Nature Communications
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2026
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IF 15.7
Sun Tianpeng,Tang Zhengjie,Liu Jiang,Sun Xuan,Luo Qun,Zhang Yu,Li Qian,Lu Yangfan
The high ductility of Mg has posed major challenges for nanofabrication utilizing mechanical ball-milling. While the addition of organic solvents is effective, it has been unclear how they improve the ball-milling effect by modifying the material’s surface properties. Herein, we report that the solvent-mediated partial ionicity plays an important role in enhancing the nanosizing effect of Mg 87.5 Ni 5.5 Y 7 alloy. This approach enables the Mg 87.5 Ni 5.5 Y 7 particles to be 88 times smaller than those of the solvent-free procedure. The Mg 87.5 Ni 5.5 Y 7 nanoparticles underwent complete dehydrogenation in 3 min at 300 °C and in 17 min at 240 °C, which can be stably cycled at least for 500 times. Solvent (THF) adsorption on Mg induces Mg δ + ‒Mg δ− dipole structure. This increases the surface hardness of Mg-based alloy and maximizes the ball milling-driven structural deformation, thereby facilitating ion migration. Mg‒Mg bond breaking is caused by the resulting Coulombic repulsion between Mg atoms. These findings provide an affordable approach for nanoparticle fabrication of highly ductile materials.
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Nature Communications
·
2026
·
IF 15.7
Dai Songjie,Zhang Hui,Liu Yang,Yi Fenghao,Shi Kaibin,Dong Guangneng
Controllable wetting of liquid on solid surface is meaningful for advanced science and engineering. Current researches about controllable liquid spreading are generally limited to unidirectional modes, while achieving multi-directional spreading on microstructured surfaces remains challenging. Herein, we propose a novel type of bulk-cusp microstructure, exhibiting 0 to 4-directional spreading of droplet without external energy input. This behavior occurs not only under single-drop deposition but also under continuous liquid injection. The bulk structure is assumed to have cross or square shape, implying relatively high and low coverage ratio of the precursor film, respectively. Owing to the drag effect of the precursor film, the cross-cusp microstructure facilitates controllable spreading of the main droplet, whereas the square-cusp microstructure just has guidance action on precursor film due to its low coverage ratio. Mechanism analysis reveals the capillary forces generated from the narrow gaps between adjacent cusps effectively separate the precursor film. The area coverage ratio of precursor film determined by the shape of the bulk influences the coupling or decoupling of the droplet body and precursor film. Such controllable multi-directional liquid spreading enables applications in lubrication enhancement and smart evaporation cooling.
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Scientific Reports
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2026
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IF 3.9
Wang Aqin,Zhou Zhengbing,Hang Zhou,Lyu Zhengbing,Yang Jingchun,Zhang Lu,Wang Meng,Liu Wei,Zou Liqiang,Yu Jun
Direct oral intervention of spleen aminopeptide (SA) would be limited because of its varied swelling and release rate in different pH environments of digestive fluids. Herein, pH-responsive hydrogel microspheres (3.67 ± 0.04 mm) with positive SA-loaded chitosan (Cs) core and negative alginate (ALG) shell were prepared. Entrapment efficiency was 76.22% and loading rate of SA was 35.17%. Besides the hydrogen bonding, a strong core/shell structure was constructed by forming imine bond via the Schiff base reaction of amino group in Cs with ketone group on SA. In vitro simulated digestion showed that the swelling rate of microspheres was 192.8% (pH 1.2), 2481.5% (pH 6.8), and 1144.3% (pH 7.4). The release rate of SA was 0.9% in simulated gastric fluid for 2 h, 6.0% in simulated intestinal fluid for 2 h and continuous release in simulated colonic fluid for 24 h with a cumulative release rate of 92.4%. After treatment, the observation group exhibited increasing levels of CD3 + , CD4 + , CD4 + /CD8 + , IgA, IgG and IgM. Total effective rate in observation group was 96.15%, being higher than that in control group (84.31%). This work provided a valuable reference for preparing drug-loaded hydrogels to improve the recurrent respiratory infection in children.
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Science China-Materials
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2026
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IF 7.4
Li Qing,Tang Jiayuan,Yang Yuhan,Chai Jun,Zhang Xiao,Shao Mingfei,Shen Hangjia
Pore-tuning engineering has been proven as an effective strategy in catalyst design for energy storage and conversion. Herein, we propose a rhombic dodecahedral iron and nitrogen co-doped carbon-based material (Fe-N-C) with hierarchical micro-mesoporous structures using mesoporous silica as the pore template and iron launch vehicle. The as-prepared catalysts (m-Fe/NC) exhibit much boosted ORR activity with half-wave potential of 0.81 V and 0.88 V in acidic and alkaline media, respectively. Furthermore, a superior specific capacity of 815 mAh g Zn −1 and stable cell voltage of 1.31 V is achieved at current density of 10 mA cm −2 when using m-Fe/NC as cathode for zinc-air batteries (ZAB). Advanced characterization techniques and theoretical calculations reveal that the introduction of mesopore structure not only improves the active site exposure, but also the proper curvature-induced strain effect from mesoporous concave surface enhances the intrinsic activity. This work provides significant insights for future development of innovative nanoporous electrocatalysts.
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Nature Communications
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2026
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IF 15.7
Zhang Xinyi,Wang Liangjie,Wei Jian,Guo Zhuang,Liu Xinyao,Duan Lijie,Zhao Huazhang,Song Yonghui
Oxygen vacancies (O v ) on metal oxide surfaces exhibit high catalytic activity for activating peroxymonosulfate (PMS) in wastewater decontamination, yet their in-situ regeneration remains a significant challenge. This study successfully achieves in-situ real-time regeneration of O v on CuO surfaces through simple alkali etching without interrupting the contaminant removal process. The surface hydroxyl groups introduced by alkali treatment significantly reduce the formation energy of O v on CuO surfaces from 1.60 eV to 0.38 eV. Both experimental results and density functional theory calculations reveal that the high activity of CuO relies on the synergy of surface hydroxyl groups and O v . This synergy increases the antibonding states below the Fermi level and the electron spin density of Cu near O v , thereby promoting electron transfer from CuO to PMS. As a result, by just adding an equimolar amount of alkali relative to PMS in CuO/PMS system, the degradation rate constant of sulfamethoxazole (SMX) greatly increases by 42 times. The primary reactive oxygen species in this system are sulfate radicals and hydroxyl radicals. Furthermore, OH - /CuO/PMS system exhibits a long-term stability (> 300 h) for SMX removal in a real water matrix. This work provides a highly executable method to in-situ real-time regenerate O v on CuO surfaces, representing significant progress in the critical yet underappreciated field of catalyst regeneration.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
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2026
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IF 3.2
Kim Jung-Min,Ko Cheon-Kwang,Lee Bong-Seop
To enable the efficient extraction of ursolic acid, a non-polar bioactive compound, the applicability of alcohol-based deep eutectic solvents (DESs) was investigated. A series of DESs were prepared by combining a fixed hydrogen bond acceptor, choline chloride (ChCl), with various hydrogen bond donors (HBDs) such as glycerol, ethylene glycol, 1,3-propanediol, 1,2-propylene glycol, and 1,4-butanediol at different molar ratios. To evaluate their potential as green solvents, the cytotoxicity of the alcohol-based DESs was assessed, and the 1,2-propylene glycol-based DESs exhibited the lowest cytotoxicity. Due to the high viscosity of DESs, direct solubility measurements of ursolic acid were limited; thus, the COSMO-SAC model was employed to predict solubility and guide the screening of suitable DESs. Computational results suggested that DESs containing 1,2-propylene glycol and 1,4-butanediol provided superior solubility for ursolic acid. Based on both cytotoxicity and predicted solubility, the DES composed of ChCl and 1,2-propylene glycol at a 1:4 molar ratio was identified as the most biocompatible solvent system. Using this DES, ursolic acid was successfully extracted from rosemary and apple peel. Experimental validation confirmed that PG-based DES (ChCl:1,2-propylene glycol = 1:4) exhibited a solubility 70% lower for ursolic acid than pure ethanol. This study supports a strategic shift toward sustainable extraction technologies using DESs and provides a foundation for future research on their industrial applicability.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2026
·Vol. 41
·期 1
·8-14
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IF 1.1
Wang Xinchi,Wang Wei,Liu Shuai,Wang Yun,Li Baohe
We prepared Co x Pt 100− x ( x = 40, 45, 50, 55, 60) nanoparticles by the sol-gel method. The phase composition and crystal structure, morphology and microstructure, and magnetic properties of the samples were characterized and tested using X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM), respectively. The results demonstrate that the coercivity of CoPt nanoparticles can be effectively controlled by adjusting the atomic ratio of Co and Pt in the samples. Among the compositions studied, the Co 45 Pt 55 sample synthesized by the sol-gel method exhibits smaller grain size and a coercivity as high as 6.65×10 5 A/m is achieved. The morphology and microstructure of the nanoparticles were analyzed by TEM images, indicating that a slight excess of Pt can effectively enhance the coercivity of CoPt nanoparticles.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 2
·101
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IF 2.8
Guo Jingyuan,Ha Yuan,Wei Cheng,Gu Ran,Chen Xing,Zhou Chaoyi,Li Zhimin
Sodium-ion batteries (SIBs) hold great promise for large-scale energy storage, but the phase instability and transition-metal valence state fluctuations of layered oxide cathodes severely limit their cycling stability and rate capability. In this work, eleven high-entropy layered oxide cathodes with the general formula NaMn x Fe y Ni 1–x–y TMzO ₂ (T = Zn, Cu, Co, Al, Li, etc.) were synthesized to investigate the impact of high-entropy doping on phase-transition behavior and ion diffusion mechanisms. Two representative compositions of N 0.25 FM-ZCCAL 0.03 and N 0.3 FM-ZCCAL 0.02 were compared in detail. Although N 0.3 FM-ZCCAL 0.02 delivered a higher initial capacity (164.46 mAh g −1 ), its cycling retention (57.98%) was significantly inferior to that of N 0.25 FM-ZCCAL 0.03 (77.73%). Ex situ XRD, XPS, GITT, and EIS analyses collectively reveal that both N 0.25 FM-ZCCAL 0.03 and N 0.3 FM-ZCCAL 0.02 benefit from the synergistic effect of multivalent cations (Zn 2+ , Cu 2+ , Al 3+ , Li + , and Co 2+ ), which effectively suppress the Mn 3+ /Mn 4+ redox fluctuation, stabilize the Fe 3+ state, and alleviate Jahn–Teller distortion. Despite these shared advantages, the two compositions exhibit markedly different structural evolution behaviors. Specifically, N 0.25 FM-ZCCAL 0.03 undergoes a highly reversible O3 → P3 → OP2 phase transition, whereas N 0.3 FM-ZCCAL 0.02 experiences multiphase coexistence and NiO precipitation, leading to irreversible structural degradation. The formation of NiO can be attributed to the interplay between nickel over-oxidation and structural instability during high-voltage cycling. Moreover, N 0.25 FM-ZCCAL 0.03 exhibits a higher Na + diffusion coefficient (5.68 × 10 –9 cm 2 s −1 ) and lower charge-transfer resistance (8.2 Ω), demonstrating markedly enhanced electrochemical kinetics compared to N 0.3 FM-ZCCAL 0.02 . This work highlights the critical role of high-entropy doping in regulating phase transitions and electronic structures, providing mechanistic guidance for the rational design of high-performance sodium-ion battery cathodes.
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INTERNATIONAL JOURNAL OF OBESITY
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2026
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IF 3.8
Li Qiuyu,Li Mengya,Zhou Jie,Huang Jianling,Xu Xiaohui,Zhang Zhongxiang,Jiang Longyang,Huang Yilan,Yang Xuping
Background Adipose lipolysis, a process involving the degradation of triglycerides and the release of fatty acids and glycerol, is an important biological event in lipid metabolism. Canagliflozin (Cana), an oral antidiabetic drug, regulates blood glucose by inhibiting sodium-glucose cotransporter 2 (SGLT2) in renal tubules and has also been shown to improve lipid metabolism in adipocytes. This study aims to determine whether Cana directly affects adipose lipolysis and to explore the underlying mechanistic pathways. Method Primary mature adipocytes and differentiated preadipocytes isolated from the epididymal fat pads of Sprague-Dawley rats were used as in vitro models. The effects of Cana on glycerol release and lipase activity were evaluated using ELISA and Western blot analyses. Results Cana treatment directly inhibited basal glycerol release and lipase activity in both primary adipocytes and topically administered adipose tissue, achieving a dose-dependent 35% to 65% suppression of lipolysis. This was associated with a 2.3-fold decrease in the level of HSL phosphorylated at the Ser660 site. Using differentiated adipocytes derived from the human Simpson-Golabi-Behmel syndrome (SGBS) pre-adipocyte cell line, we found that Cana significantly attenuated glycerol release (~32% to 53% reductions) induced by lipolysis. Moreover, Cana exerted antilipolytic effects in models of both acute (isoprenaline-induced) and chronic (tumor necrosis factor-α-induced) lipolysis. Mechanistically, the antilipolytic effect of Cana was mediated through activation of the PI3K/AKT pathway and reduction of cAMP production. Conclusion In conclusion, Cana regulates adipocyte lipolysis via an SGLT2-independent signaling pathway, which enhances our understanding of its role in modulating lipid metabolism.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2026
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IF 3
Wang Guangyan,Wang Hongji,Qian Shumin,Yao Xinyi,Bai Jianliang,Xu Cuixing,Lei Wenwei
Hydrogels have emerged as a promising class of soft materials, particularly valued for their biocompatibility and high-water content. However, conventional hydrogels are fundamentally limited by their poor mechanical stretchability and lack of self-healing capabilities, severely restricting their practical applications. Herein, we report a simple yet effective strategy to significantly enhance both the stretchability and self-healing capability of PVA-based (PVA: polyvinyl alcohol) organohydrogels by introducing glucose as a dynamic multi-hydroxyl crosslinker. The abundant hydroxyl groups on glucose molecules form additional dynamic hydrogen bonds with the PVA matrix, resulting in a denser and more dynamic physically cross-linked network. The resulting glucose-PVA organohydrogel exhibits remarkable performance: ultrahigh stretchability (16300 strain, representing a 12-fold improvement over glucose-free systems), dynamic bond-mediated ex-situ self-healing, and injectability. Remarkably, the synergistic effect between glucose-mediated plasticization and the poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) conductive network enables simultaneous acquisition of both resistive strain signals and electrophysiological signals, demonstrating significant potential for applications in disease diagnosis and motion analysis. This work not only provides a high-performance soft material for potential applications in flexible electronics and biomedical devices but also offers a novel strategy for designing advanced multifunctional gels.
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Journal of Sustainable Metallurgy
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2026
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IF 3.2
Xu Lei,Chen Wen-mi,Fan Shang,Zhang Yan-jun,Liang Gao-jie,Zhou Jian
Foam formation within decomposition tanks poses a significant issue affecting alumina production, drawing increasing attention in industrial processes. This study explores the influence of humic acid (HA) on foam formation in decomposition tanks, considering variables such as HA concentration, decomposition time, solid content, and high-temperature treatment time of HA. The findings reveal that the foaming capacity of sodium aluminate solutions containing HA increases with HA concentration. Both the foaming volume (FV) and foam stability decreases with extended decomposition time. The FV of the solution initially rises and then decrease as solid content increases. Following high-temperature degradation at 260 °C, the foaming performance (FP) of HA is reduced. Analyses using FT-IR, surface tension, and particle size measurements indicate that HA molecules modify the properties of sodium aluminate solutions and particle surfaces, resulting in foam generation within decomposition tanks. The study provides a theoretical analysis of the mechanisms underlying foam formation and decay in sodium aluminate solutions containing HA. This research provides theoretical support for foam eliminating in alumina production, facilitating the development of HA removal processes and foam control technologies. Graphical
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PLANTA
·
2026
·Vol. 264
·期 4
·102
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IF 4.4
Jiang Lili,Bai Penggang,Tang Jun,Zhuang Yibin,Yin Hua,Liu Tao
Main conclusion Two UDP-glycosyltransferases from Olea europaea were identified and characterized. Both catalyze the glycosylation of oleoside 11-methyl ester to form 7-β-1-D-glucopyranosyl 11-methyl oleoside, a putative intermediate in the oleuropein biosynthetic pathway. Introduction Oleuropein, a secoiridoid glycoside abundant in Oleaceae plants, is extensively utilized in the pharmaceutical, nutraceutical, and cosmetic industries due to its diverse pharmacological activities. The biosynthetic pathway from oleoside 11-methyl ester (OME) to oleuropein remains incompletely elucidated. In this study, two UDP-glycosyltransferases (UGTs), OeUGT1and OeUGT2, were identified in O. europaea. First, based on differential expression analysis and the characteristics of enzymes catalyzing carboxyl glycosylation, 51 differentially expressed UGTs were narrowed to 6 candidates. Both in vivo and in vitro enzyme activity assays demonstrated that OeUGT1 could catalyze OME to 7-β-1-D-glucopyranosyl 11-methyl oleoside (OME-Glc). The enzymatic properties of OeUGT1 were then characterized. The optimal reaction temperature was found to be 30 °C, and the optimal pH was 6.0. OeUGT1 exhibited a Michaelis constant ( K m ) of 1.69 ± 0.37 mM and a catalytic efficiency ( k cat / K m ) of 3.57 ± 0.84 mM⁻ 1 s⁻ 1 . OeUGT1 showed strict substrate selectivity, acting on only sinapinic acid out of other nine carboxyl-containing substrates tested. A local BLAST search of the O. europaea transcriptome using the OeUGT1 amino acid sequence was conducted and its isoenzyme was identified, OeUGT2. OeUGT2 exhibits 87.3% sequence identity to OeUGT1. Phylogenetic analysis placed OeUGT1 (designated as UGT75L98 by the UGT Nomenclature Committee) and OeUGT2 (designated UGT75L99) within the UGT75 family, a clade known to catalyze the glycosylation of carboxyl groups. OeUGT1 had a specific activity of 0.2719 μmol min −1 mg −1 , approximately 2.78-fold higher than OeUGT2 (0.0977 μmol min −1 mg −1 ), indicating that OeUGT1 is the major enzyme responsible for OME glycosylation in olive. This work advances our understanding of oleuropein biosynthesis.
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