EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2012
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IF 3.346
Lianbao Ye,Yuanxin Tian,Zhonghuang Li,Hong Jin,Zhengguang Zhu,Shanhe Wan,Junyan Zhang,Pengjiu Yu,Jiajie Zhang,Shuguang Wu
Deregulation of receptor tyrosine kinase c-Met has been reported in human cancers and is considered as an attractive target for small molecule drug discovery . In this study, a series of spiro[indoline-3, 4′-piperidine]-2-ones were designed, synthesized and evaluated as novel c-Met inhibitors. The results showed that the majority of the compounds exhibited significant inhibitory effect on c-Met with IC 50 values of 0.0147–17 μM in TR-FRET-based assay and IC 50 values of 1.56–1400 μM in cell-based assay. Furthermore, our docking experiments verified the results and explained the molecular mechanism of eminent activities to c-Met.
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PubMed
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Jun Cong,Shao-hua Luo,Peng-yu Li,Xin Yan,Li-xiong Qian,Sheng-xue Yan
Na 3 V 2 (PO 4 ) 3 (NVP) has become a hot material in the research field of sodium-ion batteries (SIBs) as a result of its unique structural advantages. Unfortunately, the poor electronic conductivity and ion diffusion ability fundamentally limit the practical development of NVP. Considering the above defects, a series of Li + doped Na 3−x Li x V 2 (PO 4 ) 3 /C cathode materials for SIBs are synthesized through hydrothermal assisted sol–gel method. The cell volume steadily decline with the raise of Li + doping amount, which is consistent with the usual doping effect. Moreover, with the increase of lithium doping amount, Li + preferentially occupies Na (2) site and then occupies Na (1) site. Through the first principles calculation, it is clear that the introduction of Li + can significantly reinforce the conductivity of the material system and diminish the electron localization phenomenon. The analysis of (1 1 6) crystal plane by TEM shows that Li doping will reduce the interplanar spacing. The change of V valence during the charge–discharge process of Na 2.8 Li 0.2 V 2 (PO 4 ) 3 /C is consistent with that of NVP by V element XANES characterization. There is no conventional phase transition phenomenon in the ex-situ XRD high-voltage charging state. The above facts indicate that lithium doping obtains a stable solid solution NVP. The electrochemical test results show that Na 2.8 Li 0.2 V 2 (PO 4 ) 3 /C can provide an amazing reversible capacity of 116.9 mAh/g (theoretical capacity of 117 mAh/g) and capacity retention rate of 99.82 % after 500 cycles. GITT results show that Li + can significantly increase the Na + diffusion coefficient of the material. Such excellent electrochemical performance is attributed to the fact that the doping of Li + activates the activity of Na + in Na (2) site and improves the reaction efficiency.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2023
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IF 4.3
Guona Li,Qingya Yang,Xiaoying Liu,Lvcheng Liu,Junshan Han,Xing Li
A very poisonous heavy metal Cd 2+ not only contaminates the living environment but also constitutes a serious menace to human health through water intake and food chains. Thus, monitoring and controlling the content of Cd 2+ with rapidity, sensitivity, and simplicity in tap water, soil, and rice samples is important especially. In the work, a high-efficiency sensor based on gold nanoparticles (AuNPs) embellished and refined with 3-(1H-Tetrazol-5-yl) aniline (TAA) for the colorimetric detection of Cd 2+ is rationally put forward. The interaction between Cd 2+ and TAA@AuNPs leads to the agglomeration of the AuNPs solutions, resulting in the color of the system changing from wine-red to gray-blue. The limit of detection (LOD) of the sensor is 1.0 μM when observe with the unaided eye, and UV–vis spectroscopy also has a LOD of 31 nM with an excellent linear relationship ( R 2 = 0.99049) in the concentration range of 0.0–8.0 μM for Cd 2+ , indicating that AuNPs modified with TAA can be effectively used for the quantitative determination of Cd 2+ . Furthermore, the colorimetric sensor has been tested on tap water, soil, and rice samples, and it shows promising potential for the practical monitoring of harmful Cd 2+ in environmental systems.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2021
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IF 3.205
Rujie Yang,Fangbo Xia,Huanxing Su,Jian-Bo Wan
n-3 polyunsaturated fatty acids (PUFAs) and their metabolites play the crucial role in a wide range of physiologic and pathologic processes, including cardiovascular, neurodegenerative diseases, and inflammation-associated disorders. However, the quantitative analysis of n-3 PUFAs and their metabolites, oxylipins , is obstructed by high structural similarity, poor ionization efficiency and low abundance. In this study, a sensitive method was developed to quantify 28 n-3 PUFAs/oxylipins using chemical isotope labeling coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Standards labeled with cholamine- d 9 were used as one-to-one internal standards to achieve accurate quantification. The cholamine- d 0 -derivatized biological samples were mixed with cholamine d 9 -labeled standards for LC-MS/MS with multiple reaction monitoring. After cholamine derivatization, both MS sensitivity and chromatographic performance of n-3 PUFAs/oxylipins were substantially improved. Furthermore, the relationship between retention time and substituent position of regioisomers, and their fragmentation patterns were investigated, which may facilitate the identification of unknown oxylipins. Additionally, the developed method was applied to quantify the target n-3 PUFAs/oxylipins in serum and brain tissue from fish oil-supplemented mice, which exhibited its great potential and practicability. Collectively, this sensitive and reliable method may facilitate the elucidation of the roles of n-3 PUFAs/oxylipins in the physiological and pathological processes.
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POWDER TECHNOLOGY
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2021
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IF 5.134
Chendong Zhang,Hangchen Li,Xinxin Guo,Shunchao Li,Han Zhang,Xuhai Pan,Min Hua
A new type of dry powder fire extinguishing agent was prepared, which was called composite superfine dry powder with Aluminum Trihydrate (CSFP-ATH). The CSFP-ATH was characterized by laser particle size analysis , scanning electron microscope (SEM), thermal gravity analyzer (TGA), transform infrared spectroscopy(FTIR) analyzer and differential scanning calorimetry (DSC). The extinguishing performance of different samples was examined in a small-scale experimental platform for the liquid hydrocarbon fire. The tests were proved that the fire-extinguishing performance was as follows: CSFP-ATH > superfine ABC dry powder(SFP) > commercial ABC dry powder(CDP). Besides, the mechanism, kinetics and thermochemical changes in the reaction process were calculated by Gaussian simulation, and the reaction path of the CSFP-ATH with free radicals in the flame was predicted. Experimental and theoretical studies have been proved that the addition of Al(OH) 3 can promote the fire extinguishing performance of superfine ABC dry powder.
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Materials Today Chemistry
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2021
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IF 8.301
J. Zeng,H. Kong,X. Du,Q. Xu,F. Jiang,B. Li,M. Yu
PBO fiber is one of the most promising reinforcements in resin matrix composite because of its excellent mechanical properties . However, the inert and smooth surfaces make it the poor interface adhesion with resin matrix, which seriously limits the application in composites. In this article, we report a method to modify the surface of PBO fibers with 2,2-Bis (3-amino-4-hydroxyphenyl) hexafluoropropane（BisAPAF）in supercritical CO 2 to enhance interfacial properties . Chemical structures , surface elemental composition and functional groups, and surface morphology were characterized by FT-IR spectrometer, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM), respectively. The mechanical properties of the samples were tested by a tensile tester. Static contact angle and microdebonding tests were used to characterize the wetting ability and interfacial shear strength (IFSS) of the fiber and epoxy resin. The results showed that the BisAPAF could be solved in scCO 2 and introduced more groups, –NH 2 , –OH, and –CF 3 on the fiber surface, resulting in the mechanical properties and the wettability of PBO fiber slightly improved. Moreover, the fiber surface roughness was also increased obviously. The IFSS between the modified PBO fiber and epoxy resin increased from 8.18 MPa to 31.4 MPa when the treating pressure was 14 MPa. In general, the method to modify PBO fibers surface using BisAPAF in scCO 2 can effectively improve their interfacial properties.
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RSC Advances
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2021
·Vol. 11
·期 43
·26502-26508
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IF 3.361
Meirong Fu,Mingqiang Li,Yingying Zhao,Yunxiang Bai,Xingzhong Fang,Xiaolong Kang,Min Yang,Yanping Wei,Xia Xu
Precious metal nanometric catalysts are widely used in the removal of harmful substances. In the process of synthesis and catalytic reaction, it is particularly important to study green and simple synthesis methods and high catalytic efficiency. In this paper, a green one-step method was used to synthesize the Fe(OH)3/Fe2O3@Au composite catalyst, in which Au was single atom-dispersed. The removal of 4-nitrophenol (4-NP), a typical dangerous chemical widely existing in factory waste gas, waste water and automobile exhaust gas, was catalysed by Fe(OH)3/Fe2O3@Au. The catalytic performance of Fe(OH)3/Fe2O3@Au with different synthesis conditions (different amounts of MES, NaBH4, FeSO4, Au and Pt) on the 4-NP reduction reaction were systematically studied. Finally, the stability and recyclability of Fe(OH)3/Fe2O3@Au composite nanocatalyst were investigated thoroughly.
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SENSORS AND ACTUATORS B-CHEMICAL
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2020
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IF 7.1
Yawen Wu,Xiaolong Chen,Xianfeng Wang,Mei Yang,Faliang Xu,Changjun Hou,Danqun Huo
The effective detection of CA15-3 is of great significance for the postoperative monitoring and early diagnosis of breast cancer. Here, a fluorescent biosensor based on the fluorescence resonance energy transfer (FRET) between the prismatic hollow Metal-polydopamine frameworks (PHMPF) and 6-carboxyfluorescein (FAM)-labeled protein aptamer (FAM-Apt) was established to detect CA15-3. Characterization of SEM, TEM, EDS, FT-IR, XRD and XPS confirmed that the synthesized PHMPF was a polyhedral prismatic hollow organometallic frame containing the elements of C, N, O, and Co. PHMPF can quench the fluorescent group modified on the aptamer efficiently. Under optimized conditions, the proposed fluorescent biosensor can detect CA15-3 low to 2.56 × 10 −5 U mL −1 . In addition, the excellent selectivity and spiked experiments indicate the proposed biosensor owns potential applications for the clinical diagnosis of tumor markers in body fluids.
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MEDICINAL CHEMISTRY RESEARCH
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2020
·Vol. 29
·期 10
·1867-1873
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IF 1.783
Yang Xin-Bin,Huang Yu
The water-soluble sulfated derivatives, apigenin-8-sulfonate sodium (AS) and apigenin-3′, 8-disulfonate sodium (ADS) derived from parent apigenin (AP), were synthesized and characterized by infrared (IR) spectra, hydrogen nuclear magnetic resonance ( 1 H NMR), carbon nuclear magnetic resonance ( 13 C NMR), high-resolution mass spectra (HRMS), and elemental analysis. The mice model of hepatotoxicity induced by d -Galactosamine ( d -GalN) was used to evaluate the hepatoprotective effects of AP, AS, and ADS. The results indicated that AP, AS, and ADS could reduce the level of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic malondialdehyde (MDA) induced by d -GalN, and restore the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) toward normal levels. The histological results also suggested that AP, AS, and ADS could alleviate liver toxicity. The possible mechanisms could be ascribed to the protection role of AP, AS, and ADS, which kept hepatic cells from oxidative damage and maintain intracellular antioxidant enzyme activity. These findings uncovered that AP, AS, and ADS were able to protect liver from d -GalN-induced acute damage, and AS was the most potent hepatoprotective drug among the three compounds.
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BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
·
2020
·Vol. 25
·期 4
·589-598
·
IF 2.213
He Jinjia,Chen Yi,Dai Luyao,Yao Jiachao,Mei Yu,Hrynsphan Dzmitry,Tatsiana Savitskaya,Chen Jun
Acrylic acid is used in various industrial applications but inflicts harm to human health and causes environmental pollution. A new bacterium, identified as Rhodococcus ruber JJ-3, was isolated, which can degrade high concentrations of acrylic acid rapidly and completely. Experimental results showed that the strain can achieve complete degradation of 1000 mg·L −1 acrylic acid in 11 h under the following conditions: pH 7, temperature 35°C, and inoculation quantity 15%. A high concentration of acrylic acid (2000 mg·L −1 ) can be completely removed in 28 h. According to the Monod model, the maximum specific degradation rate ( v max ) and half saturation rate constant ( K S ) of the strain were 0.85 h −1 and 101.83 mg·L −1 , respectively. The results of carbon balance revealed that 54.6% carbon was assimilated by R. ruber JJ-3 as biomass, and 43.0% carbon was mineralized into CO 2 . Furthermore, glycerol and lactic acid were measured as intermediates, and the possible degradation pathway was proposed during the biodegradation of acrylic acid. These results suggested that R. ruber JJ-3 completely degrades acrylic acid and might have a potential environmental implication in the purification of acrylic acid-contaminated environments.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2020
·
IF 5.774
Fekadu Tadesse Bekena,Dong-Hau Kuo,Worku Lakew Kebede
Wastewater treatment becomes an important part to improve environmental quality and protect water resources. Thus, developing a new photocatalyst is a key solution for environmental issues. Herein, universal, highly efficient, and novel Bi 2 (O,S) 3 /Mo(O,S) 2 nanocomposite photocatalyst was fabricated by a facile method and the crystal structure, morphology, composition, and optical properties of the as-prepared catalysts were characterized in details. The photocatalytic performance of the catalysts was evaluated by the photodegradation of methyl orange (MO), rhodamine B (RhB), methylene blue (MB), and neutral red (NR), the results showed that 20% Bi-MoOS nanocomposite had excellent photodegradation activity towards all dyes. 96.0% of MO, 96.6% of RhB, 98.8% of MB and 91.3% of NR dyes were removed after 180 min, 40 min, 20 min, and 25 min visible light irradiation, respectively. The photodegradation of these dyes was further confirmed with HPLC. The excellent photocatalytic activity of the nanocomposites was due to the efficient separation and transport of photogenerated charge carriers induced by the fabricated binary heterostructures. The photodegradation fitted well the pseudo-first-order kinetics. The active species capture experiment study showed that, OH, O 2 − and h + all took parts in the degradation of dyes. The stability of the catalyst and reaction mechanism also explained in this work.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2020
·
IF 1.943
Xiaoyong Huang,Heng Guo,Jia Liang,Shaoying Wang
In this paper, we reported on the photoluminescence properties of novel Eu 3+ -activated KBaLu(MoO 4 ) 3 red-emitting phosphors. Under 395 and 465 nm excitations, the as-prepared samples gave bright sharp red emissions around 592, 615, 655, and 701 nm, corresponding to 5 D 0 → 7 F J (J = 1, 2, 3, and 4) transitions of Eu 3+ ions. The 615 nm red emission due to the 5 D 0 → 7 F 2 transition was dominant in the emission spectra, indicating the Eu 3+ ions occupied non-inversion centrosymmetric sites in KBaLu(MoO 4 ) 3 host lattice. Eu 3+ doping concentration dependent luminescence properties were studied, and the KBaLu(MoO 4 ) 3 :0.8Eu 3+ sample exhibited the strongest emission intensity. The CIE color coordinates and color purity of the optimal KBaLu(MoO 4 ) 3 :0.8Eu 3+ sample were determined to be (0.6655, 0.3311) and 96.7%, respectively. Besides, temperature-dependent emission spectra demonstrated that the KBaLu(MoO 4 ) 3 :0.8Eu 3+ phosphors also exhibited excellent thermal stability (I 423k /I 303k = 88%) with activation energy △E of 0.204 eV. These obtained results indicated that the newly discovered KBaLu(MoO 4 ) 3 :Eu 3+ red phosphors were promising color converters for application in white light-emitting diodes and display devices.
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