Science Immunology
·
2025
·Vol. 10
·期 108
·
IF 16.3
Limin Cao,Li Wang,Zhihong Li,Xia Wei,Jinqiu Ding,Chun Zhou,Xia Chen,Zhicheng Huang,Zhugui Shao,Junchen Shen,Hongfei Lou,Keqing Zhao,Yuwei Huang,Yuanqin Yang,Han Liu,Yumeng Sun,Junling Niu,Shan Jiang,Rong Lu,Longhai Tang,Xiaoming Zhang,Haibing Zhang,Yichuan Xiao,Jianfeng Chen,Shixin Ma,Chengjiang Gao,Guangxun Meng,Li Liu,Zhaozhu Qiu,Haopeng Wang,Liufu Deng,Youqiong Ye,Xin-Ming Jia,Huabin Li,Hui Xiao
The volume-regulated anion channels (VRACs) transport osmolytes, neurotransmitters, and cyclic GMP-AMP (cGAMP) across the cell membrane to regulate cell volume and host defense. We report that the leucine-rich repeat–containing 8A/C (LRRC8A/C) VRAC plays a crucial role in immune responses to radiotherapy and chemotherapy for cancer. VRACs transfer cGAMP from irradiated cancer cells to infiltrating CD4 and CD8 T cells, thus enhancing their effector functions. TCR signaling acts as a physiological signal to open the VRAC pore through phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ] and reactive oxygen species (ROS). This allows the rapid uptake of cGAMP and STING activation in mouse and human T cells and induction of interferon-α/β, which up-regulate granzymes and IFN-γ in CD8 T cells. Inhibition of the extracellular hydroxylases CD39 and ENPP1 maintains extracellular ATP and cGAMP, which promotes VRAC-enhanced CD8 T cell anticancer function. Thus, the transfer of cGAMP to T cells by VRACs may be a strategy that can be targeted in future cancer therapies.
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高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Xiao-liang Zhang,Jia-le Wang,Wan-ying Hou,Zhun Gao,Wen-chao Hou,Ya-hui Zhang,Shao-hua Luo,Qing Wang,Xin Liu,Sheng-xue Yan
This study centers on the synthesis and sodium-storage properties of CoSe 2 /FeSe 2 and its carbon-coated composite (CoSe 2 /FeSe 2 @C) derived from CoFe-based Prussian blue analogues (PBAs). The material offers high theoretical capacity for sodium-ion batteries (SIBs), but it suffers from severe structural degradation and poor electrical conductivity during cycling, leading to rapid capacity decay. Carbon coating is introduced to address these challenges by enhancing electronic conductivity, buffering volume changes, and improving ion diffusion kinetics. The CoSe₂/FeSe₂@C composite with a hollow nanostructure was obtained, which was prepared via co-precipitation, selenization, and carbon coating. Electrochemical measurements reveal that the composite boasts excellent electrochemical performance. It delivers a high reversible capacity of 443.5 mAh·g −1 at 0.1 A·g −1 , with 93.4 % capacity retention after 100 cycles, and 310.3 mAh·g −1 at 2 A·g −1 , maintaining 80.1 % retention after 500 cycles. The carbon coating significantly enhances conductivity, structural stability, and ion diffusion, endowing the material with superior cycling and rate capabilities. Through ex-situ XRD scanning and other characterization verifications, this work highlights the great potential of Prussian blue analogue (PBA)-derived materials as high-performance anodes for sodium-ion batteries.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Wenhao Peng,Fan Yang,Shaorou Ke,Yuanmeng Wang,Xin Li,Shujie Yang,Ruiyu Mi,Yan’gai Liu,Zhaohui Huang,Xin Min,Minghao Fang
The development of efficient and durable electrocatalysts for the hydrogen evolution reaction (HER) is crucial for sustainable energy applications. In this study, a biomass-derived PtCe@C-N catalyst with strong metal-support interaction (SMSI) was synthesized to achieve high efficiency and long-term stability in HER. This approach employed linden wood slices as a biomass carbon support, combined with freeze-drying and in situ carbonization, facilitating the formation of a PtCe solid solution, the synthesis of an N-doped carbon matrix, and the in situ anchoring of PtCe alloy nanoparticles. The resulting PtCe@C-N-1000 catalyst exhibited uniformly dispersed PtCe nanoparticles (ranging from 3.5 to 10.96 nm) and demonstrated outstanding HER activity along with excellent catalytic stability, achieving a low overpotential of 26 mV at 10 mA/cm 2 and a Tafel slope of only 26.8 mV/dec. Moreover, the catalyst also demonstrated high mass activity (6.06 A/mg at an overpotential of 100 mV) while maintaining a low Pt content (3.24 wt%), surpassing many commercial Pt-based catalysts. Stability tests further confirmed the robustness of the catalyst, with 81.96 % of its initial activity retained after 24 h of continuous operation. This study offers a sustainable and scalable strategy for designing high-performance, low-Pt HER electrocatalysts and provides valuable insights into the development of cost-effective catalysts with improved Pt utilization and long-term operational stability.
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VACUUM
·
2026
·
IF 4.3
Junlei Qi,Yong Xia,Zhenyu Ye,Jian Cao,Yaotian Yan
As modern electronic systems advance toward compact architectures and intensified power densities, managing heat generation and dissipation has become a central challenge affecting both device stability and functional reliability. In this study, a carbon-coated three-dimensional (3D) porous copper foam composite (CFCC) was synthesized using a combined hydrothermal and annealing process to enhance heat dissipation. Optimization studies revealed that the combination of 6 g glucose with a 600 °C annealing treatment produced the most favorable coating quality. Consequently, the CFCC exhibited an in-plane thermal conductivity of 16.3 W m −1 K −1 and a thermal diffusivity of 28.5 mm 2 s −1 , representing 39.3% and 122.7% increases over pristine copper foam, respectively. Infrared thermography confirmed significantly improved heat spreading, with the optimized composite maintaining the lowest steady-state temperature (145.8 °C) under a constant 160 °C heat load. Microstructural and mechanistic investigations indicate that the improved heat-transfer capability originates from the higher ordering of the carbon domains, the decrease in structural defects, and the strengthened Cu–C interfacial interactions. These factors collectively reduce phonon scattering, extend the phonon mean free path, and minimize interfacial thermal resistance, enabling effective three-dimensional heat conduction. Overall, the integrated hydrothermal–annealing strategy presents a controllable, scalable, and cost-effective approach for producing high-quality carbon coatings on porous metal substrates, offering substantial promise for advanced thermal management in next-generation high-power electronic systems.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Huan Li,Zhiguang Suo,Xueqing Zhu,Min Wei,Huali Jin,Rui Guo,Yong Liu,Renyong Zhao
The widespread misuse of ciprofloxacin (CIP) poses a serious threat to environmental safety and human health, necessitating its trace detection in food matrices. In this study, a novel electrochemical aptasensor was developed for the highly sensitive detection of CIP. Au@ZnCoN-C nanocomposites with superior conductivity were synthesized and employed as the electrode modification material. To improve assay sensitivity, a target-triggered cyclic amplification method relying on RecJf exonuclease was adopted. Notably, a cross-linked DNA framework (CLDF) was utilized for the first time in CIP detection. Its interconnected architecture provides abundant active sites for high-density loading of methylene blue (MB), thereby significantly amplifying the electrochemical response. Under optimized conditions, the aptasensor exhibited a wide linear range from 0.005 to 1000 ng/mL, with a low limit of detection (LOD) of 3.2 pg/mL. Furthermore, the sensor was successfully applied to the analysis of CIP in milk, egg, and pork samples with satisfactory results. Leveraging its high specificity, long-term stability, and high sensitivity, this method provides a robust strategy for the precise monitoring of CIP in food safety applications.
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CANCER LETTERS
·
2026
·
IF 11.8
Shuangshuang Ma,Minxin Chen,Xiaozheng Sun,Baochao Wei,Fengxin Sun,Xueqi Xie,Yiheng Huang,Zhaoyun Liu,Rong Xiao,Ling Wei,Fei Wang,Ying Xu,Jinming Yu,Dawei Chen,Meng Wu
Tamoxifen has been commonly used in endocrinotherapy for estrogen receptor (ER)-positive breast cancer. In recent years, the immunomodulatory effects of high-dose tamoxifen have been discovered. The immunosuppressive tumor microenvironment (TME), however, remains a major obstacle to the efficacy of radiotherapy. Whether high-dose tamoxifen can reprogram TME to synergistically enhance radiation efficacy is still ambiguous. Here, we have found high-dose tamoxifen could dramatically enhance radiation-induced antitumor effects without significant side effects in immunocompetent mice. Flow cytometry and multiplex immunofluorescence experiments revealed that radiation combined with tamoxifen resulted in significant enrichment of effector CD8 + T cells and M1 tumor associated macrophages (TAMs). While depletion of TAMs and CD8 + T cells impaired the synergistic antitumor effects mediated by combination treatment of radiation and tamoxifen. Furthermore, spatial proximity analysis demonstrated a dramatically reduced nearest-neighbor distance between CD8 + T cells and M1-like TAMs in the combination group, indicating enhanced cellular interaction within the TME. In vitro experiments demonstrated that tamoxifen directly acted on TAMs, rather than CD8 + T cells, to promote M1 polarization and subsequently enhanced the activation and effector function of CD8 + T cells, regardless of ER expression in tumor cells and macrophages. Mechanistically, RNA-sequencing and experimental validation uncovered that tamoxifen and tumor cell-derived TNF-α and IL-1β after irradiation synergistically activated the JNK/c-JUN pathway and promoted M1 polarization of TAMs. In conclusion, our study revealed the immunomodulatory effects of high-dose tamoxifen in the context of radiation and provided preclinical evidence for combination therapy of high-dose tamoxifen and radiotherapy in both ER-positive and ER-negative cancers.
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高影响因子
CATALYSIS LETTERS
·
2026
·Vol. 156
·期 3
·75
·
IF 2.5
Huang Haiyun,Chen Lungang,Zhang Xinghua,Zhang Qi,Zhuang Xiuzheng,Ma Longlong
Effective utilization of lignocellulosic biomass as value-added fuels and chemicals is of great significance for achieving the dual goals of sustainable biorefinery and carbon neutrality. Here, Ni-WOx@C catalysts were synthesized for efficiently catalytic conversion of cellulose into ethylene glycol (EG). The catalyst was prepared through a one-step pyrolysis method by using citric acid and SiO 2 as the carbon source and structural template, respectively. A series of controlled experiments demonstrated that the pyrolysis temperature and the particle size of the SiO 2 template significantly affected the physicochemical properties of the catalyst, including the surface morphology, active sites provided by the loaded metals, and the distribution of Lewis acid sites. The optimized catalysts of Ni-WOx@C 600−2 , which was prepared by the pyrolysis at 600 °C with a 2 μm SiO 2 template, delivered the best performance characterized by its high specific surface area (124.86 m 2 /g), well-defined pores, as well as the cooperation between metallic species and Lewis acid sites. Under the optimized reaction conditions (220 °C, 4 MPa H 2 , 3 h), this as-prepared catalyst achieved nearly complete cellulose conversion (> 99%) and EG yield of 60.1%. Generally speaking, the design of Ni-WOx-based catalyst provides new insight for effective catalysis and has considerable application potential in cellulose conversion. Graphical
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JOURNAL OF POWER SOURCES
·
2012
·
IF 4.951
Jing Liu,Huayun Xu,Xiaolei Jiang,Jian Yang,Yitai Qian
The Li 2 MnSiO 4 /C nanocomposite has been successfully synthesized at a relatively low temperature of 650 °C by a facile solid-state reaction using citric acid as the carbon source. The highly crystalline Li 2 MnSiO 4 nanoparticles in the size of 20–50 nm are coated by a uniform carbon layer in a thickness of 2–5 nm. At a rate of 0.05 C, the Li 2 MnSiO 4 /C nanocomposite exhibits a discharge specific capacity as high as 268 mAh g −1 for the first cycle and a reversible capacity of about 136 mAh g −1 after 140 cycles at room temperature. Meanwhile, an improved rate performance is achieved by the Li 2 MnSiO 4 /C nanocomposite. These superior electrochemical properties could be attributed to the nanoscale particle size and the enhanced electronic conductivity .
研究领域:
材料科学
·
电化学
·
储能
·
纳米材料
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Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 32
·15738-15746
·
IF 9.931
Lie Yang,Liu-Yang Sun,Rong-Rong Zhang,Ya-Wen Xu,Xiao-Hui Ning,Yuan-Bin Qin,R. Lakshmi Narayan,Ju Li,Zhi-Wei Shan
SnOx exhibits a much larger theoretical capacity compared to graphite as an anode material in lithium-ion batteries (LIBs). However, the cycling stability and initial coulombic efficiency (ICE) of SnOx based electrodes need to be improved. In this study, by coating carbon on a dried SnOx electrode film using one-step chemical vapor deposition, a SnOx#C composite is obtained, wherein ∼70 nm sized SnOx nanoparticles are uniformly dispersed and embedded in a carbon matrix. Owing to its relatively small electrochemical surface area and mechanical robustness, the ICE is largely improved from ∼40% to >65%. Besides, a Li-matched full cell with 36% excess LiCoO2 cathode material can run stably for more than 100 cycles at 0.1 A g−1, delivering a gravimetric and a volumetric capacity of 456 mA h g−1 and 644 mA h cm−3, respectively, which are superior to graphite. The lithiation/delithiation process of SnOx#C observed using an in situ transmission electron microscope technique reveals that the embedded structure expands by only ∼5%. Besides, the thickness increment of the electrode film after 100 cycles is measured to be 32%, which is much smaller than the acceptable 50% in the LIB industry, illustrating the good stability of the solid-electrolyte interphase (SEI) skeleton.
研究领域:
材料科学
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储能
·
电化学
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Small
·
2026
·
IF 11.8
Ming Yue,Di Cheng,Yu Wan,Rongjie Xia,Yanhe Xiao,Baochang Cheng,Wen Chen,Shuijin Lei
Transition metal phosphosulfides (TMPs) are compelling anode candidates for sodium-ion batteries thanks to their distinctive layered structure and outstanding electrochemical properties, yet facing significant intrinsic challenges including poor electronic conductivity and severe structural degradation. To address these issues, we demonstrate the construction of yolk-double-shell ZnPS 3 /N-doped carbon@carbon (ZnPS 3 /NC@C) polyhedra through a Kirkendall-effect-mediated tannic acid (TA) etching strategy using a resorcinol-formaldehyde (RF) coated ZIF-8 precursor. This rationally designed architecture confers several synergistic advantages: (i) the N-doped carbon matrix derived from ZIF-8/TA-Zn and the carbon shell from RF form a continuous conductive network, facilitating rapid charge transfer; (ii) the yolk-double-shell framework with ample internal void space effectively accommodates the volume variations, preserving structural integrity; and (iii) the outer carbon shell serves as a physical barrier against polysulfide dissolution, enhancing reaction reversibility. Benefiting from this multi-synergistic engineering, the novel ZnPS 3 /NC@C anode exhibits impressive sodium storage performance, delivering a high charge/discharge capacity of 925.7/1128.9 mAh g −1 at 0.1 A g −1 , along with a remarkable long-term cyclability with 96.9% capacity retention over 2000 cycles at 2.0 A g −1 . This work establishes a generalizable design paradigm integrating morphological manipulation with multi-component compositing for developing advanced electrode materials.
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高影响因子
Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
·
2022
·
IF 3.549
Yike Han,Ziang Zhou,Zihan Cao,Wei Zong,Guangyuan Zhao,Xiaoyuan Wang
Alternariol (AOH) and alternariol monomethyl ether (AME) are two Alternaria mycotoxins with high occurrence rates in food systems. This study aimed to investigate the photodegradation of AOH and AME by ultraviolet-C (UV-C) irradiation. The effect of UV-C intensity, pH, treatment time, solvents and the exposure of food components were evaluated. After treated by UV-C irradiation at 3500 μW/cm2 for 90 min, AOH samples in methanol, aqueous solution and solid state were degraded by 89.1%, 72.9% and 53.2%, respectively, while the degradation percentages of AME were 86.6%, 50.1% and 11.1%, respectively. Increasing irradiation intensity and prolonging irradiation time could significantly facilitate the degradation of AOH and AME. An alkaline environment (pH = 11) was more conducive to the degradation of toxins. In addition, 2.5 mg mL−1 citric acid or malic acid increased the photodegradation of AOH and AME to 94.6% and 95.3%, 93.2% and 70.5%, respectively. However, protein, polyphenols and vitamin C exerted inhibitory effects on the degradation, while 10% glucose or sucrose reduced the photodegradation of AOH and AME to 65.9% and 40.3%. UV-C treatment could effectively reduce the content of AOH and AME, with the highest efficiency achieved in methanol and alkaline environment. By contrast, UV-C irradiation is more effective in degrading toxins in some liquid foods rich in organic acids but lacking in protein. The utilization of UV-C radiation appears to be a potentially useful approach for decreasing the underlying risk of Alternaria mycotoxin contamination in foods.
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Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 7
·3454-3463
·
IF 11.9
Lei Ding,Jinyan Zhao,Zhikang Bao,Shijie Zhang,Huaijie Shi,Jia Liu,Guoliang Wang,Xiaoge Peng,Xing Zhong,Jianguo Wang
H2O2 and O3 production through electrochemical synthesis is a promising approach to replace anthraquinone processes and corona discharge. However, the simultaneous generation of H2O2 and O3 and the use of their synergistic oxidation to degrade organic contaminants remains a challenge. Herein, heterojunction bifunctional ZnO/ZnS@C electrocatalysts were prepared by a one-step pyrolysis method. ZnO/ZnS@C-750 can achieve 90% selectivity for H2O2 and 11% Faraday efficiency for gaseous O3. The primary contributor to such a performance was exploited to accelerate the electron transfer on the heterogeneous interface and generate more reaction sites. H2O2 and O3 can also be simultaneously generated in the electrolyzer and the synergistic effect of H2O2 and O3 can be utilized to completely degrade organic pollutants, such as phenol and tetracycline. This work provided new insights into the design of the 2e− ORR (oxygen reduction reaction) and EOP (electrochemical ozone production) bifunctional electrocatalysts for pollutant degradation.
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