INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Yixuan Chen,Bing Hu,Liping Liu,Xinlong Wang,Zhaowei Qi,Jing Zhang,Yi Sun,Yue Yuan
Copper doping achieves three benefits at once: consuming GSH, amplifying the peroxidase activity of Prussian blue, and enhancing the efficiency of photothermal conversion. • Coated hyaluronic acid actively targets the CD44 receptor, increasing the accumulation of nanoparticles at tumor sites. • This nanoplatform integrates chemodynamic therapy, photothermal therapy and chemotherapy, achieving the combined application of multiple therapies. Chemodynamic therapy (CDT) has emerged as a promising anticancer strategy, yet its therapeutic efficacy is significantly hampered by the elevated glutathione (GSH) levels in the tumor microenvironment (TME) and the limited catalytic efficiency of conventional Fenton reactions. To address these challenges, we developed copper-doped Prussian blue nanoparticles (CPB NPs) for encapsulating curcumin (CUR) and further modified their surface with the active targeting molecule hyaluronic acid (HA), forming CPB@CUR-HA NPs. Notably, this nanoformulation significantly enhances solubility and bioavailability of CUR. In the constructed system, Prussian blue (PB) serves a dual function as an effective photothermal agent: it not only induces tumor cell ablation through photothermal effects but also amplifies CDT efficacy via localized temperature elevation. The incorporated copper ions play crucial roles in depleting excessive GSH and catalyzing Fenton-like reactions, thereby boosting the peroxidase-like activity of PB. Furthermore, copper doping synergistically improves the photothermal conversion efficiency of PB. The mutually reinforcing interplay between CDT and photothermal therapy (PTT), combined with the natural anticancer agent CUR, enables a powerful trimodal therapeutic approach integrating chemotherapy, CDT, and PTT, ultimately achieving remarkable tumor growth inhibition. Download: Download high-res image (187KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Yan Lu,Qianyun Ye,Can Gao,Xiaoge Li,Pan Gao,Xiaohuan Sun,Jie Han
The development of chiral type-I photosensitizers represents a significant advance, as it can not only overcome the hypoxia limitation inherent to conventional type-II agents but also leverage enantioselectivity to enhance therapeutic precision. However, this promising field remains notably underexplored. Herein, we construct chiral supramolecular self-assemblies via hydrogen-bonding interactions between l/d-arginine (l/d-Arg) and 5,10,15,20-tetrakis(4-sulfophenyl)porphyrin (TPPS). The proximity of the electron-donating porphyrin core to the arginine moiety facilitates efficient photoinduced electron transfer, enabling l/d-Arg-TPPS to operate via simultaneous type-I and type-II pathways. This dual mechanism ensures robust generation of superoxide radicals (O2•–) even under hypoxic conditions, addressing a key limitation of conventional porphyrin photosensitizers. Moreover, the self-assembly process drives effective supramolecular chirality induction, endowing TPPS with substantial dissymmetry factors (gabs) of ∼2.1 × 10–4. This chiral signature translates to significant biological enantioselectivity. d-Arg-TPPS achieves 3.87-fold greater cellular uptake and 1.85-fold higher intracellular reactive oxygen species (ROS) production than l-Arg-TPPS, resulting in markedly enhanced chirality-specific antitumor activity. Importantly, l/d-Arg-TPPS also elicits a chirality-dependent immunogenic cell death (ICD) response, facilitating antitumor immunity. This work establishes a supramolecular chiral-engineering strategy that integrates hypoxia-tolerant photodynamic behavior with stereoselective nanobio interactions, advancing both the fundamental understanding and therapeutic potential of photosensitizer design.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Youli Zhang,Lulu Wang,Yanmin Zheng,Lei Zhu,Dongsheng Li,Xinwei Zheng
Balancing the thermodynamic stability and biological clearance of supramolecular assemblies represents a fundamental challenge in the design of functional nanomedicines. To address this, we propose a concentration-responsive “assemble-for-uptake, disassemble-for-clearance” strategy implemented via rational molecular engineering of a minimalist, single-component Gd–DOTA amphiphile. We demonstrate that the alkyl chain length acts as a precise molecular dial to tune the critical micelle concentration (CMC), thereby dictating micellar stability, biological identity, and clearance pathways. Through this tuning, we identified Gd–C12 as the optimized agent, which self-assembles into spherical nanomicelles (38.6 ± 8.3 nm) with desirable T1 contrast (r2/r1 < 2) and kinetic stability surpassing unmodified Gd–DOTA. In vivo studies reveal that Gd–C12 provides potent hepatic enhancement (120% increase) via favorable MPS recognition, independent of organic anion-transporting polypeptide (OATP). Crucially, following hepatic uptake, the agent undergoes spontaneous disassembly upon physiological dilution/excretion, facilitating rapid systemic clearance (>97%) to resolve long-term retention concerns. This work presents Gd–C12 as a high-performance, transporter-independent contrast agent that bridges the gap between nanoparticles and small molecules, holding promise for providing reliable hepatic parenchymal enhancement regardless of OATP expression levels.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Wen Luo,Yana Ma,Weijia Zhu,Ruican Nie,Yue Wu,Dongqiu Shan,Shijun Xu,Ho-Young Song,Hongtao Hu
Liver cancer remains a major global public health threat, with high mortality. Lenvatinib is a tyrosine kinase inhibitor that has been used for the treatment of advanced liver cancer. However, its therapeutic efficacy is often limited by severe adverse effects and drug resistance. To overcome these challenge, we developed a biomimetic versatile nanoplatform based on Mn-doped polydopamine (PML@CM). Owing to their homologous tumor-targeting ability and pH-responsive drug release properties, PML@CM nanoparticles effectively improved the biocompatibility of lenvatinib and enhanced its tumor accumulation. Upon exposure to the tumor microenvironment, the released Mn2+ not only triggered chemodynamic therapy through Fenton-like reactions but also enabled magnetic resonance imaging (MRI). In addition, PML@CM nanoparticles exhibited an efficient photothermal conversion performance for tumor photothermal therapy. In conclusion, this nanoplatform provides a promising therapeutic strategy for MRI-enabled synergistic therapy against liver cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Guitao Tan,Huaqiang Luo,Yuxin Wang,Haonan Hu,Bingtian Tu,Huan He,Jing Tu
Bacterial infections at wound sites impede healing and pose a serious threat to human health. Conventional antibiotic therapies, however, tend to trigger resistance. Consequently, copper (Cu)-based materials have recently emerged as highly promising alternatives that synergistically kill bacteria and thereby accelerate wound healing. Herein, we developed a core–satellite nanomedicine (PZH) composed of a degradable Cu-doped phosphate-based glass (PBG) core and multiple ZIF-8/hyaluronic acid (HA) satellites. PZH shows pH-triggered behavior: at physiological pH its structure remains intact and Cu2+ release is minimal, whereas the acidic microenvironment of infected wounds triggers disassembly, releasing Cu2+ and generating •OH radicals through peroxidase-like (POD-like) activity. This dual-functional ionic-catalytic mechanism achieves potent bactericidal effects against both Gram-positive and Gram-negative bacteria. At 6 μg/mL, PZH eliminates >99% of Staphylococcus aureus. In vitro assays further confirm that PZH is cytocompatible and accelerates cell migration. To overcome the application limitations of conventional Cu nanoparticle suspensions, PZH was loaded into a thermosensitive F127 hydrogel to yield PZHF, which preserves the POD-like activity and enables minimally invasive, injectable delivery to irregular wound geometries. In vivo tests further demonstrated that the biocompatible PZHF hydrogel displayed good antibacterial properties and promoted wound healing. As a smart, clinically translatable Cu-based nanomedicine, this system provides a precision therapeutic strategy for treating bacterially infected wounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG METABOLISM AND DISPOSITION
·
2026
·
IF 3.6
Mengling Hou,Shaofei Song,Dali Gan,Sengpeng Wong,Tingting Zhao,Yanxin Zhang,Min Huang,Weiwei Zeng,Yiming Jiang
Sedum sarmentosum Bunge extract (SSBE) is widely used in clinical practice to treat various liver diseases. Cyclosporine A (CsA) is a potent immunosuppressant known to cause hepatotoxicity. However, it is unclear whether combining SSBE and CsA is effective or increases the risk of adverse reactions. This study explored the potential herb-drug interaction between SSBE and CsA. Male rats were given an oral dose of CsA (2.5 mg/kg) one hour after a single dose of SSBE (600 mg/kg) or vehicle. Blood CsA concentrations measured by UHPLC-MS/MS revealed that SSBE dramatically increased the CsA exposure; the C max and AUC 0→48h values were significantly increased by 150% and 220% (from 222.89 to 567.06 ng/mL and from 2,089.37 to 6,615.08 ng/mL∙h), respectively. In parallel, the exposure of the CsA metabolite AM1 was significantly reduced, with Cmax and AUC 0→48h decreased by 68% and 70%, respectively. In vitro study demonstrated that SSBE and its active constituents inhibited CYP3A activity and suppressed CsA metabolism to AM1. In conclusion, SSBE significantly increased the systemic exposure of CsA, and the effect might be related to inhibition of CYP3A activity. Additional caution should be exercised when treating CsA and SSBE together, as it may cause unexpected potential herb-drug interaction.
✓ 已验证
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Yishuang Wu,Mengyao Guo,Qichang Wang,Chen Deng,Richen Lin,Daolun Liang,Dekui Shen
The bandgap of biomass-derived CQDs can be tuned through the decoration of nitrogen-contained compounds. • Red-emitting CQDs exhibited the narrowest bandgap and the strongest visible light absorption capacity. • The composite photoelectrode assembled by Red-emitting CQDs and TiO 2 homojunction improved the photocurrent and H 2 production. Carbon quantum dots (CQDs) are promising photosensitizers for photoelectrochemical (PEC) water splitting. In this work, biomass-derived CQDs were synthesized by a bottom-up approach using 13 precursors. Among them, cinnamaldehyde-, isoflavone-, and hydroxy-2,5-dimethyl-3(2H)-furanone-derived CQDs were selected for further tuning based on their relatively higher quantum yields (QYs), and acceptable yields. To tune the optical properties, three nitrogen sources, namely urea, m-phenylenediamine, and neutral red, were introduced, yielding blue-, green-, and red-emitting CQDs (B-CQDs, G-CQDs, and R-CQDs) with QYs of 13.20%, 20.40%, and 25.20%, respectively. Their absorption edges were located at 376, 470, and 579 nm, corresponding to bandgaps of 3.30, 2.64, and 2.14 eV. CQDs-sensitized titanium dioxide homojunction (THJ) photoelectrodes were fabricated via surface silanization. The R-CQDs/THJ photoelectrode achieved the highest photocurrent density among the three CQDs-decorated photoelectrodes during the water splitting process. The photocurrent density of the pure THJ photoelectrode was increased markedly from 1.45 mA cm −2 to 2.56 mA cm −2 with the decoration of R-CQDs, while the hydrogen evolution rate increased from 26.17 to 44.73 μmol cm -2 h −1 , corresponding to a 1.7-fold enhancement. This work provides insight into the relationship between the tunable optical properties of biomass-derived CQDs and their PEC sensitization behavior on TiO 2 photoelectrodes. The enhanced PEC performance is attributed to the combined effects of broadened spectral absorption and improved interfacial charge separation and transfer after decoration with CQDs. Download: Download high-res image (213KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Yanzheng Feng,Sikai Di,Zhihao Kang,Xiaodi Lu,Huajin Liu,Xinyan Cong,Tiedong Sun
Single-modal therapies for bacterial infections and tumors suffer from critical bottlenecks, including insufficient reactive oxygen species (ROS) generation, glutathione (GSH)-mediated ROS scavenging, poor targeting, and non-responsive drug release. Herein, a novel biomass-based multifunctional microcomposite (Pt/TiO 2 -D@Lotus) was constructed using natural lotus pollen-derived porous microparticles as the biocompatible matrix, modified with Pt/TiO 2 Janus Schottky heterojunction, and loaded with doxorubicin (DOX). Under near-infrared (NIR) irradiation, the heterojunction efficiently separates photoexcited charges to boost ROS (•O 2 − , •OH, 1 O 2 ) production and depletes 70% of intracellular GSH (500 µg mL −1 ) to amplify oxidative stress. The microcomposite shows a high photothermal conversion efficiency of 55.4% and pH/NIR dual-responsive DOX release (90% release at pH 5.0 + NIR). In vitro experiments demonstrate >99% antibacterial efficiency against S. aureus and E. coli, and ∼85% cancer cell apoptosis rate. In vivo antitumor therapy achieves a 92% tumor inhibition rate with negligible systemic toxicity and good biocompatibility. This work innovatively constructs a biomass-derived synergistic therapeutic platform, providing a feasible strategy to overcome the core limitations of traditional antibacterial and tumor therapies, and expanding the application of biomass materials in biomedicine.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Drug Design Development and Therapy
·
2026
·
IF 6.1
Jiali Cai,Yaojian Zhang,Tian Zhang,Mengyi Wu,Dijun Wang,Chunyan Yin,Xueke Nie,Lan Chen,Zhihu Sun,Chanming Liu,Xiaojing Yan
Purpose: β-Amyrin acetate (BAA), a natural pentacyclic triterpenoid, exhibits greater lipophilicity than its antiepileptic precursor β-amyrin, implying enhanced blood-brain barrier (BBB) permeability. This study aimed to evaluate the antiepileptic efficacy of BAA and investigate its neuroprotective mechanisms, with a focus on calcium signaling.Patients and Methods: An epilepsy model was established in zebrafish using pentylenetetrazole (PTZ) to assess the effects of BAA on seizure-like behaviors, reactive oxygen species (ROS) levels, apoptosis, and inflammatory markers. Potential targets were predicted via network pharmacology and molecular docking. Furthermore, a glutamate (Glu)-induced HT-22 neuronal injury model was used to validate BAA’s effects on intracellular calcium homeostasis and downstream signaling pathways.Results: BAA significantly attenuated PTZ-induced seizure-like behaviors in zebrafish, specifically reducing the frequency of clonic and tonic-clonic seizures, as well as total movement distance and velocity. Concurrently, BAA mitigated oxidative stress, apoptosis, and neuroinflammation in the zebrafish. Network pharmacology and molecular docking analyses suggested the calcium signaling pathway as a potential target, with BAA showing high binding affinity to proteins such as Bcl-2 and JAK2. In vitro experiments suggested that BAA effectively alleviated Glu-induced calcium overload in HT-22 cells. It downregulated the Bax/Bcl-2 ratio, suppressed overactivation of the JAK2/STAT3 pathway, and consequently reduced neuronal apoptosis and inflammation. The BAPTA-AM co-treatment experiment further supported that the protective effect of BAA depends on the regulation of intracellular calcium homeostasis.Conclusion: BAA exerts antiepileptic effects by inhibiting neuronal calcium overload and modulating the JAK2/STAT3 signaling pathway, thereby attenuating neuroinflammation and apoptosis. These findings provide a solid experimental foundation for developing BAA as a promising antiepileptic candidate and elucidate its multi-target mechanism of action.
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Tao Ma,Chenxing Xu,Siyuan Li,Siqi Hu,Kaizhi Ding,Jinpeng Yu,Pengcheng Wei,Dongting Zhangsun,Xiaopeng Zhu,Sulan Luo
α6β4 nicotinic acetylcholine receptors (nAChRs) represent potential therapeutic targets for pain management; however, studies on the distribution and function of these receptors have been constrained by the scarcity of pharmacological tools. An analogue of α-conotoxin (α-CTx) LvIC from Conus lividus, [D1G, Δ14Q]LvIC, selectively inhibits heterologous rat α6/α3β4 nAChRs (where α6/α3 denotes the chimeric subunit) and represents a promising pharmacological tool. However, its limited stability may restrict further applications. Rational design based on the [D1G, Δ14Q]LvIC analogue led to the identification of a key mutant, [d-Lys11]LvIC, with a half-maximal inhibitory concentration (IC50) of 8.2 nM. The mutant retained the desired activity and substantial selectivity for 11 other nAChR subtypes while demonstrating superior stability in rat serum. Based on these favorable properties, we conjugated the analogue to a BODIPY-FL (BDP) fluorophore to obtain a high-fidelity fluorescent probe, enabling the investigation of α6β4 nAChRs tissue distribution in rats. The fluorescent probe, [d-Lys11]LvIC-BDP, was preliminarily applied to detect a reduction in α6β4 nAChRs expression in a cyclophosphamide (CYP)-induced rat model of interstitial cystitis/bladder pain syndrome (IC/BPS). The development of this fluorescent probe provides an ideal tool for investigating the tissue distribution and functional characterization of α6β4 nAChRs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Yuping Jiang,Fenglan Zhang,Junyao Song,Yi Dai,Yingshan Qu,Zhenzhen Zhu,Wenhua Xu,Jinsheng Shi,Xiaoying Kong
Metformin (Met) is recognized as a star drug with multi-pathway anti-cancer potential, yet conventional Met-based therapies remain limited by insufficient targeting and failure to reverse adaptive metabolic reprogramming. Triple-negative breast cancer (TNBC) cells develop Met resistance via dysregulated mitochondrial oxidative phosphorylation (OXPHOS) and metabolic flexibility. Herein, we present a mitochondrial metabolic reprogramming strategy that fully exploits the dependence of TNBC cells on OXPHOS to induce selective biological energy collapse. A mitochondria-targeted multifunctional nanoplatform (M@AMT NPs) was constructed via integrating ammonia borane (AB), Met, and triphenylphosphine (TPP) onto molybdenum disulfide (MoS 2 ) nanoflowers. M@AMT NPs equipped with pH/NIR-responsive modules enables synchronized hydrogen-photothermal-chemodynamic therapy. TPP moiety enables precise mitochondrial localization, triggering a self-amplifying therapeutic cycle wherein local hydrogen/photothermal/chemodynamic perturbation-induced mitochondrial dysfunction abrogates OXPHOS and consequently exacerbates subsequent metabolic catastrophe. Mitochondria-localized H 2 synergizes with Met to disrupt ATP production, downregulate heat shock proteins, and restore Met sensitivity. In contrast to conventional resistance-reversing interventions, this approach exploits the intrinsic metabolic adaptability of resistant cancer cells to provoke self-driven collapse. This work establishes a new class of metabolically adaptive nanomaterials capable of reprogramming mitochondrial energy metabolism, offering a versatile platform for precision therapy against Met-resistant TNBC.
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Haoduo Yang,Yiheng Wu,Yu Zhang,Bo Li,Yong-Jiang Xu
Sea buckthorn polyphenols (SBPs) have been reported to alleviate insulin resistance (IR), but their key bioactive compounds and underlying mechanisms remain unclear. In this study, 48 phenolics were annotated from four sea buckthorn varieties. SBPs improved glucose consumption and glycogen synthesis in IR-HepG2 cells, with MON showing the most pronounced effect. Correlation analysis suggested positive associations between several phenolics, including isorhamnetin, kaempferol, quercetin, eriodictyol, and catechin, and cellular glucose metabolism-related indicators. Network pharmacology identified these compounds as representative candidates associated with IR-related targets, including JNK, IRS-1, PI3K, and AKT. Molecular docking further suggested favorable predicted binding affinities between candidate phenolics and selected targets, with isorhamnetin showing relatively strong predicted affinity and cellular activity. Therefore, isorhamnetin was selected as a representative key candidate for mechanistic validation. Mechanistically, isorhamnetin reduced inflammatory and oxidative stress responses, modulated the JNK/IRS-1/PI3K/AKT signaling pathway, promoted glycogen synthesis, suppressed gluconeogenesis, and improved glucose utilization in IR-HepG2 cells. These findings provide preliminary in vitro evidence that isorhamnetin-rich SBPs may serve as promising dietary candidates for improving IR-related glucose metabolic dysfunction.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）