MICROPOROUS AND MESOPOROUS MATERIALS
·
2015
·
IF 3.453
Lijuan Feng,Jie Sha,Yao He,Shaopeng Chen,Bingxin Liu,Haixia Zhang,Changli Lü
A novel fluorescence resonance energy transfer (FRET)-based ratiometric nanosensor is reported for toxic Hg 2+ ions detection. Poly(p-phenylenevinylene) (PPV) chain was encapsulated into the pores of mesoporous silica nanoparticles (MSNs) by ion-exchange and in situ polymerization , and used as the energy-transfer donor. A spirolactam rhodamine-B derivative (SRhB), as an ion recognition element and energy-transfer acceptor, was embedded in the pores of MSNs to form PPV@MSN@SRhB as the nanosensor . The presence of Hg 2+ in the dispersion solution of nanoparticles can induce the ring-opening reaction of the SRhB moieties and lead to the occurrence of FRET process , affording the nanoparticle system a ratiometric sensor for Hg 2+ ions. The nanoparticle sensor can selectively detect Hg 2+ ions with a detection limit of 200 nM (ca. 40 ppb). It has been found that the fabricated FRET-based scaffold with the conjugated polymer as a donor exhibited high environmental stability and was more preferred for the accurate ratiometric sensing . Moreover, the FRET-based ratiometric nanosensor can be applicable in a relatively wide pH range (pH = 5–8) in solution.
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BIOMEDICAL CHROMATOGRAPHY
·
2026
·Vol. 40
·期 9
·e70570
·
IF 1.7
Yi Han,Renbin Li,Baobao Yao,Xuefeng Hou,Shixia Xu,Lizhen Yu,Jun Han,Huidan Huang,Di Cao
Inflammation is a defensive immune response to tissue damage or infection. Polygonatum cyrtonema Hua ( P . cyrtonema Hua, PCH) is bioactive on immune homeostasis due to its rich components and reportedly plays a therapeutic role in the treatment and prevention of diabetes. Flavonoids of PCH possess anti‐inflammatory properties, but their molecular mechanisms remain elusive. Here, chemical profiling of key flavonoids was conducted using UPLC‐QTOF‐MS/MS and the Global Natural Products Social Molecular Networking (GNPS) platform. Network pharmacology predicted potential targets and pathways, validated by molecular docking, surface plasmon resonance (SPR), and western blotting. Totally, 67 compounds were identified, with methylophiopogonanone B (MOB) as the key bioactive flavonoid. Although MOB's anti‐inflammatory activity has been previously noted, the present study provides the first evidence that this effect may be mediated through targeting SRC and modulating the PI3K/AKT signaling axis. Core therapeutic targets were identified as SRC, TNF, and AKT1 by topological analysis of network pharmacology. Molecular docking and SPR confirmed strong MOB‐SRC binding affinity. Western blotting revealed MOB dose‐dependently inhibited LPS‐induced phosphorylation of SRC, PI3K, and AKT1, without altering total protein levels. Furthermore, MOB significantly suppressed the phosphorylation of NF‐κB pathway proteins IκB and p65, confirming the involvement of NF‐κB as a downstream effector. In conclusion, this study integrates chemical profiling and network pharmacology with experimental validation to define the flavonoid composition of PCH, and is the first to implicate the SRC‐PI3K‐Akt pathway in MOB's anti‐inflammatory action and providing novel evidence supporting the mechanism and use of PCH in contemporary diabetes treatment.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Nutcha Nongyai,Jakkree Intranuwong,Seong Kyu Shin,Mooheon Kim,Yong Ku Kwon
Amphiphilic diblock copolymers of poly( γ -phenyl- ε -caprolactone)- block -methoxy poly(ethylene glycol) (PPhCL x - b -mPEG, where x represents the PhCL mol% in the copolymer) were synthesized via cationic ring-opening polymerization (CROP) and proceeded through an activated monomer mechanism (AMM), with variation of the hydrophobic block length. The introduction of phenyl substituents retarded the polymerization rate and disrupted chain packing, leading to reduced crystallinity compared to analogous poly( ε -caprolactone)- block -mPEG (PCL n - b -mPEG where n represents the PCL mol% in the copolymer) at comparable molecular weight. The micellization behavior of PPhCL x - b -mPEGs was investigated to evaluate their emulsification capability. Despite greater hydrophobicity, as evidenced by higher water contact angles, PPhCL x - b -mPEG exhibited a significantly higher critical micelle concentration (CMC), which is attributed to steric hindrance during micelle core formation. Emulsion stability measurements revealed that high internal phase emulsions (HIPEs) stabilized by PPhCL x - b -mPEGs exhibited significantly improved stability compared with those stabilized by PCL 67 - b -mPEG. PPhCL x - b -mPEGs were successfully employed as emulsifiers for HIPE polymerization, resulting in the formation of highly porous polyHIPE materials. The observed decrease in pore size with increasing PPhCL chain length demonstrated the improved structure-directing capability of PPhCL x - b -mPEG in the formation of polyHIPE foams. Compared to conventional small-molecule surfactants, this approach enables precise control over pore morphology through systematic variation of block length during synthesis, representing a versatile strategy for tailoring polyHIPE structures.
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RSC Advances
·
2026
·Vol. 16
·期 13
·11655-11667
·
IF 6.1
Xin-Yu Yang,Hong-Xi Zhang,Xun Dai,Hao-Jie Zhang,Ye Zhang,Dan Sun,Wei-Liang Tian
The biochar-supported nanoscale zero-valent iron (nZVI@BC) was synthesized in the presence of ultrasonic irradiation and applied in the heterogeneous Fenton-like degradation of rhodamine B (RhB). The property changes in the nZVI@BC synthesized in the presence and absence of ultrasonic irradiation were characterized, which confirmed that the ultrasonically irradiated catalyst had a better dispersion and higher electron transfer rate, showing better catalytic performance for RhB degradation. The effects of the catalyst dosage, pH value and H2O2 concentration were investigated, and it was found that under the conditions of initial pH = 3, H2O2 concentration = 15 mmol L−1, catalyst dosage = 1.5 g L−1 and 298 K, the RhB removal efficiency of nZVI@BC(ultrasonic irradiation) was 97.7%. Furthermore, the classical second-order kinetic model showed better fitting results, suggesting that the RhB degradation was primarily controlled by a chemical reaction, and the activation energy was calculated to be 77.8 kJ mol−1. Based on quenching experiments and electron paramagnetic resonance spectra, free radicals ˙OH and ˙O2− were detected, and ˙OH was found to be the main free radical in RhB degradation. After three cycles of catalyst reuse, its removal efficiency was still more than 70%. This work provides a new route for using ultrasonic irradiation to improve the catalyst performance in Fenton-like systems.
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Food Frontiers
·
2026
·Vol. 7
·期 4
·e70303
·
IF 6.3
Yadi Qin,Jie Qian,Jian Sun,Qinqin Li,Jun Yao,Minwei Zhang
Extensive antibiotic use has raised concerns over residues in food, necessitating rapid and accurate detection. This study integrates smartphone-assisted deep learning with aptamer-functionalized MIL-101(Fe) nanozymes to build a dual-recognition biosensor capable of simultaneously identifying and quantifying kanamycin (KAN) and kanamycin B (KMB). MIL-101(Fe) exhibited strong adsorption energies and high Langmuir-fitted capacities (28.39 mg/g for KAN; 31.36 mg/g for KMB), indicating monolayer binding at Fe─OH sites that partially suppressed catalytic activity. Aptamer modification enabled selective molecular recognition and accelerated electron transfer, synergistically enhancing nanozyme performance. Coupled with a ResNet-based multitask model, smartphone imaging achieved accurate classification of single and mixed samples and precise quantification over 5–1000 nM. Tests in honey and beef showed recoveries of 84.71%–111.50%, confirming stability and practicality. Overall, the aptamer-enhanced MIL-101(Fe) nanozyme combined with deep learning provides a sensitive, portable approach for on-site monitoring of antibiotic residues in food.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Yi Yang,Weiwei Li,Yanjia Zhao,Hanqing Xu,Xu Wang,Guode Zhao,Zixia Hu,Ying Peng,Jiang Zheng
Dioscorea bulbifera L. is a traditional Chinese herb. As its principal active component, diosbulbin B (DSB) exhibits anticancer activity by inducing cell cycle arrest and apoptosis. Cell cycle progression relies on chromatin dynamics, which is regulated by histone post-translational modifications (PTMs). DSB is metabolized by CYP3A, resulting in the formation of a cis-enedial reactive intermediate (DDE) that selectively and covalently modifies lysine residues on histones, forming pyrroline derivatives, or in cooperation with glutathione (GSH), forming pyrrole derivatives. These modifications competitively disrupted canonical histone PTMs, accompanied by chromatin decompaction. The formation of these histone adductions and the alteration of histone PTM landscapes were validated in both mouse primary hepatocytes and Cyp3a4-HepG2 cells. Molecular dynamics simulations revealed that DDE-derived lysine adductions impair histone-DNA interactions. The observed covalent modification of histone lysine residues provides a novel strategy by regulating chromatin architecture and a conceptual framework for developing antitumor agents based on epigenetic mechanisms.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Wei Hu,Minghao Ma,Bin Du,Yikan Zhao,Jiang Wang,Bing Liu,Xihui Mu,Zhangyan Hu,Zhihao Yi,Zhaoyang Tong
Staphylococcal enterotoxin B (SEB), a major foodborne toxin and bioterrorism agent, poses significant threats to global public health security. To address the urgent need for rapid on-site detection, we report an electrochemical molecularly imprinted sensor based on magnetic core-shell architecture, where two porous framework materials are covalently integrated as the imprinted matrix. The sensor exhibited high selectivity, showing a wide linear range from 5 × 10 −11 to 5 × 10 −5 g·mL −1 and a low detection limit (LOD) of 1.6 × 10 −12 g·mL −1 . Excellent stability and reproducibility were demonstrated in the analysis of spiked milk and water samples. Furthermore, the proposed imprinted nanomaterial exhibited satisfactory results in milk and water samples. Additionally, a portable smartphone-based sensing platform was constructed by integrating the Fe 3 O 4 @MOF@COF@MIP. This platform enabled the on-site determination of SEB with a LOD of 3.3 × 10 −12 g∙mL −1 . The combination of novel magnetic molecularly imprinted composites with mobile detection technology provides a powerful, field-deployable tool for SEB monitoring, advancing the application of multifunctional nanomaterials in biosensing and biodefense.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Zirui Ma,Rongyao Qiu,Yiran Luo,Tong Liu,Haonan Chen,Mengwen Fan,Yi Wan,Lin Lv,Zhishan Li,Houzhao Wan,Hao Wang
Developing non-precious-metal electrocatalysts with concurrent high activity and durability remains a grand challenge for the alkaline oxygen evolution reaction (OER). Herein, we rationally design and develop a cerium and boron co-doped ultrathin copper–cobalt carbonate hydroxide nanosheet (B-Ce-CuCo) electrocatalyst. The introduced Ce and B achieve a rare collaboration between the adsorbate evolution mechanism (AEM) and lattice oxygen oxidation mechanism (LOM) by optimizing oxygen-containing intermediate adsorption, increasing stabilized oxygen vacancies, and activating lattice oxygen. The optimized catalyst exhibits an ultralow overpotential of 208 mV at 10 mA cm −2 with a Tafel slope of 42.77 mV dec −1 and exceptional stability over 1000 h at 50 mA cm −2 . Theoretical calculations reveal that Ce modulates the electronic structure by shifting unoccupied Co/O states toward the Fermi level, optimizing the adsoprtion of oxygenated intermediate and boosting the AEM pathway. Both Ce and B promote oxygen vacancy generation, while B stabilizes these vacancies to activate lattice oxygen, enabling extensive LOM participation via Co(IV) O and *O O intermediates. 18 O-labeled differential electrochemical mass spectrometry (DEMS) directly identifies the coexistence of AEM and LOM pathways. This synergy reduces the AEM and LOM energy barriers to 0.39 eV and 0.58 eV, respectively, establishing a fundamentally new paradigm for designing high-performance electrocatalysts via dual-element doping. Download: Download high-res image (154KB) Download: Download full-size image
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DALTON TRANSACTIONS
·
2026
·
IF 3.3
Wentao Chen,Feng-Yi Qiu,Keyue Guo,Yanhong Zhou,Haoran Tian,Hongfan Hu,Xiaochao Shi
The introduction of polar functionalities into nonpolar polyolefins is highly desirable to enhance their surface properties, adhesive properties, and compatibility with other polar polymers. In this study, we report the synthesis of novel quinolinylfunctionalized dihydrocyclopenta[b]indole ligands and their corresponding rare-earth metal complexes, that the scandium complexes exhibited high syndiotacticity (>99% rrrr) in the polymerization of ortho-methoxystyrene (oMOS) upon activation with [Ph3C][B(C6F5)4] and i Bu3Al. A detailed investigation indicated that the polar methoxy group of oMOS promotes monomer activation through σ-π chelation with the central metal, in conjunction with the vinyl group, thereby revealing a notable self-assisted mechanism. Furthermore, the σ-π chelation effect remained unaffected by the presence of other polar groups in the corresponding monomers. When additional polar groups, such as fluoro-, bromo-or methoxy groups, were incorporated into oMOS, polymerization proceeded efficiently under the scandium-based catalytic system, resulting in polymers with high syndiotacticity (> 99% rrrr).
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Analytical Methods
·
2022
·Vol. 14
·期 39
·3881-3889
·
IF 3.532
Jiao Luo,Hongyan Tan,Bin Yang,Donghua Chen,Junjie Fei
In this study, a mesoporous silica fluorescence probe co-doped with manganese-doped zinc sulfide quantum dots (Mn:ZnS QDs) and rhodamine B (RB) and coated with molecularly imprinted polymer (MIP) has been prepared by sol–gel methods. The morphology and structure were characterized in detail by transmission electron microscopy (TEM), Fourier transform-infrared absorption spectroscopy (FT-IR) and ultraviolet-visible absorption spectroscopy (UV-vis). The probe exhibited two characteristic emission peaks at 411 nm and 582 nm, and the synchronous ratiometric fluorescence responses F411/F582 to different concentrations of 4-nitrophenol (4-NP) showed a good linear correlation in the range of 0.01–10 μmol L−1 besides achieving the sensitive detection of 4-NP with a detection limit as low as 3.0 nmol L−1 (3σ). The probe possesses the advantages of selectivity toward the target molecular structure, self-stability in the detection time domain and anti-interference ability, exhibiting excellent potential for application in 4-NP detection in different water environments.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Hui Luo,Yunshu Yang,Liwen Lu,Guangxu Li,Xinhua Wang,Xiantun Huang,Xiaoma Tao,Cunke Huang,Zhiqiang Lan,Wenzheng Zhou,Jin Guo,Haizhen Liu
Li–Mg–B–H composite (2LiBH 4 + MgH 2 ) possesses a very high hydrogen storage capacity of 11.4 wt%. However, it still suffers from high operating temperature, slow kinetics, and poor reversibility. In this work, the two-dimensional Ti 3 CN MXene was first synthesized and then introduced into the Li–Mg–B–H composite. The addition of 5 wt% Ti 3 CN reduces the onset dehydrogenation temperature of the 2LiBH 4 + MgH 2 composite by about 50 °C and shortens the induction period of the LiBH 4 decomposition at 400 °C from >90 min to <10 min. The reversible capacity maintains at 8.3 wt% after 20 cycles, with a capacity retention ratio of 93%. Microstructure studies show that Ti 3 CN will partially transform to a highly-dispersed nano-TiB 2 with particle size around 5 nm. Such nano-TiB 2 could serve as an active catalyst to significantly improve the kinetics and reversibility of the Li–Mg–B–H composite. This work offers a strategy to enhancing the hydrogen storage performance of the advanced metal borohydride-based composites by addition of the MXene material and provides some new insights in understanding the role of MXene in tailoring the hydrogen storage properties of the Li–Mg–B–H composite.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Yun Ji,Zhelin Song,Yu Xu,Yanlin Zhang
In this work, typical refractory pollutant Rhodamine B (RhB) was effectively degraded by Cu-Fe LDHs/Bi 2 WO 6 composite in the photo-Fenton process. The hydrothermal synthesis of Cu-Fe LDHs/Bi 2 WO 6 composite with ethylene glycol as reductant created the multivalent coexistence of the same metal element to achieve a self-circle redox reaction between metals. The photo-Fenton process by Cu-Fe LDHs/Bi 2 WO 6 incredibly eliminated the limitation of strong acidic pH value applied in the Fenton process. ∙OH generated by Cu-Fe LDHs/Bi 2 WO 6 was 5 times that of Cu-Fe LDHs during the photo-Fenton process. The complete degradation of RhB in the photo-Fenton process under the optimal conditions of initial pH= 6, 5 mmol/L of H 2 O 2 , and 1 g/L of Cu-Fe LDHs/Bi 2 WO 6 dosage was far more than 46% of RhB degradation in the photocatalytic process and 76% of RhB degradation in the Fenton process. Cu-Fe LDHs/Bi 2 WO 6 composite exhibited the excellent redox ability, electron transfer ability and reusability during the photo-Fenton process. The acceleration of Fe 3+ /Fe 2+ cycles in the Cu-Fe LDHs/Bi 2 WO 6 /H 2 O 2 /Vis system was mainly ascribable to the combination of efficient transfer of photogenerated electrons and self-circle redox of Fe 3+ /Cu + . It is expected for the promising application of multivalent bimetallic photo-Fenton catalysts and rendering enlightenments for photo-Fenton catalytic oxidation reaction.
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