Journal of Materials Chemistry C
·
2014
·Vol. 3
·期 9
·2093-2100
·
IF 0
Hanqiang Zhang,Yihong Huang,Shirong Hu,Qitong Huang,Chan Wei,Wuxiang Zhang,Lianping Kang,Zhouyi Huang,Aiyou Hao
A novel approach for preparation of graphitic carbon nitride nanosheets (CNNS) from stripping graphitic carbon nitride by strong acid and ultrasonic technology was demonstrated in this study for the first time. Transmission electron microscopy (TEM) was employed to characterize the surface morphology. Atomic force microscope (AFM) was carried out to characterize the thickness of nanosheets. X-Ray diffraction (XRD) was performed to estimate the lattice structure. X-Ray photoelectron spectroscopy (XPS) was carried out to characterize the surface composition and element analysis. Fourier transform infrared spectroscopy (FT-IR) was allowed to identify the functional groups. The as-synthesized CNNS exhibited excellent emission property as well as excitation-independent emission behavior, and fluorescence quantum yields could reach approximately 12.53%. Mercury ion (Hg2+) can make a result of quenching the significant intensity of fluorescence of CNNS by formation of a covalent bond between empty orbital of Hg2+ and the π electrons of N (turn-off). Moreover, the addition of the L-cysteine (L-Cys) can enhance the intensity of fluorescence of the CNNS– Hg2+ system through the thiol group of L-Cys anchored with Hg2+ and drag it from the surface of CNNS (turn-on). The CNNS was consequently functioned as a fluorescence probe towards “off–on” detection of Hg2+ and L-Cys with high sensitivity and selectivity. Moreover, the fluorescent probe was applied to detect tap water and well water with satisfactory results.
✓ 已验证
产品关联
DOI
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Hongyu Wu,Li Zhang,Ruiguo Cui,Chuxuan Zhang,Man Xu,Weiwei Liu,Mengshi Wang,Ruijie Liu,Long Xu,Lijun Song
This study evaluated the effects of screw pressing temperature (40 °C–200 °C) on the yields, physicochemical properties, oxidation stabilities, and antioxidant activities of apricot kernels oil (AO). Additionally, this study comparatively analyzed the functional properties of different apricot kernels protein isolates (APIs). The oil yield ranged from 30.06% to 49.07% with AO-200 showing the highest yield. Compared with cold pressing, high-temperature pressing significantly increased the trace components (such as total phenols, tocopherols, and phytosterols), oxidation stabilities, and antioxidant activities of AOs. High-temperature pressing also increased the functional properties of API. Multivariate analysis revealed that spiral pressing at 120 °C may be an optimal strategy for obtaining high-quality oil and protein isolate from apricot kernels. These findings provide a theoretical basis for the extraction and application of AO and API.
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Wenli Guo,Jinjin Zhang,Xiaoqian Zhang,Quanzhong Ren,Guangzhe Zheng,Jianxin Zhang,Guoxing Nie
Cadmium (Cd) pollution is considered a pressing challenge to eco-environment and public health worldwide. Although it has been well-documented that Cd exhibits various adverse effects on aquatic animals, it is still largely unknown whether and how Cd at environmentally relevant concentrations affects iron metabolism . Here, we studied the effects of environmental Cd exposure (5 and 50 μg/L) on iron homeostasis and possible mechanisms in common carp. The data revealed that Cd elevated serum iron, transferrin saturation and iron deposition in livers and spleens, leading to the disruption of systemic iron homeostasis. Mechanistic investigations substantiated that Cd drove hemolysis by compromising the osmotic fragility and inducing defective morphology of erythrocytes. Cd concurrently exacerbated hepatic inflammatory responses, resulting in the activation of IL6-Stat3 signaling and subsequent hepcidin transcription. Notably, Cd elicited ferroptosis through increased iron burden and oxidative stress in livers. Taken together, our findings provide evidence and mechanistic insight that environmental Cd exposure could undermine iron homeostasis via erythrotoxicity and hepatotoxicity. Further investigation and ecological risk assessment of Cd and other pollutants on metabolism-related effects is warranted, especially under the realistic exposure scenarios.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Lei Wang,Xin Zhang,Yonggang Sun,Yulong Ma,Min Xu,Juan Zhang,Yingbo Zhu,Li Zhu,Song Qiao,Jing Ma,Jinpeng Wei,Feng Lin
Environmental H 2 O has a significant effect on the reaction mechanism and process of VOC oxidation, of which the intrinsic mechanism is hardly reported. Herein, a series of PtCu δ -MnO x catalysts with different strong metal-supported interactions were constructed by replacing some Pt species with Cu species. Among them, the PtCu 3 -MnO x catalyst exhibited superior catalytic performance (T 90 = 170 ℃), high water resistance, and long-term stability. Furthermore, in-situ diffuse reflectance infrared Fourier transform spectroscopy ( in-situ DRIFTs) showed that the acetone oxidation followed synergistic cooperation of the Langmuir-Hinshelwood (L-H) and Mars van Krevelen (MvK) mechanism. Acetone oxidation over PtCu 3 -MnO x occurred via the L-H mechanism producing surface acetate and formate species intermediate. Above 100 °C, adsorbed acetone (i.e., acetate and formate species) reacts with MnO x lattice oxygen according to the MvK mechanism to form CO 2 and H 2 O. When water vapor was present, the L-H mechanism was impaired, inhibiting the deep oxidation of acetone. This research provides an in-depth exploration of how water vapor impacts the reaction mechanism of acetone oxidation. It offers valuable insights for creating dependable catalysts suitable for use in various industrial settings.
✓ 已验证
产品关联
DOI
高影响因子
FITOTERAPIA
·
2024
·
IF 2.5
Wenjun Cai,Shuo Zhang,Yaonan Wang,Changli Liu,Rong Luo
Aurantii Fructus Immaturus (AFI) was structurally divided into two parts named “peel” and “pulp”. The exocarp and mesocarp of materials named “peel”. The endocarp separated into multiple compartments and the cystic hair attached to it named “pulp”. In order to explore the distribution and content of constituents in AFI, an efficient method to explore the distribution of constituents was developed based on matrix assisted laser desorption/ionization fourier transform ion cyclotron resonance mass spectrometry imaging (MALDI-FTICR-MSI). After simple processing, thirty-two constituents with distinct localization in the mass range of 101–1200 Da were identified by MALDI-FTICR-MSI. In addition, the identified four flavnoids (poncirin, sinensetin, 3,5,6,7,8,3′,4′-heptemthoxyflavone, and tangeritin) were analyzed for differences between using LC-MS. Quantitative analysis results supported the quantitative results from MALDI-FT-ICR-MSI. The results implied that different parts had different constituents in AFI, and demonstrated MALDI-MSI have high potential in the direct analysis of constituents.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Rui Wang,Jian Zhang,Zhengyi Sun,Xuewen Jian,Yue Xu,Xuan Zhou,Xiaojie Liang,Jin Lin,Beixing Li,Wei Mu,Yuekun Li
Realizing eco-friendly, long-term, and low-risk aphid control on Lycium barbarum (medicinal cash crop) using a Cynanchum komarovii extracts and eucalyptus oil-loaded microcapsules (EOMCs) formulation compositions is viable. In this study, the aim is to optimize the composition of Cynanchum komarovii extracts and EOMCs formulation for effective control of aphids, the release of EOMCs was controlled by changing the cross-linking degree of the shell to match the aphid control characteristics of Cynanchum komarovii extracts. Four types of polyamines were used as cross-linking agents for the preparation of EOMCs by interfacial polymerization. The bioactivity, wettability, and field application efficacy of Cynanchum komarovii extracts and different EOMCs formulation compositions were evaluated. These EOMCs exhibited an encapsulation efficiency exceeding 85 %. The control efficiency of the formulation compositions of microcapsules with a moderate release rate and Cynanchum komarovii extracts on aphids remained at 62.86 %, while the control efficiency of the combination of microcapsules with the fastest and slowest rates with Cynanchum komarovii extracts was only 48.62 % and 57.11 %, respectively. The formulation compositions of Cynanchum komarovii extracts with all four types of EOMCs were found to be safe for Chinese wolfberry plants. Overall, by selecting appropriate polyamines during fabrication, the release rate can be effectively controlled to achieve sustainable and low-risk aphid control in Lycium barbarum through compounding with selected microcapsules.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Zilin Wu,Yilin Ding,Zhihao Qin,Zhipeng Sun,Zetao Wang,Xiaodong Cao
The integration of hemostats with cotton fabrics is recognized as an effective approach to improve the hemostatic performance of dressings. However, concerns regarding the uncontrollable absorption of blood by hydrophilic dressings and the risk of distal thrombosis from shed hemostatic agents are increasingly scrutinized. To address these issues, this work develops an advanced dressing (AQG) with immobilized nano-scale mesoporous bioactive glass (MBG) to safely and durably augment hemostasis. The doubly immobilized MBGs, pre-coated with ε-poly-L-lysine and alginate, demonstrate less than 1% detachment after ultrasonic washing. Notably, this MBG layer significantly promotes the adhesion, aggregation, and activation of red blood cells and platelets, adhered five times more red blood cells and 29 times more platelets than raw dressing, respectively. Specially, with the rapid formation of protein corona and amplification of thrombin, dense fibrin network is built on MBG layer and then blocked blood permeation transversely and longitudinally, showing an autophobic pseudo-dewetting behavior and allowing AQG to concentrate blood in situ and culminate in faster hemostasis with lower blood loss. Furthermore, the potent antibacterial properties of AQG extend its potential for broader application in daily care and clinical setting.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2024
·Vol. 16
·期 12
·1543
·
IF 4.9
Min Li,Wenying Li,Fang Xu,Yiping Pu,Jianguang Li
Background:L-Shikonin, an active component of Arnebia euchroma (Royle) Johnst., has remarkable pharmacological effects, particularly in its anti-tumour activity. Nonetheless, the specific targets and mechanisms of action remain to be further explored.Methods:A novel Fe3O4@L-Shikoninwas designed and synthesized in this study by linking Fe3O4andL-Shikoninthrough benzophenone. Fe3O4@L-Shikoninwas characterized using several techniques, including scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and drug removal methods, to determine the content ofL-Shikoninon the surface of the magnetic particles. Target hooking technology was utilized to identify the target proteins of the compound in melanoma. The synthesized Fe3O4@L-Shikoninwas co-incubated with A375 cell lysate, followed by the target proteins, which were purified by magnetic enrichment using magnetic microspheres and identified by high-resolution mass spectrometry.Results:AutoDock Vina software was employed for molecular docking analysis, where it was found thatL-Shikonintargets RPN1, CPEB4, and HNRNPUL1 proteins. Subsequently, A375 cells were treated withL-Shikoninat different concentrations (2.5, 5.0, 10.0 μM) for 48 h, and the expressions of the three proteins were observed. The results showed a significant reduction in the relative expression of CPEB4 in the high-dose group compared to the control group (p< 0.01). Moreover, the relative expression of HNRNPUL1 was decreased in the medium- and high-dose groups (p< 0.05).Conclusions:This study initially revealed from the source thatL-Shikoninmay regulate melanoma-specific markers, melanosomes, tyrosine kinases related to abnormal tyrosine metabolism, and melanoma through multiple targets such as CPEB4 and HNRNPUL1. Proliferation and metastasis work together to exert an anti-melanoma mechanism, which provides a new idea for the follow-up study of the molecular pharmacological mechanism of the complex system of total naphthoquinones inArnebia euchroma(Royle) Johns.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2024
·
IF 4.1
Raril Chenthattil,Sijian Luo,Hang Ao,Wencheng Xiao,Huangxian Ju
This work proposed an electrochemical biosensing method for simultaneous detection of guanine and adenine. This electrochemical biosensor was constructed by layer-by-layer assembling TiO 2 nanoparticles, poly( l -lysine) and graphene quantum dots (GQDs) on a glassy carbon electrode. The assembled film of TiO 2 /poly( l -lysine)/GQDs showed better conductivity and significantly increased effective surface area for the electrochemical oxidation of guanine and adenine along with a quasi-reversible electrode process. Under optimal preparation and square wave voltammetric detection conditions, the proposed electrochemical methods could simultaneously detect guanine and adenine ranging from 1.0 to 35.0 µM with detection limits of 0.56 µM for GA and 0.81 µM for AD. The limits of quantification for sample analysis were 1.90 and 2.70 µM, respectively. The developed electrochemical biosensor exhibited good reproducibility, anti-interfering properties, and stability, and could be practically applied in the simultaneous determination of guanine and adenine in calf thymus DNA, cow milk, and urine samples with acceptable precision.
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Liming Yu,Bowen Tao,Fangfang Zhao,Lei Ma,Liangming Wei,Gen Tang,Yue Wang,Xiang Guo
Molybdenum disulfide (MoS2) is a promising anode material for sodium-ion batteries (SIBs) due to its large layer spacing and high theoretical specific capacity. However, its electrochemical performance is hampered by large volume changes and poor ion diffusivity. Herein, a new water-based binder, sodium alginate-L-cysteine (SA-LCy), with a three-dimensional (3D) network cross-linked structure is prepared, which can effectively encapsulate the MoS2 anode materials to mitigate their pulverization. Meanwhile, the CuxS anchor, resulting from the reaction of the SA-LCy binder and the copper foil, can further enhance the binding force between electrode materials and copper foils. Owing to the advantages of the SA-LCy binder, the electrochemical performance of the MoS2 anode is significantly improved. The specific capacity of 370.8 mAh g–1 can be achieved at 0.2 A g–1 after 220 cycles, corresponding to a capacity retention of 95%. Moreover, a high reversible specific capacity of 345.3 mAh g–1 can be obtained at 10 A g–1. As for the MoS2//Na3V2(PO4)3/C-PVDF full cell, the specific capacity of 80.9 mAh g–1 can still be maintained at 0.5 A g–1 after 50 cycles. Hence, we confirm that SA-LCy is a promising binder for high-performance SIBs.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Junxi Liu,Xiaoke Zhang,Yan Liu,Zhijing Wu,Zheng Cui,Xianglin Pan,Yuheng Zheng,Jinglin Wang,Kaiping Wang,Yu Zhang
Recently, the intestinal lymphatic transport based on Peyer's patches (PPs) is emerging as a promising absorption pathway for natural polysaccharides. Herein, the aim of this study is to investigate the PP-based oral absorption of a pectic polysaccharide from Smilax china L. (SCLP), as well as its uptake and transport mechanisms in related immune cells. Taking advantages of the traceability of fluorescently labeled SCLP, we confirmed that SCLP could be absorbed into PPs and captured by their mononuclear phagocytes (dendritic cells and macrophages) following oral administration. Subsequently, the systematic in vitro study suggested that the endocytic mechanisms of SCLP by model mononuclear phagocytes (BMDCs and RAW264.7 cells) mainly involved caveolae-mediated endocytosis, macropinocytosis and phagocytosis. More importantly, SCLP directly binds and interacts with toll-like receptor 2 (TLR2) and galectin 3 (Gal-3) receptor, and was taken up by mononuclear phagocytes in receptor-mediated manner. After internalization, SCLP was intracellularly transported primarily through endolysosomal pathway and ultimately localized in lysosomes. In summary, this work reveals novel information and perspectives about the in vivo fate of SCLP, which will contribute to further research and utilization of SCLP and other pectic polysaccharides.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Science & Nutrition
·
2024
·
IF 3.5
Xin Wang,Xiaoyi Hu,Weiwei He,Jun-Yi Yin
Emerging evidence suggests that gut bacteria-derived trimethylamine N-oxide (TMAO) elevates the risk of cardiovascular disease, and dietary fiber holds the potential to attenuate TMAO formation. However, the effectiveness of dietary fiber, such as inulin, in inhibiting TMAO formation remains controversial. Therefore, this study investigated the effect of inulin supplementation on TMAO formation in mice with high TMAO levels induced by a high-fat diet (HFD) combined with choline and L-carnitine. Results showed that HFD treatment significantly elevated blood TMAO concentrations and increased the abundances of TMAO formation-associated gut bacteria, as well as the abundances of functional genes responsible for TMA formation. While the supplementation of choline and L-carnitine greatly enhanced blood trimethylamine (TMA) and TMAO levels, inulin supplementation did not significantly affect TMAO levels and had limited impact on TMA-associated gut bacteria, except for Desulfitobacterium hafniense .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）