of CeO 2 -La 2 O 3 layer, CeO 2 -La 2 O 3 /Au/C/Fe 3 O 4 microspheres showed a superior thermal stability and catalytic reactivity compared with a pure CeO 2 or La 2 O 3 layer. Accompanied by the burning of carbon layer, the specific surface could be increased by the formation of double-shelled structure. Besides, the desired samples could be separated by magnet, implying the superior recycle performance. Using the reduction of 4-nitrophenol by NaBH 4 as a model reaction, the microspheres exhibited highly reusability, superior catalytic activity, thermal stability, which are attributed to the unique double-shelled structure of the support, uniform distribution of Au nanoparticles, the highly thermal stability of CeO 2 -La 2 O 3 layer and mixed oxide synergistic effect. As a consequence, the unique nanocatalyst will open a promising way in the fabrication of the double-shelled hollow binary-metal-oxide materials for future research and has great potential in other applications.
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale Research Letters
·
2017
·Vol. 12
·期 1
·1-11
·
IF 2.833
Zhang Zheng,Chen Yunsheng,Ding Jiayue,Zhang Chunlei,Zhang Amin,He Dannong,Zhang Yixin
Biocompatible 5-aminolevulinic acid/Au nanoparticle-loaded ethosomal vesicle (A/A-ES) is prepared via ultrasonication for synergistic transdermal photodynamic/photothermal therapy (PDT/PTT) of hypertrophic scar (HS). Utilizing ultrasonication, Au nanoparticles (AuNPs) are synthesized and simultaneously loaded in ethosomal vesicles (ES) without any toxic agents, and 5-aminolevulinic acid (ALA) is also loaded in ES with 20% of the entrapment efficiency (EE). The prepared A/A-ES displays strong absorbance in 600-650 nm due to the plasmonic coupling effect between neighboring AuNPs in the same A/A-ES, which can simultaneously stimulate A/A-ES to produce heat and enhance quantum yields of reactive oxygen species (ROS) by using 632 nm laser. In vitro transdermal penetrability study demonstrates that A/A-ES acts as a highly efficient drug carrier to enhance both ALA and AuNPs penetration into HS tissue . Taking human hypertrophic scar fibroblasts (HSF) as therapeutic targets, synergistic PDT/PTT of HS indicates that A/A-ES could enhance quantum yields of ROS by photothermal effect and localized surface plasmon resonance (LSPR) of AuNPs, resulting in a high level of apoptosis or necrosis. In a word, the prepared A/A-ES shows a better synergistic PDT/PTT efficiency for HSF than the individual PDT and PTT, encouraging perspective for treatment of HS.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IONICS
·
2017
·Vol. 24
·期 8
·2465-2472
·
IF 2.062
Sun Junyong,Gan Tian,Zhai Rui,Fu Wanqiu,Zhang Miaomiao
In the current study, a simple, recoverable, and stable sensor was developed based on SiO 2 spheres functionalized with 6-nm Au nanoparticles (SiO 2 @AuNPs). Fabrication procedures and analytical application of this sensor toward quantitative determination of diuron in the presence of interfering compound indole-3-acetic acid were verified by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) methods. It has been observed that diuron oxidation at the surface of sensor occurred at a potential of about 1.09 V which was 210 mV higher than that of indole-3-acetic acid, confirming that this newly prepared sensor appeared to be a good platform for the selective detection of diuron. Moreover, DPV demonstrated a linear relationship from 0.20 to 55 μmol/L and a detection limit of 51.9 nmol/L for diuron. Finally, this sensor was utilized for the determination of diuron in complex vegetable samples.
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2012
·
IF 2.484
Da-Quan Sun,Ying Wang,Ding-Gan Liu
AU-rich elements are functional motifs in the 3′untranslated region of mRNA and are binding sites for the RNA binding protein HuR, an mRNA stabilizer and translation enhancer implicated in carcinogenesis. It is not clear whether, and, if so, how the AU-rich elements function in cells when they are separated from their mRNA and form an independent RNA species. Here, we show that a short RNA with AU-rich elements derived from C/EBPβ 3′UTR suppressed growth in a human liver cancer cell line. It specifically bound HuR, and it competed with C/EBPβ mRNA in order to bind to HuR. Our results provide evidence that the cancer cell growth suppression by this 62nt RNA containing AU-rich elements may be due to competitive binding to HuR. This work may open new options for the development of novel anti-cancer drugs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 20
·13808-13816
·
IF 3.9
Min Yang,Jian Wang,Xuan Xue,Hechun Jiang
It is imperative to develop a rapid detection method for Hg2+ due to its harm to human health and the ecological environment. In this research, CuO/Au@Cu3(BTC)2 was synthesized through reducing HAuCl4 by CuxO@Cu3(BTC)2, which was obtained by reducing Cu3(BTC)2 with hydrazine hydrate. The oxidase-mimic activity of CuO/Au@Cu3(BTC)2 can be enhanced by Hg2+ through forming a Au–Hg alloy. Therefore, a colorimetric method was designed for Hg2+ detection with a linear relationship in the 0.05–25 μM range and a limit of detection of 9.7 nM. This strategy exhibited a strong selectivity to Hg2+ and was applied in a real water sample with reliable recoveries. This work provides a possibility for the rapid detection of Hg2+.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Tao Lu,Zhiguang Suo,Min Wei,Huali Jin,Yong Liu,Baoshan He,Renyong Zhao
β-lactoglobulin (β-LG) is a major allergen in milk what can provoke intense allergic reactions. Therefore, an accurate and efficient method is required for sensitive detection of β-LG. A label-free electrochemical aptasensor utilizing Au/Ag@ZIF-8 and dual amplification strategy has been designed for the detection of β-LG. Au/Ag@ZIF-8 nanocomposite is used as the electrode modification material, which has abundant relative surface area and exceptional conductivity behavior, and it can also serve to immobilize DNA strands. By combining RecJf exonuclease and hybridization chain reaction (HCR) dual amplification strategy, an apparent enhancement of electrochemical signal is obtained. β-LG undergoes target cycling in the effect of RecJf exonuclease, which dislodges complementary strand cDNA and further triggers HCR to provide a large number of sites for methylene blue embedding. The detection range of this aptasensor is 0.01–1000 ng/mL in the optimal detection conditions, with a limit of detection (LOD) of 5.37 pg/mL. The constructed electrochemical aptasensor possesses the superiorities of good specificity, preeminent accuracy and satisfied stability in the detection of β-LG. Moreover, it also demonstrates satisfactory detection performance in the detection of real samples, which indicates that the electrochemical aptasensor has a broad application prospect in protecting food safety and health.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2024
·
IF 6.6
Yaxu Feng,Qing Sun,Pei Liu,Wei Fan,Bing Fan
Background Enterococcus faecalis (E. faecalis) is one of the main pathogens responsible for refractory root canal infections in the teeth and shows resistance against various antibacterial managements. Effective control of E. faecalis infection is a prerequisite for successful treatment of refractory apical periodontitis. This study aimed to analyze the antibacterial activity and mechanisms of Au@Ag nanoparticles (NPs) combined with photothermal therapy (PTT) against the original and Ag+-resistant E. faecalis.Methods Au@AgNPs with optimal shell thicknesses were synthesized and characterized. The antibacterial activity of Au@AgNPs with PTT against the original or Ag+-resistant E. faecalis was evaluated, and the antibiofilm activity was tested on E. faecalis biofilm on the dentin of teeth. The potential antibacterial mechanisms of Au@AgNPs combined with PTT against E. faecalis have also been studied. Moreover, its influence on dentin microhardness and cytotoxicity was assessed.Results This study revealed that Au@AgNPs combined with PTT showed enhanced antibacterial and antibiofilm effects, no negative effects on dentin microhardness, and low cytotoxicity toward human periodontal ligament cells (hPDLCs). Moreover, Au@AgNPs combined with PTT effectively inhibited the growth of Ag+-resistant E. faecalis. Its antibacterial effects may be exerted through the release of silver ions (Ag+), destruction of the cell membrane, production of reactive oxygen species (ROS) and inhibition of adenosine triphosphate (ATP) production. Hyperthermia generated by Au@AgNPs with PTT reduced membrane fluidity and enhanced Ag+ sensitivity by downregulating fabF expression. The upregulated expression of heat shock genes demonstrated that the Ag+ released from Au@AgNPs compromised the heat adaptation of E. faecalis.Conclusion PTT significantly enhanced Ag+ sensitivity of the original and Ag+-resistant E. faecalis. Au@AgNPs combined with PTT may have the potential to be developed as a new antibacterial agent to control E. faecalis infections in teeth.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2015
·
IF 5.636
Yingzi Liu,Meina Li,Fan Zhang,Anwei Zhu,Guoyue Shi
A Au disk nanoelectrode down to 3 nm in radius was developed by a facile and reliable method and successfully applied for monitoring dopamine release from single living vesicles. A fine etched Au wire was coated with cathodic electrophoretic paint followed by polyimide, which retracted from the tip end during curing to expose the Au nanotip. By cyclic voltammetric scanning the above tip in 0.5 M KCl, the transformation of a core-shaped apex into a geometrically well-defined Au disk nanoelectrode with different dimensions can be controllably and reproducibly achieved. Scanning electron microscopy, transmission electron microscopy, and steady-state voltammetry were used to determine the size of nanoelectrodes. The results showed that the specific etching and insulation method not only avoids the use of toxic etching solution and the uncontrollable treatment to expose the tip but also makes possible the controllable and reproducible fabrication of Au disk nanoelectrode down to 3 nm in radius. The nanoelectrodes with well-demonstrated analytical performance were further applied for amperometrically monitoring dopamine release from single rat pheochromacytoma cells with high spatial resolution.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2015
·
IF 2.752
Zhihai Cao,Hangnan Chen,Shudi Zhu,Zhijie Chen,Chang Xu,Dongming Qi,Ulrich Ziener
A convenient method based on the inverse miniemulsion technique was proposed to prepare raspberry-like Au/SiO 2 nanocomposite particles (NCPs). HAuCl 4 was incorporated into porous SiO 2 nano-supports through a sol–gel process of a silica precursor in inverse miniemulsions. Raspberry-like Au/SiO 2 NCPs were subsequently obtained through in situ reduction of the incorporated HAuCl 4 by hydrazine at the surface of SiO 2 nano-supports. Most of Au nanoparticles (NPs) were half-embedded in the SiO 2 nano-supports and were covered by a thin layer of porous SiO 2 , offering a good morphological stability to the Au/SiO 2 NCPs. The content of Au NPs of the Au/SiO 2 NCPs could be adjusted by the loading of HAuCl 4 . The influences of the HAuCl 4 loading on the particle size and particle morphology of the Au/SiO 2 NCPs, the pore properties of the SiO 2 nano-supports, as well as the properties of the Au NPs were systematically investigated. The formation mechanism of the raspberry-like Au/SiO 2 NCPs was discussed. All the synthesized Au/SiO 2 NCPs displayed a high catalytic activity towards the reduction of p -nitrophenol.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 106
·87061-87068
·
IF 3.84
Pei Song,Shan-Shan Li,Li-Li He,Jiu-Ju Feng,Liang Wu,Shu-Xian Zhong,Ai-Jun Wang
In this work, bimetallic Au–Pt alloyed nanowire networks (AuPt NNs) were facilely synthesized by a simple and rapid one-pot wet-chemical method on a large-scale, using N-methylimidazole as a structure-directing agent and a weak stabilizing agent. The surface of AuPt NNs was clean owing to the easy removal of the adsorbed N-methylimidazole. The control experiments demonstrated that the morphologies of AuPt NNs were strongly correlated with the amount of N-methylimidazole and reaction temperature. The formation mechanism included the four-stage growth processes: rapid nucleation, selective adsorption, π–π induced assembly, and oriented attachment growth. The as-synthesized AuPt NNs exhibited enhanced electrocatalytic activity and improved stability for methanol oxidation reaction (MOR) and oxygen reduction reaction (ORR) as compared to commercial Pt black and individual Pt nanoparticles.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL SCIENCES
·
2017
·Vol. 33
·期 3
·321-325
·
IF 1.228
Yuan-Feng WANG,Na PAN,Chi-Fang PENG
In this study, a sensitive colorimetric method for the detection of copper ion (Cu2+) was developed based on controlling the peroxidase-like activity of (gold core)@(ultrathin platinum shell) nanocatalysts (Au@Pt-NCs). It was found that D-penicillamine can effectively inhibit the activity of Au@Pt-NCs. After being incubated with Cu2+, D-penicillamine lost inhibition toward the catalytic ability of Au@Pt-NCs. Based on the above interaction, a colorimetric detection of Cu2+ was develop by measuring the colorimetric signal variation of the H2O2-3,3′,5,5′-tetramethylbenzidine (TMB) reaction. This method exhibited high sensitivity and selectivity toward Cu2+ over a panel of other metal ions. The detection limit of this method was 3.7 nM and the linear range was 20 – 300 nM. Moreover, 20 nM Cu2+ can be distinguished directly by the naked eye. Furthermore, this method was applied to the analysis of water samples with good accuracy. These results demonstrated the excellent application potential of the method.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2016
·
IF 4.803
Han Song,Lu Zhang,Feng Yu,Bang-Ce Ye,Yingchun Li
We describe here an ultrasensitive electrochemical detection of metronidazole (MNZ) by using a freestanding Au-Ag alloy microrod (AMR) as working electrode. Nanoporous Au-Ag AMR (NPAMR) was facilely prepared by dealloying of smooth AMR and further modified with electropolymerized molecularly imprinted polymer (MIP), which affords simultaneous identification and quantification of the target molecules by cyclic voltammetry (CV) with Fe(CN) 6 3−/4− as probe to indicate the current intensity. The MIP-decorated NPAMR showed a remarkably low detection limit of 2.7 × 10 −14 M (S/N = 3) and a wide determination range from 8.0 × 10 −14 to 1.0 × 10 −6 M for MNZ. The developed sensor has been successfully applied in detection of MNZ in real samples (fish tissues and drug tablet), and admirable specificity and anti-interference capability were achieved. This protocol offers great promise for cost-effective and precisely quantitative analysis of trace biological and chemical substances without assistance of any extra working electrode.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）