INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yan Wang,Menghui Wan,Yanbao Zhao,Lei Sun
Smart controlled-release nanopesticide systems offer enhanced pesticide efficiency through targeted delivery. In this study, we prepared sulfur-containing square mesoporous silica (S-MSN) carriers, combined them with carboxymethyl chitosan (CCS) to build a dual-responsive pesticide delivery platform (DNF@S-MSN@CCS) for sustained pesticide release. The S-MSN carriers demonstrated a high drug loading capacity of 21.3 %, excellent biocompatibility, responsive degradation and improved pesticide retention on hydrophobic leaves. Compared with spherical carriers, the cubic drug-loaded system shows a 33 % improvement in resistance to rain wash and a 38.8 % increase in liquid-holding capacity. Superior foliar adhesion and UV-shielding properties reduced photodegradation, extending DNF's UV half-life 6-fold compared to pure dinotefuran (DNF). Bioassays showed equivalent mortality against Plutella xylostella larvae as conventional formulations at reduced dosages. This work presents an effective strategy for sustainable pest management.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jia Wan,Meifang Yin,Feng Wang,Guangtao Huang,Ilaria Dal Pra,Yongzhi Liang,Jun Wu
Bacterial infections following skin injuries can lead to chronic, hard-healing wounds, and the overuse of antibiotics has made infection control a significant clinical challenge. Nature provides numerous antimicrobial agents, inspiring the design of novel antibacterial wound dressings; however, their solubility often presents additional hurdles. Herein, we leverage highly water-soluble chitosan oligosaccharide molecules dispersed within a gelatin-based gel network to overcome the poor solubility of chitosan, a known antibacterial agent. Notably, we first discovered that chitosan oligosaccharides can promote the solubility of poorly water-soluble antibacterial molecules like emodin through Schiff base reactions, thereby enabling synergistic antibacterial effects. The resulting eutectogel exhibits excellent antibacterial activity against both Staphylococcus aureus and Escherichia coli. Additionally, the gel demonstrates superior tensile strength, fracture strain, resistance to desiccation, and biocompatibility, with its outstanding overall performance laying a foundation for wound dressing applications. In animal models of infected wounds, the gel effectively accelerates wound healing, achieving wound closure rates of 166.9 % and 136.9 % of the control group on days 4 and 7, respectively. Mechanistic studies further reveal that the dressing promotes cellular proliferation, migration, and the regeneration of blood vessels and collagen, contributing to the wound healing process.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yanju Zhang,Meng Zhang,Yajuan Li,Xudong Yu
Conductive hydrogels are widely used in electronic skin and wearable sensors. Their inherent self-adhesion, exceptional sensitivity, and remarkable toughness guarantee the consistent and reliable operation of flexible motion sensors. However, creating chitosan-based conductive hydrogels with all these properties remains challenging. In this study, a triple-network hydrogel was synthesized by incorporating poly (vinyl alcohol) (PVA), chitosan quaternary ammonium salt (QCS) and poly(N-(2-Hydroxyethyl) acrylamide)- Co -Sodium acrylate copolymer (P(HEAA- Co -AANa)). Lithium chloride (LiCl) is introduced to enhance conductivity. The optimized hydrogel shows good conductivity (0.77 S/m), high tensile strain (~2113 %) and strong mechanical properties (463 kPa). The assembled sensors have high sensitivity, and enable precisely monitoring human motions. This study offers a simple, eco-friendly way to develop high-performance chitosan-based conductive hydrogels.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Tangyu Yang,Haiwei Jia,Yuting Song,Shiqi He,Bing Li,Lin Li,Xia Zhang
Sucrose fatty acid esters are increasingly valued as multifunctional surfactants, nutraceuticals, and bacteriostats due to their emulsifying and antimicrobial properties. While enzymatic synthesis provides an eco-friendly route to high-purity esters, challenges remain in optimizing lipase activity, reusability, and mass transfer. This study introduces a novel edible biomaterials-based catalytic system: lipase immobilized within shellac nanoparticle-coated chitosan microgels (SCL) for synthesizing sucrose laurate via Pickering interfacial catalysis (PIC). SCL stabilized oil-in-water (O/W) emulsions, with sucrose and vinyl laurate partitioned into aqueous and oil phases, respectively. Structural characterization (SEM, CLSM, Cryo-SEM) revealed SCL's localization at the O/W interface, with preferential oil-phase immersion and ordered interfacial alignment. Optimized conditions yielded a conversion rate of 55.35 ± 1.88 %, and the immobilized lipase retained >80 % activity over four cycles. Purified via solvent extraction and chromatography, the product was confirmed as 6-sucrose monolaurate (through FT-IR, NMR, XRD, and TG-DSC). Comparative analysis demonstrated its higher air/water interfacial stabilization versus commercial sucrose monoesters, evidenced by lower critical micelle concentration ( cmc ), enhanced emulsifying/foaming capacity, and improved pH/thermal stability. Collectively, this SCL-based PIC system achieved sustainable synthesis of 6-sucrose monolaurate with exceptional enzyme recyclability, overcoming limitations in lipase stability and mass transfer, and produced a surfactant with superior properties.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Hongdong Song,Yaqiong Chen,Ruihan Huang,Xiao Guan
To enhance the oral bioavailability and hypoglycemic effect of insulin, we developed a novel bilayer liposome delivery system in this study. The outer layer of this system was decorated with propanoic acid-functionalized chitosan (CS/PA) to improve gastrointestinal stability and facilitate intestinal targeting of mono-carboxylate transporter protein 1 (MCT1). We encapsulated insulin in this newly developed delivery system. The CS/PA coating significantly enhanced the protective effect of liposomes on insulin in the gastrointestinal environment. Experiments using Caco-2 cells and ligated intestinal loops showed that IN-LIP-CS/PA facilitated insulin absorption and increased intestinal permeability. Importantly, MCT1-mediated energy-dependent endocytosis played a crucial role in the absorption process. Additionally, endocytosis of IN-LIP-CS/PA was mediated through clathrin, lipid raft, caveolin, and macropinocytosis. Furthermore, the endoplasmic reticulum and Golgi apparatus were mainly involved in the intracellular transport of IN-LIP-CS/PA. The combination of MCT1-mediated endocytosis and the intracellular transport pathways may help IN-LIP-CS/PA avoid lysosomal degradation, thereby improving the intracellular transport efficiency of insulin. In vivo studies demonstrated that IN-LIP-CS/PA achieved a significantly better hypoglycemic effect. These findings suggested that the newly developed bilayer liposome delivery system holds promise as an effective platform for the oral delivery of insulin.
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Chemical Engineering Journal Advances
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2025
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IF 7.1
Wuxin Hou,Jizhuang Zuo,Yongle Gao,Yao Wang,Li Liu
The generation of humins by-products in biorefinery is often unavoidable. We here report the valorization of chitosan-derived humins for removal of heavy metal ions to enhance the atomic economy of the biomass conversion. Chitosan-derived humins were synthesized by catalysis of oxalic acid (OA), whereby the adsorption performance for Cd(II), Cr(III) and Cr(VI) was explored. The adsorption data were well fitted by the pseudo-second-order kinetic model, complemented by the Freundlich and Temkin isotherm models, revealing maximum adsorption capacities of humins for heavy metal ions as follows: 358.7 mg/g for Cr(VI), 152.6 mg/g for Cd(II), and 40.2 mg/g for Cr(III). The mechanistic studies revealed that the adsorption of Cd(II) and Cr(III) by humins mainly occurs through ion exchange (carboxyl groups) and surface complexation (hydroxyl, carbonyl, and amino groups). In comparison, the adsorption of Cr(VI) by humins involves electrostatic attraction, alongside ion exchange and surface complexation. After carbonization and activation, the specific surface area increased markedly, however the adsorption capacity decreased owing to reduced oxygen- and nitrogen-containing functional groups. Competitive adsorption studies, industrial wastewater experiments, and cyclic adsorption tests demonstrate that humins exhibit remarkable adsorption performance even in complex environments. This work highlights that chitosan-derived humins are promising adsorbents for the remediation of heavy metal ions.
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ACS Applied Polymer Materials
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2025
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IF 4.7
Shengnan Zhang,Lidan He,Shuting Fu,Yingying Zhou,Li Wang,Le Deng
Chitosan-based hydrogels, owing to their unique barrier protection properties, have garnered significant attention as wound dressings. Improving the liquid-absorption and antimicrobial capabilities of chitosan hydrogels will further broaden their applications in this field. In this study, chitosan was modified with quaternary ammonium salt and glycidyl methacrylate and then combined with negatively charged gold–platinum nanodots (AuPt NDs) to construct a type of nanocomposite antibacterial hydrogel. Structurally, the hydrogel possesses a loose and porous structure. It can absorb about 800% of its own mass in pure water and has excellent pro-coagulant activity. These properties are beneficial for wound healing. Mechanistically, the positively charged hydrogel is capable of adsorbing negatively charged bacteria, disturbing the potential balance of the bacterial cell membranes, which can reduce the activity of the bacteria and lead to dissipation of the bacterial biofilm. Furthermore, the hydrogel antimicrobial effect can be greatly enhanced by the incorporation of AuPt NDs, enabling it to catalyze the production of ·OH from a low concentration of H2O2 and generate heat under 808 nm laser irradiation, thereby further killing the bacteria and promoting the dissipation of the biofilm effectively and rapidly. More importantly, the hydrogel has excellent biocompatibility and facilitates the healing of wounds infected with bacterial biofilms, holding great potential for application as a medical wound dressing.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Zhonghao Jiang,Zhuo Yan,Shumin Yan,Zhihao Chen,Lianhai Li,Guoliang Huang,Li Li,Jiantao Lin
Diabetic wounds are one of the most problematic complications among diabetic patients, often progressing to chronic, persistent ulcers that are a leading cause of amputation and disability. The constant accumulation of reactive oxygen species (ROS) at diabetic wound sites, along with bacterial infection and an excess of pro-inflammatory M1-type macrophages, are key factors contributing to the difficulty of wound healing. Nanofibrous membranes can be used directly in diabetic wounds with the dual function of adsorbing tissue exudate and releasing drugs. Cerium oxide nanoparticles can be used in nanotherapy to reduce the accumulation of chronic inflammatory substances due to their excellent antioxidant properties. The antioxidant properties can be further improved by doping with other metal elements. In this paper, we constructed a nanofibrous membrane based on cerium manganese nanoparticles (CeMn NPs) for the treatment of diabetic wounds. The nanofibrous membrane was loaded with cerium manganese nanoparticles and nitric oxide donor SNAP, named PVA-CS-CeMn NPs-SNAP nanofibrous membrane. The PVA-CS-CeMn NPs-SNAP nanofibrous membrane was able to cover the wounds of diabetic mice with slow release of CeMn NPs and SNAP. The nanoparticles could scavenge ROS accumulated at the wound site and regulate the macrophage phenotype at the wound site, increasing the proportion of anti-inflammatory M2-type macrophages. In addition, SNAP had antimicrobial and vascular regenerative effects at the wound site. Together, these synergistic effects resulted in faster wound healing and reduced tissue inflammation in diabetic mice, and no organ toxicity was observed. Overall, our results indicate that PVA-CS-CeMn NPs-SNAP nanofibrous membranes have significant potential for the treatment of diabetic wounds and provide a strong scientific basis for the development of novel diabetic wound treatment materials.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Dingyang Chen,Zixu Ren,Minsi Shi,Rui Zhao
With the fast-growing accumulation of precious metals, especially gold ions, in wastewater and electronic waste, achieving rapid and selective gold ions capture from water while maintaining high adsorption capacity is of vital importance to the environment and economy. Herein, a self-standing, quaternary phosphonium functionalized chitosan-based electrode (MTP-CS-CC) is proposed and fabricated via coating functional materials on carbon cloth for the electrochemical capture of Au(III) ions. Abundant quaternary phosphonium sites as nanotraps in MTP-CS-CC under the action of electric field deliver a fast extraction rate with high Au(III) removal efficiency (>99.5 %), a competitive uptake capacity (2114 mg g −1 ), superior selectivity, and long-term recycling stability. In-depth exploration of relevant mechanism by multiple characterizations and density functional theory (DFT) calculations illustrates that the capture of Au(III) ions by MTP-CS-CC electrode involves the electrosorption and electroreduction processes. In addition, when used as electrodes to recover gold from real e-waste leaching solution, the purity of recovered gold from computer central processing unit (CPU) boards reaches up to 23.8 Karat (99.17 % pure). Our work puts forward a facile strategy for preparing chitosan-based electrodes that can be innovatively used for the precious metal recovery and circular economy for recycling resources.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Kexin Yi,Shiyuan Miao,Bixing Yang,Sijie Li,Yiwen Hu,Yujie Lu
As a naturally derived biomacromolecule, chitosan is widely utilized in food preservation. However, the chitosan derived from silkworm pupae and its application in food preservation are relatively unexplored. To obtain chitosan with enhanced preservation properties, silkworm pupae chitosan was extracted using dual-frequency ultrasound-assisted chemical and enzymatic methods, followed by a comparative analysis of their physicochemical properties, biological activity, and preservation efficacy on strawberries. Compared with the commercial chitosan, the yield, physicochemical properties, and biological activity of silkworm pupae chitosan using the dual-frequency ultrasound-assisted enzymatic method were increased, exhibiting a solubility of 98.1 % and a deacetylation degree of 99.12 %. The silkworm pupae chitosan demonstrated the highest antioxidant activity and effective microbial inhibition at the concentration of 1 % (w/w). When applied as a coating solution for strawberry preservation, this chitosan significantly reduced weight loss, titratable acid degradation, and polyphenol consumption. Furthermore, it decreased the decay rate by 50 % and extended shelf life by two-fold compared to untreated samples. The dual-frequency ultrasound-assisted enzymatic method provides an eco-friendly approach for chitosan extraction, with silkworm pupae-derived chitosan showing excellent potential as a biodegradable food preservative.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Xiangtao Liu,Sisi Zhang,Haiyan Zheng,Mengyao Bian,Linna Qian,Weijia Zhao,Ying Shi,Zhifang Wu
Dental caries, primarily induced by plaque biofilm, is a significant challenge in oral health due to the disruption of the equilibrium between mineralization and demineralization processes. The primary objective in caries management is to preserve biofilm homeostasis while promoting the repair and regeneration of dental hard tissues, thereby restoring the structural integrity and functionality of the affected teeth. This study aimed to develop a multifunctional film with mineralizing and antibacterial abilities by incorporating ultrasmall amorphous calcium phosphate (ACP) nanoclusters (~1 nm) into hydroxypropyl trimethyl ammonium chloride chitosan (HACC) matrix. The ACP nanoclusters were synthesized using polyacrylic acid and polyaspartic acid as stabilizers and were homogeneously dispersed into the HACC matrix to form ACP@HACC film. The capacity for Ca and P ions release from ACP@HACC film was evaluated by inductively coupled plasma-mass spectrometry, demonstrating a sustained ion release over a period of 7 days. The ACP@HACC film induced the mineralization of type I collagen fibrils within 4 days. In vivo studies further confirmed the occurrence of dentin remineralization after 4 days. The remineralization process mediated by the ACP@HACC film significantly restored the elastic modulus and microhardness of demineralized dentin. Additionally, cytotoxicity assessments confirmed the excellent biocompatibility of the ACP@HACC film. Dentin treated with the ACP@HACC film demonstrated antibacterial ability against Streptococcus mutans in vitro. The ACP@HACC film integrates the dual functionalities of mineralization and antibacterial activity while maintaining excellent biocompatibility. This innovative approach shows potential for the treatment of early carious lesions, offering a clinically viable supplement to conventional restorative strategies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Xinglei Li,Yiyang Shen,Shengye You,Luxuan Shao,Rui Bao,Diya Zhang,Wei Dong,Jun Lin
Available remedies for diabetic oral mucosa wounds often prove inadequate, chiefly due to complications like bacterial infiltration, oxidative harm, and hindered angiogenesis throughout wound restoration. This study addresses the significant gap in effective therapeutic options by developing an injectable hydrogel, DCE1, designed to enhance healing in diabetic oral ulcers. Here, we present DCE1, composed of a polysaccharide matrix of dialdehyde xanthan gum and quaternary chitosan, integrated with epigallocatechin-3-gallate nanoparticles. DCE1 generates a shielding hydrogel barrier when administered locally, exhibiting potent sterilization and reactive oxygen species-clearing properties. Such benefits shift the wound healing process from an inflammatory to a proliferative stage. Notably, the DCE1 dressing is fully biodegradable post-treatment, ensuring complete absorption by the body after fulfilling its therapeutic role. In conclusion, our findings demonstrate that the DCE1 hydrogel significantly accelerates oral mucosa wound repair in both in vitro and in vivo models. This advancement represents a promising therapeutic strategy for diabetic oral ulcers, ultimately contributing to improved clinical outcomes in the management of this challenging condition.
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