JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Xiaodeng Wang,Hongpeng Zhou,Dingke Zhang,Mingyu Pi,Jiajia Feng,Shijian Chen
Developing stable and high-efficiency hydrogen generation electrocatalysts , particularly for the cathode hydrogen evolution reaction (HER), is an urgent challenge in energy conversion technologies. In this work, we have successfully synthesized Mn-doped NiP 2 nanosheets on carbon cloth (Mn-NiP 2 NSs/CC), which behaves as a higher efficient three dimensional HER electrocatalyst with better stability at all pH values than pure NiP 2 . Electrochemical tests demonstrate that the catalytic activity of NiP 2 is enhanced by Mn doping. In 0.5 M H 2 SO 4 , this Mn−NiP 2 NSs/CC catalyst drives 10 mA cm −2 at an overpotential of 69 mV, which is 20 mV smaller than pure NiP 2 . To achieve the same current density , it demands overpotentials of 97 and 107 mV in 1.0 M KOH and phosphate-buffered saline (PBS), respectively. Compared with pure NiP 2 , higher HER electrocatalytic performance for Mn−NiP 2 NSs/CC can be attributed to its lower thermo-neutral hydrogen adsorption free energy , which is supported by density functional theory calculations.
研究领域:
材料科学
·
电化学
·
能量转换
·
纳米材料
·
催化
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Mingrui Zhou,Wenjing Liu,Yijian Wang,Guoqiang Shu,Duxian Wei,Yaoze Feng,Ming Zhu
This study aimed to enhance the solubility and functional applicability of natural pigments in chitosan-based polymer matrices. Curcumin (CUR) and alizarin (AL), two natural pigments, were grafted onto chitosan via the Mannich reaction, producing modified chitosan pigments with enhanced solubility under acidic conditions, providing a potential strategy to overcome the low water solubility of these pigments. The successful grafting was confirmed through 1 H NMR, FTIR, UV-Vis, XPS, and XRD. The modified pigments exhibited notable antioxidant activity, with DPPH radical scavenging rates of 72.13% for CS-g-CUR and 64.42% for CS-g-AL, demonstrating potential for multifunctional applications. Subsequently, chitosan/gelatin composite films incorporating the grafted pigments were fabricated via solvent casting. Characterization and molecular docking analyses revealed strengthened intermolecular interactions, particularly hydrogen bonding between the grafted pigment moieties and the amino and hydroxyl groups of chitosan, leading to a more compact and stable polymer network. Consequently, the films exhibited improved mechanical performance (tensile strength up to 22.91 MPa) and enhanced thermal stability and compatibility. In addition, the composite films showed good biocompatibility (cell viability of 92.35%). The films also exhibited pH-responsive color changes, enabling visual monitoring of food freshness. Application tests on freshwater fish demonstrated that color changes of the films accurately reflected spoilage progression. Overall, this work provides an effective strategy for improving the dispersion and functional integration of natural pigments in biopolymer matrices, potentially expanding their applicability in intelligent food packaging and providing a simple approach for real-time food quality monitoring.
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Dingxi Zhang,Yuping Xiang,Guangliang Liu,Lina Liang,Lufeng Chen,Jianbo Shi,Yongguang Yin,Yong Cai,Guibin Jiang
Methylmercury (MeHg), derived from industrial processes and microbial methylation , is still a worldwide environmental concern. A rapid and efficient strategy is necessary for MeHg degradation in waste and environmental waters. Here, we provide a new method with ligand-enhanced Fenton-like reaction to rapidly degrade MeHg under neutral pH. Three common chelating ligands were selected (nitriloacetic acid (NTA), citrate, and ethylenediaminetetraacetic disodium (EDTA)) to promote the Fenton-like reaction and degradation of MeHg. Results showed that MeHg can be rapidly degraded, with the following efficiency sequence: EDTA > NTA > citrate. Scavenger addition demonstrated that hydroxyl radical ( ▪ OH), superoxide radical (O 2 ▪– ), and ferryl (Fe Ⅳ O 2+ ) were involved in MeHg degradation, and their relative contributions highly depended on ligand type. Degradation product and total Hg analysis suggested that Hg(Ⅱ) and Hg 0 were generated with the demethylation of MeHg. Further, environmental factors, including initial pH, organic complexation (natural organic matter and cysteine), and inorganic ions (chloride and bicarbonate) on MeHg degradation, were investigated in NTA-enhanced system. Finally, rapid MeHg degradation was validated for MeHg-spiked waste and environmental waters. This study provided a simple and efficient strategy for MeHg remediation in contaminated waters , which is also helpful for understanding its degradation in the natural environment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR RESEARCH
·
2023
·Vol. 31
·期 3
·181-191
·
IF 2.4
Li Jiyu,Zhu Li,Wu Shuai,Wang Guixue,Chen Yidan,Wu Wei
Chemotherapy is the main strategy for inhibiting the tumor growth. However, during the therapy, the side effect of anti-cancer drug will injure normal cells. For reducing the toxic of the free drug, stimuli responsive nanoparticles (NPs) have been prepared base on the pathological acidic environment around tumor for safe and efficient anti-tumor applications. In this study, we fabricated the phenylboronic acid (PBA) modified monomethoxy polyethylene glycol (MEPG) for encapsulating doxorubicin (DOX NPs). In the drug delivery system (DDS), the pH-responsive boric ester could be stable during drug delivery, and enhance DOX rapidly release in tumor lesion under the acidic stimuli. In vitro studies further demonstrated that DOX NPs could efficiently endocytose by tumor cells, and exhibit the similar anti-tumor activity as the free DOX resulting from the pH-responsive drug release profiles under tumor acidic stimuli. In summary, DOX NPs could be a feasible candidate to improve the safe and efficient DOX delivery for improving the potential anti-tumor applications. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
APL Bioengineering
·
2023
·Vol. 7
·期 1
·
IF 6
Wang Jun,Wu YanYan,Liu Kai,Yang Weitao,Zeng Weiwei,Gao Xiaolong,Liu ShiYuan,Zhang Bingbo
The development of a combination of chemo/photothermal therapy could overcome the limitations of single-modality therapy and enhance therapeutic efficacy. In this study, a pH/thermal dual-responsive multifunctional drug delivery system with dual-drug loading and enhanced chemo/photothermal therapy is developed based on polydopamine-coated mesoporous silica-gold nanorods (PDA-AuNRs@MSN). Nanoscale mesoporous silica-gold nanorods encapsulating doxorubicin (DOX) are designed as a core and then modified by polydopamine. The PDA shell not only conjugates with another anticancer bortezomib (Btz) to form pH-sensitive bond through boronic acid and catechol but also acts as a gatekeeper to control the release of doxorubicin and enhance the photothermal effect. Such a nanocarrier not only acts as a contrast agent for PA imaging but also serves as a therapeutic agent for enhanced chemo/photothermal therapy. The DOX and Btz could be released in an on-demand mode under near-infrared light irradiation and acid environment. The tumor size and location could be observed via PA imaging after intravenous injection into 4T1-bearing mice. Compared with AuNRs@MSN, PDA-AuNRs@MSN exhibit an increased near-infrared (NIR) absorption at 808 nm and an enhanced photothermal effect. The integrated D/B-PDA-AuNRs@MSN nanoparticles show higher cell apoptosis and enhanced tumor treatment efficacy in vitro and in vivo in comparison with single chemotherapy or photothermal therapy. Combined together, D/B-PDA-AuNRs@MSN show pH/thermal-responsive controlled-release and synergistic chemo/photothermal therapy for tumor.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Ting Wang,Qiong Yin,Hao yang Huang,Zhenyu Wang,Haixing Song,Xiaoming Luo
Poor drug penetration in hypoxia area of solid tumor is a big challenge for intestinal tumor therapy and thus it is crucial to develop an effective strategy to overcome this challenge. Compared with other bacteria used for construction of hypoxia targeted bacteria micro-robot, the Escherichia coli Nissle 1917 (EcN) bacteria are nonpathogenic Gram-negative probiotic and can especially target and identify the signal molecules in the hypoxic region of tumor, and thus, in this study, we choose EcN to construct a bacteria propelled micro-robot for targeting intestinal tumor therapy. Firstly, the [email protected] with average diameter of 200 nm were synthesized and conjugated with EcN bacteria using EDC/NHS chemical crosslinking method to construct a EcN propelled micro-robot. The motility of micro-robot was then evaluated and the motion velocity of [email protected] was 3.78 µm/s. Compared with [email protected] without EcN driven, EcN bacteria propelled micro-robot transported much more [email protected] into the inner of HCT-116 3D multicellular tumor spheroids . However, the EcN bacteria are non-intracelluar bacteria which lead to the micro-robot can not directly enter into tumor cells. Therefore, we utilized acid-labile linkers of cis-aconitic amido bone to link EcN with [email protected] nanoparticles to achieve the pH sensitive separation of EcN with [email protected] from the micro-robot. At 4 h of incubation, the isolated [email protected] began to enter into the tumor cells through CLSM observation. In vitro live/dead staining results show that [email protected] induced much more cell death than [email protected] at 24 and 48 h of incubation with HCT-116 tumor cells in acid culture media (pH 5.3). For the validation of the therapeutic efficacy of the micro-robot for intestinal tumor, we established the HCT-116 subcutaneous transplantation tumor model. After 28 days of treatment, [email protected] dramatically inhibit tumor growth with tumor volume was around 689 mm 3 , induce much more tumor tissues necrosis and apoptosis. Finally, the toxicity of this micro-robot was investigated by pathological analysis the liver and heart tissues. We expect that the pH sensitive EcN propelled micro-robot here we constructed may be a safe and feasible strategy for intestinal tumor therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Yingjian Ma,Linjie Li,Rui Zhao,Zhe Sun,Yinmin Wang,Meng Yu,Shouhe Pan,Xinyu Guo,Yong Xu,Hongmei Wang,Ping Wang,Xuemin Wu
The development of pesticide-loaded nanocapsules responding to environmental stimuli holds great promise for sustainable disease control and may help to reduce pesticide usage while making it more efficient. Herein, pH-responsive nanocapsules containing pyraclostrobin (Pyr) were constructed by the rapid interfacial assembly of tannic acid (TA), ethylene oxide-propylene oxide block copolymer , and Cu 2+ ions using a fine reversed-phase emulsion as a template. Under acidic conditions similar to those caused by Rhizoctonia solani infestation, these nanocapsules released Pyr to achieve its intelligent delivery and, hence, efficient R. solani control. Nanoencapsulation significantly increased the photostability of Pyr, and the half-life increased by 10 times compared with the Pyr-technical (Pyr-TC). In addition, the introduction of TA enhanced its spreading performance and rainfall resistance in crops, and contact angle drops to 2.2° ± 0.1° in 100 s. Its toxicity to non-target organisms ( Daphnia magna and humans) was reduced. The fabricated nanocapsules exhibited a high antifungal activity superior to that of commercially available agents and exerted no significant adverse effects on crop growth and soil microbial communities . Thus, our work highlights the potential of nanoencapsulation for the intelligent delivery of fungicides to target crops, thus providing an effective strategy for improving the efficiency of pesticide usage and promoting sustainable pesticide development.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Jirong Wang,Chengying Zhao,Shaojie Zhao,Xingmiao Lu,Mengyu Ma,Jinkai Zheng
The amidation of pectin by amino acids has been widely applied due to its safety and excellent gelling properties. This study systematically examined the effects of pH on the gelling properties of lysine-amidated pectin during amidation and gelation . Pectin was amidated over the range of pH 4–10, and the amidated pectin obtained at pH 10 showed the highest degree of amidation (DA, 27.0 %) due to the de-esterification, electrostatic attraction, and the stretching state of pectin. Moreover, it also exhibited the best gelling properties due to its greater numbers of calcium-binding regions (carboxyl groups) and hydrogen bond donors (amide groups). During gelation, the gel strength of CP (Lys 10) at pH 3–10 first increased and then decreased, with the highest gel strength at pH 8, which was due to the deprotonation of carboxyl groups, protonation of amino groups, and β-elimination. These results show that pH plays a key role in both amidation and gelation, with distinct mechanisms, and would provide a basis for the preparation of amidated pectins with excellent gelling properties. This will facilitate their application in the food industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2023
·
IF 4.6
Xiongfei Wu,Qianyu Yang,Xuemei Zhang,Chihui Tsou,Manuel Reyes De Guzman,Xinyue Li,Li Yuan,Yiqing Xia,Yuping Sheng,Qianlong Li,Chen Gao
Hydrogels as flexible strain sensors (FSSs) have attracted tremendous interest in the area of human movement monitoring. Such an application is developing rapidly. However, it is still valuable to explore hydrogel-based FSSs with excellent mechanical properties , responsiveness to stimulus, high strain sensitivity, and reliable stability. Herein, a hydrogel with triple physical cross-linking (TPC hydrogel), whose structure also included hydrophobic association-microcrystallinity-ionic coordination, was designed and fabricated. Synthetic water-soluble polymer [poly(vinyl alcohol) (PVA)] and natural polymer [sodium alginate (SA)] were introduced into the hydrogel; PVA induced microcrystal cross-linking, while SA provided ionic conductivity for the hydrogel. TPC hydrogels exhibited high toughness (5.9 MJ/m 3 ) and excellent deformation (2490%). The introduction of SA also endowed the hydrogels with improved capability to ionize, imparting them with excellent pH-responsive swelling behavior. Impressively, TPC hydrogel-based FSSs exhibited reasonable conductivity (0.65–2.47 S/m), high sensitivity (maximum gauge factor = 10.29), and outstanding reliability and stability. This investigation broadens the avenue for the design and fabrication of hydrogels intended as FSSs with low modulus (33–45 kPa, close to human skin), excellent stretchability, and high strain sensitivity and durability.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Chaojie Lyu,Chenyang Cao,Jiarun Cheng,Yuquan Yang,Kaili Wu,Jiwen Wu,Woon-Ming Lau,Ping Qian,Ning Wang,Jinlong Zheng
Transition-metal phosphides (TMPs) are regarded as the underlying substitutes to Pt-based catalysts for electrocatalytic hydrogen evolution reaction (HER), but the poor electrical conductivity and limited catalytic activity severely hinder its employment. Interface engineering is an available arrangement to enhance the catalytic activity of TMPs for HER process. The interface−engineered Ni 2 P/Ni 5 P 4 heterostructure porous nanosheets was developed by a simple solvothermal method and a controllable low−temperature phosphorization treatment. Combining UPS characterization with DOS simulation, we disclose the existence of built-in electric field at interface region, and the electrons is transferred from Ni 2 P to Ni 5 P 4 side. The DFT calculation results indicate that the active sites at interface domain possess the optimal H* adsorption free energy and lowest H 2 O dissociation energy barrier compared with single-phased Ni 2 P and Ni 5 P 4 , which is contributed to the electrons redistribution and electronic structure optimization, thereby enhancing the HER catalytic activity of Ni 2 P/Ni 5 P 4 heterostructure nanosheets. The experimental results show it exhibits excellent HER performance in universal pH range. It merely requires the overpotentials of 78, 100, and 62 mV to achieve 10 mA/cm 2 in 0.5 M H 2 SO 4 , 1 M PBS, and 1 M KOH electrolytes, respectively. Assembled with NiFeCH anode, we fabricated NiFeCH || Ni 2 P/Ni 5 P 4 electrolyzer, which only needs the voltage of 1.52 V to achieve current density of 10 mA/cm 2 in 1 M KOH. Even in complicated seawater system, the electrode and the electrolyzer still display outstanding electrocatalytic performance for hydrogen production. This report supplies an efficient strategy to enhance the electrolytic performance for hydrogen production from water splitting.
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2023
·Vol. 15
·期 4
·981
·
IF 5
Lijian Xia,Anmin Tao,Jinyun Cui,Abin Sun,Ze Kan,Shaofeng Liu
To prepare silica/rubber composites for low roll resistance tires, a novel strategy was proposed in this study, in which autonomous monodisperse silica (AS) was prepared and modified using 3-mercaptopropyloxy-methoxyl-bis(nonane-pentaethoxy) siloxane (Si747), after which silica/emulsion styrene butadiene rubber (ESBR) master batches were produced using the latex compounding technique. Meanwhile, the commercial precipitated silica (PS) was introduced as a control. In this study, the effects of amount of Si747 and pH value on the properties of the silica/ESBR composites were systematically analyzed. Thermal gravimetric analysis (TGA) and Fourier transform infrared (FTIR) results indicated that Si747 reduced the silanol group by chemical grafting and physical shielding, and the optimum amounts of Si747 for AS and PS modification were confirmed to be 15% and 20%, respectively. Under a pH of 9, ESBR/modified AS (MAS) composites with 15% Si747 presented better silica dispersion and a weaker Payne effect, compared with ESBR/modified PS (MPS) composites with 20% Si747. Meanwhile, in terms of dynamic properties, the ESBR/MAS composites exhibited a better balance of lower rolling resistance and higher wet skid resistance than the ESBR/MPS composites.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Hongyan Cui,Ming Zhang,Liuwei Zhang,Haidong Li,Yue Wang,Yan Zhao,Qixian Chen,Jingyun Wang
Proteins have been appreciated to be a superlative modality of therapeutics in view of their direct roles in regulating diverse sets of biological events, nonetheless, the clinical applications of the proteinic therapeutics have been strictly limited to act on the cell surface receptors owing to their inherent cell-impermeable character of the proteins. To this obstacle, we contrived carboxylation reaction upon the proteins (RNase A) into the overall negatively charged pro-RNase, followed by elaboration of intelligent pH-responsive pro-RNase delivery nanocolloids based on co-precipitation of pro-RNase and Arg-Gly-Asp (RGD)-functionalized poly(ethylene glycol) (PEG)- block -polyanion with aids of inorganic calcium phosphate (CaP). The resulting nanocolloids appeared to actively accumulate into glioma due to the specific binding affinities of RGD and glioma-enriched α V β 3 and α V β 5 integrins. Furthermore, the pH responsiveness to the acidic endolysosomal microenvironment of all compositions of nanocolloids (including: decarboxylation of pro-RNase composition to restore the native RNase A, ionization of CaP composition to elicit osmotic pressure , and charge reversal of PEG- block -polyanion into membrane-disruptive polycation) could stimulate not only efficient endolysosomal escape for translocation into the cytosol but also structural disassembly for ready liberation of the RNase A payloads, eventually exerting non-specific RNA degradation for apoptosis of the affected cells. Systemic dosage of the proposed nanocolloids demonstrated potent anti-tumor efficacies towards xenograft glioma due to massive RNA degradation. Therefore, our proposed RNase A prodrug nanocolloids could represent as a versatile platform for engineering transcellular protein delivery systems, which are expected to spur thriving emergence of a spectrum of proteins in precision intervention of intractable diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）