SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yi-Hong Wu,Wei Guo,Yu-Zhu Sun,Shu-Ying Sun
Coal-based solid waste, as a secondary resource, contains significant quantities of aluminum, silicon, and lithium resources. The desilication solution is a waste solution with low concentrations of lithium ions, which is produced during the resource utilization process of coal-based solid waste. Developing adsorbents with high lithium selectivity and alkaline stability is important for the recovery of lithium in coal-solid waste alkaline leachate. In this study, resin functionalized with 2-hydroxymethyl-12-crown-4 (2H12C4) is prepared by esterification. The reaction conditions, including resin type, reaction temperature, time, and catalyst dosage, are optimized. The selective adsorption of 2H12C4-D113 is evaluated in a simulated desilication solution. The results show that 2H12C4-D113 with high selectivity for Li + adsorption is successfully synthesized at 1 g of 2H12C4 per g of resin, 110 ℃ reaction temperature, 6 h reaction time, 0.5 g of catalyst per g of resin and 1 mol of anhydrous lithium chloride per mol of 2H12C4. The adsorption rate of the 2H12C4-D113 resin is relatively rapid, and its adsorption kinetics satisfy the proposed second-order kinetic curve, and its Li + adsorption capacity is greatly influenced by Li + concentration. The peaking adsorption capacity of this resin is 58.71 mg/g in pure lithium solution (Li + =200 mg/L) with high alkalinity, and the peaking adsorptive capacity is 9 mg/g in the pre-desilication solution (Li + =274 mg/L, Na + =101 g/L). Furthermore, density functional theory (DFT) is utilized to study the selective adsorption mechanisms, geometrical characteristics, and thermodynamic parameters of the complexes between crown ether and different ions. DFT simulation reveals that 2H12C4-D113 has high selectivity for Li + adsorption with a Li + -O bond length of 1.86–1.88 Å, and an adsorption energy of 2H12C4-Li + (−369 KJ/mol) being the highest among the mental ions.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Le-Yan Feng,Zhenhua Tang,Nuan Xu,Jiaxin Huang,Yan-Ping Jiang,Xin-Gui Tang,You Zeng,Shang-Xian Chen
Antibiotics play an essential function in treating various diseases. However, their overuse has led to water pollution and food safety issues. This work discusses a highly sensitive ratiometric fluorescent flexible sensor based on multifunctional 4-MU@ZIF-8@PLA-PEG composite film prepared using a low-toxicity, eco-friendly and self-assembly method. The sensor combines the luminescent properties and structural tunability of ZIF-based composites with the processability and flexibility of polymers. The 4-MU@ZIF-8@PLA-PEG sensor can detect tetracycline (TC), oxytetracycline (OTC), chlortetracycline hydrochloride (CTC⋅HCl), and doxycycline hydrochloride (DOX⋅HCl) with dual-emission ratiometric fluorescence, exhibiting a visible color change from blue to yellow, with detection limits of 0.058 nM, 16.806 nM, 2.113 nM and 20.510 nM, respectively. The fluorescence characteristics exhibit excellent linear relationships with TC detection in tap water and milk, and show inhibition rates of 87.27 % and 76.61 % against E. coli and S. aureus . With its antibacterial activity, visual detection, high sensitivity, and short detection time, this sensor has significant potential for detecting antibiotics in aquatic environments and food safety applications.
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ACS Omega
·
2025
·
IF 4.3
Shicong Liu,Yuanyuan Zhang,Dan Jia,Junqiu Liu,Chunxi Hou
A fluorescent probe based on fluorescent resonance energy transfer (FRET) between the organic fluorophore 1,3,6,8-tetra(4-pyridyl) pyrene (TTPY) and gold nanoparticles (AuNPs) was designed for detecting glutathione (GSH) in foods. TTPY, synthesized via a Suzuki–Miyaura coupling reaction, exhibited excellent fluorescence properties with a maximum emission wavelength of 496 nm. Acting as an energy donor, TTPY transfers energy to AuNPs via FRET, resulting in fluorescence quenching of TTPY. In the presence of GSH, TTPY was displaced from the AuNP surface, restoring the fluorescence of the TTPY chromophore. The developed sensor demonstrated excellent water solubility and selectivity and a low detection limit (54 nM). Moreover, the proposed method was successfully applied for the determination of GSH in food samples, demonstrating its potential for food antioxidant analysis.
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PubMed
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 4
·756
·
IF 3.098
Ming-Xia Song,Zhen-Yuan Wang,Shi-Hui He,Sheng-Wang Yu,Shi-Long Chen,Dong-Fu Guo,Wen-Hao Zhao,Xian-Qing Deng
In this study, a novel series of 4-(2-(alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (4a–m) was designed and synthesized. The anticonvulsant activities of these compounds were evaluated by using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The neurotoxicity of these compounds was evaluated using the rotarod neurotoxicity test. The majority of compounds showed anti-MES activities at 100 or 300 mg/kg. Compound4gwas considered to be the most promising, based on its potency against MES- and PTZ-induced seizures with ED50values of 23.7 and 18.9 mg/kg, respectively. The TD50value of4gwas 284.0 mg/kg, which resulted in a higher protective index (PI = TD50/ED50) value than that of carbamazepine and valproate. In an ELISA test, compound4gsignificantly increased the γ-aminobutyric acid (GABA) content in mouse brain. In addition, pretreatment with thiosemicarbazide (an inhibitor of the GABA synthesizing enzyme) significantly decreased the activity of4gin the MES model, which suggests that the mechanism through which compound4gelicits its anticonvulsive action is at least in part through increasing the GABA level in the brain.Keywords:anticonvulsant;maximal electroshock;pentylenetetrazole;benzoxazole;triazolone
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高影响因子
JOURNAL OF FOOD BIOCHEMISTRY
·
2021
·Vol. 46
·期 3
·e13686
·
IF 2.72
Wanxiu Cao,Xin Chen,Yaoxian Chin,Jinkai Zheng,Phaik Eem Lim,Changhu Xue,Qingjuan Tang
Natural compounds have tremendous potential to regulate glucose metabolism, but conventional methods for studying their bioactivities are usually labor intensive. Here, hypoglycemic properties in 22 selected food-derived compounds were examined using molecular docking. The results indicated that curcumin is an inhibitor of both α-glucosidase and dipeptidyl-peptidase 4 (DPP-4), which are important for glycemic control. These effects of curcumin were also confirmed by enzymatic determination in vitro. Furthermore, curcumin significantly improved diet-induced hyperglycemia (e.g., fasting plasma glucose levels and glycogen storage in muscle or liver) in mice. This might be attributed to its inhibitory effects on the activities of α-glucosidase and DPP-4 in vivo. Curcumin also upregulated the expression of genes (e.g., glucagon-like peptide 1) related to DPP-4 activity in the small intestine. In conclusion, curcumin is a potential ingredient of functional foods used for diet-induced hyperglycemia management. Practical applications Curcumin has been widely used as a colorant in the food industry. Moreover, a growing number of studies have described its diverse biological functions, such as anti-inflammatory, anti-oxidant, and anti-angiogenic activities. Thus, curcumin is regarded as a potential ingredient in functional foods. Our results highlighted the hyperglycemic effect of curcumin, suggesting that curcumin may be included in food products for hyperglycemic patients.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zelin Meng,Yang Liu,Mingyang Song,Na Wang,Heming Zhao,Yang Wang,Shuai Bai,Jianglei Hu,Ruiping Shi
A sustainable one-pot co-condensation strategy was developed for the fabrication of sodium alginate (SA)-silica hybrid carriers (SA-SiO 2 ), via the covalent cross-linking via carboxyl and hydroxyl groups. The SA-SiO 2 matrix was used as a bio-based platform to immobilize Cu 2+ ions via carboxyl coordination, enabling in situ growth of MOF-199 crystals (denoted as MOF-199@xSA-SiO 2 ). FT-IR, XPS, and UV–vis demonstrated the successful cross-linking of SA with SiO 2 , the effective loading of MOF-199 through −COOH in the SA matrix, and the strong interaction between the carrier SA-SiO 2 and MOF-199. Additionally, SEM and N 2 adsorption-desorption analyses showed that the MOF-199@xSA-SiO 2 composites exhibited a spongy pore structure and possessed a typical mesoporous structure. The [email protected] 2 composite exhibited good catalytic activity in the reduction of 4-NP to 4-AP. Under optimal reaction conditions, the K app of the 4-NP reduction reaction was 0.45 min −1 . In contrast, the MOF-199/0.15SA-SiO 2 composite that was prepared using a post-synthesis method achieved a K app of only 0.11 min −1 . The catalyst maintained 98.23 % conversion of 4-NP five cycles, demonstrating good catalytic activity and stability. This study highlights the dual roles of SA as a porous guide and a metal ligand site, providing a green pathway for designing polysaccharide-MOF complexes for efficient environmental catalysis.
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高影响因子
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
·
2018
·Vol. 22
·期 2
·143-156
·
IF 3.981
Yu Hui,Zhong Jiahong,Niu Bo,Zhong Qiuping,Xiao Jiao,Xie Jinfeng,Lin Manna,Zhou Zhongzhen,Xu Jiangping,Wang Haitao
BackgroundPhosphodiesterase 4 is a promising target for developing novel antidepressants. However, prototype phosphodiesterase 4 inhibitors show severe side effects, including nausea and vomiting. N-Isopropyl-3-(cyclopropylmethoxy)-4-difluoromethoxy benzamide (FCPR03) is a novel phosphodiesterase 4 inhibitor with little emetic potential. In the present study, we investigated the inhibitory effect of FCPR03 on chronic unpredictable mild stress-induced, depressive-like behaviors in mice and explored the underlying mechanisms.MethodsThe depression model of mice was established by chronic unpredictable mild stress. Forced swim test, tail suspension test, and sucrose preference test were used to assess depressive-like behaviors. Golgi-staining was utilized to analyze dendritic morphology and spine density. The level of cAMP was measured by enzyme-linked immnosorbent assay assay. Western blot was used to evaluate protein levels of phosphorylated cAMP-response element binding protein, protein kinase B, glycogen synthase kinase-3β, and brain derived neurotrophic factor in both hippocampus and prefrontal cortex. Postsynaptic density protein 95 and synapsin 1 were also detected by western blot in the hippocampi.ResultsTreatment with FCPR03 (0.5–1.0 mg/kg, i.p.) increased consumption of sucrose in the sucrose preference test in mice exposed to chronic unpredictable mild stress. FCPR03 shortened the immobility time in forced swim test and tail suspension test without affecting locomotor activity. Furthermore, chronic unpredictable mild stress decreased the dendritic spine density and dendritic length in the hippocampus. This change was accompanied by decreased expression of postsynaptic density protein 95 and synapsin 1. Interestingly, FCPR03 prevented dendritic spine loss and increased synaptic protein levels. Moreover, the levels of cAMP, phosphorylated cAMP-response element binding protein, and brain derived neurotrophic factor were elevated in chronic unpredictable mild stress-challenged mice after treatment with FCPR03. In addition, FCPR03 also enhanced the phosphorylation of both protein kinase B and glycogen synthase kinase-3β in mice exposed to chronic unpredictable mild stress.ConclusionThe present study suggests that FCPR03 could prevent both depressive-like behaviors and spine loss induced by chronic unpredictable mild stress in the mice hippocampi.
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高影响因子
Journal of Environmental Sciences
·
2025
·
IF 6.3
Likai Wang,Donglin Liu
The degradation of persistent organic pollutants like 4-chlorophenol (4-CP) remains a critical challenge in wastewater treatment. Transition-metal sulfides have emerged as promising Fenton-like catalysts owing to their tunable electronic structures and abundant redox-active sites. Herein, we report a highly efficient Fenton-like system using ternary copper-iron sulfide (Cu x Fe y S z ) nanocatalysts for 4-CP degradation. Three Cu x Fe y S z phases—CuFe₂S₃, CuFeS₂, and Cu₅FeS₄—were synthesized and systematically evaluated, with CuFe₂S₃ demonstrating superior catalytic activity, achieving complete degradation of 20 mg/L 4-CP within 7 min using 5 mmol/L H₂O₂. Mechanistic studies reveal that sulfur vacancies in CuFe₂S₃ serve as key features, enhancing H₂O₂ adsorption and activation, as evidenced by in situ Raman spectroscopy. Comparative studies with CuFe₂S₃ analogues (0.7-CuFe₂S₃, 0.9-CuFe₂S₃, Fe₃S₄, and Cu₈S₅) confirm the unique catalytic efficiency of stoichiometric CuFe₂S₃, attributed to its optimal electronic structure and vacancy density. This work not only presents CuFe₂S₃ as a cost-effective and high-performance Fenton-like catalyst but also lays a solid foundation for the application of naturally occurring copper-iron sulfide minerals in wastewater treatment.
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Advanced Membranes
·
2023
·
IF 0
Ting He,Yinchao Jin,Jie Li,Zhaoyun Sun,Zhaohui Wang,Qingguo Li,Rizhi Chen,Zhaoliang Cui,Young Moo Lee,Enrico Drioli
Extra-corporeal membrane oxygenation (ECMO) systems can perform the roles of the human heart and lungs to realize extra-corporeal oxygenation of blood. This system mainly depends on the gas-blood exchange membrane, the quality of which impacts the oxygenation performance. Currently, the most widely used gas-blood exchange membrane is made of poly(4-methyl-1-pentene) (PMP) hollow fibers. However, plasma leakage often occurs during clinical applications, which decreases the oxygenation performance and the service life and may endanger the patient's life in serious cases. In this work, Hyflon AD/PMP hollow fiber composite membranes were prepared by coating Hyflon AD on the surfaces of PMP hollow fibers to form ultra-thin, dense layers. Compared the plasma leakage time of the composite membrane with that of the pristine PMP membrane, the Hyflon AD60 layer showed great improvement in anti-leakage performance. The Hyflon AD60/PMP hollow fiber composite membrane possessed lower platelet adhesion and protein adhesion than that of the PMP membrane, indicating better blood compatibility of the Hyflon AD60 membrane. Cytotoxicity experiments were conducted to further confirm the biosafety of Hyflon AD60 as a blood contact medical membrane material. Gas permeance and oxygenation performance of the Hyflon AD60/PMP hollow fiber composite membrane were tested to ensure gas exchange efficiency during the gas separation process. Therefore, the optimized Hyflon AD60/PMP hollow fiber composite membrane has potential for clinical use.
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JOURNAL OF MOLECULAR STRUCTURE
·
2016
·
IF 1.78
Zhi-Jian Chen,Ya-Na Chen,Chun-Na Xu,Shan-Shan Zhao,Qi-Yue Cao,Shao-Song Qian,Jie Qin,Hai-Liang Zhu
Three novel mononuclear complexes, [M Ⅱ ( L ) 2 ·2H 2 O], (M = Cu, Ni or Cd; HL = 4-(3,4-dichlorophenyl)piperazine-1-carboxylic acid)were synthesized and structurally determined by single-crystal X-ray diffraction. Molecular docking study preliminarily revealed that complex 1 had potential urease inhibitory activity. In accordance with the result of calculation, in vitro tests of the inhibitory activities of complexes 1–3 against jack bean urease showed complex 1 (IC 50 = 8.17 ± 0.91 μ M) had better inhibitory activities than the positive reference acetohydroxamic acid (AHA) (IC 50 = 26.99 ± 1.43 μ M), while complexes 2 and 3 showed no inhibitory activities., kinetics study was carried out to explore the mechanism of the inhibiting of the enzyme , and the result indicated that complex 1 was a competitive inhibitor of urease. Albumin binding experiment and in vitro toxicity evaluation of complex 1 were implemented to explore its Pharmacological properties .
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高影响因子
CHEMICAL PHYSICS
·
2020
·
IF 1.771
Lizhi Zhao,Yaxiang Zhao,Rishun Li,Dihao Wu,Xingyu Xie,Hui Ye,Yuzhong Zhang,Qingping Xin
Metal-organic frameworks (MOFs) of copper-tetrakis-(4-carboxyphenyl)-porphyrin (CuTCPP) were prepared by a solvothermal route. The two-dimensional (2D) ultrathin nanosheets with larger specific surface area show higher adsorption capacity for rhodamine B (RhB), compared with the bulk MOF of CuTCPP. The binding mechanism of the 2D nanosheets with RhB was investigated based on spectroscopic methods . The results reveal that the fluorescence of RhB is efficiently quenched by 2D CuTCPP nanosheets , and the quenching mechanism is totally the static quenching by forming a ground state RhB-CuTCPP nanosheets complex with an apparent association constant of 3.953 × 10 3 M −1 . The interaction between RhB and CuTCPP nanosheets leads to the H-aggregate of RhB in the complex. Higher-order aggregate may also be involved in the complexation. Thermodynamic studies demonstrate that RhB-CuTCPP nanosheets interaction is a spontaneous process and driven by electrostatic and hydrophobic forces . The 2D CuTCPP nanosheets can be regenerated from the complex and used repeatedly.
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MICROCHIMICA ACTA
·
2011
·Vol. 175
·期 1
·39-46
·
IF 2.578
Yin Huanshun,Shang Kun,Meng Xiaomeng,Ai Shiyun
A differential pulse voltammetric method was developed for the simultaneous determination of paracetamol, 4-aminophenol and dopamine at pH 7.0 using a glassy carbon electrode (GCE) coated with gold nanoparticles (AuNPs) and a layered double hydroxide sodium modified with dodecyl sulfate (SDS-LDH). The modified electrode displays excellent redox activity towards paracetamol, and the redox current is increased (and the corresponding over-potential decreased) compared to those of the bare GCE, the AuNPs-modified GCE, and the SDS-LDH-modified GCE. The modified electrode enables the determination of paracetamol in the concentration range from 0.5 to 400 μM, with a detection limit of 0.13 μM (at an S/N of 3). The sensor was successfully applied to the stimultaneous determination of paracetamol and dopamine, and of paracetamol and 4-aminophenol, respectively, in pharmaceutical tablets and in spiked human serum samples.
1. Gold nanoparticles and organophillic layered double hydroxide modified glassy carbon electrode was fabricated. 2. The modified electrode displayed excellent redox activity towards paracetamol. 3. This electrode was successfully applied to the simultaneous determination of paracetamol and dopamine, and of paracetamol and 4-aminophenol, respectively
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