ACS Applied Materials & Interfaces
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2022
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IF 10.383
Shu-Yi Yao,Hao Li,Min Zhou,Tian-Chi Wang,Xue Yu,Yin-Sheng Xu,Jian-Hong Yi,Jian-Bei Qiu,Jie Yu,Xu-Hui Xu
X-rays play an extremely significant role in medical diagnosis, safety testing, scientific research, and other practical applications. However, as the main sources of radioactive pollution, the hazard of X-rays to human health and the environment has been a major concern. Herein, the explored perovskite scintillator of Cs2Zr1–xPbxCl6 in this work exhibits an ultrahigh radioluminescence intensity owing to the enhanced X-ray absorption for the introduction of Pb2+ ions. The Cs2Zr1–xPbxCl6 crystals are demonstrated as efficient scintillators with a self-trapped exciton emission and extremely high steady-state light yield (∼101,944 photons meV–1). This fascinating scintillator provides a convenient visual tool for X-ray detection even for an indoor lighting environment, reaching a low detection limit of ∼14.2 nGy·s–1, which is about 1/387 of the typical medical imaging dose (5.5 μGy·s–1). Moreover, X-ray imaging with a high resolution of 16.6 lp·mm–1 is achieved with the as-explored Cs2Zr1–xPbxCl6 scintillator film. Herein, the Cs2Zr1–xPbxCl6 scintillator provides a feasible strategy for X-ray monitoring in the field of biomedicine, high-energy physics, national security, and other applications.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Yanan Jia,Lin Hao,Jun Zhang,Xing Zhang,Siying An,Ming Su,Huan Wang,Yufan Zhang
We describe a PCR-free, enzyme-free, and simple biosensing platform for the electrochemical monitoring of telomerase activity based on Au nanorods (AuNRs) as an electrocatalytic redox mediator, which enhances the electrochemical signal by catalyzing acetaminophen (AP). In this process, acid-functionalized ordered mesoporous carbon (OMC) was modified on a glassy carbon electrode (GCE) surface to offer -COOH sites. Moreover, the amino-modified S1 was fixed on the modified electrode by conducting an amide reaction. TS is extended to (TTAGGG) n repeat units in the presence of telomerase extract and dNTPs. One end (5′) is hybridized with S1 on the electrode, and the remaining end (3′) is combined with AuNRs-S2 probe. Clearly, the telomerase activity is relevant to the amount of connected AuNRs, resulting in different response signals. Therefore, with the telomerase extension triggered hybridization reaction, a large amount of AuNRs catalyst was introduced onto the surface of GCE as the sensing platform, thus achieving a sensitive electrochemical telomerase activity assay in the range of 20–2.15 × 10 6 HeLa cells mL −1 . This sensing platform shows that the limit of detection is 1.74 HeLa cells mL −1 , thus providing a promising method for the determination of telomerase activity and a powerful biosensor for accurate cancer monitoring and diagnosis.
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Catalysts
·
2022
·Vol. 12
·期 11
·1357
·
IF 4.501
Sijin Zuo,Yinqiao Zhang,Ruixin Guo,Jianqiu Chen
Spent caustic wastewater produced in a soda plant has a high concentration of ammonia nitrogen (NH4+-N). As excessive NH4+-N discharging into water bodies would cause eutrophication as well as destruction to the ecology balance, developing an efficient technology for NH4+-N removal from the spent caustic wastewater is imperative in the current society. In this study, an electrochemical process with graphene electrodes was designed for the NH4+-N removal in the spent caustic wastewater. The removal efficiency of the NH4+-N during the electrochemical process could reach 98.7% at 4 A in a short treatment time (within 120 s) with an acceptable energy consumption (6.1 kWh/m3-order). NO3−and NO2−were not detected during the electrochemical process. An insignificant amount of NH2Cl, NHCl2, and NCl3produced in the treatment suggested that little of the NH4+-N reacted with chlorine, that is, chlorination played a negligible role in the NH4+-N removal. By electron equilibrium and nitrogen conversion analysis, we think that NH4+-N was primarily converted to NH2(ads) on the surface of a graphene electrode by one-electron transfer during the direct oxidation of the electrochemical process. Due to the high calcium ion (Ca2+) in the spent caustic wastewater, the electrode scale significantly increased to 1.4 g after treatment of 240 s at 4 A. By X-ray diffraction (XRD) analysis, the composition of the electrode scale is portlandite Ca(OH)2. Although the electrode scale was obvious during the electrochemical treatment, it could be alleviated by alternating the electrode polarity. As a result, the life and efficiency of the graphene electrode for NH4+-N removal could remain stable for a long time. These results suggest that the electrochemical process with a graphene electrode may provide a competitive technology for NH4+-N removal in spent caustic wastewater treatment.Keywords:ammonia nitrogen;electrochemistry;spent caustic;graphene electrode;electrode scale
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2022
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IF 4.52
Junli Feng,Yuanyuan Wu,Jian Zhang,Renyao Jin,Yinlai Li,Qing Shen
Microcystin-LR (MC-LR) contamination in aquatic foods is a serious health threat to people. Here, a simple aptamer-based colorimetric lateral flow assay (LFA) was developed for on-site and visual detection of MC-LR for the first time. This detection system was designed on the basis of competition for Apt-A2C aptamer between MC-LR and its partial complementary sequence. Apt-A2C modified gold nanoparticles (AuNPs) were used as the signal reporter to realize the colorimetric readout by naked eyes, and the signal intensity of test line was inversely proportional to the concentration of MC-LR in the sample solution. Under optimized conditions, this aptamer-based LFA platform can visually detect MC-LR as low as 2.5 ng/mL with a linear range of 1–50 ng/mL, and an instrumental limit of detection of 0.84 ng/mL using a scanning strip reader. The whole assay can be finished within 5 min, starting from sample loading to color acquisition. The developed aptamer-based LFA was successfully applied in the detection of MC-LR in spiked fish tissue samples with the recovery rates ranged from 74.3% to 85.6%, and the results agreed well with those of tandem mass spectrometry . Besides, it had excellent selectivity toward MC-LR as the detection results were not affected by the potentially interfering molecules in real aquatic food matrix. Therefore, the LFA strip is an easy-to-use tool for instrument-free detection of MC-LR, and it can be applied to other toxins in aquatic foods with available aptamers.
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Biomass Conversion and Biorefinery
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2023
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IF 4
Si Lin,Hou Juying,Lv Wei,Hou Qin,Xu Zhixiang,Ai Shiyun
In this paper, lignocellulose components were separated under mild conditions to achieve hierarchical utilization of biomass. Cellulose was retained in cellulose pulp with highly crystalline structure, and lignin powder was recovered, which offered a possibility for the high-value utilization of lignocellulosic biomass. The extracted lignin (EL) was carbonized and activated to prepare lignin-based porous carbon microspheres (LPCMs) and further used as a substrate to interact with fluorescein-5-isothiocyanate (5-FITC) for the detection of biogenic amines (BAs). The fluorescence of 5-FITC was found to be quenched in the presence of LPCMs. And then, upon addition of BAs, 5-FITC was released from the surface of LPCMs, which resulted in the fluorescence recovery of 5-FITC. Thus, a novel “turn off–on” fluorescent probe was constructed for sensitive and visual detection of BAs. Meanwhile, the retained cellulose skeleton structure was used to prepare a smart identification label for real-time and visual evaluation of the freshness of pork and shrimp. This work realized the improvement of comprehensive utilization rate of lignocellulose and developed a rapid, efficient, and sustainable method which combined natural lignocellulose materials with green analytical technology for visually evaluating food quality.
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MATERIALS & DESIGN
·
2023
·
IF 8.4
Bo Chen,Linrui Cai,Rangrang Fan,Min Mu,Di Chuan,Yangmei Ren,Haifeng Chen,Gang Guo
Photodynamic therapy (PDT) as emerging phototherapy has attracted extensive attention in cancer therapy. However, the overexpressed glutathione (GSH) and hypoxic conditions of the tumor microenvironment (TME) sevely limit the therapeutic efficiency of PDT. Herein, we design a multifunctional nanoplatform (CBDM) for cancer therapy consisting of photosensitizer (Ce6), bovine serum albumin (BSA), and polydopamine-manganese dioxide (MnO 2 ) nanocomplex, which is simultaneously modified by nucleolin-targeting AS1411 aptamer. This MnO 2 -based nanoplatform ameliorates tumor hypoxia and promotes oxygen production via the reaction between MnO 2 and endogenous H 2 O 2 and acid H + in the TME. Besides, this biocompatibility nanoplatform exhibits an augmented PDT effect and high photothermal conversion efficiency under 808 nm laser irradiation. Importantly, the MnO 2 -based nanoplatform achieves a significant in vivo synergistic therapeutic effect and fights against liver metastasis of breast cancer. As a result, the excellent biocompatibility, especially the superior anticancer efficacy, and suppression of tumor metastasis make the MnO 2 -based nanoplatform a promising candidate for cancer therapy.
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SENSORS AND ACTUATORS B-CHEMICAL
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2022
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IF 9.221
Weiming Lin,Shuxia Lai,Dechan Lu,Qun Zhang,Xueliang Lin,Juqiang Lin,Jing Wang,Zufang Huang
Liquid-phase-based direct surface-enhanced Raman spectroscopy (SERS) has extensive applications in the field of (bio)chemical analyses. Yet, existing techniques are generally constrained by signal fluctuations caused by the evaporation effect. Liquid marbles, acting as enclosed microreactors , have been proposed to minimize the evaporation effect and have shown great application potentials in microfluidics and sensors. Herein, an acousto-assisted liquid-marble-based SERS platform was proposed to achieve non-destructive and rapid coalescence of liquid marbles and the subsequent high-sensitivity SERS detection. To evaluate the feasibility of our platform, alkaline phosphatase (ALP)—an important diagnostic indicator for specific human diseases (e.g., osteoporosis, lymphoma, leukemia, and hepatitis)—was selected. Our proposed method achieved a remarkable sensitivity of detecting the ALP activity, with a limit of detection of 0.33 UL −1 . We also determined the ALP activity in ten complex human serum samples, showing excellent consistency with the ones obtained by the commercial ALP assay kit. We envision that our acousto-assisted liquid-marble-based SERS platform could be further applied as a versatile and reliable technique for liquid-phase biomedical and chemical applications, with the advantages of negligible evaporation and fully automatic mixing operations.
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Acta Biomaterialia
·
2022
·
IF 10.633
Yingzheng Zhao,Pengpeng Xue,Gaolong Lin,Mengqi Tong,Jiaojiao Yang,Yingying Zhang,Kunjie Ran,Deli Zhuge,Qing Yao,Helin Xu
Ulcerative colitis (UC) usually occurs in the superficial mucosa of the colorectum. Here, a double-network hydrogel (PMSP) was constructed from maleimided γ-polyglutamic acid and thiolated γ-polyglutamic acid through crosslinking of thiol-maleimide and self-oxidized thiols. PMSP with a negative charge specifically adhered to the inflamed mucosa with positively charged proteins rather than to the healthy mucosa. PMSP exhibited good mechanical strength with storage modulus (G′) of 17.6 Pa and a linear viscoelastic region (LVR) of 107.2% strain. Moreover, PMSP showed a stronger bio-adhesive force toward the inflamed tissue-mimicking substrate than toward its healthy counterpart. In vivo imaging confirmed that PMSP specifically adhered to the inflamed colonic mucosa of rats with TNBS-induced UC. KPV (Lys-Pro-Val) as a model drug was easily captured by PMSP through electrostatic interactions , thus retaining its bioactivity for a longer time under high temperature conditions. Moreover, the alleviating effect of KPV on rats with TNBS-induced colitis was significantly improved by PMSP after intracolonic administration. The epithelial barrier of the colon also effectively recovered following PMSP-KPV treatment. PMSP-KPV also modulated the gut flora, markedly augmenting the abundance of beneficial microorganisms in gut homeostasis . The mechanism by which PMSP-KPV induces a therapeutic effect may be associated with the inhibition of oxidative stress . Conclusively, the PMSP hydrogel seems to be a promising rectal delivery system for the therapy of UC. Statement of significance Ulcerative colitis (UC) is a chronic and relapsing disease of the gastrointestinal tract . A key therapeutic approach to treat UC is to repair the mucosal barriers. Here, a double-network hydrogel (PMSP) was constructed from maleimided and thiolated γ-polyglutamic acid through crosslinking of thiol-maleimide and self-oxidized thiols. The negatively charged PMSP specifically adhered to the inflamed colon rather than its healthy counterpart and was retained for a longer time. KPV as a model drug was easily captured by PMSP, which provided better stability to KPV when exposed to high temperature of 50 °C. The epithelial mucosal barrier of the colon was effectively recovered by the rectal administration of PMSP-KPV to rats with TNBS-induced UC. Moreover, PMSP-KPV modulated the gut flora of colitic rats, markedly augmenting the abundance of beneficial microorganisms. Conclusively, PMSP seems to be a promising rectal delivery system for UC therapy.
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Hanxiao Zhou,Huimin Shang,Tianhui Li,Wenjing Liu,Zhihao Guo,Yuxuan Guo,Jingjing Gao,Meizhen Qu,Huan Zhang,Gongchang Peng
Lithium anodes have attracted much attention because of their high energy density, but the existence of lithium dendrites tremendously limits their practical application. Herein, it is creatively proposed to employ N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) as an electrolyte additive to stabilize the solid electrolyte interface. BSTFA is reduced on the lithium anode surface prior to other components to form a passivation layer composed of LiF, Li3N, and SiOx, which not only significantly prevents the continuous consumption of the electrolyte and reduces side reactions but also effectively promotes the uniform deposition of lithium ions with fast Li+ transmission, thereby solving the problem of lithium dendrites. Electrochemical results indicate that BSTFA can obviously reduce polarization in a Li||Li battery at a current density of 1 mA cm–2. Besides, an excellent cycling performance (107 mA h g–1) and Coulombic efficiency (99%) can be obtained for a Li||LiNi0.6Co0.2Mn0.2O2 (NCM622) battery with 0.5 wt % BSTFA at 2 C after 200 cycles, even at a high NCM622 loading of 6 mg cm–2.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Danning Fu,Ruibin Wang,Yang Wang,Qianyu Sun,Chen Cheng,Xiaohui Guo,Rendang Yang
To date, flexible pressure sensors built on silver nanowires (AgNWs) have attracted tremendous attention, owing to their versatile applications in wearable, human-interactive, health-monitoring devices. Cellulose and its derivatives, which show great promise in serving flexible pressure sensors as the desired substrate due to their natural abundance, biocompatibility, easy processibility, and low costs. Herein, we reported a rational strategy to design a silver nanowires-dual-cellulose conductive paper. Its morphology, chemical and crystal structures, thermal stability , mechanical performances, and electrical properties were carefully studied. The results suggested that good tensile properties (tensile strength ≤8.10 MPa), high electrical conductivity (≤ 1.74 × 10 4 S·m −1 ) with long-term stability, and good adhesion stability (bending cycles over 500) were obtained. Furthermore, the use of such conductive paper as substrate for versatile flexible pressure sensors was demonstrated, which exhibited fast response (~ 0.48 s) and high sensitivity, in response to finger motion, voice recognition, and human pulse, etc.
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Catalysts
·
2022
·Vol. 12
·期 1
·83
·
IF 4.501
Cuiping Yu,Weilong Wu,Min Gao,Yu Liu
Asymmetric catalysis is the preferred method for the synthesis of pure chiral molecules in the fine chemical industry. Cellulose has long been sought as a support in enantioselective catalysis. Dialdehyde cellulose (DAC) is produced by the selective oxidation of cellulose and is used to bind 5,5′-diamino Binap by forming a Schiff base. Here, we report the synthesis of modified cellulose-supported Rh as a novel biomass-supported catalyst and the characterization of its morphology, composition, and thermal stability. DAC-BINAP-Rh was a very effective catalyst in the asymmetric hydrogenation of enamides and could be easily recycled. This work provides a novel supported catalyst that broadens the applications of cellulose in asymmetric catalysis.Keywords:asymmetric hydrogenation;cellulose;BINAP;heterogeneous catalysis
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Biomass Conversion and Biorefinery
·
2022
·Vol. 13
·期 13
·11947-11957
·
IF 4.05
Xing Xiu,Zhou Zi-Wen,Wei Yun-Jie,Liu Yan-Hong,Li Kun,Yu Xiao-Qi,Wang Na
The process of jatropha oil transesterification was studied for biodiesel production. Rhizomucor miehei lipase (RML) immobilized on 3-aminopropyltriethoxysilane functionalized magnetic Fe 3 O 4 was employed as a biocatalyst. The immobilized lipase was confirmed by scanning electron microcopy (SEM), Fourier transform infrared spectra (FT-IR), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), and confocal laser scanning microscopy (CLSM) techniques. The efficient biodiesel synthesis in ionic liquids using immobilized RML was demonstrated. Fifteen kinds of ionic liquids based on different alkyl chain lengths of the methyl imidazolium cation ([C 2 MIM], [C 4 MIM], [C 8 MIM], [C 12 MIM], and [C 16 MIM]) combined with [NTf 2 ], [N(CN) 2 ], [PF 6 ] or [BF 4 ] anions were assayed as reaction media for RML producing biodiesel. The highest synthetic activity of immobilized RML appeared in [BMIM][PF 6 ], which is more than five times higher than the free enzyme. The enzyme catalytic activity remained 60% even after the magnetic nano-biocatalyst and ionic liquid had been reused 5 times in a 48-h reaction cycle. In addition, the immobilized enzyme exhibited excellent storage stability with almost no decrease in catalytic activity after storing at − 20 °C for 98 days.
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危险品化学品经营许可证（带存储）