JOURNAL OF ORGANIC CHEMISTRY
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2022
·
IF 4.198
Haiwen Li,Junhu Xin,Yuhang Xue,Cunde Wang
A pseudo-three-component annulation reaction of substituted 2-amino-4H-chromen-4-ones with aromatic aldehydes promoted by DBU was investigated to access polysubstituted 5H-chromeno[2,3-b]pyridines. This reaction included a sequential intermolecular nucleophilic addition/Michael cyclization/intramolecular epoxidation/ring opening/aromatization sequence, which possessed excellent step and atom economy in a single operation for generating 3-hydroxy-5H-chromeno[2,3-b]pyridines from readily available substrates.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 9
·4485
·
IF 6.208
Qingfeng He,Fengjiao Bu,Qizhen Wang,Min Li,Jiaying Lin,Zhijia Tang,Wen Yao Mak,Xiaomei Zhuang,Xiao Zhu,Hai-Shu Lin,Xiaoqiang Xiang
Schizandrol A (SZA) and schizandrol B (SZB) are two active ingredients of Wuzhi capsule (WZC), a Chinese proprietary medicine commonly prescribed to alleviate tacrolimus (FK-506)-induced hepatoxicity in China. Due to their inhibitory effects on cytochrome P450 (CYP) 3A enzymes, SZA/SZB may display drug–drug interaction (DDI) with tacrolimus. To identify the extent of this DDI, the enzymes’ inhibitory profiles, including a 50% inhibitory concentration (IC50) shift, reversible inhibition (RI) and time-dependent inhibition (TDI) were examined with pooled human-liver microsomes (HLMs) and CYP3A5-genotyped HLMs. Subsequently, the acquired parameters were integrated into a physiologically based pharmacokinetic (PBPK) model to quantify the interactions between the SZA/SZB and the tacrolimus. The metabolic studies indicated that the SZB displayed both RI and TDI on CYP3A4 and CYP3A5, while the SZA only exhibited TDI on CYP3A4 to a limited extent. Moreover, our PBPK model predicted that multiple doses of SZB would increase tacrolimus exposure by 26% and 57% in CYP3A5 expressers and non-expressers, respectively. Clearly, PBPK modeling has emerged as a powerful approach to examine herb-involved DDI, and special attention should be paid to the combined use of WZC and tacrolimus in clinical practice.Keywords:physiologically based pharmacokinetic (PBPK);Wuzhi capsule (WZC);tacrolimus (FK-506);CYP3A5 polymorphism;drug–drug interaction (DDI);schizandrol A (SZA);schizandrol B (SZB)
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Materials Today Chemistry
·
2023
·
IF 7.3
J. Ma,B. Zhao,N. Shao,P. Jiang,H. Yang,B. Li
Photocatalysis is considered a promising strategy for environmental remediation, and the preparation of an efficient, stable, and green photocatalyst is a current urgent need. In this work, a magnetically recoverable SnFe 2 O 4 /Bi 2 WO 6 (SFO/BWO) Z-scheme heterojunction was successfully prepared by a simple one-step hydrothermal process. The prepared 7.5%SFO/BWO nanocomposite exhibited excellent photocatalytic performance, with a degradation efficiency of 96.12% for Rhodamine B (RhB) within 120 min, which were respectively 1.64 and 2.07 times greater than that of pure Bi 2 WO 6 (BWO) and SnFe 2 O 4 (SFO). This obvious improvement in the photocatalytic performance benefited from the increase in the separation efficiency of photogenerated carriers and was based on the construction of Z-scheme heterojunction. Additionally, the radical capture tests demonstrated the main reactive radicals were electron (e − ), hole (h + ), and hydroxy radical (•OH) in the photodegradation system. Furthermore, the composite retains excellent photocatalytic performance after five cycles and is easily recoverable due to its magnetic behavior. Notably, during the toxicity assessment, it was proved that SnFe 2 O 4 /Bi 2 WO 6 could be used to eliminate the toxicities of dyes and antibiotics rapidly. Consequently, SnFe 2 O 4 /Bi 2 WO 6 is a promising and competitive photocatalyst in wastewater remediation.
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CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Zelai Cheng,Liming Xu,Xi Wang,Xiaohui Wu,Fangyi Huang,Yulan Jing,Hua Su
Gillespite-type SrCu 0.95 B 0.05 (B 2+ :Cu,Co,Mn,Ni,Mg,Zn)Si 4 O 10 (SCBS) ceramics were prepared by high-temperature solid-state method. Their microwave dielectric properties and crystal structure evolution were studied by P–V-L theory, bond valence model, and X-ray photoelectron spectroscopy. Varying B 2+ ion changed ionic polarizability and bond ionicity, causing dielectric constant ε r of SCBS to change. The change in quality factor Q × f was explained by lattice energy, oxidation state of Cu, and internal strain/fluctuation. The temperature coefficient of resonator frequency τ f was regulated by B–O bond length and valence. The optimal microwave dielectric properties were exhibited by SrCu 0.95 Mn 0.05 Si 4 O 10 after sintering at 1050 °C: ε r ∼5.8 ± 0.03, Q × f ∼65,589 ± 2611 GHz (@15.8 GHz), and τ f ∼ -50 ± 4 ppm/°C. These materials show great potential application prospects for 5G/6G wireless communication.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2020
·
IF 4.939
Asad Ali,Yang Liu,Rongcheng Mo,Pinsong Chen,Pei Kang Shen
Developing high performance, good stability and noble-metal-free electrocatalysts for renewable hydrogen evolution reaction (HER) remain a substantial challenge. Herein, we introduce a novel facile one-step in-situ strategy through pyrolysis for the synthesis of Co 2 P nanoparticles encapsulated Boron, Nitrogen, and Phosphorous tri-doped carbon nanotubes (Co 2 P/BNP-CNTs). The synergetic effect between Co 2 P nanoparticles and heteroatom doped CNTs contributes to the remarkable HER performance. The Co 2 P/BNP-CNT-900 electrocatalyst shows a low overpotential of 133 mV at a current density of 10 mA cm −2 and a small Tafel slope of 90 mV dec −1 in 0.1 M KOH media. More importantly, the Co 2 P/BNP-CNT-900 electrocatalyst exhibits superior long-term stability in alkaline solution at −0.25 V versus Reversible Hydrogen Electrode (RHE) for 15 h and up to 1000 cycles with negligible performance loss. Overall, our works suggest a one-pot facile synthesis strategy for rational designing high-performance electrocatalysts with enhanced HER performance.
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NEW CARBON MATERIALS
·
2020
·
IF 1.761
Chi Song,Lin-jie Wang,Si-miao Sun,Ying Wu,Li-jie XU,Lu Gan
A series of ternary composite photocatalysts of Bi 2 O 3 /Bi embedded in porous carbon (Bi 2 O 3 /Bi/PC) was prepared by the high-temperature pyrolysis of a bismuth-based metal organic framework (CAU-17(Bi)). They were used as photocatalysts for the degradation of organic Rhodamine B dye (RhB) in water under visible light. Results showed that the Bi 2 O 3 /Bi/PC composites with different Bi 2 O 3 /Bi ratios could be obtained through changing the extent of the carbothermal reduction of Bi 2 O 3 during pyrolysis. The photocatalystpyrolyzed at 800 o C showed the highest photocatalytic performance and had a wide applicable pH value range and excellent recyclability and stability.The components in the ternary composites exhibited a synergetic effect in the removal of RhB, where Bi 2 O 3 acted as a low-band gap semiconductor, metallic Bi transferred electrons generated by visible light excitation to the graphitic structure in porous carbon to inhibit the recombination of electrons with holes. The holes and peroxide radicals were the main active species. This study provides a new way for the design and preparation of visible-light active and high-performance photocatalysts for organic contaminant degradation in aqueous media by using metal organic frameworks as a multicomponent precursor.
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NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 44
·期 7
·3078-3086
·
IF 3.069
Shiyu Li,Zhongying Zhang,Jingdong Peng,Xiang Wang,Dengying Long,Hong Xian,Ranxi Ni,Huanjun Peng,Jun Chen
For the first time, a highly sensitive and selective detection technology of high-performance liquid chromatography associated with resonance Rayleigh scattering spectra (HPLC-RRS) is applied to analyze migraine drugs including zolmitriptan (ZON) and rizatriptan (RIN). In an HAc–NaAc buffer solution (pH = 4.5), ZON and palladium(II) chelate to form a chelating cation, namely, [Pd·ZON]2+, and then react with Erythrosin B (Ery) via electrostatic attractions and hydrophobicity to form a ternary complex, [Pd·ZON]·Ery2, resulting in a significantly enhanced RRS signal. The RRS signal was detected at the synchronous model. The calibration curves of ZON and RIN were linear in the range from 0.027 to 25 μg mL−1, and the detection limits (S/N = 3) were 9.70 ng mL−1 and 4.76 ng mL−1, respectively. In addition, the HPLC-RRS method showed that the recovery of the two migraine drugs was 98.90% to 100.87% and the RSD (n = 6) was 1.67% to 4.86%. In this study, the experiment conditions were optimized, and the reaction mechanism and reason for increment in RRS were studied. In human urine samples, the established method was applied for the synchronous detection of two antimigraine drugs with satisfactory results.
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Food Analytical Methods
·
2018
·Vol. 12
·期 3
·705-711
·
IF 2.245
Tu Xijuan,Wu Siyuan,Liu Weiyi,Gao Zhaosheng,Huang Shaokang,Chen Wenbin
An analytical method based on sugaring-out assisted liquid-liquid extraction (SULLE) and HPLC-fluorescence detection has been developed for the determination of bisphenol A (BPA) and bisphenol B (BPB) in royal jelly. Experimental parameters of SULLE including the extraction solvent, amount of phase separation agent, initial concentration of acetonitrile (ACN), and sample size were investigated. The optimal SULLE procedure involves 0.3 g sample extracted by 2 mL ACN-water mixture (50%, v / v ), followed by phase separation with the addition of 0.4 g glucose. The obtained extract was injected into the reversed-phase HPLC system without clean-up step. The chromatography separation of BPA and BPB from royal jelly matrix was achieved in the mobile phase composed of 40% ACN and 60% water with isocratic elution at 1.0 mL/min. Limits of quantification for BPA and BPB were 40 μg/kg and 45 μg/kg, respectively, and limits of detection for BPA and BPB were 16 μg/kg and 18 μg/kg, respectively. Average recoveries of BPA and BPB at three spiked levels were in the range of 88.32~93.59% and 95.14~97.48%, respectively. Precision expressed as relative standard deviations (RSDs) in the interday and intraday analysis were all lower than 5%. The developed method was applied to the analysis of ten commercial and eight raw royal jelly samples. Results indicated that none of BPA and BPB were detected in these 18 samples. The proposed method is simple, fast, and sensitive, and could be used for the monitoring of BPA and BPB contamination in royal jelly.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Yinghua Liu,Wenxiu Duan,Wei Song,Juanjuan Liu,Cuiling Ren,Jiang Wu,Dan Liu,Hongli Chen
Colorimetric and fluorescent dual mode detection methods have gained much attention in recent years; however, it is still desirable to develop new colorimetric and fluorescent dual mode nanosensors with more simple preparation procedures, low cost, and excellent biocompatibility. Herein, a colorimetric and fluorescent nanosensor based on B, N, S-co-doped carbon dots (BNS-CDs) was synthesized by one-step hydrothermal treatment of 2,5-diaminobenzenesulfonic acid and 4-aminophenylboronic acid hydrochloride. Using this nanosensor, a highly sensitive assay of Fe3+ in the range of 0.3–546 μM with a detection limit of 90 nM was provided by quenching the red emission fluorescence. It is more attractive that Fe3+ can also be visualized by this nanosensor via evident color changes of the solution (from red to blue) under sunlight without the aid of an ultraviolet (UV) lamp. Furthermore, the designed nanosensor can be applied for efficient detection of intracellular Fe3+ with excellent biocompatibility and cellular imaging capability, and it holds great promise in biomedical applications.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Haizhen Liu,Liwen Lu,Hui Luo,Jiayi Deng,Guangxu Li,Hua Ning,Yi Fan,Cunke Huang,Zhiqiang Lan,Wenzheng Zhou,Jin Guo,Xinhua Wang
The Li-Mg-B-H composite (2LiBH 4 + MgH 2 ) is acknowledged as a promising material for hydrogen storage due to its large hydrogen capacity (11.4 wt.%). However, the sluggish kinetics and poor reversibility make it difficult to be practically used. In this work, the hydrogen storage performances of 2LiBH 4 + MgH 2 have been significantly improved by a hybrid of bulk NbC and layered Nb 4 C 3 MXene (denoted as “Nb-C”). The 2LiBH 4 + MgH 2 + 6 wt.% Nb-C can release 8.5 wt.% H 2 within 30 min at 400°C and the dehydrogenated composite can absorb 9.3 wt.% H 2 within 30 min at 350°C and 7.5 MPa H 2 . The reversible dehydrogenation capacity maintains at 8.4 wt.% after 24 cycles, with a capacity retention ratio of 95.4%. By contrast, the undoped 2LiBH 4 + MgH 2 suffers from serious capacity degradation, with the capacity decreased dramatically to 3.5 wt.% after 3 cycles. Microstructural studies revealed that the doped composite has uniform particle and elemental distributions and possesses various multiphase interfaces of LiH/MgB 2 /NbC/Nb 4 C 3 , which is beneficial to hydrogen diffusion during the hydrogen uptake and release process. Theoretical studies by first principle calculation presented an extended bond length of the Mg-H and B-H bonds in the 2LiBH 4 + MgH 2 + NbC system, which may also explain the improved hydrogen storage properties of 2LiBH 4 + MgH 2 by addition of Nb-C. This work provides new insights into the role of transition metal carbides in regulating the Li-Mg-B-H hydrogen storage materials both experimentally and theoretically.
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International Journal of Medical Sciences
·
2025
·Vol. 22
·期 4
·856-872
·
IF 3.2
Li Bowei,Yang Jingyuan,Wang Zhixing,He Mingzhu,Chen Xujing,Chen Yixuan,Shen Baoying,Chen Junru,Yang Chunqi,Li Tian,Lai Chengcai,Gao Yue,Cai Hong
Introduction: Solar dermatitis, a condition triggered by excessive exposure to ultraviolet B (UVB) radiation, results in inflammatory skin damage marked by erythema, edema, and epidermal injury. Portulaca oleracea (PO) and Patrinia scabiosaefolia (PS) have been traditionally used in dermatological treatments, though their mechanistic pathways in UVB-induced skin injury are not fully understood.Methods: In this study, a mouse model of UVB-induced solar dermatitis was employed to evaluate the therapeutic potential of combined PO and PS (POPS) extracts. After UVB irradiation, POPS extracts were administered, and their bioactive compounds were identified through ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Network pharmacology, molecular docking, and pathway analysis were performed to identify key targets, focusing on the IL-17/CCL2 pathway and oxidative stress reduction.Results: Treatment with POPS extracts significantly diminished UVB-induced inflammation, erythema, and epidermal thickening in a dose-dependent manner. Network pharmacology and docking studies identified curvularin and olmesartan medoxomil as bioactive components with high affinity for IL-17 and IL-17RA targets, modulating the IL-17/CCL2 axis. In vivo experiments demonstrated that POPS extracts suppressed the expression of IL-17 and CCL2, reduced macrophage infiltration, and alleviated oxidative stress, effectively mitigating the symptoms of solar dermatitis.Conclusion: This study provides insight into the anti-inflammatory and protective properties of POPS extracts in solar dermatitis, highlighting their potential as a treatment through IL-17/CCL2 pathway modulation and oxidative stress reduction.
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MOLECULES
·
2024
·Vol. 29
·期 8
·1705
·
IF 4.2
Guoying Zhou,Yajie Cao,Yujia Yan,Haibo Xu,Xiao Zhang,Tingzi Yan,Haitong Wan
Traumatic brain injury (TBI) leads to structural damage in the brain, and is one of the major causes of disability and death in the world. Herein, we developed a composite injectable hydrogel (HA/Gel) composed of hyaluronic acid (HA) and gelatin (Gel), loaded with vascular endothelial growth factor (VEGF) and salvianolic acid B (SAB) for treatment of TBI. The HA/Gel hydrogels were formed by the coupling of phenol-rich tyramine-modified HA (HA-TA) and tyramine-modified Gel (Gel-TA) catalyzed by horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2). SEM results showed that HA/Gel hydrogel had a porous structure. Rheological test results showed that the hydrogel possessed appropriate rheological properties, and UV spectrophotometry results showed that the hydrogel exhibited excellent SAB release performance. The results of LIVE/DEAD staining, CCK-8 and Phalloidin/DAPI fluorescence staining showed that the HA/Gel hydrogel possessed good cell biocompatibility. Moreover, the hydrogels loaded with SAB and VEGF (HA/Gel/SAB/VEGF) could effectively promote the proliferation of bone marrow mesenchymal stem cells (BMSCs). In addition, the results of H&E staining, CD31 and α-SMA immunofluorescence staining showed that the HA/Gel/SAB/VEGF hydrogel possessed good in vivo biocompatibility and pro-angiogenic ability. Furthermore, immunohistochemical results showed that the injection of HA/Gel/SAB/VEGF hydrogel to the injury site could effectively reduce the volume of defective tissues in traumatic brain injured mice. Our results suggest that the injection of HA/Gel hydrogel loaded with SAB and VEGF might provide a new approach for therapeutic brain tissue repair after traumatic brain injury.
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