Nature Communications
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2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Chen Hao,Lu Gongxun,Cao Zhenjiang,Zhu Qi,Ye Yuxuan,Gao Yuxuan,Shi Yu,Zhao Qi,Li Bin,Du Zhiguo,Tao Xinyong,Yang Shubin
Although commercial lithium-ion batteries have been widely used in portable electronics and electric vehicles, they are still plagued by the uncontrollable dendritic lithium under extreme conditions. Herein, an efficient strategy is developed to produce a MXene-configured graphite via an electrostatic interaction between MXene and silane coupling agent-modified graphite. Typically, MXene layers are adhered onto the basal plane of graphite, with good preservation of the uncovered lateral edges of graphite, effectively strengthening the adsorption energy of Li + and reducing the lithium nucleation energy barrier. Moreover, the MXene interface possesses good lattice compatibility with Li (110) plane, greatly promoting the homogeneous growth of Li along the preferable plane under extreme conditions. Even at −20 °C, Ah-level pouch cell with MXene-configured graphite electrode delivers a high capacity retention of 93% after 1200 cycles (273 Wh kg −1 ) at 1 C, exceeding lithium-ion batteries with bare graphite electrode (43% capacity retention, 191 Wh kg −1 ).
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-16
·
IF 3.9
Logrado Millena,Gaddam Anuraag,Zhuo Fangping,Zhao Changhao,Gao Shuang,Breitzke Hergen,Rosenstihl Markus,Vogel Michael,Rödel Jürgen,Buntkowsky Gerd
Thermal treatments play a crucial role in tuning the functional properties of lithium-based perovskites, which are of interest for applications in energy storage, actuation and sensing. In the present work, the impact of aging and quenching on the local structure and lithium mobility in lithium sodium niobate (LNN) ceramics was investigated using Density Functional Theory (DFT), transmission electron microscopy (TEM) and solid-state Nuclear Magnetic Resonance (NMR) techniques. Our results demonstrate that quenching inhibits the formation of a lithium-rich phase, leading to significant modifications in dipolar and quadrupolar interactions. Aging induces the formation of LiNbO 3 within the perovskite matrix, with no indication of lithium mobility at the boundaries of LiNbO 3 grains. The presence of multiple lithium environments in aged samples was indicated by transmission electron microscopy and confirmed through 7 Li Magic Angle Spinning (MAS) NMR, revealing distinct structural differences between aged and unaged samples. NMR parameters were also compared with parameters calculated by Density Functional Theory. The findings suggest the formation of LiNbO 3 and an additional lithium poor phase in aged LNN samples. These results indicate that the quenching effect reduces dipolar interactions and considerably sharpens the 7 Li NMR spectra, while structural modifications induced by thermal processing affect lithium ordering, providing new insights into the phase behavior of LNN ceramics.
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European Journal of Wood and Wood Products
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2025
·Vol. 83
·期 2
·1-11
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IF 2.5
Liu Wensheng,Yu Fanjun,Gui Chengsheng,Shen Yunfang,Qiu Zhe,Xiao Zefang,Zhang Tianpeng,Xie Yanjun
Currently, wood dyeing technology plays an important role in its enhancing aesthetics and market competitiveness. However, still facing the dual challenges of insufficient color fastness of dyeing and environmental pollution caused by dye wastes generated during the dyeing process. Herein, an efficient and environmentally friendly dyeing method was proposed to improve color fastness utilizing chemisorption and electrostatic adsorption in low concentration dyeing solution. The chemical modification of Ayous wood using 2,3-epoxypropyltrimethylammonium chloride was carried out by introducing the cationic groups to reduce the dyeing resistance and increase the binding force of dye molecules on the wood. Kinetic and thermodynamic analyses revealed that the adsorption behavior between cation-modified bleached wood (CBW) and acid dyes adheres to the quasi second-order kinetic model (R 2 = 0.98) and Freundlich isothermal model (R 2 = 0.91), suggesting an adsorption process in which chemical adsorption dominated. Therefore, there was a significant increase in color fastness. Compared to the traditional dyeing method, the quantity of dyes consumed in this method can be reduced by 40%, significantly diminishing the environmental load of dyeing waste liquid. This study offers an efficient and environmentally friendly modification strategy for wood dyeing, highlighting a potential of CBW for practical applications.
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MEDICAL ONCOLOGY
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2025
·Vol. 42
·期 5
·1-11
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IF 3.5
Wang Jingsi,Deng Xufeng,Li Manyuan,Liu Xiaobing,Liu Quanxing
The treatment of lung cancer with azacitidine (AZA) is urgently in need of a novel delivery material due to its limitations, including a short half-life, high cytotoxicity, and poor tumor targeting. To overcome these limitations, the coordination of Gallic acid-catechin-gallate with Fe 3+ and its encapsulation on the surface of mPDA loaded with AZA (mA@EF) was prepared. mA@EF exhibited a uniform distribution of regular spherical particles with good stability and drug release properties. In cell experiments, mA@EF effectively inhibited cell viability, promoted cellular uptake, and downregulated the expression of DNA methyltransferases. Moreover, mA@EF demonstrated good biosafety. In animal experiments, mA@EF showed strong tumor-targeting and retention activity, and significantly inhibited the growth of tumor. This discovery provided a feasible dosing regimen for AZA treatment in lung cancer patients.
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Food Production Processing and Nutrition
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2025
·Vol. 7
·期 1
·1-14
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IF 5.7
Sun Teng,Wang Zhaojun,Dai Yiqiang,Zhai Kang,Fang Xiangna,Chen Yitian,Zhao Baomin,Dong Mingsheng
In this study, Rhizopus oligosporus RT-3 was utilized to ferment soybean meal to obtain a tempe-like food with low fat and high bioactivity. To investigate the impact of fermentation on soybean meal’s nutritional value, we detected the protein-related indices and conducted a non-targeted metabonomic analysis on both fermented soybean meal (FSM) and soybean meal (SM) in order to explore changes in a certain type of metabolite and its corresponding metabolic pathways. The results showed a significant increase in crude protein, peptides and amino acids while getting porous after fermentation. A reduction of raffinose and stachyose to 18.1% and 8.5%, respectively, due to the action of α-galactosidase and β-furanofructosidase occurred. As to amino acid metabolites, essential amino acids for human bodily functions such as lysine, histidine, and threonine were significantly upregulated. Furthermore, nine peptide metabolites were identified as angiotensin-converting enzyme (ACE) inhibitors and dipeptidyl peptidase-4 inhibitors (DPP-IV). After feeding with different doses of FSM, levels of insulin-like growth factor-1 (IGF-1), hemoglobin (HB), albumin (ALB), and total protein (TP) of malnourished mice all returned to normal. In conclusion, fermentation with Rhizopus oligosporus RT-3 can improve the quality of SM by reducing the level of oligosaccharide anti-nutrition factors and increasing the contents of free amino acid and small bioactive peptides, which provide a theoretical basis and new ideas for the application of FSM. Graphical
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JOURNAL OF POLYMER RESEARCH
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2025
·Vol. 32
·期 12
·471
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IF 2.8
Luo Shajie,Wang Yuan,Zhang Shuai,Zhou Jun,Wang Jiale,Wang Xiaohan,Jiang Lishi
Two kinds of novel poly(arylene ether nitrile) copolymers (P-HFD and P-PFD) containing pendant aliphatic rings and fluorene groups were synthesized by 4, 4’-cyclohexane-1, 1’-diyldiphenol (CHDP) or 4, 4’-cyclopentane-1, 1’-diyldiphenol (CPDP), 4, 4’-(9-fluorenylidene) diphenol and 2, 6-dichlorobenzonitrile (DCBN) in this work. The inherent viscosities of these two copolymers were 0.455 and 0.576 dL/g. The copolymers P-HFD and P-PFD exhibited good thermal property, the glass transition temperatures (T g ) were 202.2–214.9 °C, and the weight-loss temperatures (T 5% ) were 421.3–433.5 °C. The polymers’ films had good tensile strengths of 27.3–38.6 MPa. The result of dissolution experiment showed that the copolymers could be dissolved in some solutions at room temperature, such as NMP, DMF and CH 2 Cl 2 , implying they had good solubility, they can be processed by the solution method. Additionally, the optical transmittances of these two copolymers were 68.3–76.3% at 450 nm, indicating that they have the potential to be applied as the heat-resistant optical films.
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Discover Oncology
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2025
·Vol. 17
·期 1
·1
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IF 2.9
Li Mengyan,Dai Litao,Jiang Min,Lv Yuanyuan,Zhang Yahao,Wang Yuqi,Ma Yuqing
Objective All-trans retinoic acid (ATRA) has demonstrated great potential in cancer treatment; however, the molecular mechanism for the anti‐tumour effects of Cellular retinoic acid-binding protein 2 (CRABP2) and ATRA in oesophageal squamous cell carcinoma (ESCC) remains unclear. Methods A strategy of transfecting KYSE-150 cells with vectors or CRABP2 overexpression was applied in this study. Changes in cell proliferation, migration, invasion and apoptosis in OE-NC, OE-CRABP2, OE-NC + ATRA and OE-CRABP2 + ATRA groups were observed. The location of CRABP2 with ATRA and the expression of key proteins that may be involved were detected. The volume and weight of subcutaneous grafted tumours in nude mice were compared in vivo, cell morphology was observed through haematoxylin and eosin (HE) staining, and cell apoptosis was detected using TUNEL staining. Results We determined that, in vitro, CRABP2 combined with ATRA best inhibited the proliferation, migration, invasion and cell cycle of ESCC and promoted its apoptosis. Oxidative stress, the mitochondrial pathway, p53 and the NF-κB pathway may be involved in the synergistic inhibitory effect of CRABP2 and ATRA. In vivo, tumour volume in the OE-CRABP2 + ATRA group was the smallest and tumour growth was the slowest. The HE results demonstrated improved cell differentiation in the OE-CRAB2 + ATRA group, and TUNEL staining revealed that CRABP2 and ATRA had the strongest promoting effect on cell apoptosis, with the degree of cell apoptosis the greatest with the participation of ATRA. Conclusion The combination of CRABP2 overexpression and ATRA synergistically inhibits ESCC progression. All‐trans retinoic acid may be a candidate therapy for ESCC, and CRABP2 overexpression could enhance the efficacy of ATRA treatment.
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Clinical and Experimental Nephrology
·
2022
·Vol. 26
·期 7
·630-639
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IF 2.617
Xia Yangyang,Wan Cheng,Zhang Qingyan,Wang Hengjin,Feng Yuan,Jiang Chunming
Background Peritoneal fibrosis (PF) is caused by epithelial-mesenchymal transdifferentiation (EMT) in the peritoneum under high glucose (HG) conditions. The study aimed to explored the role of Insulin-like growth factor 1 receptor (IGF-1R) in the regulation of EMT in human peritoneal mesothelial cells (HPMCs). Methods We used HG peritoneal dialysis fluid (PDF) to induce in vivo PF in mice, and treated HPMCs with HG in vitro to stimulate EMT. Results In the mice, the higher the glucose concentration in the dialysate, the more obvious the peritoneal tissue thickening and the more that collagen was deposited. The in vitro study indicated that the expression of IGF-1R, α-SMA, vimentin was upregulated, while the expression of occludin, ZO-1, and E-cadherin was downregulated in HPMCs under HG and IGF-1R overexpression conditions. Conversely, the expression of IGF-1R, α-SMA, and vimentin was downregulated, while the expression of occludin, ZO-1, and E-cadherin was upregulated in IGF-1R-underexpressed HPMCs under HG conditions. The cell migration abilities were increased, while the cell adhesion abilities were reduced in HPMCs under HG and IGF-1R overexpression conditions. In contrast, cell migration abilities were reduced, while cell adhesion abilities were increased in IGF-1Runderexpressed HPMCs under HG conditions. Conclusions Targeting at IGF-1R may provide novel insights into the prevention and treatment of PF.
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BMC CANCER
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2021
·Vol. 21
·期 1
·1-14
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IF 4.43
Shi Yue,Liu Chong
Background Breast cancer (BC) is one of the major malignancies worldwide. Circular ribonucleic acids (circRNAs) are a class of conserved ribonucleic acid (RNA) molecules that play important roles in various diseases. Recently, circRNAs have been suggested to have diagnostic value and may function as potential diagnostic biomarkers for BC. Previously, hsa_circ_0043278 was found to be downregulated in human BC. However, its role in human BC has not yet been identified.Methods The levels of hsa_circ_0043278 in BC cell lines were verified by quantitative reverse transcription–polymerase chain reaction (qRT–PCR). The overexpression vector and short hairpin RNA (shRNA) of hsa_circ_0043278 were transfected into MDA-MB-231 and MCF-7 cells, respectively. The effects of hsa_circ_0043278 on tumour cell growth, migration and invasion were measured by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), colony formation, wound healing and Transwell assays in vitro. A xenograft experiment was conducted to validate the inhibitory effect of hsa_circ_0043278 on tumour growth. The interaction between hsa_circ_0043278 and miR-455-3p was confirmed by a dual-luciferase reporter assay. Mimics and inhibitors of miR-455-3p were designed to confirm the influence of hsa_circ_0043278 on the hsa_circ_0043278/miR-455-3p/etoposide-induced gene 24 (EI24) axis.Results Hsa_circ_0043278 was downregulated in BC cell lines. Furthermore, overexpression of hsa_circ_0043278 notably decreased BC cell viability and inhibited BC cell migration and invasion in vitro and suppressed tumour growth in vivo. Downregulation of hsa_circ_0043278 led to the opposite results. Hsa_circ_0043278 expression was negatively correlated with that of miR-455-3p. In addition, mechanistic investigation proved that hsa_circ_0043278 directly bound to miR-455-3p and regulated EI24 and NF-κB expression in BC cells.Conclusion Hsa_circ_0043278 acts as a tumour suppressor gene in BC through the hsa_circ_0043278/miR-455-3p/EI24 axis and may be regarded as a new prognostic predictor or potential therapeutic target in BC.
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3 Biotech
·
2021
·Vol. 11
·期 12
·1-13
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IF 2.406
Tang Miaolong,Cai Jimin,Wang Yan,Huan Zhirong,Yao Hao,Xu Ce,Ge Xin,Song Sheng
Hemorrhage shock (HS) is a major threat to patients with trauma and spontaneous bleeding, resulting in multi-organ failure including the kidney. Tyrosine kinase nonreceptor 1 (TNK1) has been shown to be upregulated in the kidney of experimental HS and patients with severe trauma . The study aims to investigate the role of TNK1 and the underlying mechanism in HS-induced kidney injury. A model of HS was established with femoral artery bloodletting, followed by resuscitation in Sprague–Dawley rats. Renal expression of TNK1 was abnormally induced by HS in rats. Knockdown of TNK1 alleviated HS-induced cell apoptosis and the level of proinflammatory cytokines (TNF-α, IL-6 and IL-1β) in the kidney. The expression of M1 macrophage markers (CD86 and iNOS) and the activation of STAT1 were inhibited by TNK1 knockdown in HS rats. In vitro, human monocyte THP-1 cells were treated with 20 ng/mL interferon-gamma plus 100 ng/mL lipopolysaccharide to induce M1 polarization. TNK1 knockdown exerted inhibitory effect on macrophage M1 polarization, M1-type inflammatory cytokine production and STAT1 activation in THP-1 cells. In conclusion, downregulation of TNK1 alleviates HS-induced kidney injury by suppressing macrophage M1 polarization, inflammation and kidney cell apoptosis, in which the deactivation of STAT1 signaling may be involved.
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BMC Chemistry
·
2025
·Vol. 19
·期 1
·223
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IF 4.6
Yuan Ming,Han Xiaofang,Zhang Zekai,Wang Ruijia,Guo Shengrong
In this study, organic halides, such as 2-bromobutane (C 4 H 9 Br), ethyl α-bromophenylacetate (BPA), ethyl 2-bromoisobutyrate (EBiB), and ethyl 2-bromopropionate (EBP) are utilized in conjunction with copper nanopowder (Nano-Cu) to initiate the polymerization of methyl methacrylate (MMA). Among these, BPA combined with nano-Cu exhibits the highest reactivity, resulting in the production of poly(methyl methacrylate) (PMMA) with a number-average molecular weight ( M n ) of 1.91 × 10 6 Da, a weight-average molecular weight ( M w ) of 3.46 × 10 6 Da, and a polydispersity index (PDI) of 1.81. A kinetic analysis of the polymerization reveals that the reaction orders for MMA, BPA, and nano-Cu concentration are 0.76, 0.49, and 0.77, respectively. The activation energy of the polymerization of MMA initiated by BPA is calculated to be 59.6 kJ/mol. The molecular weight of PMMA product is determined using gel permeation chromatography (GPC), while the structure of the synthesized PMMA is characterized through proton nuclear magnetic resonance ( 1 H NMR). Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) is employed to analyze the precise structure and molecular weight of PMMA. Additionally, the nano-Cu recovered after the polymerization is examined using X-ray photoelectron spectroscopy (XPS). An electron paramagnetic resonance (EPR) spectrometer is employed to detect the reaction intermediate formed during the polymerization. Results from MALDI-TOF, XPS and EPR reveal that the polymerization of MMA proceeds via a radical mechanism, with the combination of nano-Cu and BPA leading to the formation of BPA residual radicals that initiate the polymerization of MMA.
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HISTOCHEMISTRY AND CELL BIOLOGY
·
2021
·Vol. 156
·期 1
·47-58
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IF 4.304
Sun Yuchuan,Li Hong,Chen Qiufang,Luo Qing,Song Guanbin
The survival of cancer stem cells is usually limited to a specific tumor microenvironment, and this microenvironment plays a vital role in the development of tumors. The mechanical properties of the microenvironment differ in different regions of solid tumors. However, in solid tumors, whether the distribution of cancer stem cells relates to the mechanical microenvironment of different regions is still unclear. In this study, we undertook a biophysical and biochemical assessment of the changes in the mechanical properties of liver tissue during the progression of liver cancer and explored the distribution of liver cancer stem cells in liver cancer tissues. Our analysis confirmed previous observations that the stiffness of liver tissue gradually increased with the progress of fibrosis. In liver cancer tissues, we found obvious mechanical heterogeneity: the core of the tumor was soft, the invasive front tissue was the hardest, and the para-cancer tissue was in an intermediate state. Interestingly, the greatest number of liver cancer stem cells was found in the invasive front part of the tumor. We finally established that stroma stiffness correlated with the number of liver cancer stem cells. These findings indicate that the distribution of liver cancer stem cells correlates with the mechanical heterogeneity of liver cancer tissue. This result provides a theoretical basis for the development of targeted therapies against the mechanical microenvironment of liver cancer stem cells.
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