COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Haidong Zeng,Yingxin Zhang,Tianyu Zhou,Chunbo Liu,Dongshu Sun
In-situ preparing robust CoFe 2 O 4 /PCN PMS activator for multi-pollutant degradation. • Complete degradation TC within 3 min with the rate constant 24-fold higher than CN • Degradation intermediates, routes and toxicity were explored • Wide light absorption, exposed active sites, and charge behavior boost photocatalysis Facing the urgent environmental crisis, it is imperative to create an efficient and robust technology for treating diverse pollutants in aquatic environments. Herein, a CoFe 2 O 4 /PCN composite was designed via a facile in-situ growth method, in which CoFe 2 O 4 uniformly grows on carbon nitride. This architecture not only forms a close interface that facilitates efficient charge separation and migration, but also introduces abundant mixed-valence metal sites, that serve as superior active centers for peroxymonosulfate (PMS) activation and subsequent organic pollutant removal. Specifically, under visible light, the optimized catalyst can 100% degrade TC within 3 min (complete degrade rhodamine B within 20 s, methyl orange within 40 s, and methylene blue within 3 min), and the rate constant was 24-fold higher than pristine CN, surpassing most reported catalysts. The catalyst also demonstrates excellent recyclability and broad pH adaptability. The mechanism behind the performance enhancement stems from the significantly broadened light absorption (supported by UV–vis DRS), fully exposed active sites (evidenced by SEM/TEM/AFM and N₂ adsorption), and enhanced charge behaviors (supported by PCR, EIS, PL/TRPL and KPFM), especially caused by strong internal electric field. At last, the active species, degradation intermediates and their toxicity were investigated using TC degradation as a model, coupled with DFT theoretical calculations. This work proposes a rational design strategy toward constructing efficient and robust photocatalysts, revealing significant promise for water remediation. Download: Download high-res image (269KB) Download: Download full-size image
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JOURNAL OF RARE EARTHS
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2026
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IF 9.6
Dan Wu,Yanni Lang,Junhao Li,Qiu Fu,Yugeng Wen,Dacheng Zhou,Yong Yang,Yongjin Li,Zhiguo Song,Jin Han,Jianbei Qiu
Upconversion luminescent materials can convert near-infrared excitation into higher-energy emissions, showing great potential in applications such as temperature sensing and optical anti-counterfeiting. However, it remains challenging to simultaneously achieve high thermal stability, sensitive temperature response, and circularly polarized luminescence within a single system. In this work, chiral Bi 4 O 5 Br 2 : Yb 3+ /Er 3+ nanosheets were synthesized via a hydrothermal method combined with chiral modification and pH regulation, and their structural and luminescent properties were systematically investigated. The results indicate that pH regulation during precursor synthesis facilitates the optimization of the Bi 4 O 5 Br 2 morphology and improves its crystallinity, thereby promoting a more ordered crystal growth process. Subsequently, chiral induction introduces local lattice distortion while suppressing defect formation. The synergistic effect of both helps to significantly enhance upconversion luminescence performance. Under variable-temperature conditions, the 849 nm near-infrared emission ( 4 I 9/2 - 4 I 15/2 ) exhibits negligible thermal quenching over the temperature range of 293−533 K, in sharp contrast to the thermally quenched behavior of visible emissions. Based on this feature, a fluorescence intensity ratio (FIR) thermometry strategy was established, achieving high sensitivity with an absolute sensitivity ( S a ) of 20.73%/K and a relative sensitivity ( S r ) of 3.45%/K. Furthermore, the material exhibits pronounced emission intensity differences under circularly polarized excitation and detection. This enables the construction of a polarization-color synergistically tunable luminescent anti-counterfeiting system. This work provides a new strategy for designing multifunctional upconversion materials that integrate optical thermometry and polarization-based anti-counterfeiting capabilities.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Huidong Tang,Chen Liu,Donggou Sun,Wenbo Zhang,Xiaohua Zhu,Yixing Ma,Jiacheng Bao,Kai Li,Xin Sun,Ping Ning
Fe 2 O 3 /g-C 3 N 4 accelerates Fe redox cycling for efficient H 2 O 2 activation. • g-C 3 N 4 pumps electrons to Fe sites, boosting interfacial charge transfer. • Alkaline microenvironment uniquely steers ROS pathway toward O 2 •− generation. • Process yields 93.2% NO x removal, converting NO into valuable N-resources. To overcome the challenges associated with low-temperature industrial flue gas denitrification, this study presents a highly efficient Fe 2 O 3 /g-C 3 N 4 heterogeneous Fenton catalyst synthesized via a facile impregnation approach. This composite effectively activates H 2 O 2 for deep NO x elimination. Under optimal alkaline conditions, the Fe 2 O 3 /g-C 3 N 4 system achieved a remarkable maximum NO x removal efficiency of 93.2%, while demonstrating exceptional durability by retaining over 80% efficiency across five consecutive reaction cycles. Comprehensive experimental characterization coupled with density functional theory (DFT) calculations reveal that g-C 3 N 4 serves as an electron-rich reservoir. This framework systematically accelerates the rate-limiting Fe 2+ /Fe 3+ redox cycling on the Fe 2 O 3 surface through enhanced interfacial charge transfer. Crucially, the alkaline environment uniquely steers the reactive oxygen species (ROS) evolution pathway toward the highly selective generation of superoxide radicals (O 2 •− ). These predominant O 2 •− species rapidly oxidized NO to form peroxynitrite intermediates, thereby promoting the deep conversion of NO into recoverable nitrate and nitrite products. This work provides a robust and scalable strategy for low-temperature NO ₓ purification and offers new mechanistic insights into how the reaction microenvironment regulates radical selectivity. Download: Download high-res image (294KB) Download: Download full-size image
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MOLECULAR PHARMACEUTICS
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2026
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IF 4.9
Zhou Yuhao,Yue Zhongqun,Feng Tingting,Zhang Fangxia,Guan Jing,Luo Juanjuan,Tan Yanan,Zhou Ying,Zhu Yue,Wang Zuhua
Gastric cancer is a highly prevalent malignant tumor of the digestive system worldwide. Although andrographolide (AG) and coixol (CX) possess potential anti-gastric cancer effects, their clinical application is restricted by low bioavailability and poor targeting ability. Based on the meridian tropism theory of traditional Chinese medicine and the concept of “integrated drug and carrier”, this study constructed Bletilla striata polysaccharide-vitamin E succinate (BSP-VES) polymeric micelles co-loaded with AG and CX (AG&CX@BSP-VES) for synergistic targeted therapy of gastric cancer. In this study, AG&CX@BSP-VES was first systematically characterized in vitro to clarify its physicochemical properties, drug release behavior and hemolysis profile. Subsequently, using subcutaneous and orthotopic gastric cancer mouse models as research objects, in vitro cellular uptake and in vivo tumor targeting ability efficacy and biological safety of this drug delivery system were further evaluated. Results showed that the micelles were regularly spherical with a particle size of approximately 105 nm, exhibited favorable biological safety and asynchronous differential release characteristics, and could be specifically internalized by cells in vitro (which could be blocked by free BSP). In vivo, the accumulation of micelles in tumor masses was significantly higher than that in normal gastric tissues. Moreover, the cytotoxicity of the micelles against SGC-7901 tumor cells was remarkably higher than that of free AG or CX alone, which was attributed to enhanced cellular drug uptake and the synergistic effect between AG and CX. This study provides novel insights for the precise delivery of active ingredients from traditional Chinese medicine and individualized therapy of gastric cancer.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Siyao Liu,Danni Yang,Li Zhang,Xingping Zheng,Lilang Li,Yu Wang,Chenguang Zhou,Xiaobo Zou
Cold plasma achieved dual pesticide reduction and quality modulation in cinnamon. • Structural modification promoted the release of aroma-related volatile compounds. • Volatilomics identified key markers for CP-induced aroma quality changes. • Untargeted metabolomics revealed carbohydrate-associated metabolite changes. • CP improved antioxidant capacity while preserving antibacterial functionality. To evaluate Cold plasma (CP) for pesticide residue control in spices, dried Cinnamomum cassia Presl bark pieces fortified with eight pesticides were used as a controlled postharvest model. Volatilomics and untargeted metabolomics were further used to explore the related quality-modulation mechanisms. CP promoted pesticide degradation, with higher removal efficiencies obtained at increased power and treatment time. The mean degradation percentages generally showed an upward trend with increasing plasma power and treatment time. Among the conditions examined, treatment at 1.3 kW for 10 min produced the highest mean degradation percentage for each of the eight pesticides, with values ranging from approximately 15% to 55% in fortified cinnamon bark. CP also altered the surface structure and water status of cinnamon, as indicated by stronger surface etching, reduced contact angle, and decreased bound water content. Volatilomic analysis identified 111 volatile organic compounds, mainly terpenoids. CP increased the detectable abundance of key flavor- and function-related compounds, including d -limonene, cinnamyl acetate, β-elemene, and α−/β−pinene, and 30 volatile markers were screened. Untargeted metabolomics identified 164 metabolites and 52 differential metabolites, which were mainly annotated to carbohydrate-related pathways. Meanwhile, DPPH radical-scavenging and FRAP reducing capacities were higher after CP treatment, whereas antibacterial properties remained generally stable. These results indicate that CP can reduce pesticide residues in cinnamon while improving volatile flavor release and maintaining functional quality, providing a basis for its application in green processing of spices and plant-derived foods. Download: Download high-res image (183KB) Download: Download full-size image
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Tianlong Zhao,Zixin Rong,Demei Wang,Shiyu Liu,Zimei Chen,Yicheng Cai,Tingming Fu
Silybin is a clinically validated adjunct for liver disorders, yet poor absorption and rapid metabolism curtail its wider therapeutic use. Exploiting the distinctive hepatic distribution of glycyrrhetinic acid (GA) receptors, we augmented silybin B (SilB, an isomer of silybin) delivery by encapsulating it within GA-modified liposomes. We constructed a response-surface model to optimize liposome fabrication, identifying the optimal recipe: 5.89:1 lecithin/cholesterol, 100:2.13 lecithin/DSPE-PEG2000, and 12:5.05 lecithin/SilB. DSPE-PEG2000-GA was generated through amidation and substituted for DSPE-PEG2000 to yield GA-modified SilB liposomes (GSL). GSL exhibited 49.34 ± 0.25% encapsulation efficiency, 9.13 ± 0.04% drug loading, 148.881 ± 4.786 nm diameter, 0.269 ± 0.024 polydispersity index, and −23.433 ± 0.775 mV zeta potential. GSL remained stable for 7 days and sustained drug release for 24 h in PBS. GA-modified liposomes displayed accelerated HepG2 uptake and heightened murine hepatic retention, underpinning its superior therapeutic performance. GSL engaged non-alcoholic fatty liver disease on multiple aspects, suppressing lipid accretion, inflammation, and insulin resistance, and significantly surpassed free SilB in therapeutic magnitude. Download: Download high-res image (305KB) Download: Download full-size image
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Surfaces and Interfaces
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2026
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IF 6
Youwei Zeng,Zichun Meng,Zihan Li,Dongyun Que,Yifan Wang,Fan Chen,Bin Wen,Yuyuan Yao
The development of the high catalytic performance zinc-based catalyst featuring eco-friendly remains a considerable challenge in environmental treatment. Serving as a nitrogen-rich anchoring ligand, 3,5-diamino-1,2,4-triazole was adopted to construct a porous Zn-based catalyst through a facile grinding-assisted pyrolysis route. Zinc species served as both a pore-forming agent and active site, endowing the ZnNC with a zinc loading of 11.26 wt% with a specific surface area of 388.29 m 2 /g. The as-prepared ZnNC displayed outstanding performance in activating peroxymonosulfate (PMS), enabling complete degradation of the refractory contaminant carbamazepine (CBZ) within 15 min, and the apparent rate constant (k obs ) was 0.395 min⁻¹, surpassing the performance of most reported metal-based catalysts. Interestingly, the reaction at 0 °C was more favorable for the degradation of CBZ, which was attributed to the strengthened adsorption of CBZ on the ZnNC at low temperatures, differing from most previous reports that the degradation rate increased with rising temperature. Quenching experiments in combination with EPR characterizations revealed that 1 O 2 acted as the predominant reactive oxygen species (ROS) in the ZnNC/PMS system, endowing the catalytic system with wide pH adaptability and strong anti-interference capability against coexisting ions. Importantly, ZnNC maintained a relatively stable CBZ removal rate after five cycles and during 24 h of continuous operation, demonstrating its preliminary application potential. This work provides a viable and facile strategy for the rational construction of highly active and stable zinc-based catalysts for wastewater remediation. Download: Download high-res image (231KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Guoqing Zhang,Long Qiu,Kaiyuan Li,Jia Zhao,Xiangnan Li
ESCC samples show higher USP44 succinylation and lower expression vs adjacent non-tumor tissues. • CPT1A binds USP44 and specifically mediates its K543 succinylation, reducing USP44 stability. • K543 succinylation triggers USP44's ubiquitination-mediated degradation in ESCC tissues. • USP44 stabilizes CDK5RAP3 by K166 deubiquitylation, dependent on its catalytic C282 residue. • USP44 inhibits ESCC xenograft growth, lung and lymphatic metastasis by stabilizing CDK5RAP3. Ubiquitin-specific proteases (USPs) function in multiple types of tumor progression by controlling protein turnover. However, the regulatory mechanism of ubiquitin carboxyl-terminal hydrolase 44 (USP44) in esophageal squamous cell carcinoma (ESCC) remains incompletely understood. Here, we show that USP44 expression correlates with tumor size, tumor stage, and TNM stage in ESCC patients. In vitro gain- and loss-of-function experiments validate that USP44 acts as a tumor suppressor in ESCC. Xenograft assays further demonstrate that USP44 overexpression suppresses the growth of ESCC xenografts, as well as lymph node and lung metastasis. Analysis of collected ESCC tumor samples reveals downregulated USP44 expression and upregulated USP44 pan-succinylation, along with two opposing correlations: a negative correlation with Carnitine O-palmitoyltransferase 1 (CPT1A) and a positive correlation with CDK5 regulatory subunit-associated protein 3 (CDK5RAP3). Mechanistic studies identify CPT1A as a lysine succinyltransferase that specifically succinylates USP44 at lysine 543 (K543). Such CPT1A-mediated K543 succinylation triggers ubiquitination-dependent degradation of USP44, thus explaining the downregulation of USP44 observed in clinical ESCC samples. Moreover, ubiquitination proteomics combined with survival analysis identifies CDK5RAP3 as a key deubiquitination substrate of USP44. USP44 directly interacts with CDK5RAP3 and stabilizes CDK5RAP3 by removing its ubiquitin chains at lysine 166 (K166), in a manner dependent on the catalytic cysteine 282 (C282) within its USP domain. In rescue experiments, CDK5RAP3 overexpression reverses the promotion of malignant behavior in ESCC cells and the activation of the Wnt/β-catenin signaling pathway caused by USP44 silencing. Collectively, USP44 may serve as a promising therapeutic target for ESCC.
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Global Change Biology Bioenergy
·
2026
·Vol. 18
·期 9
·e70172
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IF 4.9
Qingsong Wang,Xin Wang,Yunkai Zhou,Wenjia Li,Jia Wang,Dongbing Li
The catalytic hydrogenolysis of glucose to produce 1,2-propylene glycol (1,2-PG) has opened promising avenues for sustainable chemical production. However, traditional Ru-based catalysts suffer from issues such as high metal loading, poor dispersion, and a tendency to agglomerate under harsh conditions, leading to rapid deactivation. This work reports a highly dispersed, low-loading Ru catalyst supported on a magnesium–aluminum ferrite (MAFO) spinel to address these limitations. Strong covalent metal–support interactions (CMSI) between Ru species and the MAFO support not only achieve efficient stabilization of Ru nanoparticles but also promote their redispersion. Under optimized reaction conditions (518 K, 5 MPa H 2 , and 1 h), the Ru/MAFO catalyst achieves 100% glucose conversion and 59.3% selectivity to 1,2-PG. Notably, the catalyst maintains outstanding activity and stability after six consecutive reaction cycles. This study provides an efficient and robust catalytic strategy for 1,2-PG production from glucose, offering significant insights for designing high-performance and stable catalysts for biomass valorization.
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ADVANCED MATERIALS
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2026
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IF 29.1
Shiyao Song,Yan-Lai Tang,Xiaoting Liu,Jiayi Zheng,Chong Wu,Tang Li,Junhong Ye,Dianmin Xia,Yong Mei,Jingxuan Ma,Libin Huang,Xuequn Luo,Liheng Chen,Yanlin Qin,Weiling He
FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers. However, the issues of excessive toxicity and prolonged treatment cycles persist. To address this limitation, we developed a novel methylated amino acid-modified lignin inspired by biological methylation, creating a pH-responsive charge-reversal drug delivery system for FOLFOX chemotherapy. This system stabilizes thymidylate synthase (TS) and combines with deoxyuridine monophosphate (dUMP) to demonstrate significantly improved therapeutic outcomes of FOLFOX against colorectal cancer (CRC). The FOLFOX-loaded nanodrug showed targeted antitumor activity against CRC and induced tumor cell death through multiple mechanisms, including apoptosis, necrosis, cell cycle regulation, DNA damage, and reactive oxygen species generation. Furthermore, the nano-formulation activated immune responses to enhance chemotherapeutic potency and effectively reducing renal toxicity associated with chemotherapy drugs. These findings suggest that protein methylation-mimicked lignin could be a valuable addition to current first-line chemotherapy options and holds promise for enhancing chemotherapy against solid tumors.
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Advanced Science
·
2026
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IF 14.1
Junzhe Fu,Fan Jia,Yixian Mu,Wanzhe Liu,Dingqi Tang,Qiao Jin,Jian Ji,Youxiang Wang
Hypertrophic scars (HS) are sustained by a self‐perpetuating extracellular matrix (ECM)–fibroblast feedback loop, in which activated fibroblasts drive excessive ECM deposition, while the resulting matrix stiffening in turn reinforces fibroblast activation. Although advanced fibroblast‐suppression strategies are being actively developed, this matrix‐driven profibrotic feedback remains poorly integrated into HS therapeutic strategies and insufficiently targeted. Here, we introduce an enzyme–nitric oxide (NO) co‐regulatory system for HS: enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated modulation of fibroblast phenotypes restrains excessive collagen synthesis, thereby inducing mutually reinforcing remodeling across the ECM–fibroblast axis. Specifically, a microneedle platform is developed for localized co‐delivery of the thermosensitive protease bromelain (Bro) and NO‐donor‐functionalized polydopamine nanoparticles (PDA‐NO). Upon near‐infrared irradiation, precise photothermal stimulation further enhances Bro activity and accelerates NO release, enabling controlled amplification of the co‐regulatory effect. In vivo studies demonstrate that this system alleviates HS and restores balanced fibrotic remodeling, as evidenced by coordinated suppression of YAP signaling and the TGF‐β1/α‐SMA/Collagen I axis, supporting effective interruption of the fibrotic feedback loop. Distinct from existing fibroblast‐centric approaches, this study establishes pathological ECM–fibroblast crosstalk as a key mechanistic entry point for HS, advancing a mechanism‐driven, materials‐enabled framework for antifibrotic strategy design. An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis. Supported by photothermal amplification and localized microneedle delivery, this strategy interrupts the fibrotic feedback loop and restores balanced remodeling to alleviate hypertrophic scarring.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 34
·45987-46006
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IF 7.8
Zhao Siyu,Zhang Jing,Li Xin,Cui Yating,Cheng Peng,Zhang Yunxiang,Hou Xinmiao,Xu Derui,Du Bolin,Song Qing,Zhao Ruijie,Wang Xiaohui,Taylor Peter R.,Li Xichuan,Jin Xinghua
Inflammatory bowel disease (IBD) is exacerbated by the excessive accumulation of reactive oxygen species (ROS). To overcome the insufficient catalytic activity of conventional cerium-based nanozymes, we designed an ultrasound-activated Bi@BTC heterojunction nanozyme. The ultrasound-activated carriers generated by bismuth core undergo effective electron-hole separation in the Janus Bi@BTC heterojunction. The holes are enriched in the valence band of the BTC shell, catalyzing the oxidation reaction of Ce 3+ . Benefiting from the proton-coupled electron transfer (PCET) effect of tannic acid and the electronic coupling at the heterointerface, Bi@BTC accelerates the Ce 3+ /Ce 4+ redox cycling, enabling a highly efficient and stable superoxide dismutase (SOD)−catalase (CAT)-like catalytic cycle and thus robust elimination of multiple ROS in the IBD microenvironment. Density functional theory (DFT) calculations elucidate the catalytic pathways and cyclic mechanisms underlying the dual enzyme-mimetic activities, revealing key intermediates, transition states, and corresponding energy profiles. In vitro and in vivo assays confirmed that Bi@BTC alleviates intestinal inflammation by eliminating excess ROS, upregulating tight-junction proteins, promoting mucosal barrier repair, and restoring gut microbiota homeostasis. This work presents a boosted ROS-elimination strategy via ultrasound-activated heterojunction-mediated effect and PCET-driven cerium redox cycling, establishing a multifunctional paradigm that integrates ROS scavenging, anti-inflammation, mucosal repair, and gut microecological regulation.
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危险品化学品经营许可证（带存储）