NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Fang Wang,Ziqi Xu,Lingqi Deng,Jiaqi Liu
In this study, chitosan (CS) microspheres incorporated with polyacrylamide (PAM)/gelatin (Gel) hydrogel were fabricated using sodium tripolyphosphate (TPP) as cross-linking agent. The addition of TPP based on the optimal CS microsphere concentration, significantly enhanced hydrogel mechanical properties. Specifically, the composite hydrogel exhibited an elongation at break and tensile strength of 900% and 268.26 kPa, respectively, compared to 135.56 kPa and 419.03% for the PAM/Gel hydrogel. Furthermore, compressive strength at 70% strain was 2.1 times greater than that of the unmodified hydrogel. The composite hydrogel's network structure, rich in non-covalent bonds such as electrostatic interactions, hydrogen bonds, π-π interactions, and metal coordination bonds, exhibits excellent self-healing and self-adhesion properties. Following 18 hours of self-healing at room temperature, 92.2% of the original tensile strength was recovered. Additionally, the PAM/Gel/CS hydrogels exhibited powerful self-adhesive ability. Even after five bonding cycles to porcine skin, a substantial adhesion strength of 36.43 kPa was maintained, corresponding to 54% of the initial strength. Finally, in vitro studies revealed a controlled and sustained release profile for both 5-Fluorouracil (5-FU) and Tetracycline hydrochloride (TH) from the composite hydrogel. The observed increase in water uptake under acidic conditions of PAM and chitosan further accelerate drug release. Therefore, this dual-drug delivery hydrogel system, exhibiting excellent mechanical properties, suggests promise for pH-responsive therapeutic applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yan Wang,Menghui Wan,Yanbao Zhao,Lei Sun
Smart controlled-release nanopesticide systems offer enhanced pesticide efficiency through targeted delivery. In this study, we prepared sulfur-containing square mesoporous silica (S-MSN) carriers, combined them with carboxymethyl chitosan (CCS) to build a dual-responsive pesticide delivery platform (DNF@S-MSN@CCS) for sustained pesticide release. The S-MSN carriers demonstrated a high drug loading capacity of 21.3 %, excellent biocompatibility, responsive degradation and improved pesticide retention on hydrophobic leaves. Compared with spherical carriers, the cubic drug-loaded system shows a 33 % improvement in resistance to rain wash and a 38.8 % increase in liquid-holding capacity. Superior foliar adhesion and UV-shielding properties reduced photodegradation, extending DNF's UV half-life 6-fold compared to pure dinotefuran (DNF). Bioassays showed equivalent mortality against Plutella xylostella larvae as conventional formulations at reduced dosages. This work presents an effective strategy for sustainable pest management.
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高影响因子
ACS Applied Polymer Materials
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2025
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IF 4.7
Shengnan Zhang,Lidan He,Shuting Fu,Yingying Zhou,Li Wang,Le Deng
Chitosan-based hydrogels, owing to their unique barrier protection properties, have garnered significant attention as wound dressings. Improving the liquid-absorption and antimicrobial capabilities of chitosan hydrogels will further broaden their applications in this field. In this study, chitosan was modified with quaternary ammonium salt and glycidyl methacrylate and then combined with negatively charged gold–platinum nanodots (AuPt NDs) to construct a type of nanocomposite antibacterial hydrogel. Structurally, the hydrogel possesses a loose and porous structure. It can absorb about 800% of its own mass in pure water and has excellent pro-coagulant activity. These properties are beneficial for wound healing. Mechanistically, the positively charged hydrogel is capable of adsorbing negatively charged bacteria, disturbing the potential balance of the bacterial cell membranes, which can reduce the activity of the bacteria and lead to dissipation of the bacterial biofilm. Furthermore, the hydrogel antimicrobial effect can be greatly enhanced by the incorporation of AuPt NDs, enabling it to catalyze the production of ·OH from a low concentration of H2O2 and generate heat under 808 nm laser irradiation, thereby further killing the bacteria and promoting the dissipation of the biofilm effectively and rapidly. More importantly, the hydrogel has excellent biocompatibility and facilitates the healing of wounds infected with bacterial biofilms, holding great potential for application as a medical wound dressing.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yuemei Zhang,Xueyu Cheng,Chenghao Guo,Lijing Lu,Lixin Lu,Yongjin Qiao
Stimuli-responsive active packaging materials represent a promising frontier in food preservation by combining controlled-release functionality with environmental adaptability. Herein, a novel pH-responsive antibacterial bioactive packaging film based on a chitosan/gelatin (CS/GA) composite was developed by incorporating nanocomposites (NP) prepared through layer-by-layer assembly of natural polyelectrolytes onto modified halloysite nanotube (HNT), with carvacrol (Car) as the encapsulated active agent. The results showed that the developed composite films exhibited pH-responsive behavior under different pH conditions (4.0, 7.0, and 9.0), with a preferential release under alkaline conditions. The release rate was governed by the synergistic effects of carrier structural relaxation/dissolution within the NP, film diffusion, and structural relaxation/dissolution. In addition, hydrogen bonding and electrostatic interactions among CS, GA, and the NP improved the dispersion of the NP within the film matrix, thereby enhancing the film's mechanical strength, gas barrier performance, and thermal stability. The resulting active film effectively inhibited the growth of E. coli and S. aureus , and markedly prolonged the shelf life of pork. Overall, the developed pH-responsive active packaging films have great potential for application in future smart food preservation systems and lay a foundation for designing stimuli-responsive materials for different food environments.
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FOOD CHEMISTRY
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2025
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IF 9.8
Simin Fan,Wenxin Wang,Qingfeng Yang,Chaoqiao Zhu,Ming Tian,Aurore Richel,Marie-Laure Fauconnier,Chengli Hou,Dequan Zhang
The development of sustainable and functional food packaging is essential for mitigating food waste. In this study, quercetin nanocrystals (QNs) are synthesized and utilized to improve functionality of chitosan/ polyvinyl alcohol (PC) films. Molecular dynamics simulations and experimental characterizations reveal that the self-assembly of QNs is primarily driven by supramolecular interactions. QNs exhibit good compatibility with PC films, acting both as a nanofiller to improve mechanical properties (tensile strength of 49.68 MPa and elongation at break of 176.02 %) and as an active agent to impart antioxidant properties (fourfold increase compared to plain PC film). Additionally, QNs enhance the thermal stability, UV-blocking capability, and water vapor barrier properties of the PC films. More importantly, the QNs-reinforced PC films significantly extend the shelf life of fresh meat to 11 days. This work provides an effective strategy for fabricating eco-friendly and functional food packaging materials, demonstrating great potential for application in food preservation.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yanju Zhang,Meng Zhang,Yajuan Li,Xudong Yu
Conductive hydrogels are widely used in electronic skin and wearable sensors. Their inherent self-adhesion, exceptional sensitivity, and remarkable toughness guarantee the consistent and reliable operation of flexible motion sensors. However, creating chitosan-based conductive hydrogels with all these properties remains challenging. In this study, a triple-network hydrogel was synthesized by incorporating poly (vinyl alcohol) (PVA), chitosan quaternary ammonium salt (QCS) and poly(N-(2-Hydroxyethyl) acrylamide)- Co -Sodium acrylate copolymer (P(HEAA- Co -AANa)). Lithium chloride (LiCl) is introduced to enhance conductivity. The optimized hydrogel shows good conductivity (0.77 S/m), high tensile strain (~2113 %) and strong mechanical properties (463 kPa). The assembled sensors have high sensitivity, and enable precisely monitoring human motions. This study offers a simple, eco-friendly way to develop high-performance chitosan-based conductive hydrogels.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jia Wan,Meifang Yin,Feng Wang,Guangtao Huang,Ilaria Dal Pra,Yongzhi Liang,Jun Wu
Bacterial infections following skin injuries can lead to chronic, hard-healing wounds, and the overuse of antibiotics has made infection control a significant clinical challenge. Nature provides numerous antimicrobial agents, inspiring the design of novel antibacterial wound dressings; however, their solubility often presents additional hurdles. Herein, we leverage highly water-soluble chitosan oligosaccharide molecules dispersed within a gelatin-based gel network to overcome the poor solubility of chitosan, a known antibacterial agent. Notably, we first discovered that chitosan oligosaccharides can promote the solubility of poorly water-soluble antibacterial molecules like emodin through Schiff base reactions, thereby enabling synergistic antibacterial effects. The resulting eutectogel exhibits excellent antibacterial activity against both Staphylococcus aureus and Escherichia coli. Additionally, the gel demonstrates superior tensile strength, fracture strain, resistance to desiccation, and biocompatibility, with its outstanding overall performance laying a foundation for wound dressing applications. In animal models of infected wounds, the gel effectively accelerates wound healing, achieving wound closure rates of 166.9 % and 136.9 % of the control group on days 4 and 7, respectively. Mechanistic studies further reveal that the dressing promotes cellular proliferation, migration, and the regeneration of blood vessels and collagen, contributing to the wound healing process.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jingru Zhao,Hong Xiang,Yurong Liu,Xiaoqing Miao
An imbalance of androgens and changes in the follicular microenvironment are the hallmarks of androgenetic alopecia (AGA), a complex disorder that causes follicular shrinkage and progressive hair loss. Although the main goal of finasteride (FIN) monotherapy is androgen control, it has systemic drawbacks such as psychiatric side effects and sexual dysfunction. FIN nanocrystals (NCs) stabilized by cationic chitosan (CS) were added to dissolving microneedles (MNs) to improve follicle targeting while reducing systemic exposure. When CS was applied to the 167.20 ± 0.01 nm FIN-NCs, which had a zeta potential of −49.70 ± 2.00 mV, the outcome was positively charged CS-FIN-NCs that ranged in size from 200 to 300 nm. This alteration resulted in improved accumulation in hair follicles (2.65-fold fluorescence enhancement) and an enlarged passive diffusion area (1.48-fold increase). CS-FIN-NCs markedly enhanced folliculogenesis and hair regrowth in a mouse model of AGA. This formulation mechanistically enhances the migration of human umbilical vein endothelial cells by inhibiting TGF-β1, upregulating β-catenin, and promoting angiogenesis. These results demonstrate that CS-FIN-NCs delivered transcutaneously via MNs produce dual therapeutic benefits for the treatment of localized AGA by modulating follicular niches and acting pharmacologically.
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高影响因子
Materials Today Communications
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2025
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IF 4.5
Yuanyuan Wang,Yingjing Xia,Xingshen Dong,Peng Qiao,Wenyi Wang,Hua Song
A series of mixed biomass-derived porous carbon materials were successfully synthesized using chitosan and hydroxypropyl cellulose (CSHPC) as precursors through K 2 CO 3 activation. Among the synthesized materials, CSHPC-3–700 demonstrated a superior hierarchical pore structure and abundant nitrogen/oxygen functional groups, exhibiting exceptional electrochemical performance: a high specific capacitance of 371.8 F·g −1 at 1 A·g −1 and an outstanding rate capability (235.2 F·g −1 at 100 A·g −1 ). In symmetric supercapacitors, CSHPC-3–700 achieved a high energy density of 10.17 Wh·kg −1 with 91.3 % capacitance retention after 20,000 cycles, significantly outperforming porous carbons derived from individual chitosan (CS-3–700) or hydroxypropyl cellulose (HPC-3–700) precursors. This study provides a viable strategy for developing high-performance supercapacitor electrodes through rational hybridization of biomass precursors.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Zhonghao Jiang,Zhuo Yan,Shumin Yan,Zhihao Chen,Lianhai Li,Guoliang Huang,Li Li,Jiantao Lin
Diabetic wounds are one of the most problematic complications among diabetic patients, often progressing to chronic, persistent ulcers that are a leading cause of amputation and disability. The constant accumulation of reactive oxygen species (ROS) at diabetic wound sites, along with bacterial infection and an excess of pro-inflammatory M1-type macrophages, are key factors contributing to the difficulty of wound healing. Nanofibrous membranes can be used directly in diabetic wounds with the dual function of adsorbing tissue exudate and releasing drugs. Cerium oxide nanoparticles can be used in nanotherapy to reduce the accumulation of chronic inflammatory substances due to their excellent antioxidant properties. The antioxidant properties can be further improved by doping with other metal elements. In this paper, we constructed a nanofibrous membrane based on cerium manganese nanoparticles (CeMn NPs) for the treatment of diabetic wounds. The nanofibrous membrane was loaded with cerium manganese nanoparticles and nitric oxide donor SNAP, named PVA-CS-CeMn NPs-SNAP nanofibrous membrane. The PVA-CS-CeMn NPs-SNAP nanofibrous membrane was able to cover the wounds of diabetic mice with slow release of CeMn NPs and SNAP. The nanoparticles could scavenge ROS accumulated at the wound site and regulate the macrophage phenotype at the wound site, increasing the proportion of anti-inflammatory M2-type macrophages. In addition, SNAP had antimicrobial and vascular regenerative effects at the wound site. Together, these synergistic effects resulted in faster wound healing and reduced tissue inflammation in diabetic mice, and no organ toxicity was observed. Overall, our results indicate that PVA-CS-CeMn NPs-SNAP nanofibrous membranes have significant potential for the treatment of diabetic wounds and provide a strong scientific basis for the development of novel diabetic wound treatment materials.
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ACS Applied Materials & Interfaces
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2025
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IF 8.2
Pengyu Hu,Xin Huang,Tao Liu,Zhihan Liu,Fangying Wu,Shasha Feng,Rui Cheng,Liqing Gao,Jun Li,Tingting Cui
The repair of chronic and infected wounds continues to present significant clinical challenges, including prolonged inflammation, impaired angiogenesis, and imbalances in the biomechanical microenvironment. This study developed an innovative thermoresponsive gel integrating Salvia miltiorrhiza-derived carbon dots (SM-CDs), designed to accelerate wound healing through a “biochemical-mechanical” synergistic regulation strategy. First, SM-CDs were synthesized via hydrothermal method. These CDs retained the triple bioactivity of S. miltiorrhiza, encompassing antimicrobial, antioxidant, and pro-angiogenic properties, thereby enhancing their interaction with biofilms and bioavailability. Second, a multistep cross-linking strategy was employed to construct a ternary gel network (denoted PCS gel) composed of N-isopropylacrylamide (NIPAM), carboxymethyl chitosan (CMCS), and sodium alginate (SA). This system demonstrated efficient drug release (67.12% cumulative release over 72 h) and mechanical contraction (83.99% volume contraction ratio) at 37 °C. These effects are attributed to the phase transition behavior of NIPAM and the electrostatic/ionic cross-linking mechanisms of CMCS/SA. In vitro and in vivo studies revealed that the SM-CDs@PCS gel promotes wound healing through a dual mechanism: (1) Biochemical modulation: suppressing oxidative stress (91% ROS scavenging rate) and inflammatory responses (TNF-α downregulated to 16.25 ± 2.69%; IL-6 downregulated to 10.49 ± 2.04%), polarizing macrophages toward the pro-repair M2 phenotype (M2/M1 ratio = 1.69 ± 0.11), and promoting angiogenesis; (2) Mechanical modulation: enhancing collagen deposition through the gel’s biomechanical contraction effect, thereby accelerating wound closure. This research provides insights into the application of herbal medicine-derived CDs materials and intelligent gels for the management of hard-to-heal wounds.
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JOURNAL OF MATERIALS SCIENCE
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2025
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IF 3.9
Jiang Shaoqi,Jiang Shan,Chen Sikui,Liu Li,Yan Jiatong,Xiang Cheng,Guo Ronghui
Cellulose aerogel fibers with their unique combination of high porosity, low density, and robust mechanical properties, show great promise as candidates for thermal insulation materials and flexible devices. However, their mechanical performance is inherently limited, and conventional drying techniques such as freeze-drying (FD) and supercritical drying (SCD) are both time-consuming and energy-intensive, posing significant challenges for large-scale industrial applications. Atmospheric pressure drying (APD) has emerged as a simple and cost-effective alternative, demonstrating considerable potential in the fabrication of aerogel fibers. In this study, chitosan was incorporated during the dissolution stage to reinforce the cellulose framework. Following solvent exchange, the material was subjected to APD in an oven, resulting in the fabrication of low-shrinkage chitosan-reinforced cellulose aerogel fibers (CKAF). The porosity of CKAF can be controlled between 38 and 75% by selecting solvents with different surface tensions for solvent exchange and adjusting the affinity between the solvent and the CKAF framework during APD. The shrinkage of atmospheric pressure drying chitosan-reinforced cellulose aerogel fibers (APD-CKAF) with a chitosan content of 10% to cellulose was 11%, which was only 1.9% higher than that of FD (9.1%). However, the pore structure of the APD-CKAF is compact and uniform, with a pore size distribution ranging from 0 to 48 nm, primarily centered around 20 nm, and a porosity of approximately 75%. The APD-CKAF exhibits superior mechanical strength (22.1 MPa, a 16.3% improvement over the FD samples) and elongation at break (55.1%, a 111.5% increase compared with the FD samples). The APD-CKAF exhibits excellent thermal insulation properties over a wide temperature range. This study presents a low-cost and high-efficiency strategy for the fabrication of cellulose aerogel fibers, advancing their potential for thermal insulation applications.
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